For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social

#FluorescentFriday The lab’s 1st slice physiology recordings! Timelapse recording of striatal neurons ex vivo using a Thy1-GCaMP mouse 🐭 🧠 + glutamate in the bath. Thanks @neuromanonyc.bsky.social! Shout out to @keyenceusa.bsky.social who has been great to work with customizing the BZ-X800🔬

This speaks to the importance of cross-species research that is constantly forward- & back-translated between the clinic & lab. The importance of animal models leading to unanticipated discoveries - even in the realm of human psychology - is invaluable, especially in psychiatry🧠 tinyurl.com/yur3j2n8

Here, we discovered LINC00473 in mPFC specifically altered change-of-mind decisions in female mice only. This was driven by enhanced sensitivity to sunk costs and how much re-evaluating recent mistakes influenced future choices. This is the 1st demo of non-coding RNA playing a role in cognition 5/6

A recent study led by @ornaissler.bsky.social found levels of the non-coding RNA LINC00473 were reduced specifically in mPFC 🧠 of women but not men diagnosed with MDD, based on post-mortem human 🧠 tissue studies. Expressing LINC00473 in mPFC promotes resilience to stress in female mice only. 4/6 🐭

Women are 2x as likely to develop depression than men. Major depressive disorder can manifest w different symptoms b/t sexes, including alterations in negative rumination on the past. Combining clinical questions, behavioral neuroscience, & translational #neuroeconomics, we dove into this deeper 3/6

We found striking sex differences in only change-of-mind choices, and not initial value-based judgements, in mice 🐭 working for food rewards of varying costs (delays ⏰) & preferences (flavors 🧀🍌🍫🍇) on our #neuroeconomic foraging task, Restaurant Row, while on a limited daily time budget. 2/6

From my graduate lab - single units in OFC & NAc as well as population decoding. Firing / representations of missed rewards into the next trial but only when encountering a worse offer on the next trial following an economic violation. Counterfactual / regret signals.

www.nature.com/articles/nn....

Hi #ACNP2024 6th conference for me! I’m a physician-scientist Asst Prof in Psychiatry & Neuroscience studying decision-making across species. Come to our poster T185 on REGRET in humans. Huge collaboration across multiple labs - we want your help as a field to define this construct!🧠 #neuroeconomics

Excited for #SfN23 this year! 🧠 🐭🧠🐭🧠🐭🧠 Come by our linked posters Sunday Morning OO21-24 to see some of the new collaborations in #NeuroEconomics that have been developing at Mount Sinai!