Sophie Breunig
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breunigsophie.bsky.social
Sophie Breunig
@breunigsophie.bsky.social
Behavioral, Psychiatric, and Statistical Genetics grad student 👩‍💻 @IBG_CUBoulder interested in all things genetics and psychopathology 🧬🧠🦠
Pinned
Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...
Reposted by Sophie Breunig
🚨 New publication: How to improve conceptual clarity in psychological science?

Thrilled to see this article with @ruimata.bsky.social out. We discuss how LLMs can be leveraged to map, clarify, and generate psychological measures and constructs.

Open access article: doi.org/10.1177/0963...
October 23, 2025 at 7:27 AM
Our new preprint is out: "Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders"! 🧬🦠

www.medrxiv.org/content/10.1...
Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders
This study explored the genetic links between 11 immune-mediated diseases and 13 psychiatric disorders, addressing the limited understanding of what links these illnesses. Utilizing genomic structural...
www.medrxiv.org
October 20, 2025 at 8:08 PM
Reposted by Sophie Breunig
Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders https://www.medrxiv.org/content/10.1101/2025.10.17.25338241v1
October 20, 2025 at 5:12 AM
Reposted by Sophie Breunig
🎉 New preprint out!

"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"

We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease

👉 doi.org/10.1101/2025...
October 16, 2025 at 9:16 PM
Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...
July 21, 2025 at 7:01 PM
Reposted by Sophie Breunig
Check out this new work from IBG graduate student @breunigsophie.bsky.social that applies Genomic SEM to examine the relationship between genomic factors for immune-mediated diseases and psychiatric disorders. www.nature.com/articles/s41...
Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders - Translational Psychiatry
Translational Psychiatry - Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders
www.nature.com
July 21, 2025 at 5:11 PM
Reposted by Sophie Breunig
Type 1 diabetes (T1D) and other autoimmune diseases often co-occur in families. Leveraging data from 12.6K genotyped trios in @finngen.bsky.social, our work - online today in Cell Genomics - studied the transmission of parental autoimmune diseases on T1D in offspring.

www.cell.com/cell-genomic...
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen, Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring T1D. Their creative and r...
www.cell.com
April 25, 2025 at 8:40 PM
Reposted by Sophie Breunig
Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing Psychopathology https://www.medrxiv.org/content/10.1101/2025.02.05.25321732v1
February 6, 2025 at 11:40 PM
Reposted by Sophie Breunig
One of my talented graduate students (@breunigsophie.bsky.social) is putting together an immune-psychiatric focused symposium submission for the Behavior Genetics Association 2025 meeting in Atlanta. She needs one more talk to fill the symposium; if interested send me a message!
January 28, 2025 at 9:52 PM
Reposted by Sophie Breunig
🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.
GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.
A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics
github.com
November 28, 2024 at 9:21 AM
Reposted by Sophie Breunig
You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2
www.medrxiv.org/content/10.1...
Genomic network analysis characterizes genetic architecture and identifies trait-specific biology
Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...
www.medrxiv.org
December 6, 2024 at 3:56 PM
Reposted by Sophie Breunig
With @kph3k.bsky.social (Paige Harden) I have a comment on an execrable paper by Rindermann et al, about the IQs of recent immigrants to Germany. Blog post and link to article below. More to come.

ericturkheimer.substack.com/p/immigratio...

journalofcontroversialideas.org/article/4/2/...
Controversy Requires Competence: Comment on Rindermann et al. (2024)
Rindermann, Klauk, and Thompson (2024) purport to give evidence regarding the determinants of intelligence test scores among refugees who have immigrated to Germany from different countries of origin,...
journalofcontroversialideas.org
October 31, 2024 at 5:58 PM
Reposted by Sophie Breunig
As an editor, I help people say what they mean--and not say what they don’t mean. Here are some common not-quite-right words or expressions that I often see. This is not to embarrass anybody--I've made many of these mistakes myself. Please share your favorite fixes at the end of the thread. (1/n)
October 1, 2024 at 12:31 PM
Come join our lab! 🧬
🚨Writing to say that I am actively recruiting PhD students in the clinical -or- behavioral, psychiatric, and statistical genetics program (BPSG) at CU Boulder for a Fall 2025 start date. My lab focuses on genomic methods development and applications to psychiatric and aging outcomes (e.g., dementia)
September 23, 2024 at 9:13 PM
Reposted by Sophie Breunig
I’ve seen the best minds of my generation ruined by Wissenschaftszeitvertragsgesetz
September 20, 2024 at 10:57 AM
Reposted by Sophie Breunig
I am recruiting a PhD student, co-supervised with George Davey-Smith, Gareth Hawkes and Laura Corbin to study trait residualized for known genetic influences, please Apply! gw4biomed.ac.uk/shining-a-li...
Shining a light on the un-common to identify novel health risk-factors - GW4 BioMed MRC DTP
Project Code MRCPHS25Br Nivard Research Theme Population Health Sciences Project Summary Download Summary Complex traits such as body mass index and height are influenced by a mixture of genetic and e...
gw4biomed.ac.uk
September 2, 2024 at 4:03 PM
New preprint just dropped! 🧬🦠
For this project, we looked at the genetic relationships between psychiatric disorders and immune-mediated diseases.

Check out the full paper here: www.medrxiv.org/content/10.1...
Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders
medRxiv - The Preprint Server for Health Sciences
www.medrxiv.org
August 15, 2024 at 4:22 PM
Reposted by Sophie Breunig
Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders https://www.medrxiv.org/content/10.1101/2024.07.18.24310651v1
Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders https://www.medrxiv.org/content/10.1101/2024.07.18.24310651v1
Importance: Autoimmune and autoinflammatory diseases have been linked to psychiatric disorders in th
www.medrxiv.org
July 19, 2024 at 6:40 PM
Reposted by Sophie Breunig
On 4th- 8th March 2024 we’ll organize the International Statistical Genetics (ISG) in Boulder, Colorado. There are still some spots open and there is financial aid available for those who meet certain criteria: www.colorado.edu/ibg/workshop
December 4, 2023 at 8:35 AM