Aoxing Liu
@aoxing2.bsky.social
postdoc with Mark Daly at Broad Institute & MGH - curious about (large) chromosome alterations & (deep) human pedigrees + immunity, cancer & their interplay :)
If you’re looking for highly heritable quantitative traits (beyond height!) to test your new methods, these “lab values” could be your next model traits!!
We did so in our pedigree-BLUP work:
we estimated family-based h2 & compared it to SNP h2 to clarify the different concepts of heritability!!
We did so in our pedigree-BLUP work:
we estimated family-based h2 & compared it to SNP h2 to clarify the different concepts of heritability!!
October 24, 2025 at 1:39 AM
If you’re looking for highly heritable quantitative traits (beyond height!) to test your new methods, these “lab values” could be your next model traits!!
We did so in our pedigree-BLUP work:
we estimated family-based h2 & compared it to SNP h2 to clarify the different concepts of heritability!!
We did so in our pedigree-BLUP work:
we estimated family-based h2 & compared it to SNP h2 to clarify the different concepts of heritability!!
New from FinnGen!! 🚀🚀🚀
FinnGen just released GWAS summary statistics for 383 lab measurements (OMOPIDs) - each based on ≥1,000 participants!!
All results are open for browsing & download:
👉 labvalues.finngen.fi.
🧬🧬🧬
Have fun!! 🏄🏄♀️🏄♂️
FinnGen just released GWAS summary statistics for 383 lab measurements (OMOPIDs) - each based on ≥1,000 participants!!
All results are open for browsing & download:
👉 labvalues.finngen.fi.
🧬🧬🧬
Have fun!! 🏄🏄♀️🏄♂️
October 24, 2025 at 12:09 AM
New from FinnGen!! 🚀🚀🚀
FinnGen just released GWAS summary statistics for 383 lab measurements (OMOPIDs) - each based on ≥1,000 participants!!
All results are open for browsing & download:
👉 labvalues.finngen.fi.
🧬🧬🧬
Have fun!! 🏄🏄♀️🏄♂️
FinnGen just released GWAS summary statistics for 383 lab measurements (OMOPIDs) - each based on ≥1,000 participants!!
All results are open for browsing & download:
👉 labvalues.finngen.fi.
🧬🧬🧬
Have fun!! 🏄🏄♀️🏄♂️
Reposted by Aoxing Liu
Comment🚨
Large biobank projects like #FinnGen help in uncovering genetic factors that influence cancer risk and outcomes, enhancing risk prediction & biomarker and drug target discovery.
@finngen.bsky.social @dalygene.bsky.social @aoxing2.bsky.social
📖 👇
Large biobank projects like #FinnGen help in uncovering genetic factors that influence cancer risk and outcomes, enhancing risk prediction & biomarker and drug target discovery.
@finngen.bsky.social @dalygene.bsky.social @aoxing2.bsky.social
📖 👇
Unlocking the potential of FinnGen to advance cancer research - Nature Reviews Cancer
Large biobank projects such as FinnGen have enabled systematic searches for inherited factors that causally influence a wide range of human traits, including cancer risk and outcome. These explorations provide genetic insights for various aspects of cancer research, including improved risk prediction, enhanced biomarker and drug target discovery, and personalized medicine.
bit.ly
October 20, 2025 at 3:01 PM
Comment🚨
Large biobank projects like #FinnGen help in uncovering genetic factors that influence cancer risk and outcomes, enhancing risk prediction & biomarker and drug target discovery.
@finngen.bsky.social @dalygene.bsky.social @aoxing2.bsky.social
📖 👇
Large biobank projects like #FinnGen help in uncovering genetic factors that influence cancer risk and outcomes, enhancing risk prediction & biomarker and drug target discovery.
@finngen.bsky.social @dalygene.bsky.social @aoxing2.bsky.social
📖 👇
Excited (😁) to share a commentary on @finngen.bsky.social & cancer research, co-written with Mervi Aavikko & @dalygene.bsky.social!!
(View-only full text -> rdcu.be/eLlJs)
(View-only full text -> rdcu.be/eLlJs)
October 16, 2025 at 10:27 PM
Excited (😁) to share a commentary on @finngen.bsky.social & cancer research, co-written with Mervi Aavikko & @dalygene.bsky.social!!
(View-only full text -> rdcu.be/eLlJs)
(View-only full text -> rdcu.be/eLlJs)
Join Jesse & me for a 🌟 #ASHG2025 Featured Symposium!!
"Decoding Human Aging: From Single-Cell Resolution to Population-Scale Insights"
⏰ Oct 17, 8:30-10:00 AM
🏡 258ABC, Level 2
With a fantastic ✨ speaker lineup - @albarmeira.bsky.social & Albert (Kejun) & Giulio & @austinargen.bsky.social!
2/n
"Decoding Human Aging: From Single-Cell Resolution to Population-Scale Insights"
⏰ Oct 17, 8:30-10:00 AM
🏡 258ABC, Level 2
With a fantastic ✨ speaker lineup - @albarmeira.bsky.social & Albert (Kejun) & Giulio & @austinargen.bsky.social!
2/n
October 14, 2025 at 3:45 PM
Join Jesse & me for a 🌟 #ASHG2025 Featured Symposium!!
"Decoding Human Aging: From Single-Cell Resolution to Population-Scale Insights"
⏰ Oct 17, 8:30-10:00 AM
🏡 258ABC, Level 2
With a fantastic ✨ speaker lineup - @albarmeira.bsky.social & Albert (Kejun) & Giulio & @austinargen.bsky.social!
2/n
"Decoding Human Aging: From Single-Cell Resolution to Population-Scale Insights"
⏰ Oct 17, 8:30-10:00 AM
🏡 258ABC, Level 2
With a fantastic ✨ speaker lineup - @albarmeira.bsky.social & Albert (Kejun) & Giulio & @austinargen.bsky.social!
2/n
Happy (😀) to invite you to our Talk/Featured Symposium/Poster/Booth at #ASHG2025!!
⏰ Oct 15, 1:30 -1:45 PM
🏡 258ABC, Level 2
I'll be giving a talk on sex chromosome trisomies (XXY, XYY, XXX) - and the surprising new biology of chromosomes X and Y!!
Link: meetings.ashg.org/event/ASHG25...
1/n
⏰ Oct 15, 1:30 -1:45 PM
🏡 258ABC, Level 2
I'll be giving a talk on sex chromosome trisomies (XXY, XYY, XXX) - and the surprising new biology of chromosomes X and Y!!
Link: meetings.ashg.org/event/ASHG25...
1/n
October 14, 2025 at 3:35 PM
Happy (😀) to invite you to our Talk/Featured Symposium/Poster/Booth at #ASHG2025!!
⏰ Oct 15, 1:30 -1:45 PM
🏡 258ABC, Level 2
I'll be giving a talk on sex chromosome trisomies (XXY, XYY, XXX) - and the surprising new biology of chromosomes X and Y!!
Link: meetings.ashg.org/event/ASHG25...
1/n
⏰ Oct 15, 1:30 -1:45 PM
🏡 258ABC, Level 2
I'll be giving a talk on sex chromosome trisomies (XXY, XYY, XXX) - and the surprising new biology of chromosomes X and Y!!
Link: meetings.ashg.org/event/ASHG25...
1/n
Reposted by Aoxing Liu
We’re getting ready for an exciting week at #ASHG2025 in Boston! Come meet the FinnGen team at booth 147 - we’ll be sharing updates and showcasing new public resources and tools. Plus, don’t miss the various presentations featuring FinnGen results across the program!
www.finngen.fi/en/meet-finn...
www.finngen.fi/en/meet-finn...
Meet FinnGen at the ASHG 2025! | FinnGen
Results based on the FinnGen data are presented in almost 40 talks or posters during the 2025 Annual Meeting of the American Society of Human Genetics (ASHG) in Boston, October 14-18. We also have a b...
www.finngen.fi
October 10, 2025 at 11:59 AM
We’re getting ready for an exciting week at #ASHG2025 in Boston! Come meet the FinnGen team at booth 147 - we’ll be sharing updates and showcasing new public resources and tools. Plus, don’t miss the various presentations featuring FinnGen results across the program!
www.finngen.fi/en/meet-finn...
www.finngen.fi/en/meet-finn...
Reposted by Aoxing Liu
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 8, 2025 at 4:31 PM
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Reposted by Aoxing Liu
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
September 22, 2025 at 5:29 AM
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
Our trisomy work is now online! 🚀
Got curious after reading our short PheWAS paper? 👀
Catch me 🌠 & my talk 🎤 this October at #ASHG25 in Boston!
Yes, I am still endlessly curious about sex chromosome aneuploidies - whether it's somatic (X/Y loss) or germline (trisomies)!! 💘
Got curious after reading our short PheWAS paper? 👀
Catch me 🌠 & my talk 🎤 this October at #ASHG25 in Boston!
Yes, I am still endlessly curious about sex chromosome aneuploidies - whether it's somatic (X/Y loss) or germline (trisomies)!! 💘
August 20, 2025 at 11:25 PM
Our trisomy work is now online! 🚀
Got curious after reading our short PheWAS paper? 👀
Catch me 🌠 & my talk 🎤 this October at #ASHG25 in Boston!
Yes, I am still endlessly curious about sex chromosome aneuploidies - whether it's somatic (X/Y loss) or germline (trisomies)!! 💘
Got curious after reading our short PheWAS paper? 👀
Catch me 🌠 & my talk 🎤 this October at #ASHG25 in Boston!
Yes, I am still endlessly curious about sex chromosome aneuploidies - whether it's somatic (X/Y loss) or germline (trisomies)!! 💘
And Figure 1 in the preview summarizes everything so nicely - way better than we authors could!!
Preview: www.cell.com/cell-genomic...
Original research article: www.cell.com/cell-genomic...
Preview: www.cell.com/cell-genomic...
Original research article: www.cell.com/cell-genomic...
June 11, 2025 at 10:05 PM
And Figure 1 in the preview summarizes everything so nicely - way better than we authors could!!
Preview: www.cell.com/cell-genomic...
Original research article: www.cell.com/cell-genomic...
Preview: www.cell.com/cell-genomic...
Original research article: www.cell.com/cell-genomic...
Wow!! Big thanks for the very lovely preview!! 🫶🫶🫶
TOO MANY analyses -> very DIFFERENT feedback on (several of) our submissions - some thought it was too lengthy, others considered the design creative, rigorous.
Perhaps no need to do standard analyses if the data/question itself is not standard...
TOO MANY analyses -> very DIFFERENT feedback on (several of) our submissions - some thought it was too lengthy, others considered the design creative, rigorous.
Perhaps no need to do standard analyses if the data/question itself is not standard...
@agacita.bsky.social & I preview: "Parental autoimmunity genetics & offspring T1D risk" www.cell.com/cell-genomic... for new #CellGenomics study: "Effects of parental autoimmune diseases on T1D in offspring can be partially explained by HLA & non-HLA polymorphisms" www.cell.com/cell-genomic...
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen,
Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring
T1D. Their creative and r...
www.cell.com
June 11, 2025 at 9:14 PM
Wow!! Big thanks for the very lovely preview!! 🫶🫶🫶
TOO MANY analyses -> very DIFFERENT feedback on (several of) our submissions - some thought it was too lengthy, others considered the design creative, rigorous.
Perhaps no need to do standard analyses if the data/question itself is not standard...
TOO MANY analyses -> very DIFFERENT feedback on (several of) our submissions - some thought it was too lengthy, others considered the design creative, rigorous.
Perhaps no need to do standard analyses if the data/question itself is not standard...
Thanks to the @finngen.bsky.social team for years of effort 🫶 in making it a unique resource for genetic discovery, and congratulations to FinnGen researchers (including us 😉) for utilizing the resources smartly!!
May 26, 2025 at 3:53 PM
Thanks to the @finngen.bsky.social team for years of effort 🫶 in making it a unique resource for genetic discovery, and congratulations to FinnGen researchers (including us 😉) for utilizing the resources smartly!!
Hi - Excited to share our two talks at @eshg.bsky.social about @finngen.bsky.social!
Because of ... I cannot join in person, but I will answer your questions online (or write to me)! 🧬
Feiyi & Zhiyu are in Milan now; discuss the BLUP work with them (if you can catch them❤️🔥)!
Enjoy the conference!
Because of ... I cannot join in person, but I will answer your questions online (or write to me)! 🧬
Feiyi & Zhiyu are in Milan now; discuss the BLUP work with them (if you can catch them❤️🔥)!
Enjoy the conference!
May 24, 2025 at 1:31 PM
Hi - Excited to share our two talks at @eshg.bsky.social about @finngen.bsky.social!
Because of ... I cannot join in person, but I will answer your questions online (or write to me)! 🧬
Feiyi & Zhiyu are in Milan now; discuss the BLUP work with them (if you can catch them❤️🔥)!
Enjoy the conference!
Because of ... I cannot join in person, but I will answer your questions online (or write to me)! 🧬
Feiyi & Zhiyu are in Milan now; discuss the BLUP work with them (if you can catch them❤️🔥)!
Enjoy the conference!
Type 1 diabetes (T1D) and other autoimmune diseases often co-occur in families. Leveraging data from 12.6K genotyped trios in @finngen.bsky.social, our work - online today in Cell Genomics - studied the transmission of parental autoimmune diseases on T1D in offspring.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen,
Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring
T1D. Their creative and r...
www.cell.com
April 25, 2025 at 8:40 PM
Type 1 diabetes (T1D) and other autoimmune diseases often co-occur in families. Leveraging data from 12.6K genotyped trios in @finngen.bsky.social, our work - online today in Cell Genomics - studied the transmission of parental autoimmune diseases on T1D in offspring.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Join us April 8-9 for @geneticssociety.bsky.social Spring Symposium on Cancer Genetics!! 🧬
I will present our work on #mCAs & #solid_tumors in @finngen.bsky.social.
Register link: learning.ashg.org/products/202...
Excited to connect with you virtually months before the Boston annual meeting!! 🫶
I will present our work on #mCAs & #solid_tumors in @finngen.bsky.social.
Register link: learning.ashg.org/products/202...
Excited to connect with you virtually months before the Boston annual meeting!! 🫶
March 25, 2025 at 10:47 PM
Join us April 8-9 for @geneticssociety.bsky.social Spring Symposium on Cancer Genetics!! 🧬
I will present our work on #mCAs & #solid_tumors in @finngen.bsky.social.
Register link: learning.ashg.org/products/202...
Excited to connect with you virtually months before the Boston annual meeting!! 🫶
I will present our work on #mCAs & #solid_tumors in @finngen.bsky.social.
Register link: learning.ashg.org/products/202...
Excited to connect with you virtually months before the Boston annual meeting!! 🫶
Thanks @jakphd.bsky.social for the nice introduction about our trisomy work!!! 🫶🫶🫶
Nice paper showing ~1/540 people have a sex chromosome trisomy from 3 large biobanks (UKB, FinnGen, MVP) comprising 1.5 million individuals along with their phenotypic impact.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
February 6, 2025 at 3:41 PM
Thanks @jakphd.bsky.social for the nice introduction about our trisomy work!!! 🫶🫶🫶