Blake R Peterson
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blakerpeterson.bsky.social
Blake R Peterson
@blakerpeterson.bsky.social
1.1K followers 2.3K following 9 posts
Professor and Chair of Medicinal Chemistry at Ohio State; researcher at the interface of chemistry and biology, creating chemical tools for drug discovery
https://pharmacy.osu.edu/directory/blake-r-peterson
https://u.osu.edu/petersonlab/
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Reposted by Blake R Peterson
mcnees.bsky.social
Fly high, metal grandpa.
July 25, 2025 at 2:17 AM
Reposted by Blake R Peterson
ikinglab.bsky.social
I have no other way to say it. This paper blows my f@&!ing mind:

www.science.org/doi/10.1126/...
In vivo CAR T cell generation to treat cancer and autoimmune disease
Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity f...
www.science.org
July 10, 2025 at 3:59 PM
Reposted by Blake R Peterson
aaandmoore.bsky.social
This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.
June 11, 2025 at 12:55 AM
Reposted by Blake R Peterson
chemjobber.bsky.social
The 2026 Chemistry Faculty Jobs List has 4 tenure-track positions: docs.google.com/spreadsheets... #facultychemjobs #chemsky #chemjobs
The 2026 Chemistry Faculty Jobs List
docs.google.com
June 10, 2025 at 3:14 PM
Reposted by Blake R Peterson
tiffweinkopff.bsky.social
“universities contributed patents underpinning 50% of FDA-approved drugs…

NIH-funded basic science has contributed to the development of more than 90% of new medicines, vaccines, and devices…

75% of scientists in America were considering leaving the country.”

www.statnews.com/2025/06/06/u...
We set out to quantify U.S. academic contributions to medicines. The results stunned even us
From 2020 to 2024, universities contributed patents underpinning 50% of FDA-approved drugs. 87% of those academic breakthroughs came from American institutions.
www.statnews.com
June 7, 2025 at 5:21 PM
Reposted by Blake R Peterson
antoniohenriques.bsky.social
God, it's brutal out here
April 6, 2025 at 8:06 PM
Reposted by Blake R Peterson
science.org
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 6:05 PM
Reposted by Blake R Peterson
erictopol.bsky.social
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
graph of NIH basisfor new drugs
March 23, 2025 at 4:17 PM
Reposted by Blake R Peterson
hartungingo.bsky.social
Summary: 1st Ph3 readout for a #PROTAC; likely path-to-approval in metastatic breast cancer patients w/ ESR1 mutations after having received endocrine therapy & CDK4/6 inhibitors; in line with previous clinical data; stock brokers don‘t understand Ph1/2 data. www.fiercebiotech.com/biotech/pfiz...
Pfizer, Arvinas post mixed breast cancer survival results in first phase 3 test for a PROTAC degrader
Pfizer and Arvinas’ estrogen receptor (ER) degrader has
www.fiercebiotech.com
March 12, 2025 at 6:44 AM
Reposted by Blake R Peterson
krhornberger.bsky.social
There’s a frequent perception among recent entrants to drug discovery world that if we could just find drug candidates faster, this will be a useful accelerant to the overall process. The issue is: this thinking is mostly (but not entirely) incorrect. 🧵 1/
January 16, 2024 at 6:31 PM
blakerpeterson.bsky.social
Happy Holidays from the Peterson lab and the OSUCCC Drug Discovery Shared Resource HTS lab at Ohio State!
@osucccjames.bsky.social
Members of the Peterson lab and the Drug Discovery Shared Resource High Throughput Screening lab at The Ohio State University celebrating the holidays in December 2024.
December 15, 2024 at 3:33 PM
blakerpeterson.bsky.social
Super proud of Xiaojun Hu for a successful defense of his PhD in Pharmaceutical Chemistry (Medicinal Chemistry specialization)! Xiaojun was the first Ohio State graduate student to join my group after I moved here in 2019.
Celebrating Xiaojun Hu's successful defense of his PhD in Pharmaceutical Sciences (Medicinal Chemistry specialization)
December 11, 2024 at 4:40 PM
Reposted by Blake R Peterson
scientificdiscovery.dev
Americans are now one-third less likely to die from cancer at the same ages as Americans in 1990
How has the risk of dying from cancer changed in the United States? To understand this, we can look at national cancer death rates in the United States. The gray line shows the crude rate, which is the rate of deaths from cancer per 100,000 people. It has risen between 1950 and 1990 and has fallen slightly since then. However, cancer death rates rise sharply with age, and the age of the US population has increased since 1950, so we would expect cancer death rates to rise for that reason alone. What if we adjust for the increased age of the US population? The red line, the age-standardized rate, shows this. It shows the cancer death rate if the age structure of the US population was held constant throughout. This shows a slight rise until 1990 and then a significant decline; rates have fallen by one-third. This means Americans are now one-third less likely to die from cancer at the same ages as Americans in 1990. This comes from several factors: better screening and earlier diagnosis, medical advances in cancer treatments, and public health efforts to reduce risk factors like smoking and exposure to carcinogens.
December 9, 2024 at 10:02 AM
Reposted by Blake R Peterson
dereklowe.bsky.social
Fluorescently labeled proteins are essential to research. But we should never forget how messed-up their behavior can be. An example from condensates:
Fluorescent Tags Are Basically Never Silent
www.science.org
December 2, 2024 at 6:56 PM
Reposted by Blake R Peterson
timobrien.bsky.social
“Scientists..found that those who often smoked, drank or ate processed meats were prone to accelerated organ aging, while anyone who regularly exercised or ate oily fish was far more likely to have youthful organs.” www.washingtonpost.com/wellness/202...
Inside your body, aging unfolds at remarkably different rates
New research shows aging is not a uniform process. Parts of our bodies start aging earlier than others, right down to our organs and cells.
www.washingtonpost.com
November 30, 2024 at 4:15 PM
Reposted by Blake R Peterson
dittie.sheshed.rocks
If you have a PC or Mac, with a Chrome browser, use Sky Follower Bridge to find the followers that you had on Twitter over here.

It’s very easy to use !

chromewebstore.google.com/detail/sky-f...
Sky Follower Bridge - Chrome Web Store
Instantly find and follow the same users from your Twitter follows on Bluesky.
chromewebstore.google.com
November 25, 2024 at 5:48 PM
Reposted by Blake R Peterson
georgetakei.bsky.social
Anyone who is anti-vax is pro-death. Period. The science and data do not lie. And they don’t care about your podcast.
Post showing precipitous decline of share of deaths in Massachusetts from diseases for which vaccines are now available, from 70% in 1840 to low digits % by 1950-60 where it is stayed. Caption: There are not many places on earth where we have detailed cause-of-death data from before the era of widespread vaccination. Massachusetts is one of those places. From 1842-1877, 70% of all deaths were from diseases which we today have vaccines to prevent.
November 24, 2024 at 10:52 PM
Reposted by Blake R Peterson
drannecarpenter.bsky.social
Cartoon of man on plane with hand raised, saying “These smug pilots have lost touch with regular passengers like us. Who thinks I should fly the plane?”
November 15, 2024 at 11:16 AM
Reposted by Blake R Peterson
bagphos.bsky.social
Types of MedChem papers
#ChemSky
November 12, 2024 at 1:41 AM
Reposted by Blake R Peterson
krhornberger.bsky.social
Skeetorial time! We need to chat about pharmacokinetics & pubs. If you plan to publish in vivo PD/efficacy studies, the minimum credible accompanying PK package is an IV leg + an IP/PO leg if that's your eventual route. In the same species, preferably at the planned efficacy dose. 1/
a close up of a hamster 's face and paws
ALT: a close up of a hamster 's face and paws
media.tenor.com
November 9, 2024 at 5:53 PM