Bernat Olle
@bernatolle.bsky.social
Founder and CEO at Vedanta Biosciences
Reposted by Bernat Olle
Countdown to #GAMRIC2025: The inaugural Global AMR Innovators Conference kicks off tomorrow in London!
Join CARB-X and global leaders as we dive into discussions about #AMR policy and antimicrobial research and development. #GlobalHealth #CARBX #IDSky 🧪
Join CARB-X and global leaders as we dive into discussions about #AMR policy and antimicrobial research and development. #GlobalHealth #CARBX #IDSky 🧪
September 30, 2025 at 8:00 AM
Countdown to #GAMRIC2025: The inaugural Global AMR Innovators Conference kicks off tomorrow in London!
Join CARB-X and global leaders as we dive into discussions about #AMR policy and antimicrobial research and development. #GlobalHealth #CARBX #IDSky 🧪
Join CARB-X and global leaders as we dive into discussions about #AMR policy and antimicrobial research and development. #GlobalHealth #CARBX #IDSky 🧪
Reposted by Bernat Olle
My new review article covers key points I have not seen in any other review of cancer immunotherapy: i) the difference between IFN-a and IFN-b; ii) the unique role of P1 pDC among all DC subsets; iii) the unique role of TLR7/8/9 among TLRs
nam10.safelinks.protection.outlook.com?url=http%3A%...
nam10.safelinks.protection.outlook.com?url=http%3A%...
New insights into the role of IFN-α/β and TLR7/8/9 in cancer immunotherapy and systemic autoimmunity
The role of type I interferon (IFN) in mediating tumor immunosurveillance, in situ vaccination, and response to other cancer immunotherapies is well established. The biologic and species-specific diff...
nam10.safelinks.protection.outlook.com
September 19, 2025 at 12:57 PM
My new review article covers key points I have not seen in any other review of cancer immunotherapy: i) the difference between IFN-a and IFN-b; ii) the unique role of P1 pDC among all DC subsets; iii) the unique role of TLR7/8/9 among TLRs
nam10.safelinks.protection.outlook.com?url=http%3A%...
nam10.safelinks.protection.outlook.com?url=http%3A%...
Reposted by Bernat Olle
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense
M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...
www.biorxiv.org
July 28, 2025 at 9:43 PM
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Reposted by Bernat Olle
We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome.
See thread for more information and reach out!
See thread for more information and reach out!
July 22, 2025 at 7:34 PM
We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome.
See thread for more information and reach out!
See thread for more information and reach out!
Reposted by Bernat Olle
There is only one way to end the war: put pressure on the Russians. The Trump people did the opposite: put pressure on Ukraine, and relieved pressure on Russia. They have made the war worse while talking of "peace."
April 19, 2025 at 1:18 PM
There is only one way to end the war: put pressure on the Russians. The Trump people did the opposite: put pressure on Ukraine, and relieved pressure on Russia. They have made the war worse while talking of "peace."
Reposted by Bernat Olle
Merci, EmmanuelMacron 💙💛
Every European will be safer if every part of Ukraine is sovereign and pro-European.
russian occupation of an independent country creates a precedent that endangers the entire continent.
Every European will be safer if every part of Ukraine is sovereign and pro-European.
russian occupation of an independent country creates a precedent that endangers the entire continent.
April 23, 2025 at 7:11 PM
Merci, EmmanuelMacron 💙💛
Every European will be safer if every part of Ukraine is sovereign and pro-European.
russian occupation of an independent country creates a precedent that endangers the entire continent.
Every European will be safer if every part of Ukraine is sovereign and pro-European.
russian occupation of an independent country creates a precedent that endangers the entire continent.
Reposted by Bernat Olle
A lot of what looks like microbial engraftment after FMT might actually be noise. Using placebo sequencing and culture-enriched metagenomics, we sort signal from noise. Our latest from the Surette lab: www.nature.com/articles/s41... @surettem.bsky.social @mcmasteruniversity.bsky.social
Detecting microbial engraftment after FMT using placebo sequencing and culture enriched metagenomics to sort signals from noise - Nature Communications
Here, the authors profile bacterial engraftment in UC patients receiving FMT from a single donor and placebo samples to estimate noise, showing a significant level of false-positive engraftment, which...
www.nature.com
April 25, 2025 at 3:22 PM
A lot of what looks like microbial engraftment after FMT might actually be noise. Using placebo sequencing and culture-enriched metagenomics, we sort signal from noise. Our latest from the Surette lab: www.nature.com/articles/s41... @surettem.bsky.social @mcmasteruniversity.bsky.social
Reposted by Bernat Olle
Reposted by Bernat Olle
Sign of the day…Chicago
April 6, 2025 at 4:45 PM
Sign of the day…Chicago
Reposted by Bernat Olle
looking forward to #ESCMIDGlobal next week in Vienna. I'd love to connect and discuss developing microbiome drugs to prevent infection. Come to the Innovation Theater 12 April at 11:30!
April 5, 2025 at 8:13 PM
looking forward to #ESCMIDGlobal next week in Vienna. I'd love to connect and discuss developing microbiome drugs to prevent infection. Come to the Innovation Theater 12 April at 11:30!
I have a trade deficit with Trader Joe's, who are so unfair because they never buy anything back from me, so I will have to impose some tariffs.
April 3, 2025 at 10:17 PM
I have a trade deficit with Trader Joe's, who are so unfair because they never buy anything back from me, so I will have to impose some tariffs.
Reposted by Bernat Olle
I can feel the pain in this summary at the end of the day. A lot of people trying to collect themselves. More pain to come. Will need to strengthen our common ties to advance the public health and individual medical outcomes.
yourlocalepidemiologist.substack.com/p/why-we-kee...
yourlocalepidemiologist.substack.com/p/why-we-kee...
Why we keep going
Today thousands of health workers at the CDC and FDA lost their jobs—effective immediately.
yourlocalepidemiologist.substack.com
April 2, 2025 at 12:41 AM
I can feel the pain in this summary at the end of the day. A lot of people trying to collect themselves. More pain to come. Will need to strengthen our common ties to advance the public health and individual medical outcomes.
yourlocalepidemiologist.substack.com/p/why-we-kee...
yourlocalepidemiologist.substack.com/p/why-we-kee...
Reposted by Bernat Olle
From an operational security perspective, this is the highest level of fuckup imaginable. These people cannot keep America safe.
The Trump Administration Accidentally Texted Me Its War Plans
U.S. national-security leaders included me in a group chat about upcoming military strikes in Yemen. I didn’t think it could be real. Then the bombs started falling.
www.theatlantic.com
March 24, 2025 at 8:13 PM
From an operational security perspective, this is the highest level of fuckup imaginable. These people cannot keep America safe.
How Beethoven could come up with this absolute marvel when he was dealing with hearing loss is beyond my comprehension. It's like he found a secret shortcut to reach the soul.
youtu.be/ESilvOS2O9k
youtu.be/ESilvOS2O9k
Gustavo Dudamel - Beethoven: Symphony No. 7 - Mvmt 2 (Orquesta Sinfónica Simón Bolívar)
YouTube video by Gustavo Dudamel
youtu.be
March 18, 2025 at 9:36 PM
How Beethoven could come up with this absolute marvel when he was dealing with hearing loss is beyond my comprehension. It's like he found a secret shortcut to reach the soul.
youtu.be/ESilvOS2O9k
youtu.be/ESilvOS2O9k
Reposted by Bernat Olle
Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective @jclinical-invest.bsky.social www.jci.org/articles/vie...
February 3, 2025 at 10:11 PM
Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective @jclinical-invest.bsky.social www.jci.org/articles/vie...
I hope the new administration can appreciate that basic research in infectious diseases is also a matter of national security, which we all care about no matter who we vote for
www.propublica.org/article/nih-...
www.propublica.org/article/nih-...
The Second Trump White House Could Drastically Reshape Infectious Disease Research. Here’s What’s at Stake.
Donald Trump’s pick to lead the federal health agency has vowed to replace hundreds of staffers and shift research away from infectious diseases and vaccines. Such an overhaul could imperil the develo...
www.propublica.org
January 17, 2025 at 11:37 AM
I hope the new administration can appreciate that basic research in infectious diseases is also a matter of national security, which we all care about no matter who we vote for
www.propublica.org/article/nih-...
www.propublica.org/article/nih-...
Reposted by Bernat Olle
Well, I went back to see if the birds came out again yesterday. And it was even more stunning. At first, it seemed like little was going on & then my brother Matt, who came out with/ me to record sound (he's a sound engineer) told us to look up. #birds
youtu.be/r_1OX3LVK1g
youtu.be/r_1OX3LVK1g
January 4, 2025 at 5:21 PM
Well, I went back to see if the birds came out again yesterday. And it was even more stunning. At first, it seemed like little was going on & then my brother Matt, who came out with/ me to record sound (he's a sound engineer) told us to look up. #birds
youtu.be/r_1OX3LVK1g
youtu.be/r_1OX3LVK1g
Reposted by Bernat Olle
Assessing Live Microbial Therapeutic Transmission, from Jay Faith
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Assessing live microbial therapeutic transmission
The development of fecal microbiota transplantation and defined live biotherapeutic products for the treatment of human disease has been an empirically driven process yielding a notable success of ...
www.tandfonline.com
January 5, 2025 at 6:16 PM
Assessing Live Microbial Therapeutic Transmission, from Jay Faith
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Today our team published additional results from the Phase 2 CONSORTIUM study for our lead candidate, VE303, a potential first-in-class Live Biotherapeutic Product which is being evaluated for prevention of recurrent Clostridioides difficile infection (rCDI).
full-text access: rdcu.be/d5ovX
full-text access: rdcu.be/d5ovX
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection
Nature Medicine - Results of multi-omic profiling of the microbiome and host immunity of individuals treated with VE303 to prevent recurrent Clostridioides difficile infection in the context of a...
rdcu.be
January 2, 2025 at 9:35 PM
Today our team published additional results from the Phase 2 CONSORTIUM study for our lead candidate, VE303, a potential first-in-class Live Biotherapeutic Product which is being evaluated for prevention of recurrent Clostridioides difficile infection (rCDI).
full-text access: rdcu.be/d5ovX
full-text access: rdcu.be/d5ovX
My parents' work today:
December 16, 2024 at 1:44 AM
My parents' work today:
Reposted by Bernat Olle
(1/5) Traditionally, antibiotic discovery has centered on bacteria and fungi—until now.
For the first time, we present a systematic exploration of Archaea—a major yet underexplored branch of the tree of life—as a source of novel antimicrobial compounds. www.biorxiv.org/content/10.1...
For the first time, we present a systematic exploration of Archaea—a major yet underexplored branch of the tree of life—as a source of novel antimicrobial compounds. www.biorxiv.org/content/10.1...
December 12, 2024 at 10:56 AM
(1/5) Traditionally, antibiotic discovery has centered on bacteria and fungi—until now.
For the first time, we present a systematic exploration of Archaea—a major yet underexplored branch of the tree of life—as a source of novel antimicrobial compounds. www.biorxiv.org/content/10.1...
For the first time, we present a systematic exploration of Archaea—a major yet underexplored branch of the tree of life—as a source of novel antimicrobial compounds. www.biorxiv.org/content/10.1...
On the definition of Live Biotherapeutic Product.
Online today @jidjournal.bsky.social
academic.oup.com/jid/advance-...
Online today @jidjournal.bsky.social
academic.oup.com/jid/advance-...
Correspondence to “Escape Velocity—The Launch of Microbiome Therapies”
To the Editor—We congratulate Kelly et al on an excellent review of advances in microbiome therapeutic development [1]. The article states that the Food an
academic.oup.com
December 13, 2024 at 9:50 PM
On the definition of Live Biotherapeutic Product.
Online today @jidjournal.bsky.social
academic.oup.com/jid/advance-...
Online today @jidjournal.bsky.social
academic.oup.com/jid/advance-...