Ayusman Sen
ayusmansen.bsky.social
Ayusman Sen
@ayusmansen.bsky.social
Active autonomous systems; synthetic nano and micromotors; micropumps; nanotechnology, systems chemistry. https://sites.psu.edu/sengroup/
“It's tough to make predictions, especially about the future.” Yogi Berra
Me too!
My inner state always tells me that I need to take a nap.
How should we structure our time? A Zen monk suggests that we let our inner states dictate what we do when. https://newyorkermag.visitlink.me/Me9nfq
November 16, 2025 at 1:40 AM
Reposted by Ayusman Sen
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 1:03 AM
Reposted by Ayusman Sen
RIP Jim Watson. You inspired many of us to pursue a life in research. I wish you had made it easier for us to celebrate your legacy.
November 7, 2025 at 11:11 PM
Congratulations, @sanjanakmani.bsky.social! Nice work!
November 3, 2025 at 7:48 PM
Reposted by Ayusman Sen
This is a job for referees, not AI. (And any referee worth their salt would see that this example is an interesting hypothesis worth testing, not wild speculation beyond the data.)
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting

I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
November 3, 2025 at 2:44 PM
Reposted by Ayusman Sen
October 31, 2025 at 1:18 PM
Reposted by Ayusman Sen
October 28, 2025 at 10:42 PM
Spiral patterns form by simply dropping protein solutions on to denser sugar solutions, showing reaction-diffusion pattern formation can be replicated by replacing the reaction-induced inhomogeneous solute distribution by evaporation-induced inhomogeneity: rdcu.be/eMUyR
Pattern formation in isothermal miscible protein-sugar systems driven by Marangoni effects and evaporation
Communications Physics - Pattern formation in miscible fluid systems is typically driven by reaction-diffusion processes or thermal gradients. This study demonstrates pattern formation in an...
rdcu.be
October 27, 2025 at 1:53 PM
Reposted by Ayusman Sen
A modeling study shows how chemical reactions can stimulate motion in simple systems, like the structure here—made of enzyme coated beads connected to tentacles—that resembles a jellyfish. cen.acs.org/biological-c... #chemsky 🧪
Chemical reactions set soft materials in motion
Modeling study shows how chemistry can trigger autonomic motion in soft materials
cen.acs.org
October 26, 2025 at 8:24 PM
Reposted by Ayusman Sen
Someday, Donald Trump will be celebrated on Donald Trump day in the same way that Guy Fawkes is celebrated on Guy Fawkes day in England.
October 18, 2025 at 3:54 PM
Reposted by Ayusman Sen
Our latest work in @jacs.acspublications.org!
Artificial system that can sense, grow, and adapt—just like cells! Our #droplets form directional filopodia in response to chemical cues- a step toward life-like materials. #SoftMatter #MatterToLife
🔗https://pubs.acs.org/doi/10.1021/jacs.5c11719
October 16, 2025 at 4:03 PM
Reposted by Ayusman Sen
Deeply grateful to my advisor @ayusmansen.bsky.social for his invaluable guidance, and to Dr. Lauren Zarzar, and all the amazing collaborators who made this work possible!
@pennstatechemistry.bsky.social @pennstatescience.bsky.social
Our latest work in @jacs.acspublications.org!
Artificial system that can sense, grow, and adapt—just like cells! Our #droplets form directional filopodia in response to chemical cues- a step toward life-like materials. #SoftMatter #MatterToLife
🔗https://pubs.acs.org/doi/10.1021/jacs.5c11719
October 16, 2025 at 4:09 PM
Our latest: Like bacteria, oil-in-water emulsions sense specific amino acids, sending out finger-like projections towards or away from the source! Droplets as Cell Models: Chemical Gradient-Induced Directional Filopodia Formation. Great work by @sanjanakmani.bsky.social pubs.acs.org/doi/full/10....
Droplets as Cell Models: Chemical Gradient-Induced Directional Filopodia Formation
Cells are complex chemical systems capable of sensing and responding to environmental cues by dynamically reshaping themselves, e.g., by forming arm-like protrusions such as filopodia. Recapitulating cellular behavior in artificial systems is a long-standing goal in understanding the matter-to-life transition and designing responsive soft materials. Here, we use oil-in-water emulsions that mimic cellular environmental sensing and form directional arm-like filopodia in response to external chemical cues. Our work analyzes the step-by-step process involved in the formation of artificial filopodia, and we engineer ways to direct filopodia growth through different chemical gradients. The process is driven by asymmetric surfactant partitioning across the oil–water interface, followed by ordering at the interface to form lamellar structures, which are projected out as filopodia. We observe filopodia growing away from the source of kosmotropic anions and toward the source of chaotropic anions from the Hofmeister series. Significantly, these systems also respond to amino acid gradients, similar to cells: tryptophan gradients favor growth toward the source, while lysine and arginine gradients cause growth away from the amino acid source. Our findings open new avenues for fabricating life-like materials that sense and grow in response to external signals.
pubs.acs.org
October 15, 2025 at 7:29 PM
Reposted by Ayusman Sen
This book has never been more timely. Thanks to @sonali-m-19.bsky.social for writing it and for sending me a copy.
October 10, 2025 at 8:16 PM
Wonderful story!
Fun piece for @science.org that pretty much wrote itself. Interview with AP photographer Lindsey Wasson telling the story of being the one to tell a disbelieving Mary Brunkow that she’d just won the @nobelprize.bsky.social Prize in Medicine— www.science.org/content/arti...
What’s it like to tell someone she won a Nobel Prize?
Science chats with photographer Lindsey Wasson, who captured how Nobel winner Mary Brunkow reacted to life-changing news
www.science.org
October 10, 2025 at 6:19 PM
Reposted by Ayusman Sen
Fun piece for @science.org that pretty much wrote itself. Interview with AP photographer Lindsey Wasson telling the story of being the one to tell a disbelieving Mary Brunkow that she’d just won the @nobelprize.bsky.social Prize in Medicine— www.science.org/content/arti...
What’s it like to tell someone she won a Nobel Prize?
Science chats with photographer Lindsey Wasson, who captured how Nobel winner Mary Brunkow reacted to life-changing news
www.science.org
October 10, 2025 at 2:14 AM
Reposted by Ayusman Sen
"Immigrants, we get the job done"

www.economist.com/graphic-deta...
October 10, 2025 at 2:44 AM
Very well said!!
Chemistry research is fueling Pennsylvania’s economy — so why are we defunding it? penncapital-star.com/commentary/c...
Chemistry research is fueling Pennsylvania’s economy — so why are we defunding it? • Pennsylvania Capital-Star
Chemistry research is fueling Pennsylvania’s economy — so why are we defunding it?
penncapital-star.com
October 3, 2025 at 10:05 PM
Reposted by Ayusman Sen
I didn't know Jane Goodall, but it's pretty clear the world is a poorer place without her, and that she wished and worked for a better world than the one we're making.
October 1, 2025 at 8:07 PM
Reposted by Ayusman Sen
FT piece on the decline of Chemistry (from January). www.ft.com/content/563f...
September 15, 2025 at 10:17 AM
Reposted by Ayusman Sen
Being a professor is so weird. You are constantly having to act like you know things.
September 11, 2025 at 7:18 PM
Non-reciprocal predator-prey behavior among enzyme-attached particles. Nanobots play 'follow the leader' by chasing chemical trails in microfluidic device phys.org/news/2025-09... via
@physorg_com
Nanobots play 'follow the leader' by chasing chemical trails in microfluidic device
Researchers at Penn State demonstrate the first steps in the design of tiny particles that can perform specialized tasks, such as targeted delivery of drugs or other cargo.
phys.org
September 10, 2025 at 3:46 PM
Reposted by Ayusman Sen
Delighted that a new paper highlighting the role of the Curie principle for understanding kinetic asymmetry and directional motion by molecular ratchets!

www.nature.com/articles/s42...
Interpreting molecular ratchets, directionality, and kinetic asymmetry through the work of Curie, Einstein, and Lewis - Communications Physics
Scalar energy can drive formation of non-equilibrium steady-states or power directional processes such as chemotaxis, ion transport across a membrane, or walking along a polar track. This work focuses...
www.nature.com
September 8, 2025 at 9:13 PM
Not my experience too. I get many, many more likes and reposts from X. I suspect that Bluesky is mostly confined to the US and UK, while X has many more international scientific subscribers.
not my experience... 🧪⚗️#chemsky
With social media site Bluesky growing in popularity among academics, a new study has revealed how it measures up against X when it comes to sharing and promoting scientific research.
September 7, 2025 at 1:56 AM