Dan Auclair
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auclairdan.bsky.social
Dan Auclair
@auclairdan.bsky.social
770 followers 830 following 86 posts
Blood cancer translational scientist with a special love for #myeloma, animals and nature friend | Opinions are my own #MyelomaSky #HemeSky
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Reposted by Dan Auclair
labwaggoner.bsky.social
PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
September 2, 2025 at 1:54 AM
auclairdan.bsky.social
#IMS25 full abstracts are out! #myelomasky #hemesky
hematocure.bsky.social Hematocure @hematocure.bsky.social · Aug 28
The full abstracts selected for #IMS25 have just been released!

conferenceabstracts.com/uploads/docume…

We are eagerly anticipating the great science to be showcased in Toronto in three weeks. Hematocure will attend, provide updates, and looks forward to reconnecting with colleagues.#mmsmsm
August 28, 2025 at 10:59 PM
Reposted by Dan Auclair
ascocancer.bsky.social
For breaking news and expert analysis during #ASCO25, turn to #ASCODailyNews! During and after the Meeting, ASCO Daily News has coverage of all the practice-changing research being presented. Bookmark us now: dailynews.ascopubs.org/meetings/asc... #oncsky
May 30, 2025 at 2:27 PM
auclairdan.bsky.social
Now that the final #ASCO25 abstracts are out, here are my top #myelomasky ones

Etentamig
meetings.asco.org/abstracts-pr...

IberVd
meetings.asco.org/abstracts-pr...

5-Year Follow-up on CARTITUDE-1

meetings.asco.org/abstracts-pr...
May 25, 2025 at 9:06 AM
auclairdan.bsky.social
The US has world-class scientific talent. The rest of the world is hoping to lure that away

www.yahoo.com/news/us-worl...
The US has world-class scientific talent. The rest of the world is hoping to lure that away
As the Trump administration cut billions of dollars in federal funding to scientific research, thousands of scientists in the U.S. lost their jobs or grants — and governments and universities around t...
www.yahoo.com
May 25, 2025 at 8:27 AM
auclairdan.bsky.social
Roche taps Broad Institute to test SBX sequencing in the clinic

www.fiercebiotech.com/medtech/roch...
Roche taps Broad Institute to test SBX sequencing in the clinic
Roche raised the curtain on its novel approach to DNA sequencing earlier this year, and now it's working with the Broad Institute to explore its use cases, ahead of a full public launch s | Roche tapp...
www.fiercebiotech.com
May 23, 2025 at 4:29 PM
auclairdan.bsky.social
An ultrasensitive method gor detection of cell-free RNA

www.nature.com/articles/s41...
An ultrasensitive method for detection of cell-free RNA - Nature
A method, RARE-seq, for sensitive detection of cell-free RNAs in blood is demonstrated to have diverse clinical applications including diagnosing and characterizing human cancers, and tracking respons...
www.nature.com
April 18, 2025 at 1:30 PM
Reposted by Dan Auclair
weldeiry.bsky.social
Challenging times.

Harvard at risk of losing $9 billion in federal funds as US launches review

www.reuters.com/world/us/us-...
US reviewing federal contracts, grants to Harvard over antisemitism allegations
The administration of Republican President Donald Trump announced a review on Monday of federal contracts and grants at Harvard University over allegations of antisemitism.
www.reuters.com
April 1, 2025 at 12:19 AM
Reposted by Dan Auclair
cellpress.bsky.social
Check out our #50ScientistsThatInspire interviews with Drs. Madhukar Pai, Johanna Joyce, Juan-Pablo Correa-Baena, & Hanna Kokko threaded below🧵

@madhupai.bsky.social @johannajoyce.bsky.social @jpcorreabaena.bsky.social @kokkonut.bsky.social
Cell Press banner that reads "50 Scientists that Inspire: Putting a spotlight on researchers who drive innovation" The headshots of Drs. Madhukar Pai, Johanna Joyce, Juan-Pablo Correa-Baena, & Hanna Kokko are illuminated under a spotlight.
March 19, 2025 at 4:06 PM
Reposted by Dan Auclair
erictopol.bsky.social
Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue
journals.plos.org/plosbiology/...
March 18, 2025 at 6:25 PM
auclairdan.bsky.social
BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement ⁦‪⁦‪#MyelomaSky

ashpublications.org/bloodadvance...
March 18, 2025 at 6:14 PM
auclairdan.bsky.social
Advantages of a NGS assay for detection of mutant NPM1 MRD in AML #HemeSky

- Detection of mNPM1 MRD by NGS overcomes several limitations of RT-qPCR

- Prognostic significance of mNPM1 MRD appears greatest in patients with AML with a concomitant FLT3-ITD

ashpublications.org/bloodadvance...
March 18, 2025 at 6:10 PM
auclairdan.bsky.social
Large-scale dependency and drug screens characterize the therapeutic vulnerabilities of Multiple Myeloma with 1q+ @ireneghobrial.bsky.social #MyelomaSky

ashpublications.org/blood/articl...
March 13, 2025 at 9:58 PM
auclairdan.bsky.social
Nice review: Hallmarks of AI contributions to precision oncology

www.nature.com/articles/s43...
Hallmarks of artificial intelligence contributions to precision oncology - Nature Cancer
Ruppin and colleagues overview recent research on the use of AI frameworks in precision oncology, describe ten hallmarks of their contributions across cancer detection, therapy optimization and treatm...
www.nature.com
March 11, 2025 at 2:51 PM
auclairdan.bsky.social
New SEC filings reveal potential further impact of federal cuts

www.wired.com/story/trump-...
Trump's FDA Cuts Are Putting Drug Development at Risk
New SEC filings from pharmaceutical companies reveal Donald Trump and Elon Musk's cost-cutting measures could slow drug research and delay FDA approvals.
www.wired.com
March 3, 2025 at 10:53 PM
auclairdan.bsky.social
Dissecting tumor cell programs through biology estimation in clinic single-cell transcriptomics
www.nature.com/articles/s41...
Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics - Nature Communications
Existing methods for identifying differential gene expression signatures for clinical case/control analyses with high throughput sequencing data present various challenges. Here, the authors develop B...
www.nature.com
March 3, 2025 at 10:45 PM
auclairdan.bsky.social
Francis Collins retires from NIH

www.npr.org/sections/sho...
Legendary former NIH director retires from embattled agency
Dr. Francis Collins is leaving the National Institutes of Health, where he served as director from 2009 to 2021. The agency is facing cutbacks and restrictions under the Trump administration.
www.npr.org
March 1, 2025 at 6:34 PM
auclairdan.bsky.social
Coming together for sciences

www.science.org/doi/10.1126/...
Come together, right now
The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...
www.science.org
February 27, 2025 at 5:15 PM
auclairdan.bsky.social
Lung-MAP 3.0. Adding NGS screening options for patient recruitment

ascopost.com/issues/febru...
Lung-MAP 3.0: Simplifying the Process to Meet Patients’ Needs
The Lung Cancer Master Protocol (Lung-MAP) is an innovative clinical trial designed to efficiently address the unmet needs of patients with advanced non–small cell lung cancer (NSCLC) following front-...
ascopost.com
February 24, 2025 at 5:31 PM
Reposted by Dan Auclair
erictopol.bsky.social
The time relegated to being data clerks among US physicians is increasing
jamanetwork.com/journals/jam...
Trends in Physician Electronic Health Record Time and Message Volume
This cohort study uses national electronic health record data to assess patient medical advice request message volume and the time physicians spend in the records.
jamanetwork.com
February 24, 2025 at 5:25 PM
Reposted by Dan Auclair
madamescientist.bsky.social
Pitt to pause PhD admissions, following Vanderbilt and USC, because of uncertainty of NIH funding to academic universities.

Who will teach and train US scientists for pharma and biotech? Should we import them from countries that do?

www.wesa.fm/health-scien...
The University of Pittsburgh pauses its Ph.D. admissions process amid research funding uncertainty
A spokesperson for the University told WESA Friday that the school has "temporarily paused additional Ph.D. offers of admission," while Pitt works to understand how proposed federal funding cuts could...
www.wesa.fm
February 22, 2025 at 12:53 PM
auclairdan.bsky.social
One of many similar stories to come out in the last week. A sad state of affairs.
February 22, 2025 at 1:40 PM
auclairdan.bsky.social
Turmoil at FDA and fears it might impact new drug approvals

www.biospace.com/fda/fda-reel...
FDA Reels From ‘Indiscriminate’ Job Cuts Under Trump as Biopharma Appeals for Clarity
Morale is low at the FDA, which was hit with layoffs this week following RFK Jr.’s confirmation. Biopharma leaders and agency insiders fear further workforce cuts could delay new medicines.
www.biospace.com
February 20, 2025 at 6:20 PM
auclairdan.bsky.social
Illumina unveils its novel spatial transcriptomics platform

www.illumina.com/company/news...
Illumina unveils first-of-its-kind spatial transcriptomics technology
www.illumina.com
February 20, 2025 at 6:03 PM
auclairdan.bsky.social
US researchers are in shock. What to expect next.

www.nature.com/articles/d41...
Trump’s siege of science: how the first 30 days unfolded and what’s next
The breakneck pace and devastating impact of the administration’s policy changes has researchers shocked.
www.nature.com
February 20, 2025 at 4:43 PM