Dan Auclair
@auclairdan.bsky.social
Blood cancer translational scientist with a special love for #myeloma, animals and nature friend | Opinions are my own #MyelomaSky #HemeSky
BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement #MyelomaSky
ashpublications.org/bloodadvance...
ashpublications.org/bloodadvance...
March 18, 2025 at 6:14 PM
BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement #MyelomaSky
ashpublications.org/bloodadvance...
ashpublications.org/bloodadvance...
Advantages of a NGS assay for detection of mutant NPM1 MRD in AML #HemeSky
- Detection of mNPM1 MRD by NGS overcomes several limitations of RT-qPCR
- Prognostic significance of mNPM1 MRD appears greatest in patients with AML with a concomitant FLT3-ITD
ashpublications.org/bloodadvance...
- Detection of mNPM1 MRD by NGS overcomes several limitations of RT-qPCR
- Prognostic significance of mNPM1 MRD appears greatest in patients with AML with a concomitant FLT3-ITD
ashpublications.org/bloodadvance...
March 18, 2025 at 6:10 PM
Advantages of a NGS assay for detection of mutant NPM1 MRD in AML #HemeSky
- Detection of mNPM1 MRD by NGS overcomes several limitations of RT-qPCR
- Prognostic significance of mNPM1 MRD appears greatest in patients with AML with a concomitant FLT3-ITD
ashpublications.org/bloodadvance...
- Detection of mNPM1 MRD by NGS overcomes several limitations of RT-qPCR
- Prognostic significance of mNPM1 MRD appears greatest in patients with AML with a concomitant FLT3-ITD
ashpublications.org/bloodadvance...
Large-scale dependency and drug screens characterize the therapeutic vulnerabilities of Multiple Myeloma with 1q+ @ireneghobrial.bsky.social #MyelomaSky
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
March 13, 2025 at 9:58 PM
Large-scale dependency and drug screens characterize the therapeutic vulnerabilities of Multiple Myeloma with 1q+ @ireneghobrial.bsky.social #MyelomaSky
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
Characterization of plasma cell-free DNA variants as of tumor- or clonal hematopoiesis-origin in 16,812 advanced cancer patients
aacrjournals.org/clincancerre...
aacrjournals.org/clincancerre...
February 11, 2025 at 9:36 PM
Characterization of plasma cell-free DNA variants as of tumor- or clonal hematopoiesis-origin in 16,812 advanced cancer patients
aacrjournals.org/clincancerre...
aacrjournals.org/clincancerre...
Bold editorial by the Lancet today
American chaos: standing up for health and medicine
American chaos: standing up for health and medicine
February 8, 2025 at 2:33 PM
Bold editorial by the Lancet today
American chaos: standing up for health and medicine
American chaos: standing up for health and medicine
February 8, 2025 at 2:24 PM
T-cell immune cluster analysis using CyTOF identifies unique subgroups of patients with acute myeloid leukemia #HemeSky
ashpublications.org/bloodadvance...
ashpublications.org/bloodadvance...
February 4, 2025 at 7:17 PM
T-cell immune cluster analysis using CyTOF identifies unique subgroups of patients with acute myeloid leukemia #HemeSky
ashpublications.org/bloodadvance...
ashpublications.org/bloodadvance...
#WorldCancerDay coincides with my dad’s birthday whom I lost to DLBCL. Great hope with new tools (immune & cell therapies, degraders, molecular glues, etc.). Cancer cells are smart, we still have lot to learn about biology & get better at early #detection #interception Keep fighting and innovating!
February 4, 2025 at 2:19 PM
#WorldCancerDay coincides with my dad’s birthday whom I lost to DLBCL. Great hope with new tools (immune & cell therapies, degraders, molecular glues, etc.). Cancer cells are smart, we still have lot to learn about biology & get better at early #detection #interception Keep fighting and innovating!
On #NationalWomenPhysiciansDay remembering Dr. Elizabeth Blackwell, US first female doctor. After dozens of rejections, she finally got into GMCNY in 1847, her acceptance having been put to vote before the medical class. Legend has it they thought it was a joke
healthmatters.nyp.org/happened-dr-...
healthmatters.nyp.org/happened-dr-...
February 3, 2025 at 8:08 PM
On #NationalWomenPhysiciansDay remembering Dr. Elizabeth Blackwell, US first female doctor. After dozens of rejections, she finally got into GMCNY in 1847, her acceptance having been put to vote before the medical class. Legend has it they thought it was a joke
healthmatters.nyp.org/happened-dr-...
healthmatters.nyp.org/happened-dr-...
The current landscape and emerging challenges of benchmarking single-cell methods
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 31, 2025 at 10:17 PM
The current landscape and emerging challenges of benchmarking single-cell methods
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 25, 2025 at 9:16 PM
Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 25, 2025 at 1:49 PM
Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
From Cornell’s team (Melnick, Beguelin, Chadburn et al). Includes the development of syngeneic models recapitulating human follicular lymphoma and DLBCL and cool effect of EZH2i on these models to induce lymphoma immunogenicity and improve T-cell function. #HemeSky
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
January 14, 2025 at 11:15 PM
From Cornell’s team (Melnick, Beguelin, Chadburn et al). Includes the development of syngeneic models recapitulating human follicular lymphoma and DLBCL and cool effect of EZH2i on these models to induce lymphoma immunogenicity and improve T-cell function. #HemeSky
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
At this time of the year, in between parties and the great outdoors, I love to get lazy near the fireplace reading a few good books. BTW, I highly recommend “Race for a Remedy” by a dear work colleague of mine.
December 21, 2024 at 6:07 PM
At this time of the year, in between parties and the great outdoors, I love to get lazy near the fireplace reading a few good books. BTW, I highly recommend “Race for a Remedy” by a dear work colleague of mine.
Beautiful fresh coat of snow at our home in CT this morning. Santa must be coming to town soon.
December 21, 2024 at 2:39 PM
Beautiful fresh coat of snow at our home in CT this morning. Santa must be coming to town soon.
Nice evening with the team last night on Coronado Island #ASH24 #MyelomaSky
December 8, 2024 at 2:10 PM
Nice evening with the team last night on Coronado Island #ASH24 #MyelomaSky
Fabulous here in San Diego at #ASH24 . Meanwhile in Connecticut my dogies are getting some nice snow today, good thing I flew yesterday.
December 5, 2024 at 2:54 PM
Fabulous here in San Diego at #ASH24 . Meanwhile in Connecticut my dogies are getting some nice snow today, good thing I flew yesterday.
On my way to #ASH24 , see you all soon! (don’t think I am getting an upgrade on this flight 🤣) #MyelomaSky #HemeSky
December 4, 2024 at 1:12 PM
On my way to #ASH24 , see you all soon! (don’t think I am getting an upgrade on this flight 🤣) #MyelomaSky #HemeSky
So excited, #ASH24 starts this week!! Looking forward to the great science and seeing all of you. And of course, to the ASH 5k Run/Walk in support of a great cause - #ASHThrowback to ASH23. @ash-hematology.bsky.social #MyelomaSky #HemeSky
December 1, 2024 at 4:41 PM
So excited, #ASH24 starts this week!! Looking forward to the great science and seeing all of you. And of course, to the ASH 5k Run/Walk in support of a great cause - #ASHThrowback to ASH23. @ash-hematology.bsky.social #MyelomaSky #HemeSky
Outcome of incidentally diagnosed LBCL. Lower stage and IPI score compared to symptomatic patients. Food for thought for early detection and interception #HemeSky
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
November 26, 2024 at 5:11 PM
Outcome of incidentally diagnosed LBCL. Lower stage and IPI score compared to symptomatic patients. Food for thought for early detection and interception #HemeSky
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Nice review.
Natural killer cell biology and therapy in #Myeloma : challenges and opportunities #MyelomaSky #HemeSky
pmc.ncbi.nlm.nih.gov/articles/PMC...
Natural killer cell biology and therapy in #Myeloma : challenges and opportunities #MyelomaSky #HemeSky
pmc.ncbi.nlm.nih.gov/articles/PMC...
November 26, 2024 at 4:03 PM
Nice review.
Natural killer cell biology and therapy in #Myeloma : challenges and opportunities #MyelomaSky #HemeSky
pmc.ncbi.nlm.nih.gov/articles/PMC...
Natural killer cell biology and therapy in #Myeloma : challenges and opportunities #MyelomaSky #HemeSky
pmc.ncbi.nlm.nih.gov/articles/PMC...
My freshman son taking a course on global microbial threats recently told me that by 2050 the #1 cause of death might well be drug resistant bacteriae and that phages could be a new tool in the fight. In that context I found this phage DisCo approach interesting
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 24, 2024 at 3:08 PM
My freshman son taking a course on global microbial threats recently told me that by 2050 the #1 cause of death might well be drug resistant bacteriae and that phages could be a new tool in the fight. In that context I found this phage DisCo approach interesting
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Big shout out and congrats to my friend @szusmani.bsky.social and the rest of the organizing committee for what I hear was a very successful Inaugual Kyle-Barlogie MSKCC-Mayo Plasma Cell Disorders Symposium. #MyelomaSky #HemeSky
November 24, 2024 at 2:43 PM
Big shout out and congrats to my friend @szusmani.bsky.social and the rest of the organizing committee for what I hear was a very successful Inaugual Kyle-Barlogie MSKCC-Mayo Plasma Cell Disorders Symposium. #MyelomaSky #HemeSky
The Human Cell Atlas Consortia just released its initial efforts in a series of articles. #MedSky #ScienceSky
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
November 21, 2024 at 12:44 PM
The Human Cell Atlas Consortia just released its initial efforts in a series of articles. #MedSky #ScienceSky
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...