𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
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arnaudjlegrand.bsky.social
𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
@arnaudjlegrand.bsky.social
1.1K followers 760 following 87 posts
👨‍🔬 Interdisciplinary #CancerResearch | CRUK Convergence Science Centre, The ICR & Imperial College London | #Metalhead 🤘| Views my own.
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Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
crukconvergence.bsky.social
A study led by our Scientific Director Prof Axel Behrens, found that blocking protein SPP1 can boost survival & stop the spread of #PancreaticCancer in mice. A breakthrough that could pave the way for new targeted treatments.
👉 bit.ly/4gTvG6q
@icr.ac.uk @imperialsandc.bsky.social @nature.com
September 30, 2025 at 1:53 PM
arnaudjlegrand.bsky.social
How does one go about electing a new Prince of Darkness? Or does what the Darkness giveth the Darkness taketh away and leaderless Metal will stay?
July 22, 2025 at 6:41 PM
Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
crukconvergence.bsky.social
🚨 New cross-institutional study from researchers at @imperialcollegeldn.bsky.social, @icr.ac.uk & @cruk-mi.bsky.social use microfluidic “vessel-on-chip” technology to reveal how circulating tumour cells release “shearosomes” and promote metastasis.

👉 bit.ly/3Ib6paq

#Cancer #ConvergenceScience
July 4, 2025 at 12:35 PM
Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
udaibanerji.bsky.social
Published today @natmed.nature.com www.nature.com/articles/s41...
Thank you to all patients, families and research staff. @icr.ac.uk @icrdduiit.bsky.social‬ ‪@icr-ctsu.bsky.social @royalmarsden.org @ecmc-uk.bsky.social‬
@nihr.bsky.social @crukconvergence.bsky.social @cancerresearchuk.org

‪
June 27, 2025 at 10:48 AM
Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
cp-cell.bsky.social
Now online! Microtubules in Asgard archaea
Microtubules in Asgard archaea
Discovery of heterodimeric, microtubule-forming tubulins in Asgard archaea, the closest known relatives of eukaryotes, reveals snapshots of microtubule evolution.
dlvr.it
March 21, 2025 at 6:51 PM
arnaudjlegrand.bsky.social
Metabolic engineering to facilitate anti-tumor immunity

www.cell.com/cancer-cell/...
Metabolic engineering to facilitate anti-tumor immunity
While high fructose intake has been implicated in the progression of metabolic disease and cancer, Schild et al. take advantage of the availability of fructose in the tumor microenvironment. Engineere...
www.cell.com
February 28, 2025 at 8:10 AM
arnaudjlegrand.bsky.social
👀 Intrinsic electrical activity drives small-cell lung cancer progression

www.nature.com/articles/s41...
Intrinsic electrical activity drives small-cell lung cancer progression - Nature
Electrical excitability in neuroendocrine SCLC cells promotes tumour progression through action potential firing, increasing ATP demand and oxidative phosphorylation dependency, whereas non-neuroendoc...
www.nature.com
February 12, 2025 at 7:45 PM
arnaudjlegrand.bsky.social
Protein codes promote selective subcellular compartmentalization | Science

www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 9, 2025 at 8:50 AM
arnaudjlegrand.bsky.social
Engineered commensals for targeted nose-to-brain drug delivery: Cell

www.cell.com/cell/fulltex...
Engineered commensals for targeted nose-to-brain drug delivery
Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic mo...
www.cell.com
February 6, 2025 at 7:38 PM
arnaudjlegrand.bsky.social
📰High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning

www.cell.com/cell/fulltex...
High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning
PLATO, a high-resolution and high-throughput spatial mass spectrometry proteomics platform, identifies distinct tumor subtypes and key dysregulated proteins in human breast cancer.
www.cell.com
January 24, 2025 at 8:19 AM
Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
frezzalab.bsky.social
Immune evasion through mitochondrial transfer in the tumour microenvironmenthttps://

www.nature.com/articles/s41586-024-08439-0
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 22, 2025 at 6:54 PM
arnaudjlegrand.bsky.social
Rapid and scalable personalized ASO screening in patient-derived organoids

www.nature.com/articles/s41...
Rapid and scalable personalized ASO screening in patient-derived organoids - Nature
A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.
www.nature.com
January 22, 2025 at 7:37 PM
Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
cantorlab.bsky.social
Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td
Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability
Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...
rdcu.be
January 21, 2025 at 5:26 PM
Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
imperialcollegeldn.bsky.social
🧠 How can we safely target structures deep inside the brain linked to disease?

Imperial researchers hope to find out, thanks to ARIA funding!

The project will develop minimally invasive brain stimulation methods to target regions and influence their activity 🔽

www.imperial.ac.uk/news/260073/...
Imperial receives £15m ARIA funding for breakthrough brain research | Imperial News | Imperial College London
Imperial researchers will receive almost £15m in funding to embark on cutting edge research to help overcome neurodegenerative disease.
www.imperial.ac.uk
January 20, 2025 at 10:16 AM
arnaudjlegrand.bsky.social
Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics

www.cell.com/molecular-ce...
Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics
Xiang Zheng et al. develop an advanced approach combining multiplexed imaging and deep visual proteomics to spatially map the tumor microenvironment. By analyzing colorectal and tonsil cancer tissues,...
www.cell.com
January 15, 2025 at 8:27 AM
Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
crukconvergence.bsky.social
Therapeutic ultrasound is a prime example of convergence science - using the physics behind high frequency waves and applying it to biological systems to better diagnose, monitor and even target specific tumour sites. We support research that harnesses the power of ultrasound technologies. 1/3
January 14, 2025 at 4:37 PM
arnaudjlegrand.bsky.social
🔥It's #MetalFriday! Time for my #AOTY 2024!

Great millesime for \m/ music

Starting at:

*10 🇫🇷 #Alcest - Les Chants De L'Aurore (Blackgaze)

*9 🇵🇹 #Gaerea - Coma (Black Metal)

*8 🇮🇸 #ÁrstíðirLífsins - Aldrlok (Black/Folk Metal)

*7 🇫🇮 #Wintersun - Time II (Ext. Power Metal)

#MetalHeads #MetalSky
Alcest - Les Chants De L'Aurore Gaerea - Coma ÁrstíðirLífsins - Aldrlok Wintersun - Time II
January 10, 2025 at 6:42 PM
arnaudjlegrand.bsky.social
📰Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells

www.cell.com/cell/abstrac...
Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells
Expanding the consequences of pyroptosis, this study reveals that GSDMD pore-laden pyroptotic EVs transplant GSDMD pores on neighboring cell surfaces and propagate cell death to bystander cells.
www.cell.com
January 1, 2025 at 9:33 AM
Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
natcellbio.nature.com
☕This year, in our #CellDeath focus:
Toshitaka Nakamura & Marcus Conrad reviewed the susceptibility of #tumors to #ferroptosis, which could be exploited to treat #cancer.
👉https://rdcu.be/d493Q
www.nature.com/articles/s41...
Exploiting ferroptosis vulnerabilities in cancer - Nature Cell Biology
Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferropto...
www.nature.com
December 29, 2024 at 6:59 PM
arnaudjlegrand.bsky.social
Finally, I'm in possession of one of the greatest albums ever made... in giant format!

🇺🇸 #Agalloch - The Mantle (2002)

##MetalHeads #MetalSky
Agalloch - The Mantle (2002)
December 28, 2024 at 4:43 PM
arnaudjlegrand.bsky.social
🔥It's #MetalFriday! Next week, I'll be dropping my top 20 LPs of 2024. This week, my top 10 EPs!

Starting at:

*10: 🇺🇸 #Meanstreak - Blood Moon
*9: 🇬🇧 #ColdInBerlin - The Body Is The Wound
*8: 🇺🇸 #NokturnalFrost - Cold Grim Dead
*7: 🇺🇸 #Enforced - A Leap Into The Dark

#MetalHeads #MetalSky

👇*6 to *3
Meanstreak - Blood Moon Cold In Berlin - The Body Is The Wound Nokturnal Frost - Cold Grim Dead Enforced - A Leap Into The Dark
December 27, 2024 at 10:26 AM
Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
lozanzi.bsky.social
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
December 26, 2024 at 5:24 PM
arnaudjlegrand.bsky.social
📰Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes

www.cell.com/cell/fulltex...
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes
Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.
www.cell.com
December 21, 2024 at 8:15 AM
Reposted by 𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡
nandangokhale.bsky.social
Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology

@ramlabuw.bsky.social

www.science.org/doi/10.1126/...
Cellular RNA interacts with MAVS to promote antiviral signaling
Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...
www.science.org
December 19, 2024 at 8:13 PM
arnaudjlegrand.bsky.social
🔥It's #MetalFriday! Here are recent highlights:

💀Best album: 🇩🇪 #Grundeis - Every Second An Ocean

🤘Hon. mentions:
🇦🇺 #Mesarthim - Anthropic Bias / Departure
🇦🇺 #AtraVetosus - Undying Splendour

Only 1 \m/ Friday left! I'll drop my top EP 2024 before my top LP after new year.

#MetalHeads #MetalSky
Album cover: Grundeis - Every Second An Ocean
December 20, 2024 at 1:51 PM