Anthony R. Sloan, Ph.D
@anthonysloan.bsky.social
NCI NRSA Postdoctoral Fellow at @CCLRI and @ClevelandClinic | Lathia Laboratory | Cameron laboratory | @CWRUSOM Alum | Husband |Twin Girl dad | Tweets are my own
#thrombosis #plateletimmunecellcrosstalk #Braintumors #sexdifferencesincancer
#thrombosis #plateletimmunecellcrosstalk #Braintumors #sexdifferencesincancer
Excited to share our new preprint. We are only beginning to understand the role of platelets in sex-biased immunity in glioblastoma. Grateful for awesome colleagues, collaborators and the fantastic mentorship from @gbm-maestro.bsky.social and @2scottish.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Platelets drive immune suppression and glioblastoma growth in a sex-dependent manner via PAR4 signaling
Sex differences in cancer outcomes, including glioblastoma (GBM), are shaped by biological, hormonal, and immune factors, influencing disease progression, treatment responses, survival, and the tumor ...
www.biorxiv.org
August 13, 2025 at 12:42 PM
Excited to share our new preprint. We are only beginning to understand the role of platelets in sex-biased immunity in glioblastoma. Grateful for awesome colleagues, collaborators and the fantastic mentorship from @gbm-maestro.bsky.social and @2scottish.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Thank you ISTH for the oppurtunity to present our work on sex biased platelet mediated immune surpression in GBM. A great few days of inspiring discussion with old and new friends. So much work to be done, but until next time. #ISTH
June 25, 2025 at 2:52 PM
Thank you ISTH for the oppurtunity to present our work on sex biased platelet mediated immune surpression in GBM. A great few days of inspiring discussion with old and new friends. So much work to be done, but until next time. #ISTH
Reposted by Anthony R. Sloan, Ph.D
Amazing times — Exciting science, great discussions, & even better company. It wasn’t just about cutting-edge research; it was about forming lasting friendships w/ people who share the same passion. Grateful to be part of such an inspiring community. Looking forward to the next one in Italy!
March 12, 2025 at 7:40 PM
Amazing times — Exciting science, great discussions, & even better company. It wasn’t just about cutting-edge research; it was about forming lasting friendships w/ people who share the same passion. Grateful to be part of such an inspiring community. Looking forward to the next one in Italy!
Reposted by Anthony R. Sloan, Ph.D
Thousands “Stand Up for Science” Across the Country
Including Nobel laureates, climate researchers, and parents of kids saved by groundbreaking drugs.
www.motherjones.com/politics/202...
Including Nobel laureates, climate researchers, and parents of kids saved by groundbreaking drugs.
www.motherjones.com/politics/202...
Thousands “Stand Up for Science” across the country
Including Nobel laureates, climate researchers, and parents of kids saved by groundbreaking drugs.
www.motherjones.com
March 9, 2025 at 2:36 AM
Thousands “Stand Up for Science” Across the Country
Including Nobel laureates, climate researchers, and parents of kids saved by groundbreaking drugs.
www.motherjones.com/politics/202...
Including Nobel laureates, climate researchers, and parents of kids saved by groundbreaking drugs.
www.motherjones.com/politics/202...
Brilliant science and discussions this past week at the Gordon Research Conference and Seminar on Platelets and Megacaryoctes. Grateful to have been given the opportunity to talk about my work. Also, great talks by two of my closest mentors and collaborators. @2scottish.bsky.social @EviStavrou
March 7, 2025 at 6:27 PM
Brilliant science and discussions this past week at the Gordon Research Conference and Seminar on Platelets and Megacaryoctes. Grateful to have been given the opportunity to talk about my work. Also, great talks by two of my closest mentors and collaborators. @2scottish.bsky.social @EviStavrou
Reposted by Anthony R. Sloan, Ph.D
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
February 21, 2025 at 7:07 PM
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Anthony R. Sloan, Ph.D
Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.
https://go.nature.com/4gM6oW4
https://go.nature.com/4gM6oW4
Revealed: NIH research grants still frozen despite lawsuits challenging Trump order
The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
go.nature.com
February 20, 2025 at 8:04 PM
Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.
https://go.nature.com/4gM6oW4
https://go.nature.com/4gM6oW4
Reposted by Anthony R. Sloan, Ph.D
Do you care about equity in science education? Do you want to diversify the professoriate?
Follow @riseupneo.bsky.social to learn more about what we are doing to transform public education in #Cleveland and/or donate to the cause! 🧪
Follow @riseupneo.bsky.social to learn more about what we are doing to transform public education in #Cleveland and/or donate to the cause! 🧪
February 12, 2025 at 11:12 PM
Do you care about equity in science education? Do you want to diversify the professoriate?
Follow @riseupneo.bsky.social to learn more about what we are doing to transform public education in #Cleveland and/or donate to the cause! 🧪
Follow @riseupneo.bsky.social to learn more about what we are doing to transform public education in #Cleveland and/or donate to the cause! 🧪
Reposted by Anthony R. Sloan, Ph.D
Roughly 9% of NIH employees fired yesterday - rumors are IC directors may be next. Please call your senators and representatives!
Checking in with sources this morning...
The total from NIH was apparently slightly more than 1500 people (out of 5200 HHS Department-wide)
1/n
The total from NIH was apparently slightly more than 1500 people (out of 5200 HHS Department-wide)
1/n
February 15, 2025 at 12:18 PM
Roughly 9% of NIH employees fired yesterday - rumors are IC directors may be next. Please call your senators and representatives!
Reposted by Anthony R. Sloan, Ph.D
@hhmijanelia.bsky.social researchers led by the Spruston Lab have systematically tracked the activity of thousands of neurons over days & weeks during learning activities. They described, step by step, how cognitive maps form in the brain’s hippocampus – a region responsible for learning and memory.
February 13, 2025 at 4:45 PM
@hhmijanelia.bsky.social researchers led by the Spruston Lab have systematically tracked the activity of thousands of neurons over days & weeks during learning activities. They described, step by step, how cognitive maps form in the brain’s hippocampus – a region responsible for learning and memory.
Reposted by Anthony R. Sloan, Ph.D
A useful source if you want some good information about NIH accomplishments
www.nih.gov/research-tra....
www.nih.gov/research-tra....
NIH Research Highlights
A small sampling of clinical advances, promising medical advances, and insights from the lab by NIH-supported scientists.
www.nih.gov
February 13, 2025 at 6:19 PM
A useful source if you want some good information about NIH accomplishments
www.nih.gov/research-tra....
www.nih.gov/research-tra....
Reposted by Anthony R. Sloan, Ph.D
@gbm-maestro.bsky.social & team discover glioblastoma tumors produce spermidine and drive tumor progression by inducing T cell death: https://www.jci.org/articles/view/177824
January 28, 2025 at 4:33 PM
@gbm-maestro.bsky.social & team discover glioblastoma tumors produce spermidine and drive tumor progression by inducing T cell death: https://www.jci.org/articles/view/177824
Reposted by Anthony R. Sloan, Ph.D
Copied over from that other platform from Ankur Singh: x.com/Dr_ASingh/st...
February 12, 2025 at 2:46 AM
Copied over from that other platform from Ankur Singh: x.com/Dr_ASingh/st...
Reposted by Anthony R. Sloan, Ph.D
Defying defiance to the laws. Good for NIH!
BREAKING
On Monday, Popular Information broke the news that the NIH had frozen virtually all grant funding in violation of 2 federal court orders
On Wednesday, NIH leadership distributed a memo, acknowledging that its funding freeze was illegal and directing staff to resume issuing grants.
On Monday, Popular Information broke the news that the NIH had frozen virtually all grant funding in violation of 2 federal court orders
On Wednesday, NIH leadership distributed a memo, acknowledging that its funding freeze was illegal and directing staff to resume issuing grants.
BREAKING: NIH admits funding freeze is illegal, will resume issuing grants
An internal memo issued February 12 was obtained by Popular Information.
popular.info
February 12, 2025 at 7:39 PM
Defying defiance to the laws. Good for NIH!
Reposted by Anthony R. Sloan, Ph.D
To my friends and colleagues at UAB, IU, UF, FSU, UL, WashU, OSU, CWRU, etc, etc. Call both your senators and your representative. They listen. Emphasize the direct economic impact of NIH research, and the indirect impacts on pharmaceutical/biotech. Underscore its relevance to national security.
The Senate HELP Committee has jurisdiction over NIH.
GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC.
Research universities and hospitals in those states need to be extra loud.
GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC.
Research universities and hospitals in those states need to be extra loud.
February 8, 2025 at 3:27 AM
To my friends and colleagues at UAB, IU, UF, FSU, UL, WashU, OSU, CWRU, etc, etc. Call both your senators and your representative. They listen. Emphasize the direct economic impact of NIH research, and the indirect impacts on pharmaceutical/biotech. Underscore its relevance to national security.
Checkout our pre-print where we conducted a large scale clinical analysis looking at VTE rates in GBM. Excited to share mechanistic work in the near future showing how thrombosis drives GBM progression.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
VTE incidence shortens survival in IDH-WT glioblastoma
Abstract: Background: Venous thromboembolisms (VTEs) are the second leading cause of death in cancer patients. While previous analyses have demonstrated VTE rates are greater in GBM patients using sma...
www.medrxiv.org
January 11, 2025 at 2:52 PM
Checkout our pre-print where we conducted a large scale clinical analysis looking at VTE rates in GBM. Excited to share mechanistic work in the near future showing how thrombosis drives GBM progression.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Great time celebrating the holidays at our annual holiday party @gbm-maestro.bsky.social @oconnor-lab.bsky.social @emulkearns.bsky.social
December 8, 2024 at 3:32 PM
Great time celebrating the holidays at our annual holiday party @gbm-maestro.bsky.social @oconnor-lab.bsky.social @emulkearns.bsky.social
Reposted by Anthony R. Sloan, Ph.D
Ageing of stem cells reduces their capacity to form tumors by reprogramming iron homeostasis
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
December 5, 2024 at 12:12 AM
Ageing of stem cells reduces their capacity to form tumors by reprogramming iron homeostasis
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
With grace and gratitude, Happy Thanksgiving to you and your loved ones!
November 28, 2024 at 7:44 PM
With grace and gratitude, Happy Thanksgiving to you and your loved ones!
Reposted by Anthony R. Sloan, Ph.D
Please help me spread the word about this amazing two-year pre-doc opportunity. Research with faculty is optional. Get paid to take classes that prepare you for PhD. Deadline 11/15: stern.nyu.edu/programs-adm...
Pre-Doctoral Program - NYU SternArtboard 1Artboard 1
stern.nyu.edu
November 26, 2024 at 1:38 PM
Please help me spread the word about this amazing two-year pre-doc opportunity. Research with faculty is optional. Get paid to take classes that prepare you for PhD. Deadline 11/15: stern.nyu.edu/programs-adm...
Reposted by Anthony R. Sloan, Ph.D
Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity - Nature Aging
Exploring how aging compromises antitumor immunity, the authors reveal an age-related impairment of cytotoxic CD8+ TRM cells in mouse tumor models and clinical samples. They implicate BFAR signaling a...
www.nature.com
November 27, 2024 at 2:26 AM
Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Anthony R. Sloan, Ph.D
Thank you to everyone who made #SNO2024 a successful event! 🙌 From inspiring sessions to invaluable connections, we’re proud to advance the field of neuro-oncology together. 🌟
Let’s close with a commitment to innovation and collaboration. Safe travels, and see you in Hawaii #SNO2025!
Let’s close with a commitment to innovation and collaboration. Safe travels, and see you in Hawaii #SNO2025!
November 24, 2024 at 6:09 PM
Great time and good discussion with brilliant scientists at SNO2024. Already looking forward to next years meeting! @neuroonc.bsky.social @gbm-maestro.bsky.social @oconnor-lab.bsky.social @dbayik.bsky.social
November 24, 2024 at 11:18 PM
Great time and good discussion with brilliant scientists at SNO2024. Already looking forward to next years meeting! @neuroonc.bsky.social @gbm-maestro.bsky.social @oconnor-lab.bsky.social @dbayik.bsky.social