Anna Dart
@annaedart.bsky.social
Chief Editor of Nature Reviews Cancer
Views are my own
Views are my own
Check out our latest Focus issue highlighting why the mechanisms of ageing, which contribute to cancer development, progression & treatment are so important in our rapidly ageing global population 👇
New online: #Focus on ageing and cancer
Today, on #WorldCancerResearchDay we publish the first of our two focus issues highlighting current research at the intersection between #ageing and #cancer.
Read all about it in our #editorial 👇
Today, on #WorldCancerResearchDay we publish the first of our two focus issues highlighting current research at the intersection between #ageing and #cancer.
Read all about it in our #editorial 👇
Focusing on the complex and dynamic interplay between ageing and cancer - Nature Reviews Cancer
This Focus issue highlights current research at the intersection of ageing and cancer, and explores how insights gained from this may lead to better cancer prevention strategies and diagnostics, enhanced therapeutic efficacy and improvements to both patient quality of life and outcomes.
bit.ly
September 24, 2025 at 12:58 PM
Check out our latest Focus issue highlighting why the mechanisms of ageing, which contribute to cancer development, progression & treatment are so important in our rapidly ageing global population 👇
Reposted by Anna Dart
#Comment 🚨
Asghar&Chung highlight cancer applications of digital twins, integrating molecular data & drug responses to inform personalized treatment & accelerate drug development through clinical trial simulation.
📖⬇️
Asghar&Chung highlight cancer applications of digital twins, integrating molecular data & drug responses to inform personalized treatment & accelerate drug development through clinical trial simulation.
📖⬇️
Application of digital twins for personalized oncology - Nature Reviews Cancer
Digital twins are virtual representations that evolve over time with new data inputs. In this Comment, Asghar and Chung describe cancer applications of digital twins that include the integration of molecular information and individual drug responses of patients, and explain how they can inform individualized treatment, accelerate drug development through clinical trial simulation and enable the exploration of multiscale relationships in the entire human body to drive new therapeutic discoveries.
bit.ly
July 16, 2025 at 2:20 PM
#Comment 🚨
Asghar&Chung highlight cancer applications of digital twins, integrating molecular data & drug responses to inform personalized treatment & accelerate drug development through clinical trial simulation.
📖⬇️
Asghar&Chung highlight cancer applications of digital twins, integrating molecular data & drug responses to inform personalized treatment & accelerate drug development through clinical trial simulation.
📖⬇️
Reposted by Anna Dart
#Review 🚨
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Modelling the ageing dependence of cancer evolutionary trajectories - Nature Reviews Cancer
In this Review, Henry and DeGregori discuss the contributions of the various models and methods used to study the connection between ageing and cancer, highlighting the strengths and limitations of those models and technologies, as well as advocating for the wider adoption of age-appropriate models of cancer to improve our clinical translation of approaches to prevent and treat human cancers.
bit.ly
July 17, 2025 at 2:25 PM
#Review 🚨
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Reposted by Anna Dart
#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer
In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.
bit.ly
July 18, 2025 at 10:29 AM
#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Reposted by Anna Dart
NEW content online!
Metabolic adaptations of brain metastasis
Nature Reviews Cancer, Published online: 24 July 2025; doi:10.1038/s41568-025-00848-1In this Review, Parida and Malladi summarize the metabolic adaptations of tumour cells upon dissemination to the brain, outline the metabolic crosstalk between cancer and brain-resident cells and discuss potential strategies to target these adaptations to improve outcomes for patients with brain metastasis.
www.nature.com
July 24, 2025 at 4:23 PM
NEW content online!
Reposted by Anna Dart
Perspective 🚨
Orsolya Vincze @OVincze, Thomas Pradeu &Co discuss how cancer research can be advanced using comparative oncology and call for the increased use of non-conventional model organisms to advance cancer prevention and treatment.
📖 ⬇️
Orsolya Vincze @OVincze, Thomas Pradeu &Co discuss how cancer research can be advanced using comparative oncology and call for the increased use of non-conventional model organisms to advance cancer prevention and treatment.
📖 ⬇️
Advancing cancer research via comparative oncology - Nature Reviews Cancer
Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms underlying the remarkable cancer resistance of some taxa. Therefore, this Perspective by Vincze et al. calls for the increased use of non-conventional model organisms in cancer research to advance cancer prevention and treatment strategies.
bit.ly
July 3, 2025 at 1:30 PM
Perspective 🚨
Orsolya Vincze @OVincze, Thomas Pradeu &Co discuss how cancer research can be advanced using comparative oncology and call for the increased use of non-conventional model organisms to advance cancer prevention and treatment.
📖 ⬇️
Orsolya Vincze @OVincze, Thomas Pradeu &Co discuss how cancer research can be advanced using comparative oncology and call for the increased use of non-conventional model organisms to advance cancer prevention and treatment.
📖 ⬇️
Reposted by Anna Dart
Our July issue is LIVE! 🌞🥵🏖️
It features articles on:
- Targeted protein degradation for cancer therapy
- Advances in therapeutic cancer vaccines
- The TGFβ paradox in HPV-driven cancer
- The paths to metastasis
Happy reading! 👇 📖
https://www.nature.c...
It features articles on:
- Targeted protein degradation for cancer therapy
- Advances in therapeutic cancer vaccines
- The TGFβ paradox in HPV-driven cancer
- The paths to metastasis
Happy reading! 👇 📖
https://www.nature.c...
June 27, 2025 at 2:51 PM
Our July issue is LIVE! 🌞🥵🏖️
It features articles on:
- Targeted protein degradation for cancer therapy
- Advances in therapeutic cancer vaccines
- The TGFβ paradox in HPV-driven cancer
- The paths to metastasis
Happy reading! 👇 📖
https://www.nature.c...
It features articles on:
- Targeted protein degradation for cancer therapy
- Advances in therapeutic cancer vaccines
- The TGFβ paradox in HPV-driven cancer
- The paths to metastasis
Happy reading! 👇 📖
https://www.nature.c...
Reposted by Anna Dart
Our June issue is now LIVE!🌞
It features articles on:
- Challenges of SCLC heterogeneity & phenotypic plasticity
- The fibroinflammatory response in #cancer
- Moonlighting functions of glucose metabolic enzymes & metabolites in cancer
- PIPKs in cancer
📖👇 www.nature.com/nrc/volumes/...
It features articles on:
- Challenges of SCLC heterogeneity & phenotypic plasticity
- The fibroinflammatory response in #cancer
- Moonlighting functions of glucose metabolic enzymes & metabolites in cancer
- PIPKs in cancer
📖👇 www.nature.com/nrc/volumes/...
May 30, 2025 at 4:15 PM
Our June issue is now LIVE!🌞
It features articles on:
- Challenges of SCLC heterogeneity & phenotypic plasticity
- The fibroinflammatory response in #cancer
- Moonlighting functions of glucose metabolic enzymes & metabolites in cancer
- PIPKs in cancer
📖👇 www.nature.com/nrc/volumes/...
It features articles on:
- Challenges of SCLC heterogeneity & phenotypic plasticity
- The fibroinflammatory response in #cancer
- Moonlighting functions of glucose metabolic enzymes & metabolites in cancer
- PIPKs in cancer
📖👇 www.nature.com/nrc/volumes/...
Reposted by Anna Dart
I don't think I posted about this yet. COME WORK WITH US AT NATURE METHODS! This is a rare opportunity, and we can't wait for our new colleague. Feel free to contact me with questions.
Our colleagues at the Nature Research Cross-Journal Editorial team are also hiring for two new positions! 👇
Metabolism/cancer/aging/immunology/cell bio:
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Neuroscience/genetics/genomics/mol bio:
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Metabolism/cancer/aging/immunology/cell bio:
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Neuroscience/genetics/genomics/mol bio:
springernature.wd3.myworkdayjobs.com/SpringerNatu...
May 21, 2025 at 2:19 PM
I don't think I posted about this yet. COME WORK WITH US AT NATURE METHODS! This is a rare opportunity, and we can't wait for our new colleague. Feel free to contact me with questions.
I'll be there, so make sure you sign up for what promises to be a fantastic meeting!
Free to attend Nature conference in collaboration with @mdanderson.bsky.social exploring breakthroughs in understanding the #tumour ecosystem and its influence in #cancer development, progression, diagnosis & treatment
👉https://go.nature.com/44vavDt
👉https://go.nature.com/44vavDt
May 16, 2025 at 9:08 AM
I'll be there, so make sure you sign up for what promises to be a fantastic meeting!
What an honour to be part of this meeting! Fantastic scientists and clinicians in a fantastic setting, brainstorming how to advance this field and find life-saving cures for patients with glioblastoma.
Thank you to participants of "Glioblastoma" for productive and invigorating discussions, with special thanks to organizers Drs. Melissa Bondy, Peter Dirks, and Bill Weiss. We are grateful to the @cshlnews.bsky.social - @northwellhealth.bsky.social Affiliation for support.
Agenda: bit.ly/GBM-25
Agenda: bit.ly/GBM-25
April 17, 2025 at 6:32 PM
What an honour to be part of this meeting! Fantastic scientists and clinicians in a fantastic setting, brainstorming how to advance this field and find life-saving cures for patients with glioblastoma.
And the moment you have all been waiting for...our top downloaded article of 2024! 👏 Well worth a read!
FINALLY 🥁...our top most downloaded article of the year is…. 🥁🥁🥁
Why do patients with cancer die? By @tcox.bsky.social, Erik Sahai, et al.
https://bit.ly/3WIyl...
#metastasis #cancertherapy #cancermodels
@crick.ac.uk @natureportfolio.bsky.social #NRCtop10of2024
Why do patients with cancer die? By @tcox.bsky.social, Erik Sahai, et al.
https://bit.ly/3WIyl...
#metastasis #cancertherapy #cancermodels
@crick.ac.uk @natureportfolio.bsky.social #NRCtop10of2024
Why do patients with cancer die? - Nature Reviews Cancer
In this Roadmap, Boire et al. consider the immediate causes of mortality in patients with cancer, a topic not often considered in either preclinical or clinical research, and provide recommendations for how we can stimulate research to advance our mechanistic understanding of these causes with a....
bit.ly
February 14, 2025 at 7:13 PM
And the moment you have all been waiting for...our top downloaded article of 2024! 👏 Well worth a read!
And just off the top spot....👇
🥳 Our 2nd most downloaded article in 2024:
Cancer therapy with antibodies by Paul, Gabelli, Ho, van Elsas et al.
https://bit.ly/3EjrG...
#drugdevelopment #cancertherapy #antibodytherapy
@natureportfolio.bsky.social #NRCtop10of2024
Cancer therapy with antibodies by Paul, Gabelli, Ho, van Elsas et al.
https://bit.ly/3EjrG...
#drugdevelopment #cancertherapy #antibodytherapy
@natureportfolio.bsky.social #NRCtop10of2024
Cancer therapy with antibodies - Nature Reviews Cancer
In this Review, Paul et al. provide an overview of therapeutic antibodies as an important modality in cancer therapy today. They summarize the different approaches used by antibodies to target cancer cells including those of immune checkpoint inhibitors, bispecific antibodies...
bit.ly
February 13, 2025 at 6:43 PM
And just off the top spot....👇
And number 3....👇
🥳 Our 3rd most downloaded article in 2024:
A guide to artificial intelligence for cancer researchers by @jnkt.bsky.social and colleagues
https://bit.ly/3yEzl...
#AI #artificialintelligence #cancermodelling
@natureportfolio.bsky.social #NRCtop10of2024
A guide to artificial intelligence for cancer researchers by @jnkt.bsky.social and colleagues
https://bit.ly/3yEzl...
#AI #artificialintelligence #cancermodelling
@natureportfolio.bsky.social #NRCtop10of2024
A guide to artificial intelligence for cancer researchers - Nature Reviews Cancer
This Review provides an introductory guide to artificial intelligence (AI)-based tools for non-computational cancer researchers. Here, Perez-Lopez et al. outline the general principles of AI for image analysis, natural language processing and drug discovery...
bit.ly
February 12, 2025 at 9:16 PM
And number 3....👇
In at number 4....
🥳 Our 4th most downloaded article in 2024:
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel by @thefuchslab.bsky.social & colleagues
https://bit.ly/42Cvr...
@rockefelleruniv.bsky.social @hhmi.bsky.social @natureportfolio.bsky.social #NRCtop10of2024
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel by @thefuchslab.bsky.social & colleagues
https://bit.ly/42Cvr...
@rockefelleruniv.bsky.social @hhmi.bsky.social @natureportfolio.bsky.social #NRCtop10of2024
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel - Nature Reviews Cancer
In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic factors induce the epigenetic changes necessary for tumorigenesis.
bit.ly
February 12, 2025 at 9:02 AM
In at number 4....
And the countdown begins again this week with number 5...👇
🥳 Our 5th most downloaded article in 2024:
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment by Calvin Kuo, Polk & Elisa Zhang
https://bit.ly/4jAOu...
@stanfordpress.bsky.social @stanfordmedicine.bsky.social @natureportfolio.bsky.social #NRCtop10of2024
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment by Calvin Kuo, Polk & Elisa Zhang
https://bit.ly/4jAOu...
@stanfordpress.bsky.social @stanfordmedicine.bsky.social @natureportfolio.bsky.social #NRCtop10of2024
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment - Nature Reviews Cancer
In this Review, Polak, Zhang and Kuo discuss the currently available and rapidly evolving 3D tumour organoid models that capture the tumour immune microenvironment. They highlight opportunities for organoid-based investigations of tumour immunity, drug development and precision medicine.
bit.ly
February 10, 2025 at 7:52 PM
And the countdown begins again this week with number 5...👇
Reposted by Anna Dart
And in at number 6 👇 Top 5 coming next week! 👏 Exciting!
🥳 Our 6th most downloaded article in 2024:
The evolutionary theory of cancer: challenges and potential solutions by @lucielaplane.bsky.social & @cmaley.bsky.social
https://bit.ly/3PWjS...
#cancermodels #evolutionarybiology
@sorbonne-universite.fr @natureportfolio.bsky.social #NRCtop10of2024
The evolutionary theory of cancer: challenges and potential solutions by @lucielaplane.bsky.social & @cmaley.bsky.social
https://bit.ly/3PWjS...
#cancermodels #evolutionarybiology
@sorbonne-universite.fr @natureportfolio.bsky.social #NRCtop10of2024
The evolutionary theory of cancer: challenges and potential solutions - Nature Reviews Cancer
Clonal evolution is now a central theoretical framework in cancer research. In this Perspective, Laplane and Maley identify challenges to that theory such that some non-evolutionary phenomena in cancer cannot be captured by the theory.
bit.ly
February 7, 2025 at 7:19 PM
And in at number 6 👇 Top 5 coming next week! 👏 Exciting!
And at number 7....👇
🥳 Our 7th most downloaded article in 2024:
Cancer drug-tolerant persister cells: from biological questions to clinical opportunities by Bardelli, Russo et. al
https://bit.ly/3CkSE...
#persistercells #DTPs #cancerresistance
@natureportfolio.bsky.social #NRCtop10of2024
Cancer drug-tolerant persister cells: from biological questions to clinical opportunities by Bardelli, Russo et. al
https://bit.ly/3CkSE...
#persistercells #DTPs #cancerresistance
@natureportfolio.bsky.social #NRCtop10of2024
Cancer drug-tolerant persister cells: from biological questions to clinical opportunities - Nature Reviews Cancer
Resistance to therapy remains the biggest challenge to achieving cures in patients with cancer. In this Roadmap, Russo et al. overview the field of cancer drug-tolerant persister cells providing paths to advance our understanding of their biology with innovative technologies...
bit.ly
February 6, 2025 at 7:40 PM
And at number 7....👇
In at number 8...👇
🥳 Our 8th most downloaded article in 2024:
Exploiting temporal aspects of cancer immunotherapy by Lesterhuis et al.
https://bit.ly/3Xs8l...
#immunotherapy
@natureportfolio.bsky.social #NRCtop10of2024
Exploiting temporal aspects of cancer immunotherapy by Lesterhuis et al.
https://bit.ly/3Xs8l...
#immunotherapy
@natureportfolio.bsky.social #NRCtop10of2024
Exploiting temporal aspects of cancer immunotherapy - Nature Reviews Cancer
The tumour immune microenvironment greatly affects responses to immune checkpoint therapies. In this Perspective, Zemek et al. explore the dynamic changes in response to both immunotherapy and conventional treatment and advocate for strategic combination therapies over time....
bit.ly
February 5, 2025 at 4:11 PM
In at number 8...👇
And in at number 9....👇
🥳 Our 9th most downloaded article in 2024:
Tertiary lymphoid structures in anticancer immunity by Dieu-Nosjean et al.
https://bit.ly/3WGcv...
#cancermicroenvironment
@inserm.fr @natureportfolio.bsky.social #NRCtop10of2024
Tertiary lymphoid structures in anticancer immunity by Dieu-Nosjean et al.
https://bit.ly/3WGcv...
#cancermicroenvironment
@inserm.fr @natureportfolio.bsky.social #NRCtop10of2024
Tertiary lymphoid structures in anticancer immunity - Nature Reviews Cancer
Transient ectopic lymphoid structures known as tertiary lymphoid structures (TLS) have been observed in many solid tumour types. Teillaud et al. discuss how these TLS potentially orchestrate immune responses against tumours locally...
bit.ly
February 4, 2025 at 8:59 PM
And in at number 9....👇
And in at number 10 is....👇
🥳 First up in #NRCtop10of2024:
Emerging strategies to investigate the biology of early cancer by Zhou, Tang & Wang
https://bit.ly/4hE1x...
#cancerimaging #cancerscreening #cancerprevention
@natureportfolio.bsky.social #NRCtop10of2024
Emerging strategies to investigate the biology of early cancer by Zhou, Tang & Wang
https://bit.ly/4hE1x...
#cancerimaging #cancerscreening #cancerprevention
@natureportfolio.bsky.social #NRCtop10of2024
Emerging strategies to investigate the biology of early cancer - Nature Reviews Cancer
Understanding the early steps of cancer development is crucial for cancer prevention. In this Review, the authors summarize the advantages and limitations of clinical samples, autochthonous mouse models and organoid models, alongside advanced techniques such as direct imaging, lineage tracing...
bit.ly
February 3, 2025 at 6:27 PM
And in at number 10 is....👇
Well worth a read! Hanahan et al. argue that many normal cell types are hard-wired with latent functions that can be triggered to prevent inappropriate immune attack. An intrinsic capability that is co-opted by tumours 👇
#REVIEW 🚨
Hanahan, Michielin & Pittet discuss how, nearly all cell types in the tumour microenvironment can be programmed to mediate — as functionally distinct subtypes — immunosuppressive programmes.
📖 👇
https://bit.ly/3NGkl...
Hanahan, Michielin & Pittet discuss how, nearly all cell types in the tumour microenvironment can be programmed to mediate — as functionally distinct subtypes — immunosuppressive programmes.
📖 👇
https://bit.ly/3NGkl...
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment - Nature Reviews Cancer
In this Review, Hanahan et al. discuss how, in response to tumorigenesis, nearly all cell types in the tumour microenvironment can be programmed to mediate — as functionally distinct subtypes — immunosuppressive programmes.
bit.ly
January 29, 2025 at 7:35 PM
Well worth a read! Hanahan et al. argue that many normal cell types are hard-wired with latent functions that can be triggered to prevent inappropriate immune attack. An intrinsic capability that is co-opted by tumours 👇
Reposted by Anna Dart
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X
https://go.nature.com/42tH8Ai
https://go.nature.com/42tH8Ai
Bluesky’s science takeover: 70% of Nature poll respondents use platform
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.
go.nature.com
January 24, 2025 at 11:52 AM
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X
https://go.nature.com/42tH8Ai
https://go.nature.com/42tH8Ai
Reposted by Anna Dart
Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉)
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...
January 24, 2025 at 3:22 PM
Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉)
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...