Van Hooff et al. reconstruct the evolutionary histories of eukaryotic SMC complexes, molecular machineries that organize chromosomes. SMC complexes were fully present in the last eukaryotic common ancestor (LECA) but have been frequently lost during evolution. Remarkably, these complexes originated from an ancient duplication in archaeal ancestors, suggesting that sophisticated chromosome organization predated eukaryotes.

Adhikashreni et al. use quantitative live-cell imaging to track cell-cycle dynamics in hundreds of individual bacteria. They observe nutrient-dependent regulation of replication elongation rates that ...

In September 2023, the Biology and Physics of Prokaryotic Chromosomes meeting ran at the Lorentz Center in Leiden, The Netherlands. As part of the workshop, those in attendance developed a series of ....

RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage...

Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...

The structure of PafBC in its active conformation reveals the binding mode of the activating ligand at the PafBC WYL domains.

In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

by Roberto – The short answer to that question is an enthusiastic YES! Of course, there is a future for STC, and I think it is bright. The long answer, well... that's what this post is all about It r...