Alyssa Johnson
@alyssajohnson.bsky.social
Associate Professor at LSU using worms and flies to study lysosomes, aging, and age-related diseases. Lab website: https://faculty.lsu.edu/johnsona/index.php
In our newest paper published in @natcomms.nature.com, we show that DAF-16/FOXO and HLH-30/TFRB promote healthy aging, in part, by activating lipid metabolism genes that remodel lysosomes into tubular networks (more in comments below).
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans - Nature Communications
This study reveals that transcription factors DAF-16/FOXO and HLH-30/TFEB promote healthy aging in C. elegans, in part, by activating lipid metabolism genes that remodel lysosomes into tubular network...
www.nature.com
November 11, 2025 at 4:14 PM
In our newest paper published in @natcomms.nature.com, we show that DAF-16/FOXO and HLH-30/TFRB promote healthy aging, in part, by activating lipid metabolism genes that remodel lysosomes into tubular networks (more in comments below).
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In our newest paper, we show that expression of a familial natural short sleep mutation in flies extends lifespan through enhanced mitochondrial physiology. First first-author paper for former graduate student Pritika Pandey! @pritika26.bsky.social
@lsuscience.bsky.social @lsu.bsky.social
@lsuscience.bsky.social @lsu.bsky.social
A familial natural short sleep mutation in dec2 extends healthspan and lifespan in Drosophila
Biological sciences; Genetics; Neuroscience
www.cell.com
September 27, 2025 at 12:46 AM
In our newest paper, we show that expression of a familial natural short sleep mutation in flies extends lifespan through enhanced mitochondrial physiology. First first-author paper for former graduate student Pritika Pandey! @pritika26.bsky.social
@lsuscience.bsky.social @lsu.bsky.social
@lsuscience.bsky.social @lsu.bsky.social
Congratulations to Dr. Pritika Pandey! 2nd PhD student from the lab and now she is off to do a postdoc at UNC! 🎉 🎓
@lsuscience.bsky.social
@lsuscience.bsky.social
May 17, 2025 at 2:08 AM
Congratulations to Dr. Pritika Pandey! 2nd PhD student from the lab and now she is off to do a postdoc at UNC! 🎉 🎓
@lsuscience.bsky.social
@lsuscience.bsky.social
Reposted by Alyssa Johnson
This is a useful distinction - generative vs non-generative AI for writing, and how it relates to the writer's own input
As promised, here are the slides I shared with students to convince them to NOT use chatGPT and other artificial stupidity.
TL;DR? AI is evil, unsustainable and stupid, and I'd much rather they use their own brains, make their own mistakes, and actually learn something. 🪄
TL;DR? AI is evil, unsustainable and stupid, and I'd much rather they use their own brains, make their own mistakes, and actually learn something. 🪄
February 24, 2025 at 11:36 PM
This is a useful distinction - generative vs non-generative AI for writing, and how it relates to the writer's own input
Great video explaining indirect costs from the AAU. I shared this with my lab members.
Facilities and Administrative (F&A) Costs Explainer
YouTube video by Association of American Universities
www.youtube.com
February 22, 2025 at 1:17 AM
Great video explaining indirect costs from the AAU. I shared this with my lab members.
Reposted by Alyssa Johnson
ER - a "neuron within a neuron". Fascinating work on signal spread via the ER in dendrites. Still leaves open the role of ER continuity in axons.
🥼 New research from the Lippincott-Schwartz Lab reveals a novel mechanism for signal transmission in brain cells & helps answer an open question in neuroscience about how intracellular signals travel over long distances in neurons.
From muscle to memory: new research uses clues from the body to understand signaling in the brain
New research led by the Lippincott-Schwartz Lab shows that a network of subcellular structures similar to those responsible for propagating molecular signals that make muscles contract are also respon
www.janelia.org
February 16, 2025 at 5:50 PM
ER - a "neuron within a neuron". Fascinating work on signal spread via the ER in dendrites. Still leaves open the role of ER continuity in axons.
Some good news amidst all the chaos…New paper published in Biology Open! This work was initiated by two undergraduates (Brennan Mercola and Tatiana Villalobos) and completed by graduate students Jocelyn Wood and Ankita Basu!
@biologyopen.bsky.social @lsuscience.bsky.social @lsuresearch.bsky.social
@biologyopen.bsky.social @lsuscience.bsky.social @lsuresearch.bsky.social
Increased expression of the small lysosomal gene SVIP in the Drosophila gut suppresses pathophysiological features associated with a high-fat diet
Summary: Increasing lysosome activity in the fly midgut offsets negative effects of an obesogenic high-fat diet.
journals.biologists.com
February 1, 2025 at 4:01 PM
Some good news amidst all the chaos…New paper published in Biology Open! This work was initiated by two undergraduates (Brennan Mercola and Tatiana Villalobos) and completed by graduate students Jocelyn Wood and Ankita Basu!
@biologyopen.bsky.social @lsuscience.bsky.social @lsuresearch.bsky.social
@biologyopen.bsky.social @lsuscience.bsky.social @lsuresearch.bsky.social
Reposted by Alyssa Johnson
Light-activated binding of a protein to tubular lysosomes:
January 31, 2025 at 3:06 AM
Light-activated binding of a protein to tubular lysosomes:
Reposted by Alyssa Johnson
Are you a graduating undergrad looking for research experience?
Come to @lsu.bsky.social and join @lsulagniappe.bsky.social
Louisiana Graduate Network in Applied Evolution ("LAGNiAppE": a 1-yr research training program for recent college graduates)
Deadline 3/16/25
www.lsu.edu/science/bios...
Come to @lsu.bsky.social and join @lsulagniappe.bsky.social
Louisiana Graduate Network in Applied Evolution ("LAGNiAppE": a 1-yr research training program for recent college graduates)
Deadline 3/16/25
www.lsu.edu/science/bios...
LSU LAGNiAppE!
www.lsu.edu
January 29, 2025 at 1:14 PM
Are you a graduating undergrad looking for research experience?
Come to @lsu.bsky.social and join @lsulagniappe.bsky.social
Louisiana Graduate Network in Applied Evolution ("LAGNiAppE": a 1-yr research training program for recent college graduates)
Deadline 3/16/25
www.lsu.edu/science/bios...
Come to @lsu.bsky.social and join @lsulagniappe.bsky.social
Louisiana Graduate Network in Applied Evolution ("LAGNiAppE": a 1-yr research training program for recent college graduates)
Deadline 3/16/25
www.lsu.edu/science/bios...
Reposted by Alyssa Johnson
Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org
Kim Lab at UC Irvine
Visit the post for more.
sskimlab.org
January 20, 2025 at 11:08 PM
Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org
Reposted by Alyssa Johnson
January 3, 2025 at 2:25 PM
Reposted by Alyssa Johnson
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
Hahn et al. report the presence of 6mA, a DNA modification, on the mitochondrial (mt)DNA of various animal and plant species. Modulating the activity of 6mA enzymatic modifiers implicates 6mA in regulating mtDNA replication and expression and the transmission of mtDNA mutations across generations, ultimately affecting mitochondrial health and organismal lifespan.
www.cell.com
December 8, 2024 at 8:25 PM
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Reposted by Alyssa Johnson
#PaperAlert we bring wonderful news about
@WAutophagy
... our Mericka McCabe and our founders just published a
@NatureCellBio
article explaining the wonders of our Network...don't miss a bit!! With very valuables testimonials of our volunteers...
rdcu.be/d10N6
@WAutophagy
... our Mericka McCabe and our founders just published a
@NatureCellBio
article explaining the wonders of our Network...don't miss a bit!! With very valuables testimonials of our volunteers...
rdcu.be/d10N6
Women in Autophagy: an initiative to promote gender parity in science
Nature Cell Biology - Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. Initiatives such as the Women in...
rdcu.be
December 5, 2024 at 7:44 PM
#PaperAlert we bring wonderful news about
@WAutophagy
... our Mericka McCabe and our founders just published a
@NatureCellBio
article explaining the wonders of our Network...don't miss a bit!! With very valuables testimonials of our volunteers...
rdcu.be/d10N6
@WAutophagy
... our Mericka McCabe and our founders just published a
@NatureCellBio
article explaining the wonders of our Network...don't miss a bit!! With very valuables testimonials of our volunteers...
rdcu.be/d10N6
Reposted by Alyssa Johnson
My first Bluesky paper post! I’m pleased to announce the publication of our single-nucleus atlas of adult neurons from wild-type and long-lived, better performing insulin receptor (daf-2) mutants, by Jon St. Ange and Yifei Weng et al.DOI: 10.1016/j.xgen.2024.100720
December 5, 2024 at 2:19 PM
My first Bluesky paper post! I’m pleased to announce the publication of our single-nucleus atlas of adult neurons from wild-type and long-lived, better performing insulin receptor (daf-2) mutants, by Jon St. Ange and Yifei Weng et al.DOI: 10.1016/j.xgen.2024.100720
Reposted by Alyssa Johnson
Reposted by Alyssa Johnson
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
November 25, 2024 at 2:44 PM
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
Reposted by Alyssa Johnson
Hi! I study how cells form memories. Our lab's most recent study in Nature Commmunications shows that non-neural cells, including kidney cells, can count, detect precise time patterns, and form lasting memories in ways similar to neurons.🧵https://www.nature.com/articles/s41467-024-53922-x
November 23, 2024 at 12:02 AM
Hi! I study how cells form memories. Our lab's most recent study in Nature Commmunications shows that non-neural cells, including kidney cells, can count, detect precise time patterns, and form lasting memories in ways similar to neurons.🧵https://www.nature.com/articles/s41467-024-53922-x
Reposted by Alyssa Johnson
FlyWire #Neuroscience data (green) is now in neuronbridge.janelia.org for matching against #Drosophila light #microscopy data (magenta). Thanks to Cristian Goina, Hideo Otsuna, Rob Svirskas, Konrad Rokicki. See a match in the browser, using mixed surface / volume rendering implemented with #threejs.
November 23, 2024 at 10:27 AM
FlyWire #Neuroscience data (green) is now in neuronbridge.janelia.org for matching against #Drosophila light #microscopy data (magenta). Thanks to Cristian Goina, Hideo Otsuna, Rob Svirskas, Konrad Rokicki. See a match in the browser, using mixed surface / volume rendering implemented with #threejs.
Reposted by Alyssa Johnson
Cool new work from the lab by @chris-morrow.bsky.social: Often we think of auto-fluorescence as a hindrance to experiments - but endogenous metabolites have specific fluorescence we can use to determine the metabolic state of the cell - and predict lifespan.. www.nature.com/articles/s42...
Endogenous mitochondrial NAD(P)H fluorescence can predict lifespan - Communications Biology
Endogenous mitochondrial NAD(P)H fluorescence enables label-free and subcellular resolution quantification of aging, prediction of remaining lifespan and tracking of age-dependent changes to mitochond...
www.nature.com
November 22, 2024 at 2:59 PM
Cool new work from the lab by @chris-morrow.bsky.social: Often we think of auto-fluorescence as a hindrance to experiments - but endogenous metabolites have specific fluorescence we can use to determine the metabolic state of the cell - and predict lifespan.. www.nature.com/articles/s42...
Reposted by Alyssa Johnson
mTORC1 activity licenses its own release from the lysosomal surface
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
mTORC1 activity licenses its own release from the lysosomal surface
The activation of mTORC1 is intricately linked to its subcellular localization, with
the Rag GTPases controlling its lysosomal recruitment in response to nutrient cues.
Acharya and Demetriades uncover...
www.cell.com
November 23, 2024 at 11:13 AM
mTORC1 activity licenses its own release from the lysosomal surface
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Alyssa Johnson
Finally moved to #Bluesky and happy to share our recent work! We found that hexokinase 1 rapidly forms rings around #mitochondria during energy stress to regulate mitochondrial fission:
www.cell.com/molecular-ce...
For a quick summary of our findings, check out the comment section.
www.cell.com/molecular-ce...
For a quick summary of our findings, check out the comment section.
November 23, 2024 at 9:35 AM
Finally moved to #Bluesky and happy to share our recent work! We found that hexokinase 1 rapidly forms rings around #mitochondria during energy stress to regulate mitochondrial fission:
www.cell.com/molecular-ce...
For a quick summary of our findings, check out the comment section.
www.cell.com/molecular-ce...
For a quick summary of our findings, check out the comment section.