Alina Nicheperovich
@alinanich.bsky.social
(Epi)Genomics of placental cancer🤰🏻
PhD candidate & Clarendon scholar @ Ludwig Institute for Cancer Research, University of Oxford
PhD candidate & Clarendon scholar @ Ludwig Institute for Cancer Research, University of Oxford
Reposted by Alina Nicheperovich
Gestational trophoblastic disease encompasses rare benign and malignant placental lesions. @alinanich.bsky.social @dagams.bsky.social & @mnileathlobhair.bsky.social examine #GTD from a molecular perspective, providing a unique framework for understanding this rare disease. doi.org/10.1242/dmm....
![Gestational trophoblastic disease (GTD) classification. GTD encompasses a spectrum of benign and malignant lesions in the placenta. Benign lesions include atypical placental site nodule (APSN) and molar pregnancies [partial hydatidiform moles (PHMs) and complete hydatidiform moles (CHMs)]. Malignant gestational lesions, also known as gestational trophoblastic neoplasia (GTN), include invasive moles, choriocarcinoma (CC), placental site trophoblastic tumour (PSTT) and epithelioid trophoblastic tumour (ETT). Whereas all invasive moles follow a molar pregnancy, other cancers can be of molar or non-molar origin. The arrow indicates metastasis.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5jupfg23qpjk2643o6aeftly/bafkreigf5opmbrwobb7ukzlgr3uq6fshaz7gid3wwqxk7kh2qf7pcpqkle@jpeg)
April 10, 2025 at 3:17 PM
Gestational trophoblastic disease encompasses rare benign and malignant placental lesions. @alinanich.bsky.social @dagams.bsky.social & @mnileathlobhair.bsky.social examine #GTD from a molecular perspective, providing a unique framework for understanding this rare disease. doi.org/10.1242/dmm....
Reposted by Alina Nicheperovich
Really nice study from Marketa Tomkova's group @ndm.ox.ac.uk drawing link between DNAme, polycomb-antagonism and gene activation in cancer. A nice complement to our paper in ESCs (plus some rad epigenome editing experiments 😍). Congrats to all the authors! www.biorxiv.org/content/10.1...
De-novo DNA Methylation of Bivalent Promoters Induces Gene Activation through PRC2 Displacement
Promoter DNA methylation is a key epigenetic mark, commonly associated with gene silencing. However, we noticed that a positive association between promoter DNA methylation and expression is surprisin...
www.biorxiv.org
February 10, 2025 at 3:05 PM
Really nice study from Marketa Tomkova's group @ndm.ox.ac.uk drawing link between DNAme, polycomb-antagonism and gene activation in cancer. A nice complement to our paper in ESCs (plus some rad epigenome editing experiments 😍). Congrats to all the authors! www.biorxiv.org/content/10.1...
Reposted by Alina Nicheperovich
New review paper out, in which we delve into the fascinating world of gestational trophoblastic disease. Never heard of it? Let me fill you in: (a 🧵) #epigenetics #cancer
Gestational trophoblastic disease: understanding the molecular mechanisms of placental tumours
Summary: Gestational trophoblastic disease (GTD) encompasses rare benign and malignant placental lesions. This Review explores the potential genetic, epigenetic and microRNA drivers of GTD, highlighti...
journals.biologists.com
January 28, 2025 at 12:57 PM
New review paper out, in which we delve into the fascinating world of gestational trophoblastic disease. Never heard of it? Let me fill you in: (a 🧵) #epigenetics #cancer
Did you know the complete T2T sequence of a human genome was achieved by sequencing a cell line derived from a pre-cancerous placental lesion? 🧬🤰
📃 Our latest review explores the molecular mechanisms behind placental tumours and highlights why studying them matters:
doi.org/10.1242/dmm....
📃 Our latest review explores the molecular mechanisms behind placental tumours and highlights why studying them matters:
doi.org/10.1242/dmm....
Gestational trophoblastic disease: understanding the molecular mechanisms of placental tumours
Summary: Gestational trophoblastic disease (GTD) encompasses rare benign and malignant placental lesions. This Review explores the potential genetic, epigenetic and microRNA drivers of GTD, highlighti...
doi.org
January 28, 2025 at 1:47 PM
Did you know the complete T2T sequence of a human genome was achieved by sequencing a cell line derived from a pre-cancerous placental lesion? 🧬🤰
📃 Our latest review explores the molecular mechanisms behind placental tumours and highlights why studying them matters:
doi.org/10.1242/dmm....
📃 Our latest review explores the molecular mechanisms behind placental tumours and highlights why studying them matters:
doi.org/10.1242/dmm....
Reposted by Alina Nicheperovich
Are you into #rustlang and looking for (remote) #work? Want to help #cancer #research? We're planning to add some major features to a CLI app that require some serious software engineering skills. Understanding of stats a big +, genetics knowledge a bonus. Send me a DM! (Plz RT for reach) #rustjobs
January 18, 2025 at 9:12 AM
Reposted by Alina Nicheperovich
Excited to share our most recent work in Cell Stem Cell, led by @georgiaplea.bsky.social, characterising determinants of DNA methylation patterning in human trophoblast stem cells! A great collaboration with @vpglab.bsky.social.
tinyurl.com/93mchcd2
@loke-ctr.bsky.social @cam-repro.bsky.social
tinyurl.com/93mchcd2
@loke-ctr.bsky.social @cam-repro.bsky.social
Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome
The placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs). The placental “methylome” is conserved across …
tinyurl.com
January 8, 2025 at 4:21 PM
Excited to share our most recent work in Cell Stem Cell, led by @georgiaplea.bsky.social, characterising determinants of DNA methylation patterning in human trophoblast stem cells! A great collaboration with @vpglab.bsky.social.
tinyurl.com/93mchcd2
@loke-ctr.bsky.social @cam-repro.bsky.social
tinyurl.com/93mchcd2
@loke-ctr.bsky.social @cam-repro.bsky.social