The constant arms race of bacteriophages and their bacterial hosts has inspired major breakthroughs in biotechnology and shaped phages as fierce predators with great clinical potential to fight multid...

Phage Felix O1 (FO1) is one of the most widely used bacteriophages for targeting <i>Salmonella enterica</i> and is applied in both research and food safety settings. Despite its broad host range, we observed significantly reduced efficiency of plating (EOP) on a subset of <i>Salmonella enterica</i> …

Bacteriophages show therapeutic promise for treating bacterial pathogens including nontuberculous mycobacteria (NTM). A major impediment is the paucity of therapeutically useful phages and the great variation in the phage infection profiles, especially among <i><i>Mycobacterium</i> abscessus</i> cli …

Phage infection begins with the adsorption of the phage particle to the bacterial cell surface, followed by the injection of the phage genome into the cell. In the encapsulated hypervirulent <i>K. pneumoniae</i> (hv<i>Kp</i>), the capsular polysaccharide (CPS) surrounding the bacterium was assumed t …

Plasmids are pinnacle tools in synthetic biology and other biotechnological applications. They serve as the simplest approach to introduce recombinant DNA, which is then transcribed into RNA that func...

Understanding host-range determinants in temperate bacteriophages is critical for elucidating phage-host co-evolution and advancing phage therapies. We analysed 3,900 Klebsiella genomes from diverse e...

npj Viruses - Bacteriophages (phages) are viruses that kill bacteria, with potential as antibacterial agents in industrial settings, agriculture, and human health. Here, we identified two phages,...