Afif Jati
@afifjati.bsky.social
PhD student at Trevor Lithgow's group Monash BDI. Facultative bioinformatician who in love with phages and their dark matters.
Much appreciated George!
July 29, 2025 at 8:11 AM
Much appreciated George!
Reposted by Afif Jati
This work was equally driven by two PhD students, Aleksandra Otwinowska (experiments) and Janusz Koszucki (bioinformatics). Check out the preprint or DM if you want to learn more.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Capsular specificity in temperate phages of Klebsiella pneumoniae is driven by diverse receptor-binding enzymes
Understanding host-range determinants in temperate bacteriophages is critical for elucidating phage-host co-evolution and advancing phage therapies. We analysed 3,900 Klebsiella genomes from diverse e...
www.biorxiv.org
June 26, 2025 at 7:13 AM
This work was equally driven by two PhD students, Aleksandra Otwinowska (experiments) and Janusz Koszucki (bioinformatics). Check out the preprint or DM if you want to learn more.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Afif Jati
We discovered a widespread class of SGNH hydrolase–containing RBPs — enzymes structurally related to deacetylases.
They likely modify capsules (e.g. by removing acetyl groups) instead of degrading them — a very different phage infection strategy!
They likely modify capsules (e.g. by removing acetyl groups) instead of degrading them — a very different phage infection strategy!
June 26, 2025 at 7:13 AM
We discovered a widespread class of SGNH hydrolase–containing RBPs — enzymes structurally related to deacetylases.
They likely modify capsules (e.g. by removing acetyl groups) instead of degrading them — a very different phage infection strategy!
They likely modify capsules (e.g. by removing acetyl groups) instead of degrading them — a very different phage infection strategy!