Adhithya Sankar
@adhithyasankar.bsky.social
Endocrinolologist. Salford Royal Hospital, UK. Previously @UoM. Interested in diabetes, obesity and CNS control of metabolism & glucoregulation 🧠. Hiker and nature lover 🏞️.
Pinned
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
Time for wider adoption of salivary cortisone in endocrinology?
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone
jamanetwork.com/journals/jam...
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone
jamanetwork.com/journals/jam...
Time for wider adoption of salivary cortisone in endocrinology?
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone
jamanetwork.com/journals/jam...
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone
jamanetwork.com/journals/jam...
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
October 17, 2025 at 9:00 AM
Time for wider adoption of salivary cortisone in endocrinology?
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone
jamanetwork.com/journals/jam...
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone
jamanetwork.com/journals/jam...
Reposted by Adhithya Sankar
Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam...
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
October 15, 2025 at 8:58 PM
Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam...
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
Reposted by Adhithya Sankar
Does every person with type 2 diabetes respond the same way to GLP-1 receptor agonists? Recent clinical data suggest otherwise. #GLP1 #diabetes link.springer.com/article/10.1... 🔓
Heterogeneity in response to GLP-1 receptor agonists in type 2 diabetes in real-world clinical practice: insights from the DPV register – an IMI-SOPHIA study - Diabetologia
Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a cornerstone in type 2 diabetes management. In this study we evaluated heterogeneity in body weight and glycaemic responses t...
link.springer.com
June 3, 2025 at 3:50 PM
Does every person with type 2 diabetes respond the same way to GLP-1 receptor agonists? Recent clinical data suggest otherwise. #GLP1 #diabetes link.springer.com/article/10.1... 🔓
Reposted by Adhithya Sankar
#Adrenocortical #carcinoma is a rare malignancy, in contrast to benign #adrenal tumours, which are among the most common human neoplasias with a prevalence of greater than 3% in adults older than 50 years www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #OncSky
#OpenAccess
#MedSky #EndoSky #OncSky
Adrenocortical carcinoma: a practical guide for clinicians
Adrenocortical carcinoma is a rare endocrine malignancy. The management of patients
with adrenocortical carcinoma is challenging for several reasons, including its heterogeneous
but frequently aggress...
www.thelancet.com
March 29, 2025 at 5:22 PM
#Adrenocortical #carcinoma is a rare malignancy, in contrast to benign #adrenal tumours, which are among the most common human neoplasias with a prevalence of greater than 3% in adults older than 50 years www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #OncSky
#OpenAccess
#MedSky #EndoSky #OncSky
Reposted by Adhithya Sankar
How to think about evaluation of low testosterone levels, SHBG, clinical symptoms and possible benefits vs. real risks of treatment in the context of #obesity academic.oup.com/jcem/advance...
Approach to the patient: Low testosterone concentrations in men with obesity
Abstract. Pathologic hypogonadism occurs when serum testosterone is significantly and persistently reduced by irreversible organic (structural, genetic) di
academic.oup.com
March 8, 2025 at 6:34 PM
How to think about evaluation of low testosterone levels, SHBG, clinical symptoms and possible benefits vs. real risks of treatment in the context of #obesity academic.oup.com/jcem/advance...
Reposted by Adhithya Sankar
#Finerenone: CV & renal protection across all #T2D therapies❗️
🔹 Pooled analysis: 15,365 pts w/ T2D + CKD or CV
🔸 Consistent benefit on 💔☠️, 🏥💔& kidney outcomes
🔹 ⤴️K+ ⤵️ with SGLT2i use
🔸 Benefit independent of SGLT2i/GLP-1 use
👉 Supports finerenone as a 🎯 in high-risk #T2D❗️
🔗 ggdocs.co/tx2a5r
🔹 Pooled analysis: 15,365 pts w/ T2D + CKD or CV
🔸 Consistent benefit on 💔☠️, 🏥💔& kidney outcomes
🔹 ⤴️K+ ⤵️ with SGLT2i use
🔸 Benefit independent of SGLT2i/GLP-1 use
👉 Supports finerenone as a 🎯 in high-risk #T2D❗️
🔗 ggdocs.co/tx2a5r
March 5, 2025 at 7:54 PM
#Finerenone: CV & renal protection across all #T2D therapies❗️
🔹 Pooled analysis: 15,365 pts w/ T2D + CKD or CV
🔸 Consistent benefit on 💔☠️, 🏥💔& kidney outcomes
🔹 ⤴️K+ ⤵️ with SGLT2i use
🔸 Benefit independent of SGLT2i/GLP-1 use
👉 Supports finerenone as a 🎯 in high-risk #T2D❗️
🔗 ggdocs.co/tx2a5r
🔹 Pooled analysis: 15,365 pts w/ T2D + CKD or CV
🔸 Consistent benefit on 💔☠️, 🏥💔& kidney outcomes
🔹 ⤴️K+ ⤵️ with SGLT2i use
🔸 Benefit independent of SGLT2i/GLP-1 use
👉 Supports finerenone as a 🎯 in high-risk #T2D❗️
🔗 ggdocs.co/tx2a5r
Pleased to share our case report!
RAI is known to worsen TED in Graves’ disease, but what about nodular thyroid disease?
Assessment of TPO antibody, and not just TRAb prior to RAI may be informative in guiding decision-making around steroid prophylaxis.
casereports.bmj.com/content/18/2...
RAI is known to worsen TED in Graves’ disease, but what about nodular thyroid disease?
Assessment of TPO antibody, and not just TRAb prior to RAI may be informative in guiding decision-making around steroid prophylaxis.
casereports.bmj.com/content/18/2...
De novo Graves’ thyroid eye disease after radioiodine treatment for toxic nodular thyroid disease
It is well known that radioactive iodine treatment (RAI) for thyrotoxicosis in Graves’ disease can precipitate worsening of thyroid eye disease (TED), particularly in susceptible patients. Less common...
casereports.bmj.com
February 11, 2025 at 5:44 PM
Pleased to share our case report!
RAI is known to worsen TED in Graves’ disease, but what about nodular thyroid disease?
Assessment of TPO antibody, and not just TRAb prior to RAI may be informative in guiding decision-making around steroid prophylaxis.
casereports.bmj.com/content/18/2...
RAI is known to worsen TED in Graves’ disease, but what about nodular thyroid disease?
Assessment of TPO antibody, and not just TRAb prior to RAI may be informative in guiding decision-making around steroid prophylaxis.
casereports.bmj.com/content/18/2...
Reposted by Adhithya Sankar
Obesity is the third most important predictor of heart disease. We discuss pathophysiology and management including roles of anti-obesity medications and bariatric surgery.
@ncaresearchnhs.bsky.social
www.sciencedirect.com/science/arti...
@ncaresearchnhs.bsky.social
www.sciencedirect.com/science/arti...
Obesity Management for Patients with Coronary Artery Disease and Heart Failure
www.sciencedirect.com
February 7, 2025 at 3:03 PM
Obesity is the third most important predictor of heart disease. We discuss pathophysiology and management including roles of anti-obesity medications and bariatric surgery.
@ncaresearchnhs.bsky.social
www.sciencedirect.com/science/arti...
@ncaresearchnhs.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Adhithya Sankar
Accurate prediction of long-term postoperative weight loss is important for advising patients undergoing bariatric surgery.
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/
@ncaresearchnhs.bsky.social
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/
@ncaresearchnhs.bsky.social
Actual weight loss trajectories after bariatric surgery compared with the SOPHIA prediction tool: An observational comparison study - PubMed
The SOPHIA study tool provides accurate postoperative weight forecasts for some subgroups of patients, but its precision diminishes with time. This study reiterates the necessity for better personaliz...
pubmed.ncbi.nlm.nih.gov
February 3, 2025 at 9:23 PM
Accurate prediction of long-term postoperative weight loss is important for advising patients undergoing bariatric surgery.
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/
@ncaresearchnhs.bsky.social
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/
@ncaresearchnhs.bsky.social
How well can we predict weight loss after bariatric surgery?
Our study assessed the SOPHIA weight prediction tool in our patient population.
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
Our study assessed the SOPHIA weight prediction tool in our patient population.
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
January 30, 2025 at 11:36 AM
How well can we predict weight loss after bariatric surgery?
Our study assessed the SOPHIA weight prediction tool in our patient population.
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
Our study assessed the SOPHIA weight prediction tool in our patient population.
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
Reposted by Adhithya Sankar
Peri-operative management of GLP-1 RAs & SGLT2 inhibitors❗️
🔹 New 🇬🇧 consensus: GLP-1 RAs can continue, but risks of aspiration must be assessed.
🔸SGLT2i should be stopped 1 day pre-op to avoid euglycemic DKA.
❗️shared decision-making & tailored approaches to optimise safety.
🔗 ggdocs.co/4r995z
🔹 New 🇬🇧 consensus: GLP-1 RAs can continue, but risks of aspiration must be assessed.
🔸SGLT2i should be stopped 1 day pre-op to avoid euglycemic DKA.
❗️shared decision-making & tailored approaches to optimise safety.
🔗 ggdocs.co/4r995z
January 18, 2025 at 2:30 PM
Peri-operative management of GLP-1 RAs & SGLT2 inhibitors❗️
🔹 New 🇬🇧 consensus: GLP-1 RAs can continue, but risks of aspiration must be assessed.
🔸SGLT2i should be stopped 1 day pre-op to avoid euglycemic DKA.
❗️shared decision-making & tailored approaches to optimise safety.
🔗 ggdocs.co/4r995z
🔹 New 🇬🇧 consensus: GLP-1 RAs can continue, but risks of aspiration must be assessed.
🔸SGLT2i should be stopped 1 day pre-op to avoid euglycemic DKA.
❗️shared decision-making & tailored approaches to optimise safety.
🔗 ggdocs.co/4r995z
Reposted by Adhithya Sankar
🧵 Cancer Cachexia and the Brain Stem (a thread)
In NEJM, Groarke et al. report the results of a phase 2 clinical trial of ponsegromab therapy for cancer cachexia in patients with elevated humoral levels of growth differentiation factor 15 (GDF-15). nej.md/3XE645a 1/10
#MedSky #ScienceSky
In NEJM, Groarke et al. report the results of a phase 2 clinical trial of ponsegromab therapy for cancer cachexia in patients with elevated humoral levels of growth differentiation factor 15 (GDF-15). nej.md/3XE645a 1/10
#MedSky #ScienceSky
December 23, 2024 at 2:10 PM
🧵 Cancer Cachexia and the Brain Stem (a thread)
In NEJM, Groarke et al. report the results of a phase 2 clinical trial of ponsegromab therapy for cancer cachexia in patients with elevated humoral levels of growth differentiation factor 15 (GDF-15). nej.md/3XE645a 1/10
#MedSky #ScienceSky
In NEJM, Groarke et al. report the results of a phase 2 clinical trial of ponsegromab therapy for cancer cachexia in patients with elevated humoral levels of growth differentiation factor 15 (GDF-15). nej.md/3XE645a 1/10
#MedSky #ScienceSky
Reposted by Adhithya Sankar
Eye-opening patient story regarding ACC and mitotane
A physician’s personal story of his battle vs Adrenal Cancer published in #EndocrinePractice via Adrenocortical Carcinoma and the Mitotane Morass: A Physician/Patient Perspective #endosky www.endocrinepractice.org/article/S153...
December 9, 2024 at 12:47 PM
Eye-opening patient story regarding ACC and mitotane
Reposted by Adhithya Sankar
It’s a big day for @genesandhealth.bsky.social @samcbhodgson.bsky.social @moneeza-ks.bsky.social Genes & Health, with @ Sam Hodgson, Moneeza Kalhan Siddiqui and I, as we publish our paper rdcu.be/d1vj0 on the genetic basis of #type2diabetes & #gestationaldiabetes (#T2D and #GDM) in south Asians. A🧵
Genetic basis of early onset and progression of type 2 diabetes in South Asians
Nature Medicine - In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key...
rdcu.be
November 26, 2024 at 5:52 PM
It’s a big day for @genesandhealth.bsky.social @samcbhodgson.bsky.social @moneeza-ks.bsky.social Genes & Health, with @ Sam Hodgson, Moneeza Kalhan Siddiqui and I, as we publish our paper rdcu.be/d1vj0 on the genetic basis of #type2diabetes & #gestationaldiabetes (#T2D and #GDM) in south Asians. A🧵
Reposted by Adhithya Sankar
Presentation and management of patients with adrenal masses: a large tertiary centre experience by Onnicha Suntornlohanakul et al @Bham_AT doi.org/10.1093/ejen... #adrenal #phaeochromocytoma #ACC
Presentation and management of patients with adrenal masses: a large tertiary centre experience
AbstractBackground. Adrenal masses are found in up to 5%-7% of adults. The 2016 European guidelines on the management of adrenal incidentalomas have standa
doi.org
November 20, 2024 at 4:58 AM
Presentation and management of patients with adrenal masses: a large tertiary centre experience by Onnicha Suntornlohanakul et al @Bham_AT doi.org/10.1093/ejen... #adrenal #phaeochromocytoma #ACC
Reposted by Adhithya Sankar
How the #brain talks to the #gut and vice versa!
🧪🧠💩
Check out the great primer on gut-brain communication and #interoception by @amberalhadeff.bsky.social and Nilay Yapici
👇👇👇
www.cell.com/current-biol...
🧪🧠💩
Check out the great primer on gut-brain communication and #interoception by @amberalhadeff.bsky.social and Nilay Yapici
👇👇👇
www.cell.com/current-biol...
November 25, 2024 at 11:25 PM
How the #brain talks to the #gut and vice versa!
🧪🧠💩
Check out the great primer on gut-brain communication and #interoception by @amberalhadeff.bsky.social and Nilay Yapici
👇👇👇
www.cell.com/current-biol...
🧪🧠💩
Check out the great primer on gut-brain communication and #interoception by @amberalhadeff.bsky.social and Nilay Yapici
👇👇👇
www.cell.com/current-biol...
Reposted by Adhithya Sankar
Honey, stop what you're doing, new hyponatremia research just dropped!
What's it say?
It looks like slow correction is associated with worse outcomes, like death and length of stay!
Was it just a small study?
No, it was a meta-analysis of almost 12,000 patients!
jamanetwork.com/journals/jam...
What's it say?
It looks like slow correction is associated with worse outcomes, like death and length of stay!
Was it just a small study?
No, it was a meta-analysis of almost 12,000 patients!
jamanetwork.com/journals/jam...
Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia
This systematic review and meta-analysis evaluates the association of sodium correction rates with mortality among hospitalized adults with severe hyponatremia.
jamanetwork.com
November 19, 2024 at 4:51 AM
Honey, stop what you're doing, new hyponatremia research just dropped!
What's it say?
It looks like slow correction is associated with worse outcomes, like death and length of stay!
Was it just a small study?
No, it was a meta-analysis of almost 12,000 patients!
jamanetwork.com/journals/jam...
What's it say?
It looks like slow correction is associated with worse outcomes, like death and length of stay!
Was it just a small study?
No, it was a meta-analysis of almost 12,000 patients!
jamanetwork.com/journals/jam...
Reposted by Adhithya Sankar
Expert statement on Diagnosis & Mx of peripheral neuropathy in #diabetes & pre-diabetes (Gulf region)
🔸suggest routine screening (patient questionnaire & clinical assessment)
🔹Universal B12 Rx
🔸Check B 1&6 levels
🔹Use of CGM
🔸Use of GLP1
🔗 link.springer.com/article/10.1...
🔸suggest routine screening (patient questionnaire & clinical assessment)
🔹Universal B12 Rx
🔸Check B 1&6 levels
🔹Use of CGM
🔸Use of GLP1
🔗 link.springer.com/article/10.1...
November 16, 2024 at 10:33 AM
Expert statement on Diagnosis & Mx of peripheral neuropathy in #diabetes & pre-diabetes (Gulf region)
🔸suggest routine screening (patient questionnaire & clinical assessment)
🔹Universal B12 Rx
🔸Check B 1&6 levels
🔹Use of CGM
🔸Use of GLP1
🔗 link.springer.com/article/10.1...
🔸suggest routine screening (patient questionnaire & clinical assessment)
🔹Universal B12 Rx
🔸Check B 1&6 levels
🔹Use of CGM
🔸Use of GLP1
🔗 link.springer.com/article/10.1...