Adam Snook, PhD
@adamsnookphd.bsky.social
Associate Professor, Thomas Jefferson University
Co-Leader, Immune Cell Regulation and Targeting Program of the Sidney Kimmel Comprehensive Cancer Center | creating new #cancer #immunotherapy |
Co-Leader, Immune Cell Regulation and Targeting Program of the Sidney Kimmel Comprehensive Cancer Center | creating new #cancer #immunotherapy |
Reposted by Adam Snook, PhD
The Sengupta lab is seeking research technicians to join its team. Ideal candidates must possess a passion for research and exceptional communication skills. Both early-career and experienced candidates are welcome. Email SenguptaS@chop.edu with CV and letter of interest with goals and expectations.
May 20, 2025 at 2:22 AM
The Sengupta lab is seeking research technicians to join its team. Ideal candidates must possess a passion for research and exceptional communication skills. Both early-career and experienced candidates are welcome. Email SenguptaS@chop.edu with CV and letter of interest with goals and expectations.
Great work by Alex, Elda, and team!
Now online in Cancer Discovery: Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response - by Alexandra Redding, Elda Grabocka, and colleagues doi.org/10.1158/2159...
March 21, 2025 at 11:53 PM
Great work by Alex, Elda, and team!
Reposted by Adam Snook, PhD
Ongoing studies of adoptive cellular therapies for GI cancers are reshaping treatment options. SITC’s ACI: A Focus on Gastrointestinal Cancers program will describe management approaches for difficult or refractory irAEs. Join live April 23: www.sitcancer.org/education/ac...
@lesinskilab.bsky.social
@lesinskilab.bsky.social
March 18, 2025 at 4:06 PM
Ongoing studies of adoptive cellular therapies for GI cancers are reshaping treatment options. SITC’s ACI: A Focus on Gastrointestinal Cancers program will describe management approaches for difficult or refractory irAEs. Join live April 23: www.sitcancer.org/education/ac...
@lesinskilab.bsky.social
@lesinskilab.bsky.social
Reposted by Adam Snook, PhD
Wistar's Dr. Kristy Shuda McGuire strongly believes, “To learn science, you need to do science.” She comes from a long line of teachers & has her hand on the pulse of the latest training needed for next-gen science careers. Learn more: bit.ly/4iJaDD6
The Wistar Institute’s Commitment to Teaching the Next Generation of Biomedical Researchers
The Wistar Institute’s Commitment to Teaching the Next Generation of Biomedical Researchers Featured News
bit.ly
March 13, 2025 at 2:47 PM
Wistar's Dr. Kristy Shuda McGuire strongly believes, “To learn science, you need to do science.” She comes from a long line of teachers & has her hand on the pulse of the latest training needed for next-gen science careers. Learn more: bit.ly/4iJaDD6
Reposted by Adam Snook, PhD
This #ColorectalCancerAwarenessMonth, we continue to highlight that significant disparities exist in #colorectalcancer.
For a healthier nation, we must address health inequities.
#CRC #ColorectalCancer #UCLAColonChampion #colonoscopy #screening #FIT #ColorectalCancerAwarenessMonth #DressInBlueDay
For a healthier nation, we must address health inequities.
#CRC #ColorectalCancer #UCLAColonChampion #colonoscopy #screening #FIT #ColorectalCancerAwarenessMonth #DressInBlueDay
March 12, 2025 at 8:05 PM
This #ColorectalCancerAwarenessMonth, we continue to highlight that significant disparities exist in #colorectalcancer.
For a healthier nation, we must address health inequities.
#CRC #ColorectalCancer #UCLAColonChampion #colonoscopy #screening #FIT #ColorectalCancerAwarenessMonth #DressInBlueDay
For a healthier nation, we must address health inequities.
#CRC #ColorectalCancer #UCLAColonChampion #colonoscopy #screening #FIT #ColorectalCancerAwarenessMonth #DressInBlueDay
Reposted by Adam Snook, PhD
#preprint alert! Excited to share a #biobank of patient-derived #appendix cancer models, including matched primary-metastasis pairs, with novel insights into mechanisms and drug targeting of #peritoneal #carcinomatosis. Led by our 1st PhD student Ahmed Mahmoud
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer
Peritoneal carcinomatosis is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on a...
www.biorxiv.org
February 24, 2025 at 12:24 AM
#preprint alert! Excited to share a #biobank of patient-derived #appendix cancer models, including matched primary-metastasis pairs, with novel insights into mechanisms and drug targeting of #peritoneal #carcinomatosis. Led by our 1st PhD student Ahmed Mahmoud
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Adam Snook, PhD
🚨PA colleagues:
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
Microsoft Forms
forms.office.com
February 22, 2025 at 8:12 PM
🚨PA colleagues:
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
Reposted by Adam Snook, PhD
NOW AVAILABLE: SITC Fellowships totaling $300,000 in funding! SITC is calling early career investigators looking for potential funding opportunities to apply with a Letter of Intent. Learn more about the application process here: sitcancer.org/fellowships #SITCFellowship #IO #grant #funding
February 19, 2025 at 6:07 PM
NOW AVAILABLE: SITC Fellowships totaling $300,000 in funding! SITC is calling early career investigators looking for potential funding opportunities to apply with a Letter of Intent. Learn more about the application process here: sitcancer.org/fellowships #SITCFellowship #IO #grant #funding
Reposted by Adam Snook, PhD
Fellowship opportunities open Feb. 19! Preview the available opportunities now, and discover the new application process consisting of two stages. SITC Fellowships are only available to SITC members! sitcancer.org/fellowships #SITCFellowship #IO #immunotherapy #grant #funding
February 14, 2025 at 7:30 PM
Fellowship opportunities open Feb. 19! Preview the available opportunities now, and discover the new application process consisting of two stages. SITC Fellowships are only available to SITC members! sitcancer.org/fellowships #SITCFellowship #IO #immunotherapy #grant #funding
Reposted by Adam Snook, PhD
The incidence of early-onset colorectal #cancer is surging
By 2030, 1/3 of all CRCs will occur before the typical recommended screening age of 50 years
In this #Cell commentary, Mauri et al. discuss the potential causes 🧪- and the importance of determining "tumor age"
www.cell.com/cell/fulltex...
By 2030, 1/3 of all CRCs will occur before the typical recommended screening age of 50 years
In this #Cell commentary, Mauri et al. discuss the potential causes 🧪- and the importance of determining "tumor age"
www.cell.com/cell/fulltex...
February 6, 2025 at 8:26 PM
The incidence of early-onset colorectal #cancer is surging
By 2030, 1/3 of all CRCs will occur before the typical recommended screening age of 50 years
In this #Cell commentary, Mauri et al. discuss the potential causes 🧪- and the importance of determining "tumor age"
www.cell.com/cell/fulltex...
By 2030, 1/3 of all CRCs will occur before the typical recommended screening age of 50 years
In this #Cell commentary, Mauri et al. discuss the potential causes 🧪- and the importance of determining "tumor age"
www.cell.com/cell/fulltex...
Reposted by Adam Snook, PhD
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies in 783 Patients (38 clinical trials)
-Analysis in 169 patients = no pathological insertions linked to secondary malignancies
-Highlights safety of vector gene engineered T cell therapies www.nature.com/articles/s41...
-Analysis in 169 patients = no pathological insertions linked to secondary malignancies
-Highlights safety of vector gene engineered T cell therapies www.nature.com/articles/s41...
January 22, 2025 at 3:01 PM
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies in 783 Patients (38 clinical trials)
-Analysis in 169 patients = no pathological insertions linked to secondary malignancies
-Highlights safety of vector gene engineered T cell therapies www.nature.com/articles/s41...
-Analysis in 169 patients = no pathological insertions linked to secondary malignancies
-Highlights safety of vector gene engineered T cell therapies www.nature.com/articles/s41...
Reposted by Adam Snook, PhD
Calling all cell therapists!
The SITC Spring Scientific on Cellular Therapy for Solid Tumors takes place March 12-14 2025 in sunny San Diego. Fantastic speaker lineup, and slots for abstract talks
www.sitcancer.org/education/sp...
Early registration deadline is THIS FRIDAY. Abstracts due Jan 8th.
The SITC Spring Scientific on Cellular Therapy for Solid Tumors takes place March 12-14 2025 in sunny San Diego. Fantastic speaker lineup, and slots for abstract talks
www.sitcancer.org/education/sp...
Early registration deadline is THIS FRIDAY. Abstracts due Jan 8th.
2025 Spring Scientific
The 2025 SITC Spring Scientific, Cellular Therapy for Solid Tumors, will address the recent advances in adoptive cellular therapy for solid tumors and rate-limiting challenges that impede bringing the...
www.sitcancer.org
December 17, 2024 at 6:52 PM
Calling all cell therapists!
The SITC Spring Scientific on Cellular Therapy for Solid Tumors takes place March 12-14 2025 in sunny San Diego. Fantastic speaker lineup, and slots for abstract talks
www.sitcancer.org/education/sp...
Early registration deadline is THIS FRIDAY. Abstracts due Jan 8th.
The SITC Spring Scientific on Cellular Therapy for Solid Tumors takes place March 12-14 2025 in sunny San Diego. Fantastic speaker lineup, and slots for abstract talks
www.sitcancer.org/education/sp...
Early registration deadline is THIS FRIDAY. Abstracts due Jan 8th.
Reposted by Adam Snook, PhD
A grant from the AACR propelled Marco Ruella's research in CAR T-cell therapy. Learn how his work could benefit some patients whose disease had evaded prior immunotherapy and gone into relapse in #AACRStories. www.aacr.org/about-the-aa.... #AACRGrants #CancerResearchSavesLives®
AACR Grant Propels Progress in Immunotherapy Research
Using funding from the AACR, early-career investigator Marco Ruella, MD, found a way to improve immunotherapy for B-cell acute lymphoblastic leukemia. A grant from the American Association for Cancer ...
www.aacr.org
December 16, 2024 at 4:42 PM
A grant from the AACR propelled Marco Ruella's research in CAR T-cell therapy. Learn how his work could benefit some patients whose disease had evaded prior immunotherapy and gone into relapse in #AACRStories. www.aacr.org/about-the-aa.... #AACRGrants #CancerResearchSavesLives®
Reposted by Adam Snook, PhD
Chart of the night.
In 1952, there were nearly 58,000 cases of paralytic polio in the US.
In 2023, there were 0.
As @meganranney.bsky.social said on CNN tonight, revoking the polio vaccine would result in generations of kids experiencing disability and death.
graphics.wsj.com/infectious-d...
In 1952, there were nearly 58,000 cases of paralytic polio in the US.
In 2023, there were 0.
As @meganranney.bsky.social said on CNN tonight, revoking the polio vaccine would result in generations of kids experiencing disability and death.
graphics.wsj.com/infectious-d...
December 14, 2024 at 3:36 AM
Chart of the night.
In 1952, there were nearly 58,000 cases of paralytic polio in the US.
In 2023, there were 0.
As @meganranney.bsky.social said on CNN tonight, revoking the polio vaccine would result in generations of kids experiencing disability and death.
graphics.wsj.com/infectious-d...
In 1952, there were nearly 58,000 cases of paralytic polio in the US.
In 2023, there were 0.
As @meganranney.bsky.social said on CNN tonight, revoking the polio vaccine would result in generations of kids experiencing disability and death.
graphics.wsj.com/infectious-d...
Reposted by Adam Snook, PhD
The wellness industry is the monetization of medical conspiracism.
By convincing you data is wrong, scientists & healthcare providers are corrupt & “making you sick”, they create customers.
Customers that will now buy “alternatives” they sell.
Wellness influencers undermine science for profit.
By convincing you data is wrong, scientists & healthcare providers are corrupt & “making you sick”, they create customers.
Customers that will now buy “alternatives” they sell.
Wellness influencers undermine science for profit.
December 15, 2024 at 3:11 AM
The wellness industry is the monetization of medical conspiracism.
By convincing you data is wrong, scientists & healthcare providers are corrupt & “making you sick”, they create customers.
Customers that will now buy “alternatives” they sell.
Wellness influencers undermine science for profit.
By convincing you data is wrong, scientists & healthcare providers are corrupt & “making you sick”, they create customers.
Customers that will now buy “alternatives” they sell.
Wellness influencers undermine science for profit.
Reposted by Adam Snook, PhD
If you joined @bsky.app during @ash-hematology.bsky.social #ASH24 here’s a starter pack for transplant, cell & gene therapy #bmtsm #CARTcells #generherapy go.bsky.app/7xxh8WW
December 10, 2024 at 5:35 PM
If you joined @bsky.app during @ash-hematology.bsky.social #ASH24 here’s a starter pack for transplant, cell & gene therapy #bmtsm #CARTcells #generherapy go.bsky.app/7xxh8WW
Reposted by Adam Snook, PhD
#ASH24 Improving CAR T Cell potency by ketogenic diet, beta hydroxy butyrate in particular, and clinical trial open! #tcell #tcellrx #immunotherapy @pennmedicine.bsky.social
December 8, 2024 at 11:43 PM
#ASH24 Improving CAR T Cell potency by ketogenic diet, beta hydroxy butyrate in particular, and clinical trial open! #tcell #tcellrx #immunotherapy @pennmedicine.bsky.social
Trang Vu gave a fantastic talk on her work exploring JAK/STAT signaling in the enhanced antitumor efficacy of CD5-deleted CAR-T cells. This technology from @ruellalab.bsky.social might improve CART efficacy in several cancers. Thank you #ASH24 for letting us share!
ash.confex.com/ash/2024/web...
ash.confex.com/ash/2024/web...
December 10, 2024 at 10:12 PM
Trang Vu gave a fantastic talk on her work exploring JAK/STAT signaling in the enhanced antitumor efficacy of CD5-deleted CAR-T cells. This technology from @ruellalab.bsky.social might improve CART efficacy in several cancers. Thank you #ASH24 for letting us share!
ash.confex.com/ash/2024/web...
ash.confex.com/ash/2024/web...
Reposted by Adam Snook, PhD
A starter pack for PhD students and Postdocs in Immunology to connect 🔽
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
December 4, 2024 at 7:14 AM
A starter pack for PhD students and Postdocs in Immunology to connect 🔽
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
Reposted by Adam Snook, PhD
I’m thankful for the top ten scientific developments that improve health:
Vaccines
Antibiotics & antimicrobials
Clean water, sanitation, & hygiene
Food safety & fortification innovations
Modern agriculture methods
Public health education campaigns
1/
Vaccines
Antibiotics & antimicrobials
Clean water, sanitation, & hygiene
Food safety & fortification innovations
Modern agriculture methods
Public health education campaigns
1/
November 28, 2024 at 1:46 PM
I’m thankful for the top ten scientific developments that improve health:
Vaccines
Antibiotics & antimicrobials
Clean water, sanitation, & hygiene
Food safety & fortification innovations
Modern agriculture methods
Public health education campaigns
1/
Vaccines
Antibiotics & antimicrobials
Clean water, sanitation, & hygiene
Food safety & fortification innovations
Modern agriculture methods
Public health education campaigns
1/
Reposted by Adam Snook, PhD
🧪Dear Grad student,
Are you overdue for a thesis committee meeting but feel like you have nothing to show since your last meeting? I'm begging you to schedule that meeting now!
1/🧵
Are you overdue for a thesis committee meeting but feel like you have nothing to show since your last meeting? I'm begging you to schedule that meeting now!
1/🧵
November 29, 2024 at 9:28 PM
🧪Dear Grad student,
Are you overdue for a thesis committee meeting but feel like you have nothing to show since your last meeting? I'm begging you to schedule that meeting now!
1/🧵
Are you overdue for a thesis committee meeting but feel like you have nothing to show since your last meeting? I'm begging you to schedule that meeting now!
1/🧵
Reposted by Adam Snook, PhD
💥 #Cancer #Vaccines in combo IO are #HOT!! Wasn’t on Bsky 11/8 so posting now/@ #SITC2024 we reported tripling of response rate & progression-free survival #PFS in #HNSCC + COOL #TCR #LAG3 & #DarkMatter data @patrickhwumd.bsky.social @chrystalpaulos.bsky.social www.einpresswire.com/article/7584...
November 30, 2024 at 8:12 PM
💥 #Cancer #Vaccines in combo IO are #HOT!! Wasn’t on Bsky 11/8 so posting now/@ #SITC2024 we reported tripling of response rate & progression-free survival #PFS in #HNSCC + COOL #TCR #LAG3 & #DarkMatter data @patrickhwumd.bsky.social @chrystalpaulos.bsky.social www.einpresswire.com/article/7584...
Reposted by Adam Snook, PhD
Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Wonderful to see the #immunology community growing here.
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
November 29, 2024 at 4:47 PM
Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
Reposted by Adam Snook, PhD
Only a subset of patients respond to immunotherapy
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
November 27, 2024 at 2:13 PM
Only a subset of patients respond to immunotherapy
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...