Karuna Ganesh
@karunamdphd.bsky.social
Physician Scientist at Memorial Sloan Kettering | Metastasis | Plasticity | Colorectal Cancer | Regeneration | Stem Cells | Organoids | posts my own and do not represent MSK
Super proud of all our amazing postdocs and the brilliant ideas and energy you contribute!
Meet #MSKPostdoc @chris-cowley14.bsky.social in the @karunamdphd.bsky.social lab! Chris studies colitis-associated cancer, an aggressive form of colorectal cancer linked to IBD. Using patient-derived organoids, he is uncovering how inflammation drives cancer susceptibility. #NPAW2025 🇿🇦
September 19, 2025 at 2:43 PM
Super proud of all our amazing postdocs and the brilliant ideas and energy you contribute!
Congratulations Ellie @elliebenitez.bsky.social @mskeducation.bsky.social Tri-I MD/PhD student on being awarded the NIH/NCI F30 award! #proudPI
July 18, 2025 at 6:43 PM
Congratulations Ellie @elliebenitez.bsky.social @mskeducation.bsky.social Tri-I MD/PhD student on being awarded the NIH/NCI F30 award! #proudPI
Reposted by Karuna Ganesh
Immigrant workers, on average, are earning 17.9% less than a country’s native population, according to a paper in Nature. Three-quarters of the pay gap between the two correspond to a lack of accessible high-paying jobs for immigrants. go.nature.com/4nYgb0a #econsky 🧪
July 17, 2025 at 1:41 PM
Immigrant workers, on average, are earning 17.9% less than a country’s native population, according to a paper in Nature. Three-quarters of the pay gap between the two correspond to a lack of accessible high-paying jobs for immigrants. go.nature.com/4nYgb0a #econsky 🧪
Congratulations to our recent Ganesh lab alumni Ahmed Mahmoud, Emile de Vet @emiliedevet.bsky.social, Aileen Rodriguez, Xiang (Molly Han) @xianghan.bsky.social - we are so proud and wish you all the best for career success! @mskeducation.bsky.social @mskcancercenter.bsky.social
July 8, 2025 at 7:44 AM
Congratulations to our recent Ganesh lab alumni Ahmed Mahmoud, Emile de Vet @emiliedevet.bsky.social, Aileen Rodriguez, Xiang (Molly Han) @xianghan.bsky.social - we are so proud and wish you all the best for career success! @mskeducation.bsky.social @mskcancercenter.bsky.social
Check out this elegant paper by Kevin Myant and team implicating ATRX mutations and loss of colon identity in #plasticity and #metastasis 👇@nature.com @edinburgh-uni.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Loss of colonic fidelity enables multilineage plasticity and metastasis - Nature
The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.
www.nature.com
June 4, 2025 at 8:09 PM
Check out this elegant paper by Kevin Myant and team implicating ATRX mutations and loss of colon identity in #plasticity and #metastasis 👇@nature.com @edinburgh-uni.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Karuna Ganesh
Ready for an amazing educational session on tumor dormancy @theaacr.bsky.social with Drs. Isacke and Ganesh.
April 26, 2025 at 4:50 PM
Ready for an amazing educational session on tumor dormancy @theaacr.bsky.social with Drs. Isacke and Ganesh.
Congratulations Manisha Raghavan on winning both science and service awards at the Gerstner Sloan Kettering Graduate School retreat! #proudPI @mskeducation.bsky.social @mskcancercenter.bsky.social
April 11, 2025 at 10:14 PM
Congratulations Manisha Raghavan on winning both science and service awards at the Gerstner Sloan Kettering Graduate School retreat! #proudPI @mskeducation.bsky.social @mskcancercenter.bsky.social
Looking forward to sharing our work and learning about GI oncology research @mdanderson.bsky.social this week!
April 5, 2025 at 9:15 PM
Looking forward to sharing our work and learning about GI oncology research @mdanderson.bsky.social this week!
#preprint alert! Excited to share a #biobank of patient-derived #appendix cancer models, including matched primary-metastasis pairs, with novel insights into mechanisms and drug targeting of #peritoneal #carcinomatosis. Led by our 1st PhD student Ahmed Mahmoud
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer
Peritoneal carcinomatosis is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on a...
www.biorxiv.org
February 24, 2025 at 12:24 AM
#preprint alert! Excited to share a #biobank of patient-derived #appendix cancer models, including matched primary-metastasis pairs, with novel insights into mechanisms and drug targeting of #peritoneal #carcinomatosis. Led by our 1st PhD student Ahmed Mahmoud
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Some great news: incredibly proud of our Medical Oncology Fellow Jaeyop Lee MD, PhD, comentored by David Scheinberg, who just received the NoA for an NCI K99/R00 award!!! Stay tuned for his groundbreaking work on CRC immunotherapy
February 14, 2025 at 10:17 PM
Some great news: incredibly proud of our Medical Oncology Fellow Jaeyop Lee MD, PhD, comentored by David Scheinberg, who just received the NoA for an NCI K99/R00 award!!! Stay tuned for his groundbreaking work on CRC immunotherapy
Reposted by Karuna Ganesh
📣The Beatson International Cancer Conference #BICC2025 is returning on Tuesday 27th – Thursday 29th May 2025 at the impressive Glasgow Science Centre!
Celebrating 30 years of events, join us for 3 days of inspiring talks, posters and networking focusing on Data Science
www.beatsonconference.org
Celebrating 30 years of events, join us for 3 days of inspiring talks, posters and networking focusing on Data Science
www.beatsonconference.org
January 24, 2025 at 1:37 PM
📣The Beatson International Cancer Conference #BICC2025 is returning on Tuesday 27th – Thursday 29th May 2025 at the impressive Glasgow Science Centre!
Celebrating 30 years of events, join us for 3 days of inspiring talks, posters and networking focusing on Data Science
www.beatsonconference.org
Celebrating 30 years of events, join us for 3 days of inspiring talks, posters and networking focusing on Data Science
www.beatsonconference.org
Thank you @trevorgraham.bsky.social and Freddie Whiting for this nice commentary on our recent paper on progressive plasticity in colorectal cancer metastasis
Freddie Whiting in our group wrote this thoughtful commentary on @karunamdphd.bsky.social's recent paper that explored cell state changes and plasticity in colorectal cancer evolution. He concludes we need to better understand epigenetic control of plasticity. authors.elsevier.com/c/1kTSf5Sx5g...
authors.elsevier.com
January 20, 2025 at 6:18 PM
Thank you @trevorgraham.bsky.social and Freddie Whiting for this nice commentary on our recent paper on progressive plasticity in colorectal cancer metastasis
Starting 2025 with gratitude for @damonrunyon.org and all those who support our quest to understand and develop more effective treatments for metastatic cancer.
Metastasis accounts for most cancer deaths. A study from Damon Runyon alum @karunamdphd.bsky.social reveals why metastatic tumors are so much harder to treat than primary tumors—and how the process of metastasis may be curbed.
New Discoveries and Honors in Cancer Research | Damon Runyon
www.damonrunyon.org
January 3, 2025 at 4:41 AM
Starting 2025 with gratitude for @damonrunyon.org and all those who support our quest to understand and develop more effective treatments for metastatic cancer.
Reposted by Karuna Ganesh
2/Discover how colorectal cancer evolves during metastasis. This study reveals metastases shifting from stem-like to fetal progenitor states, driving squamous & neuroendocrine traits linked to poor outcomes.
@karunamdphd.bsky.social @mskcancercenter.bsky.social
www.nature.com/articles/s41...
@karunamdphd.bsky.social @mskcancercenter.bsky.social
www.nature.com/articles/s41...
Progressive plasticity during colorectal cancer metastasis - Nature
Colorectal cancer metastasis involves dramatic plasticity and loss of PROX1-mediated repression of non-intestinal lineages.
www.nature.com
December 23, 2024 at 3:55 PM
2/Discover how colorectal cancer evolves during metastasis. This study reveals metastases shifting from stem-like to fetal progenitor states, driving squamous & neuroendocrine traits linked to poor outcomes.
@karunamdphd.bsky.social @mskcancercenter.bsky.social
www.nature.com/articles/s41...
@karunamdphd.bsky.social @mskcancercenter.bsky.social
www.nature.com/articles/s41...
Happy Nearly Holidays from the Ganesh lab!
Got some pretty cool science cookin in the Ganesh Lab! @mskcc.bsky.social @karunamdphd.bsky.social
December 18, 2024 at 3:38 AM
Happy Nearly Holidays from the Ganesh lab!
Reposted by Karuna Ganesh
Join us in Austin, TXm Feb 9-10 2025, for an Abcam-sponsored symposium on Cancer and Metabolism. -RJD
events.abcam.com/event/cancer...
events.abcam.com/event/cancer...
Home - Cancer and Metabolism
events.abcam.com
December 5, 2024 at 11:18 PM
Join us in Austin, TXm Feb 9-10 2025, for an Abcam-sponsored symposium on Cancer and Metabolism. -RJD
events.abcam.com/event/cancer...
events.abcam.com/event/cancer...
Congratulations #ObenaufLab on this amazing study of how MAPK-induced PGE2 secretion induces tumor immunosuppression. Impressive work!
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 9:55 PM
Congratulations #ObenaufLab on this amazing study of how MAPK-induced PGE2 secretion induces tumor immunosuppression. Impressive work!
Reposted by Karuna Ganesh
I've started a list of people working on #cancer #evolution. Many more to be added, so do let me know if that is you. Also if you would like to be removed. go.bsky.app/QuAF4Mo
November 12, 2024 at 11:49 AM
I've started a list of people working on #cancer #evolution. Many more to be added, so do let me know if that is you. Also if you would like to be removed. go.bsky.app/QuAF4Mo
First post on this platform - thank you Elena @natrevgastrohep.bsky.social for this nice highlight of our recent Nature paper 👇🏽
www.nature.com/articles/s41...
rdcu.be/d02rZ
www.nature.com/articles/s41...
rdcu.be/d02rZ
Non-canonical metastatic colorectal cancer - Nature Reviews Gastroenterology & Hepatology
Nature Reviews Gastroenterology & Hepatology - Non-canonical metastatic colorectal cancer
www.nature.com
November 21, 2024 at 9:49 PM
First post on this platform - thank you Elena @natrevgastrohep.bsky.social for this nice highlight of our recent Nature paper 👇🏽
www.nature.com/articles/s41...
rdcu.be/d02rZ
www.nature.com/articles/s41...
rdcu.be/d02rZ
Reposted by Karuna Ganesh
Getting in on the starter pack game for folks focusing on studying tumor-immune interactions during metastasis — DM/comment if you want to be added!
go.bsky.app/GyZxUDH
go.bsky.app/GyZxUDH
November 21, 2024 at 6:28 PM
Getting in on the starter pack game for folks focusing on studying tumor-immune interactions during metastasis — DM/comment if you want to be added!
go.bsky.app/GyZxUDH
go.bsky.app/GyZxUDH