Mathias V. Schmidt
LightNews LightNews
banner
mathiasvschmidt.bsky.social
Mathias V. Schmidt
@mathiasvschmidt.bsky.social
1.7K followers 450 following 51 posts

Unraveling the molecular basis of stress resilience | Group leader at MPI of Psychiatry | Secretary General Elect of FENS | Editor-in-Chief Neurobiology of Stress

Videos
History 35%
Political science 18%
Posts Replies Media Videos
Pinned
mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 14
New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature Communications
Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...
www.nature.com

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · 20h
This is the path to robust, translational data. 𝐃𝐨𝐧'𝐭 𝐏𝐚𝐧𝐢𝐜! Read the full guide and join the shift to deep phenotyping.
Thanks to all co-authors and the incredible teamwork including @benjurek.bsky.social, Patrick Schlegel, @london-k-aman.bsky.social, Bartosz Zglinicki and @mikeyslezak.bsky.social

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · 20h
We provide:

- A standardized workflow for long-term home-cage monitoring in mice.
- A practical guidance on experimental setups for 24-hour recordings.
- A comparison of contrast- vs. ML-based tracking tools, with pros, cons, and use-cases
.. and much more!

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · 20h
Check out our new paper in Neuroscience & Biobehavioral Reviews: "𝑳𝒐𝒏𝒈-𝒕𝒆𝒓𝒎 𝒅𝒆𝒆𝒑 𝒑𝒉𝒆𝒏𝒐𝒕𝒚𝒑𝒊𝒏𝒈 𝒐𝒇 𝒃𝒆𝒉𝒂𝒗𝒊𝒐𝒓𝒂𝒍 𝒕𝒓𝒂𝒊𝒕𝒔 𝒊𝒏 𝒎𝒊𝒄𝒆 𝒖𝒔𝒊𝒏𝒈 𝒉𝒐𝒎𝒆𝒄𝒂𝒈𝒆 𝒎𝒐𝒏𝒊𝒕𝒐𝒓𝒊𝒏𝒈"
This paper is your essential 𝐇𝐢𝐭𝐜𝐡𝐡𝐢𝐤𝐞𝐫'𝐬 𝐆𝐮𝐢𝐝𝐞 to achieving unprecedented insight into complex rodent behavior. www.sciencedirect.com/science/arti...
Long-term deep phenotyping of behavioral traits in mice using homecage monitoring
Neuropsychiatric disorders represent a significant global health challenge, and a deeper understanding of their underlying neurobiology is urgently ne…
www.sciencedirect.com

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · 20h
To truly understand the neurobiological basis of complex behaviors - the real 𝐦𝐞𝐚𝐧𝐢𝐧𝐠 𝐨𝐟 𝐥𝐢𝐟𝐞, 𝐭𝐡𝐞 𝐮𝐧𝐢𝐯𝐞𝐫𝐬𝐞, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐫𝐲𝐭𝐡𝐢𝐧𝐠 - we must overcome the limitations of traditional, short-term behavioral tests.

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · 8d
Interesting talk by @kgoepfrich.bsky.social on RNA design and synthetic cells.

Reposted by Mathias Schmidt

fens.org
Federation of European Neuroscience Societies - FENS @fens.org · 25d
🚨Open position at #FENS!

💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!

🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Oct 10
Looking forward to this exciting conference. If you are interested in the latest science on the developmental origins of mental illness, join me and my co-chair @talliezee.bsky.social for our session on Sunday morning at 11:20am.

Reposted by Mathias Schmidt

carmensandi10.bsky.social
Carmen Sandi @carmensandi10.bsky.social · Oct 7
Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.

Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!

🔗 Paper: doi.org/10.1016/j.bi...
Redirecting
doi.org

Reposted by Mathias Schmidt

nataliematosin.bsky.social
Natalie Matosin @nataliematosin.bsky.social · Sep 25
Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in:

www.biorxiv.org/content/10.1...
Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling
Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...
www.biorxiv.org

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Aug 21
Important initiative 👇

Reposted by Peter Rodgers, Mathias Schmidt

behrenstimb.bsky.social
Tim Behrens @behrenstimb.bsky.social · Jan 30
Hope you'll forgive a quick thread as I take over as the new EiC of @elife.bsky.social

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Jun 30
Ready for some really hot 🔥🥵 data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.

Reposted by Mathias Schmidt

ebbsociety.bsky.social
ebbsociety.bsky.social @ebbsociety.bsky.social · Jun 28
The heat won’t stop the energy — science (and fans!) in full swing!
🔆🪭💪
#EBBS2025

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Jun 28
In Bordeaux for the #EBBS meeting. Looking forward to 4 exciting days of science

Reposted by Mathias Schmidt

nataliematosin.bsky.social
Natalie Matosin @nataliematosin.bsky.social · Jun 10
🚨 NEW PAPER 🚨
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides
Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…
sciencedirect.com

Reposted by Mathias Schmidt

eara.eu
EARA @eara.eu · Jun 2
The Be Open about Animal Research Day is starting now!
Show your support and share on #BOARD25

Reposted by Mathias Schmidt

olibosch.bsky.social
Oliver Bosch @olibosch.bsky.social · May 26
🎉It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here:
www.neurobiologyofgrief.org/events
Events — Neurobiology of Grief International Network
www.neurobiologyofgrief.org

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · May 23
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
The evolving neurobiology of early-life stress
This review explores the effects of early-life stress on brain development and cognitive function, highlighting gaps in understanding perceived stress, vulnerable developmental stages, underlying mole...
www.cell.com

Reposted by Mathias Schmidt

jamielarsh.bsky.social
Jamie Hanson @jamielarsh.bsky.social · May 5
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry
Autoimmune diseases are a heterogeneous category of disorders caused by an interaction between genetic and environmental factors which lead to a dysre…
www.sciencedirect.com

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Apr 23
Read about our recent discoveries on mechanisms that can drive resilience in females.
www.psych.mpg.de/2949097/news...
Early Life Stress Can Build Resilience in Females
Stress in early life can improve emotional regulation and cognitive function in female mice. This is a significant departure from the traditional view that such stress is solely detrimental. The study...
www.psych.mpg.de

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Apr 2
So well deserved! Congratulations 👏🏻👏🏻👏🏻

Reposted by Mathias Schmidt

bellonec.bsky.social
Camilla Bellone @bellonec.bsky.social · Mar 24
The Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. 🔬 Celebrate bold science. Nominate now.
#Neuroscience #BrainResearch

www.sfn.org/careers/awar...
Peter Seeburg Integrative Neuroscience Prize
www.sfn.org

Reposted by Mathias Schmidt

bertogliolab.bsky.social
Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · Mar 23
Intergenerational Effects of Stress - A Focus on Learning and Memory
doi.org/10.1007/7854...
Intergenerational Effects of Stress – A Focus on Learning and Memory
Stress is a ubiquitous facet of life. Ranging in form (e.g., psychosocial, physical, nutritional, economic) and longevity (e.g., acute, chronic), stressors affect the biology of those directly in thei...
doi.org

Reposted by Mathias Schmidt

briantrainor.bsky.social
Brian Trainor @briantrainor.bsky.social · Mar 15
We're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/
lab but aesthetic 🤩 comment how a typical day looks for you #sza #dayinlife #interviews #science #lablife #labtech #behindthescene
TikTok video by trainor lab
www.tiktok.com

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 14
Thanks to all the co-authors and collaborators! I also want to point out the important contribution of our transgenic (not transgender) mice to this study.

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 14
Our data especially highlight the importance of studying sex differences in how individuals cope with stress.

Reposted by Mathias Schmidt

bertogliolab.bsky.social
Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · Mar 10
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis
www.nature.com/articles/s41...
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis - Nature Communications
Early life experience modulates stress resilience in later life. Here the authors show that maternal care triggers microglia-derived IGF-1 levels, which suppresses the neuronal C/EBPβ-DRP1 axis, promo...
www.nature.com

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 5
Very interesting paper on social behavior analysis 👇🏻
olveczky.bsky.social Bence Ölveczky @olveczky.bsky.social · Mar 4
Excited to present the latest from the lab out today in Cell www.cell.com/cell/fulltex.... See Thread! 1/8

mathiasvschmidt.bsky.social
Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 5
European Neuroscience Societies stand up for science to support our U.S. colleagues 💪🏻
fens.org Federation of European Neuroscience Societies - FENS @fens.org · Mar 5
📣 Science matters!

#FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬

🔗 Read the full statement: loom.ly/cn7vJR4

#sciencematters #standupforscience #sciencenotsilence #scienceforall