Mathias V. Schmidt
@mathiasvschmidt.bsky.social
Unraveling the molecular basis of stress resilience | Group leader at MPI of Psychiatry | Secretary General Elect of FENS | Editor-in-Chief Neurobiology of Stress
Pinned
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature Communications
Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...
www.nature.com
New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...
To truly understand the neurobiological basis of complex behaviors - the real 𝐦𝐞𝐚𝐧𝐢𝐧𝐠 𝐨𝐟 𝐥𝐢𝐟𝐞, 𝐭𝐡𝐞 𝐮𝐧𝐢𝐯𝐞𝐫𝐬𝐞, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐫𝐲𝐭𝐡𝐢𝐧𝐠 - we must overcome the limitations of traditional, short-term behavioral tests.
November 10, 2025 at 2:54 PM
To truly understand the neurobiological basis of complex behaviors - the real 𝐦𝐞𝐚𝐧𝐢𝐧𝐠 𝐨𝐟 𝐥𝐢𝐟𝐞, 𝐭𝐡𝐞 𝐮𝐧𝐢𝐯𝐞𝐫𝐬𝐞, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐫𝐲𝐭𝐡𝐢𝐧𝐠 - we must overcome the limitations of traditional, short-term behavioral tests.
Interesting talk by @kgoepfrich.bsky.social on RNA design and synthetic cells.
November 3, 2025 at 7:17 AM
Interesting talk by @kgoepfrich.bsky.social on RNA design and synthetic cells.
Reposted by Mathias V. Schmidt
🚨Open position at #FENS!
💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!
🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8
💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!
🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8
October 16, 2025 at 4:00 PM
🚨Open position at #FENS!
💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!
🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8
💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!
🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8
Reposted by Mathias V. Schmidt
Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Redirecting
doi.org
October 7, 2025 at 8:43 AM
Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Reposted by Mathias V. Schmidt
Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling
Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...
www.biorxiv.org
September 25, 2025 at 10:12 PM
Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Important initiative 👇
August 21, 2025 at 9:18 AM
Important initiative 👇
Ready for some really hot 🔥🥵 data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.
June 30, 2025 at 11:48 AM
Ready for some really hot 🔥🥵 data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.
Reposted by Mathias V. Schmidt
June 28, 2025 at 2:47 PM
Reposted by Mathias V. Schmidt
🚨 NEW PAPER 🚨
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides
Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…
sciencedirect.com
June 10, 2025 at 10:40 PM
🚨 NEW PAPER 🚨
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
Reposted by Mathias V. Schmidt
🎉It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here:
www.neurobiologyofgrief.org/events
www.neurobiologyofgrief.org/events
Events — Neurobiology of Grief International Network
www.neurobiologyofgrief.org
May 26, 2025 at 12:07 PM
🎉It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here:
www.neurobiologyofgrief.org/events
www.neurobiologyofgrief.org/events
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
The evolving neurobiology of early-life stress
This review explores the effects of early-life stress on brain development and cognitive
function, highlighting gaps in understanding perceived stress, vulnerable developmental
stages, underlying mole...
www.cell.com
May 23, 2025 at 9:35 AM
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
Reposted by Mathias V. Schmidt
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry
Autoimmune diseases are a heterogeneous category of disorders caused by an interaction between genetic and environmental factors which lead to a dysre…
www.sciencedirect.com
May 5, 2025 at 2:01 PM
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...
Read about our recent discoveries on mechanisms that can drive resilience in females.
www.psych.mpg.de/2949097/news...
www.psych.mpg.de/2949097/news...
Early Life Stress Can Build Resilience in Females
Stress in early life can improve emotional regulation and cognitive function in female mice. This is a significant departure from the traditional view that such stress is solely detrimental. The study...
www.psych.mpg.de
April 23, 2025 at 1:52 PM
Read about our recent discoveries on mechanisms that can drive resilience in females.
www.psych.mpg.de/2949097/news...
www.psych.mpg.de/2949097/news...
Reposted by Mathias V. Schmidt
The Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. 🔬 Celebrate bold science. Nominate now.
#Neuroscience #BrainResearch
www.sfn.org/careers/awar...
#Neuroscience #BrainResearch
www.sfn.org/careers/awar...
Peter Seeburg Integrative Neuroscience Prize
www.sfn.org
March 24, 2025 at 7:58 PM
The Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. 🔬 Celebrate bold science. Nominate now.
#Neuroscience #BrainResearch
www.sfn.org/careers/awar...
#Neuroscience #BrainResearch
www.sfn.org/careers/awar...
Reposted by Mathias V. Schmidt
Intergenerational Effects of Stress - A Focus on Learning and Memory
doi.org/10.1007/7854...
doi.org/10.1007/7854...
Intergenerational Effects of Stress – A Focus on Learning and Memory
Stress is a ubiquitous facet of life. Ranging in form (e.g., psychosocial, physical, nutritional, economic) and longevity (e.g., acute, chronic), stressors affect the biology of those directly in thei...
doi.org
March 23, 2025 at 12:05 PM
Intergenerational Effects of Stress - A Focus on Learning and Memory
doi.org/10.1007/7854...
doi.org/10.1007/7854...
Reposted by Mathias V. Schmidt
We're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/
lab but aesthetic 🤩 comment how a typical day looks for you #sza #dayinlife #interviews #science #lablife #labtech #behindthescene
TikTok video by trainor lab
www.tiktok.com
March 15, 2025 at 8:09 PM
We're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/
New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature Communications
Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...
www.nature.com
March 14, 2025 at 4:24 PM
New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...
Reposted by Mathias V. Schmidt
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis - Nature Communications
Early life experience modulates stress resilience in later life. Here the authors show that maternal care triggers microglia-derived IGF-1 levels, which suppresses the neuronal C/EBPβ-DRP1 axis, promo...
www.nature.com
March 10, 2025 at 10:25 AM
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mathias V. Schmidt
🚨🧠 New paper alert: Stress alters neuronal balance in the developing brain 🧠🚨
Our latest study in @science.orgAdvances explores how glucocorticoid exposure—a key environmental risk factor—shapes early human brain development using #organoids.
@mpi-psychiatry.bsky.social @drcricru.bsky.social
🧵👇
Our latest study in @science.orgAdvances explores how glucocorticoid exposure—a key environmental risk factor—shapes early human brain development using #organoids.
@mpi-psychiatry.bsky.social @drcricru.bsky.social
🧵👇
Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids
Chronic exposure to glucocorticoids during brain development leads to priming of the inhibitory neuron lineages in organoids.
www.science.org
February 21, 2025 at 10:14 AM
🚨🧠 New paper alert: Stress alters neuronal balance in the developing brain 🧠🚨
Our latest study in @science.orgAdvances explores how glucocorticoid exposure—a key environmental risk factor—shapes early human brain development using #organoids.
@mpi-psychiatry.bsky.social @drcricru.bsky.social
🧵👇
Our latest study in @science.orgAdvances explores how glucocorticoid exposure—a key environmental risk factor—shapes early human brain development using #organoids.
@mpi-psychiatry.bsky.social @drcricru.bsky.social
🧵👇
Very interesting paper on social behavior analysis 👇🏻
Excited to present the latest from the lab out today in Cell www.cell.com/cell/fulltex.... See Thread! 1/8
March 5, 2025 at 5:12 PM
Very interesting paper on social behavior analysis 👇🏻
European Neuroscience Societies stand up for science to support our U.S. colleagues 💪🏻
📣 Science matters!
#FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬
🔗 Read the full statement: loom.ly/cn7vJR4
#sciencematters #standupforscience #sciencenotsilence #scienceforall
#FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬
🔗 Read the full statement: loom.ly/cn7vJR4
#sciencematters #standupforscience #sciencenotsilence #scienceforall
March 5, 2025 at 4:06 PM
European Neuroscience Societies stand up for science to support our U.S. colleagues 💪🏻
Reposted by Mathias V. Schmidt
A new initiative to connect #stress and #resilience researchers around the world. A global platform, needed more than ever in these times: gsr-net.org @gsrnet.bsky.social
Resources to learn, teach, find labs, methods, conferences, workshops, jobs. Benefits for early-career researchers.
1/3
Resources to learn, teach, find labs, methods, conferences, workshops, jobs. Benefits for early-career researchers.
1/3
GSRNet - Empowering collaboration and knowledge sharing
The Global Stress & Resilience Network (GSRNet) is a global community connecting stress and resilience researchers and national networks.
gsr-net.org
March 5, 2025 at 9:59 AM
A new initiative to connect #stress and #resilience researchers around the world. A global platform, needed more than ever in these times: gsr-net.org @gsrnet.bsky.social
Resources to learn, teach, find labs, methods, conferences, workshops, jobs. Benefits for early-career researchers.
1/3
Resources to learn, teach, find labs, methods, conferences, workshops, jobs. Benefits for early-career researchers.
1/3