Cellular senescence in precancer lesions and early-stage cancers
Cellular senescence in precancer lesions and early-stage cancers
Cellular senescence plays dual roles in precancer lesions: initially serving as a tumor-suppressive barrier within the epithelial compartment and later contributing to a pro-tumoral precancer tissue microenvironment (PreTME) via a sustained, paracrine secretome known as senescent-associated secretory phenotype (SASP). This commentary highlights the role of senescence across various PreTME cell types, explores emerging pharmacologic and lifestyle interception strategies, and outlines current challenges for advancing biomarkers and clinical translation.
dlvr.it
January 19, 2026 at 12:52 PM
Cellular senescence in precancer lesions and early-stage cancers
SO, I don't have cancer or precancer. I do have overgrown endometrial tissue (adenomyosis) and tbh my pain levels are getting worse. We are adjusting hormones but istg I need them to fix this. I can't go back on anything with estrogen so it's progesterone. Which may be causing nausea.
January 16, 2026 at 7:50 PM
SO, I don't have cancer or precancer. I do have overgrown endometrial tissue (adenomyosis) and tbh my pain levels are getting worse. We are adjusting hormones but istg I need them to fix this. I can't go back on anything with estrogen so it's progesterone. Which may be causing nausea.
This review traces #precancer history and biology, spotlighting dysregulated TGF-β, p53, Wnt, PI3K, and MAPK pathways and a “soil degeneration” hypothesis favoring #microenvironmental dominance with dual-window interventions.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
January 9, 2026 at 8:30 PM
This review traces #precancer history and biology, spotlighting dysregulated TGF-β, p53, Wnt, PI3K, and MAPK pathways and a “soil degeneration” hypothesis favoring #microenvironmental dominance with dual-window interventions.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Man is either some ugly inside scars, precancer or cancer
We're hoping for the first one
We're hoping for the first one
January 8, 2026 at 10:20 PM
Man is either some ugly inside scars, precancer or cancer
We're hoping for the first one
We're hoping for the first one
The Cimarron Hills Fire Department (CHFD) said it is hosting an esophageal precancer screening event for at-risk firefighters.
Cimarron Hills Fire Department holds cancer screenings for at-risk firefighters
The Cimarron Hills Fire Department (CHFD) said it is hosting an esophageal precancer screening event for at-risk firefighters.
www.kktv.com
January 6, 2026 at 3:43 AM
The Cimarron Hills Fire Department (CHFD) said it is hosting an esophageal precancer screening event for at-risk firefighters.
Among #SGM individuals, home-based self-sampling for anal precancer screening was associated with increased participation and was cost-effective compared with clinic-based sampling, especially when accounting for societal costs. ja.ma/3N2IlsO
January 5, 2026 at 8:00 PM
Among #SGM individuals, home-based self-sampling for anal precancer screening was associated with increased participation and was cost-effective compared with clinic-based sampling, especially when accounting for societal costs. ja.ma/3N2IlsO
Ouch! My first experience with precancer spots. My dermatologist froze them. My face, arm and thigh feel like I fought with a swarm of bees.
December 30, 2025 at 2:49 PM
Ouch! My first experience with precancer spots. My dermatologist froze them. My face, arm and thigh feel like I fought with a swarm of bees.
Viewpoint: #Melanoma in situ is a main contributor to melanoma overdiagnosis, and reframing it as a precancer could help mitigate emotional and physical harms for patients. ja.ma/3YbCjIG
December 30, 2025 at 1:00 PM
Viewpoint: #Melanoma in situ is a main contributor to melanoma overdiagnosis, and reframing it as a precancer could help mitigate emotional and physical harms for patients. ja.ma/3YbCjIG
JAG ÄR PRECANCER-FRI 🥂
Äntligen, efter över tio års hängande hos gynekolog, har jag varken cellförändringar eller HPV och jag kommer nu bara behöva gå på vanliga cellprover som först är om fem år.
Fyfan vad skönt!! 🙏
Och nu blir det vaccinering för mig så snart som möjligt.
Äntligen, efter över tio års hängande hos gynekolog, har jag varken cellförändringar eller HPV och jag kommer nu bara behöva gå på vanliga cellprover som först är om fem år.
Fyfan vad skönt!! 🙏
Och nu blir det vaccinering för mig så snart som möjligt.
December 22, 2025 at 1:24 PM
JAG ÄR PRECANCER-FRI 🥂
Äntligen, efter över tio års hängande hos gynekolog, har jag varken cellförändringar eller HPV och jag kommer nu bara behöva gå på vanliga cellprover som först är om fem år.
Fyfan vad skönt!! 🙏
Och nu blir det vaccinering för mig så snart som möjligt.
Äntligen, efter över tio års hängande hos gynekolog, har jag varken cellförändringar eller HPV och jag kommer nu bara behöva gå på vanliga cellprover som först är om fem år.
Fyfan vad skönt!! 🙏
Och nu blir det vaccinering för mig så snart som möjligt.
cn: health, precancer, cancer, cervix, gyno
soo - let's do some real talk now! if i can raise awareness and it reaches just one person, i am more than happy!
in november they found cin3 in my cervix --> the highest grade of precancerous cells. usually this doesn't develop super quickly but i think
soo - let's do some real talk now! if i can raise awareness and it reaches just one person, i am more than happy!
in november they found cin3 in my cervix --> the highest grade of precancerous cells. usually this doesn't develop super quickly but i think
December 19, 2025 at 8:33 PM
cn: health, precancer, cancer, cervix, gyno
soo - let's do some real talk now! if i can raise awareness and it reaches just one person, i am more than happy!
in november they found cin3 in my cervix --> the highest grade of precancerous cells. usually this doesn't develop super quickly but i think
soo - let's do some real talk now! if i can raise awareness and it reaches just one person, i am more than happy!
in november they found cin3 in my cervix --> the highest grade of precancerous cells. usually this doesn't develop super quickly but i think
December 16, 2025 at 8:57 AM
cn: health, precancer, cancer, cervix, gyno
soo - let's do some real talk now! if i can raise awareness and it reaches just one person, i am more than happy!
in november they found cin3 in my cervix --> the highest grade of precancerous cells. usually this doesn't develop super quickly but i think
soo - let's do some real talk now! if i can raise awareness and it reaches just one person, i am more than happy!
in november they found cin3 in my cervix --> the highest grade of precancerous cells. usually this doesn't develop super quickly but i think
It absolutely saves lives. 3 yrs ago they saw something in my mammo. Had me stay for an ultrasound. Turns out I was at the very beginning of precancer. I had it removed and on a hormone blocker to help with prevention.
December 13, 2025 at 2:57 PM
It absolutely saves lives. 3 yrs ago they saw something in my mammo. Had me stay for an ultrasound. Turns out I was at the very beginning of precancer. I had it removed and on a hormone blocker to help with prevention.
Lucid Diagnostics Reveals Breakthrough in Esophageal Precancer Detection with Largest Real-World Study Results#USA#New_York#Lucid_Diagnostics#Esophageal_Cancer#Lucida
Lucid Diagnostics Reveals Breakthrough in Esophageal Precancer Detection with Largest Real-World Study Results
Lucid Diagnostics has announced impressive results from a large-scale study on esophageal precancer detection, confirming the effectiveness of their non-invasive testing methods.
third-news.com
December 9, 2025 at 1:11 PM
Lucid Diagnostics Reveals Breakthrough in Esophageal Precancer Detection with Largest Real-World Study Results#USA#New_York#Lucid_Diagnostics#Esophageal_Cancer#Lucida
#LUCD #PAVM Lucid Diagnostics Announces Positive Data from the Largest Reported Real-World Experience of Esophageal Precancer Detection
https://www.stocktitan.net/news/LUCD/lucid-diagnostics-announces-positive-data-from-the-largest-reported-81exsvqnyhwo.html
https://www.stocktitan.net/news/LUCD/lucid-diagnostics-announces-positive-data-from-the-largest-reported-81exsvqnyhwo.html
Lucid Diagnostics Announces Positive Data from the Largest Reported Real-World Experience of Esophageal Precancer Detection
Lucid Diagnostics (Nasdaq: LUCD) reported real-world data from an 18-month retrospective analysis of 11,991 at-risk patients who underwent EsoCheck cell collection and EsoGuard DNA testing between January 2023 and June 2024.Key findings: 95% technical success, 95% of collections completed in under two minutes, and no serious adverse events. Authors concluded the results show safety, tolerability, scalability, and appropriate physician use consistent with prior studies.
www.stocktitan.net
December 9, 2025 at 1:01 PM
#LUCD #PAVM Lucid Diagnostics Announces Positive Data from the Largest Reported Real-World Experience of Esophageal Precancer Detection
https://www.stocktitan.net/news/LUCD/lucid-diagnostics-announces-positive-data-from-the-largest-reported-81exsvqnyhwo.html
https://www.stocktitan.net/news/LUCD/lucid-diagnostics-announces-positive-data-from-the-largest-reported-81exsvqnyhwo.html
Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition | PNAS
Higher exercise capacity and regular exercise training improve cancer prognosis at
all stages of disease. However, the metabolic adaptations to aer...
www.pnas.org
December 2, 2025 at 4:23 PM
Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
HPV vaccination is doing exactly what it was supposed to do. It slashes high-grade cervical precancer and cervical cancer. This is a cancer-prevention shot. Not a “nice to have.” pic.x.com/h24bCwPBob - https://x.com/outbreakupdates/status/1994027238551875646
November 27, 2025 at 1:04 PM
HPV vaccination is doing exactly what it was supposed to do. It slashes high-grade cervical precancer and cervical cancer. This is a cancer-prevention shot. Not a “nice to have.” pic.x.com/h24bCwPBob - https://x.com/outbreakupdates/status/1994027238551875646
🎓 IARC’s Dr. Partha Basu presents a new course on cervical cancer screening and management, now available on the WHO Academy platform, designed to support the prevention and treatment of cervical precancer and cancer: buff.ly/IPqqzEp
🧵 7/11
🧵 7/11
November 25, 2025 at 8:00 AM
🎓 IARC’s Dr. Partha Basu presents a new course on cervical cancer screening and management, now available on the WHO Academy platform, designed to support the prevention and treatment of cervical precancer and cancer: buff.ly/IPqqzEp
🧵 7/11
🧵 7/11
Well, my progesterone script had my age written on it for the first time ever!
Also, my Gynaecologist said Pharmac only covers up to 100mg a day but I need 200mg daily (to try to slowdown estrogen sensitive precancer cells).
Also, my Gynaecologist said Pharmac only covers up to 100mg a day but I need 200mg daily (to try to slowdown estrogen sensitive precancer cells).
November 20, 2025 at 2:03 AM
Well, my progesterone script had my age written on it for the first time ever!
Also, my Gynaecologist said Pharmac only covers up to 100mg a day but I need 200mg daily (to try to slowdown estrogen sensitive precancer cells).
Also, my Gynaecologist said Pharmac only covers up to 100mg a day but I need 200mg daily (to try to slowdown estrogen sensitive precancer cells).
New data shows HPV vaccination has led to a sharp drop in cervical cancer and precancer rates worldwide, confirming the vaccine’s remarkable effectiveness and safety. More than a decade of progress is now clear. www.gavi.org/vaccineswork...
The HPV vaccine is erasing cancer – here's the proof
More than a decade after the first HPV vaccination programmes rolled out, data from multiple countries reveals a dramatic fall in cervical cancers and precancers, confirming that HPV vaccines are…
www.gavi.org
November 18, 2025 at 5:19 PM
New data shows HPV vaccination has led to a sharp drop in cervical cancer and precancer rates worldwide, confirming the vaccine’s remarkable effectiveness and safety. More than a decade of progress is now clear. www.gavi.org/vaccineswork...
Yikes! And I thought it was bad that my dad's primary doctor thought the flaking skin on his temple was precancer and froze it off, only it was a basal cell carcinoma the size of a silver dollar.
November 18, 2025 at 6:03 AM
Yikes! And I thought it was bad that my dad's primary doctor thought the flaking skin on his temple was precancer and froze it off, only it was a basal cell carcinoma the size of a silver dollar.
I get it. I have an oncologist appointment tomorrow about my breast cancer risk. Right now at 20%. Had precancer cells removed with lumpectomy.
November 12, 2025 at 11:49 PM
I get it. I have an oncologist appointment tomorrow about my breast cancer risk. Right now at 20%. Had precancer cells removed with lumpectomy.
Hi Julie! Hi Phee! I hope you both have a wonderful day. Bryan is being treated for precancer on his face. Isn’t he handsome? Strides were being made under Biden funding but canceled under the ghoul regime.
November 8, 2025 at 5:16 PM
Hi Julie! Hi Phee! I hope you both have a wonderful day. Bryan is being treated for precancer on his face. Isn’t he handsome? Strides were being made under Biden funding but canceled under the ghoul regime.
Online Now: Cellular senescence in precancer lesions and early-stage cancers
Cellular senescence in precancer lesions and early-stage cancers
Cellular senescence plays dual roles in precancer lesions: initially serving as a tumor-suppressive barrier within the epithelial compartment and later contributing to a pro-tumoral precancer tissue microenvironment (PreTME) via a sustained, paracrine secretome known as senescent-associated secretory phenotype (SASP). This commentary highlights the role of senescence across various PreTME cell types, explores emerging pharmacologic and lifestyle interception strategies, and outlines current challenges for advancing biomarkers and clinical translation.
dlvr.it
November 7, 2025 at 3:18 PM
Online Now: Cellular senescence in precancer lesions and early-stage cancers
I am fighting precancer in my breast. I already had surgery, now trying meds and mammograms to monitor.
November 5, 2025 at 1:52 PM
I am fighting precancer in my breast. I already had surgery, now trying meds and mammograms to monitor.
Integrative analysis of genomic and transcriptomic data informs precancer progression in the pancreas [new]
Multi-omic IPMN phenotypes linked to PDAC via integrative analyses. Defines spatial, genetic, transcriptional programs.
Multi-omic IPMN phenotypes linked to PDAC via integrative analyses. Defines spatial, genetic, transcriptional programs.
November 4, 2025 at 4:13 PM
Integrative analysis of genomic and transcriptomic data informs precancer progression in the pancreas [new]
Multi-omic IPMN phenotypes linked to PDAC via integrative analyses. Defines spatial, genetic, transcriptional programs.
Multi-omic IPMN phenotypes linked to PDAC via integrative analyses. Defines spatial, genetic, transcriptional programs.