#mechanism-based
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entirelyharmless.bsky.social
“While the [“evidence-based-medicine”] movement has indeed contributed greatly to the push for better quality evidence […] it has also created a plausible mechanism for opponents of scientific progress to discount enormous volumes of data using scientific language and ritual as a costume.”

👏🏻👀👇🏻
jessdkant.bsky.social Jesspooka Kant 🎃 @jessdkant.bsky.social · 21h
In sorting my own thoughts about the moment, I began writing about the way science is being used by bad actors under the guise of "evidence-based medicine". I also talk about the limits of our ability to fully boil down evidence into axioms that make subjectivity irrelevant.
The myth of an apolitical science — Jessica Kant
What we might call the modern anti-science movement, starting with efforts to hide the obvious linkage between tobacco and cancer, and the rise of “climate skepticism”, has grown in scale enormously i...
jessk.org
November 19, 2025 at 7:31 AM
enb.iisd.org
Many delegates at #COP30 are getting ready to continue working through the evening, with consultations scheduled until midnight on issues such as market-based cooperative approaches for implementing the Paris Agreement, national adaptation plans, & the Clean Development Mechanism
An image of one of the cafés within the COP 30 venue, with a vendor setting up a new tray of croissants to keep delegates feed through the evening.
November 18, 2025 at 10:22 PM
brap.bsky.social
The two distinct developmental paths are a single binary unit because they answer one fundamental question about the species: "Which of the two primary reproductive roles define this organism's reproductive system?" This classification is based on evolutionary mechanism, not “purpose.”
November 18, 2025 at 10:06 PM
cslg-bot.bsky.social
Meng Zhu, Quan Xiao, Weidong Min: AdamX: An Adam improvement algorithm based on a novel exponential decay mechanism for the second-order moment estimate https://arxiv.org/abs/2511.13465 https://arxiv.org/pdf/2511.13465 https://arxiv.org/html/2511.13465
November 18, 2025 at 6:37 AM
matdotpng.bsky.social
Their "learning" argument is beyond stupid.

Machines *need* to ingest millions of examples to produce images. A child can create original work based on lived experience. Humans also need only a few examples to learn, not ginormous datasets.

The mechanism is fundamentally different.
November 18, 2025 at 1:31 AM
sciencex.bsky.social
A unified neural network model based on Hebbian learning explains both contraction and repulsion biases in perceptual memory, suggesting diverse memory effects arise from a single adaptive mechanism. doi.org/hbbqj9
A unified model of memory and perception: How Hebbian learning explains our recall of past events
A collaboration between SISSA's Physics and Neuroscience groups has taken a step forward in understanding how memories are stored and retrieved in the brain.
medicalxpress.com
November 17, 2025 at 8:55 PM
komex.bsky.social
🔍How do you prove what happened in between cause and outcome?

Join our 5-day online Intro to Causal Process Tracing and learn to design a mechanism-based case study at #KOMEX2026.

Instructor: @hildevanmeegdenburg.com
23–27 Feb 2026
€440 early bird

🔗 Register: afww.uni-konstanz.de/en/microcred...
November 17, 2025 at 3:44 PM
cryptovka-feed.bsky.social
🦄 Brevis has released a whitepaper for ProverNet – a decentralized ZK-proof marketplace. This project, based on the TODA mechanism and integrated with PancakeSwap, Uniswap, Euler, Linea, and MetaMask, aims to improve the performance and efficiency of ZK systems

#CAKE #UNI #TBA
November 17, 2025 at 12:59 PM
karlbarn.bsky.social
Oh dang! Been dreading my skylight ever becoming a skyleak as well. Usually it's either the wire-based pulley mechanism that closes it being effed, or the rubber that's sealing the whole window in when it's closed being old and cracked.

The Car Care nut on YouTube helped me with my Toyota on that 1
November 17, 2025 at 11:17 AM
mannlab.bsky.social
Great to see Brenda Schulman’s team post their new bioRxiv paper. MS-based proteomics helped uncover a beautifully simple mechanism: cysteine levels tune metabolism by flipping the inverse stability of LRRC58 and its substrate CDO1.
www.biorxiv.org/content/bior...
www.biorxiv.org
November 17, 2025 at 10:27 AM
ca-nb.bsky.social
FDA unveils swift route to market for personalised drugs

https://www.newsbeep.com/ca/288600/

A new regulatory pathway for personalised therapies based on ‘plausible mechanism’, which could see therapies authorised after testing…
FDA unveils swift route to market for personalised drugs - Canada News Beep
A new regulatory pathway for personalised therapies based on 'plausible mechanism', which could see therapies authorised after testing on a tiny number of
www.newsbeep.com
November 17, 2025 at 9:50 AM
osna-fm.bsky.social
The European Commission is increasingly leaning on nature-based credits as a crucial funding mechanism to meet ambitious restoration targets, signaling a shift... https://news.osna.fm/?p=23731 |# news# certificates# eu# fund# nature
November 17, 2025 at 5:29 AM
sothatimayserve.bsky.social
Very interesting write up, thank you. The recent reports on the GLP-1 drugs is fascinating that it seems to have such cross over aside from just the weight loss. Must be a mechanism there! I had never heard of the retinal based evaluations before!
November 17, 2025 at 3:23 AM
eprint.ing.bot
Quantum-safe Identity-binding Password Authenticated Key Exchange Protocols (Pratima Jana, Ratna Dutta) ia.cr/2025/2107
Abstract. Password-based Authenticated Key Exchange (${\sf PAKE}$) is a widely acknowledged, promising security mechanism for establishing secure communication between devices. It enables two parties to mutually authenticate each other over insecure networks and generate a session key using a low-entropy password. However, the existing PAKE protocols encounter significant challenges concerning both security and efficiency in the context of the (IoT). In response to these challenges, we contribute to the advancement of post-quantum secure PAKE protocols tailored for IoT applications, enriching the existing landscape. In this study, we introduce two novel protocols, PAKE- and PAKE-, designed to address these concerns and enhance the security standards of PAKE protocol. While PAKE- is secure under lattice-based hardness assumptions, PAKE- derives its security from isogeny-based hard problems. Our lattice-based protocol PAKE- is secure based on the (PWE) assumption and the (DRLWE) assumption and our isogeny-based protocol PAKE- is secure based on the hardness of the (GAIP) and the (CSSDH) problem in the Random Oracle Model (ROM). We present a comprehensive security proof in a conventional game-based indistinguishability security model that addresses offline dictionary attacks, replay attacks, compromise attacks for both parties (client and server) and perfect forward secrecy. Additionally, our proposed PAKE protocols are the first post-quantum secure PAKEs that achieve identity privacy and resistance to pre-computation attacks. Through rigorous performance evaluations, the paper demonstrates that the proposed PAKE schemes are ultralight and exhibit notable advantages in terms of total computation cost and enhanced security properties when compared to the existing protocols. More positively, both the proposed PAKE are optimal in the sense that they achieve mutual authentication explicitly in only three rounds which is the least number of rounds required for acquiring mutual authentication between two parties. Image showing part 2 of abstract.
November 17, 2025 at 2:24 AM
eprint.ing.bot
Threshold Batched Identity-Based Encryption from Pairings in the Plain Model (Junqing Gong, Brent Waters, Hoeteck Wee, David J. Wu) ia.cr/2025/2103
Abstract. In a batched identity-based encryption (IBE) scheme, ciphertexts are associated with a batch label tag^(*) and an identity id^(*) while secret keys are associated with a batch label tag and a set of identities S. Decryption is possible whenever tag = tag^(*) and id^(*) ∈ S. The primary efficiency property in a batched IBE scheme is that the size of the decryption key for a set S should be independent of the size of S. Batched IBE schemes provide an elegant cryptographic mechanism to support encrypted memory pools in blockchain applications. In this work, we introduce a new algebraic framework for building pairing-based batched IBE. Our framework gives the following: First, we obtain a selectively-secure batched IBE scheme under a q-type assumption in the plain model. Both the ciphertext and the secret key consist of a constant number of group elements. This is the first pairing-based batched IBE scheme in the plain model. Previous pairing-based schemes relied on the generic group model and the random oracle model. Next, we show how to extend our base scheme to a threshold batched IBE scheme with silent setup. In this setting, users independently choose their own public and private keys, and there is a non-interactive procedure to derive the master public key (for a threshold batched IBE scheme) for a group of users from their individual public keys. We obtain a statically-secure threshold batched IBE scheme with silent setup from a q-type assumption in the plain model. As before, ciphertexts and secret keys in this scheme contain a constant number of group elements. Previous pairing-based constructions of threshold batched IBE with silent setup relied on the generic group model, could only support a polynomial number of identities (where the size of the public parameters scaled linearly with this bound), and ciphertexts contained O(λ/log λ) group elements, where λ is the security parameter. Finally, we show that if we work in the generic group model, then we obtain a (threshold) batched IBE scheme with shorter ciphertexts (by 1 group element) than all previous pairing-based constructions (and without impacting the size of the secret key). Our constructions rely on classic algebraic techniques underlying pairing-based IBE and do not rely on the signature-based witness encryption viewpoint taken in previous works. Image showing part 2 of abstract. Image showing part 3 of abstract.
November 17, 2025 at 2:09 AM
ac74394.bsky.social
I look at all these people with advanced degrees from the most prestigious colleges in the world and think:

1) No way they were admitted based on academics/intelligence, and

2) the same mechanism that provided acceptance is also what ensured their graduation.

I'm absolutely sure of this.
November 16, 2025 at 10:47 PM
secretsongoflight.bsky.social
Xenomorph head appears to be an echolocation based sensory/communication system. Possibly gaseous home environment where eyes would be of little use. The back vents could indicate a cooling system/process exotic atmospheric toxins. Waste processing mechanism unclear. Ambush predation/reproduction.
secretsongoflight.bsky.social Jessica Shadowless🏴‍☠️🏳️‍⚧️ @secretsongoflight.bsky.social · 2d
Quick 2 min sketch of this little rascal! Always getting into mischief.
#xenovember
#alien
#sci-fi
#horror
November 16, 2025 at 10:41 PM
market-ocean-en.bsky.social
🧵 Trump's $2,000 Tariff Dividend: Understanding Revenue-Based Government Transfers

President Trump's announcement of potential $2,000 payments funded by tariff revenue introduces an unconventional fiscal mechanism.
November 16, 2025 at 10:00 PM
ie-news.bsky.social
FDA unveils swift route to market for personalised drugs

https://www.europesays.com/ie/184196/

A new regulatory pathway for personalised therapies based on ‘plausible mechanism’, which could see therapies authorised after testing…
FDA unveils swift route to market for personalised drugs - Ireland
A new regulatory pathway for personalised therapies based on 'plausible mechanism', which could see therapies authorised after testing on a tiny number of
www.europesays.com
November 16, 2025 at 8:45 PM
unclerobin.bsky.social
Nope. She works at a weird, offbeat bookstore (en.wikipedia.org/wiki/Village... - the #jDrama is a series of episodic stories based on events at the real store, background provided in the credits by real staff) and it turns out complicated speech is her defence mechanism when under stress. 🙂
Village Vanguard (Japanese bookstore) - Wikipedia
en.wikipedia.org
November 16, 2025 at 7:44 PM
bigearthdata.bsky.social
Enhanced exploration in reinforcement learning using graph neural network based intrinsic reward mechanism
->Nature | #neural network | More from Lil Dr Glen EcoChat at BigEarthData.ai
Enhanced exploration in reinforcement learning using graph neural network based intrinsic reward mechanism
In Reinforcement Learning (RL), exploration refers to the process by which an agent discovers new states and actions to maximize its cumulative reward20. Effective exploration is essential, particularly when an agent faces sparse rewards or complex state-action spaces that include...
www.nature.com
November 16, 2025 at 5:15 PM
slandernlies.bsky.social
March 2012. Mostly as a mechanism to give my FLGS more money (the game I played there more was cheap) and to get better at card games in General. Fell in love with various Blue based Tempo decks in Standard and Modern.
carmparens.bsky.social Carmen Klomparens @carmparens.bsky.social · 3d
What's the lore behind you getting into @magic.wizards.com?

#WOTCstaff
November 16, 2025 at 1:14 PM
thebrainofchris.bsky.social
Fun fact - the internal mechanism for selecting and launching the nuclear bombs is based on the internal workings of a Coca Cola bottle vending machine.
This is historically accurate!
theycallmejc.bsky.social They call me JC @theycallmejc.bsky.social · 3d
Orion drive section detail (cont.):
Cabling and access hatch (?) modelled on Fermi Orion Drive section
November 16, 2025 at 9:43 AM
ecohacker.bsky.social
Yup

Blind faith in technology without a mechanism to make it sustainable and functional is often the part missed in venture capital profit seeking

We need a different set of business models based on sustainability

Green tech is profitable

Oil is cancerous and short lived

China is winning tech
the word sustainability is on a purple background surrounded by stars
ALT: the word sustainability is on a purple background surrounded by stars
media.tenor.com
November 16, 2025 at 4:52 AM
eu-health.bsky.social
FDA unveils swift route to market for personalised drugs

https://www.europesays.com/uk/572941/

A new regulatory pathway for personalised therapies based on ‘plausible mechanism’, which could see therapies authorised after testing…
FDA unveils swift route to market for personalised drugs - United Kingdom
A new regulatory pathway for personalised therapies based on 'plausible mechanism', which could see therapies authorised after testing on a tiny number of
www.europesays.com
November 15, 2025 at 11:40 PM