#epiboly
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biorxiv-devbio.bsky.social
Dorsal forerunner cells transmit epiboly forces to extend the zebrafish notochord https://www.biorxiv.org/content/10.1101/2025.10.24.684459v1
October 25, 2025 at 10:31 AM
biorxivpreprint.bsky.social
Dorsal forerunner cells transmit epiboly forces to extend the zebrafish notochord https://www.biorxiv.org/content/10.1101/2025.10.24.684459v1
October 25, 2025 at 10:31 AM
lepuslapis.bsky.social
We also discover an emergent contribution of an inhomogeneous cable to the dynamics of gap closure. Our work thus explains the mechanical roles of tissue fluidisation and cable inhomogeneities in Tribolium serosa closure and processes of epiboly and wound healing more generally.
September 8, 2025 at 7:51 AM
ejwillingham.bsky.social
35. Dev bio is packed w/delicious terminology. Such as "epiboly," the thinning/spreading of tissue over, eg, yolk, like paint spreading on a beachball. This image is the zebrafish--the embryo head is the left of the structure on top, the backbone forms the curve, and the tail is the right
An image showing a cartoon version of epiboly progressing in a zebrafish embryo and real pictures of a series of embryos showing the same progression, with the embryo extended around a sphere of yolk
July 26, 2025 at 5:19 AM
dev-journal.bsky.social
Mind the pores: studying morphogen gradients

Read this Research Highlight showcasing work from Justina Stark, Rohit Krishnan Harish, Ivo Sbalzarini @mosaicgroup.bsky.social and Michael Brand @tudresden.bsky.social:
journals.biologists.com/dev/article/...
Figure 1 (D-G) Visualization of the sparse-grid discretization of the ECS at ≈60% epiboly.
July 15, 2025 at 3:29 PM
tushnakapoor.bsky.social
Excited to be at #EMBOcellPolarity25 and speak about my work on the role of polarity in zebrafish epiboly!
heisenbergcplab.bsky.social Heisenberg Lab @heisenbergcplab.bsky.social · May 18
Are you attending #EMBOcellPolarity25? Our postdoc @tushnakapoor.bsky.social will talk about her work on how #polarity controls #epiboly movements in #zebrafish, TOMORROW at Session 1, 11:15am! 🐟
May 18, 2025 at 9:31 PM
heisenbergcplab.bsky.social
Are you attending #EMBOcellPolarity25? Our postdoc @tushnakapoor.bsky.social will talk about her work on how #polarity controls #epiboly movements in #zebrafish, TOMORROW at Session 1, 11:15am! 🐟
May 18, 2025 at 2:47 PM
dev-journal.bsky.social
In preprints: expanded insight into epithelial spreading during zebrafish epiboly

Donna Guan and Ashley Bruce discuss two recent #preprints from Suyash Naik & @heisenbergcplab.bsky.social et al. and Sharon Minsuk & James Glazier et al.:
journals.biologists.com/dev/article/...
May 15, 2025 at 9:51 AM
biorxivpreprint.bsky.social
Regulation of the Yolk Microtubule and Actin Cytoskeleton by Dachsous Cadherins during Zebrafish Epiboly https://www.biorxiv.org/content/10.1101/2025.05.10.653271v1
May 14, 2025 at 2:32 PM
biorxiv-devbio.bsky.social
Regulation of the Yolk Microtubule and Actin Cytoskeleton by Dachsous Cadherins during Zebrafish Epiboly https://www.biorxiv.org/content/10.1101/2025.05.10.653271v1
May 14, 2025 at 2:32 PM
zebrafishrock.bsky.social
@marymullins.bsky.social (Epithelial morphogenesis/ Epiboly/ Enveloping layer)
https://www.biorxiv.org/content/10.1101/2025.02.12.637977v1

@heisenbergcplab.bsky.social (Synchrony/ Early embryonic geometry)
https://www.biorxiv.org/content/10.1101/2025.02.03.636134v1

(24/39)
March 14, 2025 at 2:33 PM
amichaut.bsky.social
So, how can a fluid and an elastic response coexist in the epiblast? To answer this question, we formulated a physical model in which the epiblast flows in response to shear forces (that shape the embryo) and elastically stretches in response to isotropic forces (arising during epiboly).
March 13, 2025 at 11:32 AM
amichaut.bsky.social
In this paper, we have studied how epiboly takes place in birds, which is the process during which the epithelial extraembryonic tissue expands to engulf the entire yolk.
March 13, 2025 at 11:32 AM
stetavano.bsky.social
I hypothesized that the substrate could tell the LME when and where to stop the animal migration. We first found that the LME migrates on the ectoderm, which the epiboly causes to move passively in the opposite direction. Does the ectoderm cause the LME to start tumbling?
March 12, 2025 at 1:01 PM
stetavano.bsky.social
I hypothesized that the substrate could tell the LME when and where to stop the animal migration. We first found that the LME migrates on the ectoderm, which the epiboly causes to move passively in the opposite direction. Does the ectoderm cause the LME to start tumbling?
March 12, 2025 at 12:56 PM
cammorphoseries.bsky.social
How are tissue spreading and gastrulation coupled to ensure the formation of the initial body plan? By looking at the cellular mechanics underlying epiboly in developing chicken blastoderm, Fengzhu Xiong et al. illuminate the role of the ECM in this process. Join us today at 2:30 pm for more!
March 10, 2025 at 8:12 AM
biorxiv-devbio.bsky.social
Modeling Epithelial Morphogenesis and Cell Rearrangement during Zebrafish Epiboly: Tissue Deformation, Cell-Cell Coupling, and the Mechanical Response to Stress https://www.biorxiv.org/content/10.1101/2025.02.12.637977v1
February 13, 2025 at 6:31 PM
biorxivpreprint.bsky.social
Modeling Epithelial Morphogenesis and Cell Rearrangement during Zebrafish Epiboly: Tissue Deformation, Cell-Cell Coupling, and the Mechanical Response to Stress https://www.biorxiv.org/content/10.1101/2025.02.12.637977v1
February 13, 2025 at 6:31 PM
hoxinsocks.bsky.social
Oh, my god, eyeball feast

www.cellimagelibrary.org/groups/20089
Image 20062 in the linked image group. Its description reads: Camera lucida sketches of the zebrafish embryo at selected stages. This image is in the Zygote period at the 0.2 hour 1 cell stage. The animal pole is to the top for the early stages, and anterior is to the top later, except for the two animal polar (AP) views shown below their side view counterparts for germ-ring and shield gastrulas. Face views are shown during cleavage and blastula stages. After shield stage, the views are of the embryo's left side, but before the shield arises one cannot reliably ascertain which side is which. Pigmentation is omitted. Arrowheads indicate the early appearance of some key diagnostic features at the following stages: 1 k-cell: YSL nuclei. Dome: the doming yolk syncytium. Germ ring: germ ring. Shield: embryonic shield. 75%-epiboly: Brachet's cleft. 90%-epiboly: blastoderm margin closing over the yolk plug. Bud: polster. 3-somite: third somite. 6-somite: eye primordium (upper arrow), Kupffer's vesicle (lower). 10-somite: otic placode. 21-somite: lens primordium. Prim-6: primordium of the posterior lateral line (on the dorsal side), hatching gland (on the yolk ball). Prim-16: heart. High-pec: pectoral fin bud. Composite image CIL: 20098 is a low resolution image with a scale bar = 250 microns that shows the entire set of image. Images correspond to Fig 1 of Developmental Dynamics 203:253-310 (1995). Image 20068 in the linked image group. Its description reads: Camera lucida sketches of the zebrafish embryo at selected stages. This image is in the Cleavage period at the 2 hour 64 cell stage. The animal pole is to the top for the early stages, and anterior is to the top later, except for the two animal polar (AP) views shown below their side view counterparts for germ-ring and shield gastrulas. Face views are shown during cleavage and blastula stages. After shield stage, the views are of the embryo's left side, but before the shield arises one cannot reliably ascertain which side is which. Pigmentation is omitted. Arrowheads indicate the early appearance of some key diagnostic features at the following stages: 1 k-cell: YSL nuclei. Dome: the doming yolk syncytium. Germ ring: germ ring. Shield: embryonic shield. 75%-epiboly: Brachet's cleft. 90%-epiboly: blastoderm margin closing over the yolk plug. Bud: polster. 3-somite: third somite. 6-somite: eye primordium (upper arrow), Kupffer's vesicle (lower). 10-somite: otic placode. 21-somite: lens primordium. Prim-6: primordium of the posterior lateral line (on the dorsal side), hatching gland (on the yolk ball). Prim-16: heart. High-pec: pectoral fin bud. Composite image CIL: 20098 is a low resolution image with a scale bar = 250 microns that shows the entire set of image. Images correspond to Fig 1 of Developmental Dynamics 203:253-310 (1995). Image 20081 in the linked image group. Its description reads: Camera lucida sketches of the zebrafish embryo at selected stages. This image is in the Gastrula period at the 8 hour 75% epiboly stage. The animal pole is to the top for the early stages, and anterior is to the top later, except for the two animal polar (AP) views shown below their side view counterparts for germ-ring and shield gastrulas. Face views are shown during cleavage and blastula stages. After shield stage, the views are of the embryo's left side, but before the shield arises one cannot reliably ascertain which side is which. Pigmentation is omitted. Arrowheads indicate the early appearance of some key diagnostic features at the following stages: 1 k-cell: YSL nuclei. Dome: the doming yolk syncytium. Germ ring: germ ring. Shield: embryonic shield. 75%-epiboly: Brachet's cleft. 90%-epiboly: blastoderm margin closing over the yolk plug. Bud: polster. 3-somite: third somite. 6-somite: eye primordium (upper arrow), Kupffer's vesicle (lower). 10-somite: otic placode. 21-somite: lens primordium. Prim-6: primordium of the posterior lateral line (on the dorsal side), hatching gland (on the yolk ball). Prim-16: heart. High-pec: pectoral fin bud. Composite image CIL: 20098 is a low resolution image with a scale bar = 250 microns that shows the entire set of image. Images correspond to Fig 1 of Developmental Dynamics 203:253-310 (1995). Image 20082 in the linked image group. Its description reads: Camera lucida sketches of the zebrafish embryo at selected stages. This image is in the Gastrula period at the 9 hour 90% epiboly stage. The animal pole is to the top for the early stages, and anterior is to the top later, except for the two animal polar (AP) views shown below their side view counterparts for germ-ring and shield gastrulas. Face views are shown during cleavage and blastula stages. After shield stage, the views are of the embryo's left side, but before the shield arises one cannot reliably ascertain which side is which. Pigmentation is omitted. Arrowheads indicate the early appearance of some key diagnostic features at the following stages: 1 k-cell: YSL nuclei. Dome: the doming yolk syncytium. Germ ring: germ ring. Shield: embryonic shield. 75%-epiboly: Brachet's cleft. 90%-epiboly: blastoderm margin closing over the yolk plug. Bud: polster. 3-somite: third somite. 6-somite: eye primordium (upper arrow), Kupffer's vesicle (lower). 10-somite: otic placode. 21-somite: lens primordium. Prim-6: primordium of the posterior lateral line (on the dorsal side), hatching gland (on the yolk ball). Prim-16: heart. High-pec: pectoral fin bud. Composite image CIL: 20098 is a low resolution image with a scale bar = 250 microns that shows the entire set of image. Images correspond to Fig 1 of Developmental Dynamics 203:253-310 (1995).
January 18, 2025 at 5:47 AM
biorxiv-devbio.bsky.social
Epiboly in zebrafish requires reactive oxygen species produced by NADPH oxidases for the regulation of vesicular trafficking https://www.biorxiv.org/content/10.1101/2024.12.13.628279v1
December 18, 2024 at 6:31 AM
biorxivpreprint.bsky.social
Epiboly in zebrafish requires reactive oxygen species produced by NADPH oxidases for the regulation of vesicular trafficking https://www.biorxiv.org/content/10.1101/2024.12.13.628279v1
December 18, 2024 at 6:31 AM
amichaut.bsky.social
This can be explained by a reversible stretching of these cells, as columnar cells adopt a squamous morphology during epiboly and revert to their columnar conformation upon laser-induced relaxation.
November 21, 2024 at 12:55 PM
loicaroyer.bsky.social
My BlueSky 'inaugural' post is our classic rotating embryo video from our recently published Zebrahub paper
www.cell.com/cell/fulltex...

“Zebrahub | Supp. Video 3: Light-sheet time-lapse of Tg(h2afva:h2afva-mcherry ; mezzo:eGFP) embryo starting at 50% epiboly.”
on #Vimeo vimeo.com/803719225
Zebrahub | Supp. Video 3: Light-sheet time-lapse of Tg(h2afva:h2afva-mcherry ; mezzo:eGFP) embryo starting at 50% epiboly.
This is "Zebrahub | Supp. Video 3: Light-sheet time-lapse of Tg(h2afva:h2afva-mcherry ; mezzo:eGFP) embryo starting at 50% epiboly." by Loic A. Royer on…
vimeo.com
November 20, 2024 at 9:29 PM