Now something that is extremely hard to sample with all-atom MD: a big intrinsically disordered protein (IDP) like Complexin II. Different answers depending on MD forcefield. BioEmu - not traind on IDPs - looks reasonable, agrees with experimental evidence and is super fast.
December 6, 2024 at 8:39 AM
Now something that is extremely hard to sample with all-atom MD: a big intrinsically disordered protein (IDP) like Complexin II. Different answers depending on MD forcefield. BioEmu - not traind on IDPs - looks reasonable, agrees with experimental evidence and is super fast.
I’m complexin, and I should just do art in the bathroom 😂😂😂
November 21, 2024 at 3:37 AM
I’m complexin, and I should just do art in the bathroom 😂😂😂
Nope, he is just Arni. and Icelandic. https://x.com/complexin/status/695723675044057088
x.com
x.com
November 9, 2024 at 7:07 AM
Nope, he is just Arni. and Icelandic. https://x.com/complexin/status/695723675044057088
Key determinants of the dual clamp/activator function of Complexin https://www.biorxiv.org/content/10.1101/2023.10.03.560784v1
Key determinants of the dual clamp/activator function of Complexin https://www.biorxiv.org/content/10.1101/2023.10.03.560784v1
Complexin determines magnitude and kinetics of synchronized secretion, but the underlying molecular
www.biorxiv.org
October 6, 2023 at 12:16 AM
Key determinants of the dual clamp/activator function of Complexin https://www.biorxiv.org/content/10.1101/2023.10.03.560784v1
💬 Seminari: 'The presynaptic dimension of brain pathologies: Munc13-1 and Complexin and their control over synaptic (dys)function' a càrrec del Dr. Francisco J. López-Murcia, professor de la @ub.edu / @idibell.bsky.social
📆 31 gener
🕑 13:00
📍 IDIBELL. Edifici Jardí (Aula Blava)
📆 31 gener
🕑 13:00
📍 IDIBELL. Edifici Jardí (Aula Blava)
January 28, 2025 at 2:36 PM
💬 Seminari: 'The presynaptic dimension of brain pathologies: Munc13-1 and Complexin and their control over synaptic (dys)function' a càrrec del Dr. Francisco J. López-Murcia, professor de la @ub.edu / @idibell.bsky.social
📆 31 gener
🕑 13:00
📍 IDIBELL. Edifici Jardí (Aula Blava)
📆 31 gener
🕑 13:00
📍 IDIBELL. Edifici Jardí (Aula Blava)
The good, the bad and the ugly of being an #ECR:
http://t.co/cWF2G3rCXw & http://t.co/QTUKcuiEnV
via @PhdGeek @complexin
http://t.co/cWF2G3rCXw & http://t.co/QTUKcuiEnV
via @PhdGeek @complexin
October 8, 2014 at 10:13 AM
The good, the bad and the ugly of being an #ECR:
http://t.co/cWF2G3rCXw & http://t.co/QTUKcuiEnV
via @PhdGeek @complexin
http://t.co/cWF2G3rCXw & http://t.co/QTUKcuiEnV
via @PhdGeek @complexin
Good morning BlueSky! May you all have the Bluest of skies today with nice breeze, gentle warmth, and those cool little puffy cumulus clouds just a blowin' along while the butterflies dance. And also:
Evil Laugh Ensues MUHUAHAHA! Being able to program is its own high. I'm God-complexin' today. >:-)
Evil Laugh Ensues MUHUAHAHA! Being able to program is its own high. I'm God-complexin' today. >:-)
December 3, 2024 at 4:42 PM
Good morning BlueSky! May you all have the Bluest of skies today with nice breeze, gentle warmth, and those cool little puffy cumulus clouds just a blowin' along while the butterflies dance. And also:
Evil Laugh Ensues MUHUAHAHA! Being able to program is its own high. I'm God-complexin' today. >:-)
Evil Laugh Ensues MUHUAHAHA! Being able to program is its own high. I'm God-complexin' today. >:-)
How is SNARE-mediated synaptic vesicle release regulated in inhibitory #synapses? This study reveals that the #exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner in #Celegans inhibitory synapses 🧪 @plosbiology.org plos.io/4jRm255
February 7, 2025 at 1:28 PM
How is SNARE-mediated synaptic vesicle release regulated in inhibitory #synapses? This study reveals that the #exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner in #Celegans inhibitory synapses 🧪 @plosbiology.org plos.io/4jRm255
How is SNARE-mediated synaptic vesicle release regulated in inhibitory #synapses? This study reveals that the #exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner in #Celegans inhibitory synapses 🧪 @plosbiology.org plos.io/4jRm255
February 10, 2025 at 10:42 AM
How is SNARE-mediated synaptic vesicle release regulated in inhibitory #synapses? This study reveals that the #exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner in #Celegans inhibitory synapses 🧪 @plosbiology.org plos.io/4jRm255
This study by Justine A. Lottermoser research-and-innovation.cornell.edu et al. investigates how #complexin gains effective access to the assembling SNAREs via its membrane-binding C-terminal domain 🔎 🧠
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
October 27, 2025 at 2:04 PM
This study by Justine A. Lottermoser research-and-innovation.cornell.edu et al. investigates how #complexin gains effective access to the assembling SNAREs via its membrane-binding C-terminal domain 🔎 🧠
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Single residues in the complexin N-terminus exhibit distinct phenotypes in synaptic vesicle fusion https://www.biorxiv.org/content/10.1101/2024.01.12.575336v1
Single residues in the complexin N-terminus exhibit distinct phenotypes in synaptic vesicle fusion https://www.biorxiv.org/content/10.1101/2024.01.12.575336v1
The release of neurotransmitters at central synapses is dependent on a cascade of protein interactio
www.biorxiv.org
January 13, 2024 at 12:15 AM
Single residues in the complexin N-terminus exhibit distinct phenotypes in synaptic vesicle fusion https://www.biorxiv.org/content/10.1101/2024.01.12.575336v1
Differential Regulation of Excitatory vs Inhibitory Synaptic Release by Complexin/CPX-1 and CAPS/UNC-31 at the C. elegans Neuromuscular Junctions https://www.biorxiv.org/content/10.1101/2023.08.25.554737v1
August 25, 2023 at 5:17 PM
Differential Regulation of Excitatory vs Inhibitory Synaptic Release by Complexin/CPX-1 and CAPS/UNC-31 at the C. elegans Neuromuscular Junctions https://www.biorxiv.org/content/10.1101/2023.08.25.554737v1
Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans https://www.biorxiv.org/content/10.1101/2024.10.28.620710v1
Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans https://www.biorxiv.org/content/10.1101/2024.10.28.620710v1
Regulated secretion of insulin from {beta}-cells, glucagon from -cells, and somatostatin from {delta
www.biorxiv.org
October 31, 2024 at 6:30 AM
Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans https://www.biorxiv.org/content/10.1101/2024.10.28.620710v1
Tänään Hanauta e.p.:n julkaisupäivänä on hyvä hetki tutustua @herocomplexKKK:in rentoon soundiin. https://www.jame-world.com/fi/news/151336-hero-complexin-viisiraitainen-ep-nyt-ulkona.html
HERO COMPLEXin viisiraitainen EP nyt ulkona
Kyseessä on pop punk -bändin ensimmäinen julkaisu tänä vu...
www.jame-world.com
November 14, 2024 at 11:56 AM
Tänään Hanauta e.p.:n julkaisupäivänä on hyvä hetki tutustua @herocomplexKKK:in rentoon soundiin. https://www.jame-world.com/fi/news/151336-hero-complexin-viisiraitainen-ep-nyt-ulkona.html
Single residues in the complexin N-terminus exhibit distinct phenotypes in synaptic vesicle fusion https://www.biorxiv.org/content/10.1101/2024.01.12.575336v1
Single residues in the complexin N-terminus exhibit distinct phenotypes in synaptic vesicle fusion https://www.biorxiv.org/content/10.1101/2024.01.12.575336v1
The release of neurotransmitters at central synapses is dependent on a cascade of protein interactio
www.biorxiv.org
January 13, 2024 at 12:15 AM
Single residues in the complexin N-terminus exhibit distinct phenotypes in synaptic vesicle fusion https://www.biorxiv.org/content/10.1101/2024.01.12.575336v1
Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans https://www.biorxiv.org/content/10.1101/2024.10.28.620710v1
Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans https://www.biorxiv.org/content/10.1101/2024.10.28.620710v1
Regulated secretion of insulin from {beta}-cells, glucagon from -cells, and somatostatin from {delta
www.biorxiv.org
October 31, 2024 at 6:30 AM
Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans https://www.biorxiv.org/content/10.1101/2024.10.28.620710v1
How is SNARE-mediated synaptic vesicle release regulated in inhibitory #synapses? This study reveals that the #exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner in #Celegans inhibitory synapses 🧪 @plosbiology.org plos.io/4jRm255
February 7, 2025 at 6:20 PM
How is SNARE-mediated synaptic vesicle release regulated in inhibitory #synapses? This study reveals that the #exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner in #Celegans inhibitory synapses 🧪 @plosbiology.org plos.io/4jRm255
RRID:SCR_006457, was just reported to be used in "Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping abili…". Thank you for making your methods matter! #ReproducibleResearch #accelerateopenscience
doi.org
February 11, 2025 at 8:02 AM
RRID:SCR_006457, was just reported to be used in "Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping abili…". Thank you for making your methods matter! #ReproducibleResearch #accelerateopenscience
Govern canvia algunes condicions per facilitar l’entrada de gent gran al registre i també facilita que ho puguin fer aquelles famílies on no tots els membres adults complexin amb els cinc anys de residència al país
Requisits més flexibles per accedir als pisos públics: s’acceptarà qui només cobri el salari mínim
www.altaveu.com
March 26, 2025 at 4:51 PM
Govern canvia algunes condicions per facilitar l’entrada de gent gran al registre i també facilita que ho puguin fer aquelles famílies on no tots els membres adults complexin amb els cinc anys de residència al país
BioEmu emulates MD equilibrium distributions significantly faster than running actual simulations (pg. 6). Figure 3 compares BioEmu's performance to that of extensive all-atom MD simulations on a set of fast-folding proteins, CATH domains, Complexin II, and ACE2. The model predicts native...
December 6, 2024 at 5:17 PM
BioEmu emulates MD equilibrium distributions significantly faster than running actual simulations (pg. 6). Figure 3 compares BioEmu's performance to that of extensive all-atom MD simulations on a set of fast-folding proteins, CATH domains, Complexin II, and ACE2. The model predicts native...
Yordan Alvarez is basically fantasy baseball's Exodia The Forbidden One
August 12, 2025 at 12:01 AM
Yordan Alvarez is basically fantasy baseball's Exodia The Forbidden One
What? I just wanna play some board games with her~! Jokes aside, I LOVE Poison, she's the reason I stop complexin' on my thighs and got the strength to do my comin' out as trans~
November 8, 2025 at 7:42 PM
What? I just wanna play some board games with her~! Jokes aside, I LOVE Poison, she's the reason I stop complexin' on my thighs and got the strength to do my comin' out as trans~
Synaptotagmin-1 and complexin inhibit spontaneous vesicle fusion by masking PIP2, not by clamping SNARE assembly https://www.biorxiv.org/content/10.1101/2025.03.24.644869v1
March 24, 2025 at 4:18 PM
Synaptotagmin-1 and complexin inhibit spontaneous vesicle fusion by masking PIP2, not by clamping SNARE assembly https://www.biorxiv.org/content/10.1101/2025.03.24.644869v1
Synaptotagmin-1 and complexin inhibit spontaneous vesicle fusion by masking PIP2, not by clamping SNARE assembly https://www.biorxiv.org/content/10.1101/2025.03.24.644869v1
March 24, 2025 at 4:18 PM
Synaptotagmin-1 and complexin inhibit spontaneous vesicle fusion by masking PIP2, not by clamping SNARE assembly https://www.biorxiv.org/content/10.1101/2025.03.24.644869v1
Key determinants of the dual clamp/activator function of Complexin https://www.biorxiv.org/content/10.1101/2023.10.03.560784v1
Key determinants of the dual clamp/activator function of Complexin https://www.biorxiv.org/content/10.1101/2023.10.03.560784v1
Complexin determines magnitude and kinetics of synchronized secretion, but the underlying molecular
www.biorxiv.org
October 6, 2023 at 12:16 AM
Key determinants of the dual clamp/activator function of Complexin https://www.biorxiv.org/content/10.1101/2023.10.03.560784v1