#microsky #phagesky #phage defence
Anti-CRISPR protein hijacks host’s enolase to tackle and block CRISPR-Cas
www.nature.com/articles/s41...
Anti-CRISPR protein hijacks host’s enolase to tackle and block CRISPR-Cas
www.nature.com/articles/s41...
A phage-encoded anti-CRISPR protein co-opts host enolase to prevent type III CRISPR immunity - Nature Microbiology
Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding.
www.nature.com
November 11, 2025 at 4:27 PM
#microsky #phagesky #phage defence
Anti-CRISPR protein hijacks host’s enolase to tackle and block CRISPR-Cas
www.nature.com/articles/s41...
Anti-CRISPR protein hijacks host’s enolase to tackle and block CRISPR-Cas
www.nature.com/articles/s41...
Deadline for abstracts: 12th Dec 2025.
Deadline for registration: 9th Jan 2026.
#microsky #phagesky #phage
Deadline for registration: 9th Jan 2026.
#microsky #phagesky #phage
hosting.northumbria.ac.uk/nu-omics/vom...
#phagesky #phage #microsky
Come and join us for Viruses of Microbes UK 2026 at @northumbriauni.bsky.social ! Fantastic chance for ECRs to showcase their work 🙂
#phagesky #phage #microsky
Come and join us for Viruses of Microbes UK 2026 at @northumbriauni.bsky.social ! Fantastic chance for ECRs to showcase their work 🙂
VOM-UK Conferences - NU-OMICS
Viruses of Microbes UK (VoM-UK) Conference The Virus of Microbes UK (VoM-UK) Conference is hosted by Microbiome Excellence Peak of Excellence at Northumbria University. This two-day conference takes place annually at the end of January/beginning of February and is a chance for researchers to gather and share their knowledge. The VoM-UK conference is designed to […]
hosting.northumbria.ac.uk
November 7, 2025 at 8:18 AM
🚨New preprint out!
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...
November 7, 2025 at 7:03 AM
🐝🦠 New paper: rdcu.be/eOf7A
Phages may drive microbial diversity, yet we often don’t even know how phages & bacteria correlate in nature. Our new study tackles this in the honeybee gut, thanks to the great work of PhD student @malickndiaye.bsky.social at @dmf-unil.bsky.social @fbm-unil.bsky.social
Phages may drive microbial diversity, yet we often don’t even know how phages & bacteria correlate in nature. Our new study tackles this in the honeybee gut, thanks to the great work of PhD student @malickndiaye.bsky.social at @dmf-unil.bsky.social @fbm-unil.bsky.social
Phage diversity mirrors bacterial strain diversity in the honey bee gut microbiota - Nature Communications
Authors analyse paired viral and bacterial shotgun metagenomics data from individual honeybee guts, revealing modular, nested phage–bacteria networks, with viral diversity mirroring bacterial strain c...
www.nature.com
November 4, 2025 at 8:39 PM
Hi everyone, a few years ago, we started a list of labs studying bacterial immunty for students, editors, conference organizers... (currently n=79).
Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky #Microsky
Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky #Microsky
Labs in bacterial immunity
docs.google.com
November 4, 2025 at 3:06 PM
Hi everyone, a few years ago, we started a list of labs studying bacterial immunty for students, editors, conference organizers... (currently n=79).
Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky #Microsky
Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky #Microsky
In a world where an ancient evil has been awaken. Tom Cruise in "Phage." Coming Summer 2026
Needed a laugh/joke today.
#phage #microsky #giantvirus #phagesky
Needed a laugh/joke today.
#phage #microsky #giantvirus #phagesky
November 3, 2025 at 9:57 PM
In a world where an ancient evil has been awaken. Tom Cruise in "Phage." Coming Summer 2026
Needed a laugh/joke today.
#phage #microsky #giantvirus #phagesky
Needed a laugh/joke today.
#phage #microsky #giantvirus #phagesky
#microsky #phagesky #phage defence
Novel bacterial ubiquitination-like pathway!
www.nature.com/articles/s41...
Novel bacterial ubiquitination-like pathway!
www.nature.com/articles/s41...
Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway - Nature Structural & Molecular Biology
Ye et al. define the structure and mechanisms of a bacterial pathway that performs ubiquitination-like protein conjugation, revealing new insights into the evolution and biological roles of ubiquitina...
www.nature.com
November 3, 2025 at 8:56 PM
#microsky #phagesky #phage defence
Novel bacterial ubiquitination-like pathway!
www.nature.com/articles/s41...
Novel bacterial ubiquitination-like pathway!
www.nature.com/articles/s41...
#microsky #phagesky #phage plasmids & other #MGE in the bee #microbiome
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Nested Connections: Local Phage and Broad Plasmid Sharing in the Honey Bee Mobilome
Honey bees rely on bacterial symbionts for their nutritional needs and for protection against invading pathogens. Genetic diversity among strains within the colony has the potential to impact symbiont...
www.biorxiv.org
November 2, 2025 at 6:52 AM
#microsky #phagesky #phage plasmids & other #MGE in the bee #microbiome
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
#microsky #phagesky
Mycobacterium #phage review by Graham Hatfull covering the state of the art
www.pnas.org/doi/10.1073/...
Mycobacterium #phage review by Graham Hatfull covering the state of the art
www.pnas.org/doi/10.1073/...
All the world’s a phage | PNAS
A renewed interest in bacteriophages has emerged from the explosive discovery of the
complex pan-immune bacterial defense system and a revival of t...
www.pnas.org
October 31, 2025 at 10:00 AM
#microsky #phagesky
Mycobacterium #phage review by Graham Hatfull covering the state of the art
www.pnas.org/doi/10.1073/...
Mycobacterium #phage review by Graham Hatfull covering the state of the art
www.pnas.org/doi/10.1073/...
#phagesky #microsky #phage defence #microbiome
CRISPR-cas activated by anoxia and regulated by Fnr in Citrobacter rodentium
www.nature.com/articles/s41...
CRISPR-cas activated by anoxia and regulated by Fnr in Citrobacter rodentium
www.nature.com/articles/s41...
Anoxia activates CRISPR–Cas immunity in the mouse intestine - Nature Microbiology
The Citrobacter rodentium CRISPR–Cas system is activated by the oxygen-responsive transcriptional regulator Fnr in the anoxic environment of the mouse gut.
www.nature.com
October 30, 2025 at 8:05 AM
#phagesky #microsky #phage defence #microbiome
CRISPR-cas activated by anoxia and regulated by Fnr in Citrobacter rodentium
www.nature.com/articles/s41...
CRISPR-cas activated by anoxia and regulated by Fnr in Citrobacter rodentium
www.nature.com/articles/s41...
New pre-print: Plasmid dependent phage effectively eliminate AMR bacteria and block plasmid transmission in the chicken gut microbiome
Fun collaboration with Tao He lab (JAAS) and @brockhurstlab.bsky.social lab (Manchester)
#phagesky#microsky
www.biorxiv.org/content/10.1...
Fun collaboration with Tao He lab (JAAS) and @brockhurstlab.bsky.social lab (Manchester)
#phagesky#microsky
www.biorxiv.org/content/10.1...
Plasmid dependent phage eliminate pathogenic bacteria and antibiotic resistance plasmids from the chicken gut microbiome
Conjugative plasmids are a key reservoir of antimicrobial resistance (AMR) in commensal and pathogenic bacteria within the gut microbiome. Plasmid-dependent phage (PDPs) are a promising therapeutic op...
www.biorxiv.org
October 27, 2025 at 8:19 AM
New pre-print: Plasmid dependent phage effectively eliminate AMR bacteria and block plasmid transmission in the chicken gut microbiome
Fun collaboration with Tao He lab (JAAS) and @brockhurstlab.bsky.social lab (Manchester)
#phagesky#microsky
www.biorxiv.org/content/10.1...
Fun collaboration with Tao He lab (JAAS) and @brockhurstlab.bsky.social lab (Manchester)
#phagesky#microsky
www.biorxiv.org/content/10.1...
This study has been really intriguing. What does this mean? There is no host specificity that we see in the lab? 😳
#phage #phagesky #microsky
#phage #phagesky #microsky
A nice study combining newly generated and existing #HiC data to explore virus-host interactions across ecosystems (although very small sample number) -
#Phages with a broad host range are common across ecosystems
www.nature.com/articles/s41...
#Phages with a broad host range are common across ecosystems
www.nature.com/articles/s41...
Phages with a broad host range are common across ecosystems - Nature Microbiology
Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.
www.nature.com
October 25, 2025 at 12:32 PM
Now published in PLOS Biology! We found new retron containing bacteria in the wild, figured out defense mechanisms, and turned them into genome editors. From a cupful of dirt to new parts for genome editing in one story! journals.plos.org/plosbiology/...
October 24, 2025 at 2:26 PM
Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1...
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
October 24, 2025 at 2:25 PM
who would have thought! phage N15 TelN telomerase has more than one job!
(and no, it's not 'moonlighting')
great work from the gruber lab 👏
#MicroSky + #PhageSky
(and no, it's not 'moonlighting')
great work from the gruber lab 👏
#MicroSky + #PhageSky
E. coli bacteriophage N15 suppresses Mre11-Rad50-mediated end degradation of its linear genome via a telomere-resolution-independent function of its telomere resolvase TelN
#RefereedPreprint c/o @reviewcommons.org by @gruberlab.bsky.social
www.embopress.org/doi/full/10....
#RefereedPreprint c/o @reviewcommons.org by @gruberlab.bsky.social
www.embopress.org/doi/full/10....
October 20, 2025 at 8:59 PM
Important paper #microsky
#phage #phagesky #microbiomesky
Bacteriophage Mu contamination impacts interbacterial competition | Infection and Immunity journals.asm.org/doi/10.1128/...
#phage #phagesky #microbiomesky
Bacteriophage Mu contamination impacts interbacterial competition | Infection and Immunity journals.asm.org/doi/10.1128/...
Bacteriophage Mu contamination impacts interbacterial competition | Infection and Immunity
The Cpx envelope stress response is a conserved two-component system comprised of
the sensor histidine kinase CpxA and response regulator CpxR which together monitor
and maintain the integrity of the ...
journals.asm.org
October 20, 2025 at 5:43 AM
Important paper #microsky
#phage #phagesky #microbiomesky
Bacteriophage Mu contamination impacts interbacterial competition | Infection and Immunity journals.asm.org/doi/10.1128/...
#phage #phagesky #microbiomesky
Bacteriophage Mu contamination impacts interbacterial competition | Infection and Immunity journals.asm.org/doi/10.1128/...
