**Abstract:** This research introduces a novel framework for predicting high-resolution calcium oscillation dynamics within neuronal networks, leveraging a multi-modal federated learning approach. Dysregulation of calcium signaling is implicated in a multitude of neurological disorders, but accurately predicting spatiotemporal calcium fluctuations remains a significant challenge. Our system combines optical microscopy data with multi-electrode array (MEA) recordings and computational models, distributed across multiple research institutions, to achieve a 10x improvement in predictive accuracy compared to existing single-modality approaches.

Abstract. Insomnia is a serious public health concern. As the widely prescribed hypnotics that positively modulate gamma-aminobutyric acid (GABA)A receptor

With novel insights in understanding and treating substance use disorder that have redirected neuropsychopharmacological dogma, Erin Calipari receives award from the American College of Neuropsycho…

✨ HBK-15 reverses memory deficits and restores hippocampal plasticity✨ Over the past few years, our team has been investigating whether and how HBK-15, a multimodal compound, could help restore prope...

Tropisetron is a potent, selective 5?HT? serotonin receptor antagonist (antiemetic) marketed for IV use. Each vial contains 5?mg of tropisetron hydrochloride (C??H??N?O?·HCl), provided in a 6?vial box by Harbin Sanlian Pharmaceutical (Approval No. H20050971; Code 86903662001692; Barcode 6941959000168). Strictly intended for laboratory research only—not for clinical, diagnostic, therapeutic, or veterinary use.?Please consult the staff for other purposes?

Covalent anchoring of tethered ligands to chemogenetic handles (CATCH) is a chemogenetic approach that enables sustained, localized, and pharmacologically specific receptor antagonism. Here, we present a protocol for designing and applying CATCH in mice. We describe how to integrate CATCH with ex vivo and in vivo electrophysiological recordings, as well as detail procedures for combining CATCH with behavioral assays. CATCH enables the specific control of neurotransmitter receptor function, offer...

Match each receptor type with its corresponding physiological function. Carefully drag the receptor name (e.g., Nn, Nm, M1, M2, M3, M4, M5) into the correct box describing its primary action. Focus on understanding which receptors are nicotinic (autonomic and neuromuscular) and which are muscarinic (parasympathetic targets). This exercise helps reinforce your knowledge of cholinergic receptor physiology — an essential topic for USMLE Step 1 and pharmacology exams.