International Journal of Neuropsychopharmacology
@ijnp.bsky.social
The official journal of
The International College of Neuropsychopharmacology (CINP)
https://linktr.ee/ijnp
The International College of Neuropsychopharmacology (CINP)
https://linktr.ee/ijnp
The Orexin System: Understanding the Modern Insomnia Treatment
By pharmacologically targeting dual orexin receptor antagonists (DORAs), this class of agents promotes sleep through a fundamentally different mechanism
DORAs ⬇️ the "wake drive" rather than inducing widespread neuronal inhibition
By pharmacologically targeting dual orexin receptor antagonists (DORAs), this class of agents promotes sleep through a fundamentally different mechanism
DORAs ⬇️ the "wake drive" rather than inducing widespread neuronal inhibition
Current and novel dual orexin receptor antagonists for the treatment of insomnia: the emergence of vornorexant
Abstract. Insomnia is a serious public health concern. As the widely prescribed hypnotics that positively modulate gamma-aminobutyric acid (GABA)A receptor
doi.org
January 10, 2026 at 3:38 PM
The Orexin System: Understanding the Modern Insomnia Treatment
By pharmacologically targeting dual orexin receptor antagonists (DORAs), this class of agents promotes sleep through a fundamentally different mechanism
DORAs ⬇️ the "wake drive" rather than inducing widespread neuronal inhibition
By pharmacologically targeting dual orexin receptor antagonists (DORAs), this class of agents promotes sleep through a fundamentally different mechanism
DORAs ⬇️ the "wake drive" rather than inducing widespread neuronal inhibition
As the year draws to a close, we wish you and your loved ones a very Happy Holiday season and a peaceful, healthy, and productive New Year.
We look forward to the continued collaboration of the IJNP community in 2026.
On behalf of the IJNP Editorial Management Group
We look forward to the continued collaboration of the IJNP community in 2026.
On behalf of the IJNP Editorial Management Group
December 22, 2025 at 1:32 PM
As the year draws to a close, we wish you and your loved ones a very Happy Holiday season and a peaceful, healthy, and productive New Year.
We look forward to the continued collaboration of the IJNP community in 2026.
On behalf of the IJNP Editorial Management Group
We look forward to the continued collaboration of the IJNP community in 2026.
On behalf of the IJNP Editorial Management Group
Dopamine's link to positive affect isn't linear—it could be U-shaped🧠
The recently published paper in IJNP shows that an individual's trait positive affectivity critically moderates how dopamine modulation influences state positive affect.
In a double-blind design:
The recently published paper in IJNP shows that an individual's trait positive affectivity critically moderates how dopamine modulation influences state positive affect.
In a double-blind design:
December 19, 2025 at 3:31 PM
Dopamine's link to positive affect isn't linear—it could be U-shaped🧠
The recently published paper in IJNP shows that an individual's trait positive affectivity critically moderates how dopamine modulation influences state positive affect.
In a double-blind design:
The recently published paper in IJNP shows that an individual's trait positive affectivity critically moderates how dopamine modulation influences state positive affect.
In a double-blind design:
Connect with the international community of neuropsychopharmacology!
Follow us across our Social Media Platforms.
linktr.ee/ijnp
Follow us across our Social Media Platforms.
linktr.ee/ijnp
November 27, 2025 at 10:48 PM
Connect with the international community of neuropsychopharmacology!
Follow us across our Social Media Platforms.
linktr.ee/ijnp
Follow us across our Social Media Platforms.
linktr.ee/ijnp
Editor’s Pick of the month!
This month’s featured paper delivers important insights for the large group of patients with major depressive disorder who achieve only limited improvement on standard antidepressants.
This month’s featured paper delivers important insights for the large group of patients with major depressive disorder who achieve only limited improvement on standard antidepressants.
November 21, 2025 at 12:26 PM
Editor’s Pick of the month!
This month’s featured paper delivers important insights for the large group of patients with major depressive disorder who achieve only limited improvement on standard antidepressants.
This month’s featured paper delivers important insights for the large group of patients with major depressive disorder who achieve only limited improvement on standard antidepressants.
Opioid and Ketamine in the clinic: key methodological considerations
The question of whether ketamine’s antidepressant effects are mediated by glutamatergic plasticity or opioid receptor signalling remains a subject of considerable debate.
The question of whether ketamine’s antidepressant effects are mediated by glutamatergic plasticity or opioid receptor signalling remains a subject of considerable debate.
November 14, 2025 at 7:45 PM
Opioid and Ketamine in the clinic: key methodological considerations
The question of whether ketamine’s antidepressant effects are mediated by glutamatergic plasticity or opioid receptor signalling remains a subject of considerable debate.
The question of whether ketamine’s antidepressant effects are mediated by glutamatergic plasticity or opioid receptor signalling remains a subject of considerable debate.
🧠 Do dopamine D₂ partial agonists all bind the same way? Maybe not.
New evidence challenges the idea that all “third-generation” antipsychotics share a single D₂ receptor binding mode.
#Neuropsychopharmacology #Antipsychotics #Dopamine
New evidence challenges the idea that all “third-generation” antipsychotics share a single D₂ receptor binding mode.
#Neuropsychopharmacology #Antipsychotics #Dopamine
November 7, 2025 at 12:57 PM
🧠 Do dopamine D₂ partial agonists all bind the same way? Maybe not.
New evidence challenges the idea that all “third-generation” antipsychotics share a single D₂ receptor binding mode.
#Neuropsychopharmacology #Antipsychotics #Dopamine
New evidence challenges the idea that all “third-generation” antipsychotics share a single D₂ receptor binding mode.
#Neuropsychopharmacology #Antipsychotics #Dopamine
🧠 Hyperprolactinemia is usually seen as a side effect of antipsychotics — but could it be part of schizophrenia itself?
In first-episode, non- to minimally treated patients, there was a clear sex-specific endocrine disturbance.
In first-episode, non- to minimally treated patients, there was a clear sex-specific endocrine disturbance.
October 27, 2025 at 1:16 PM
🧠 Hyperprolactinemia is usually seen as a side effect of antipsychotics — but could it be part of schizophrenia itself?
In first-episode, non- to minimally treated patients, there was a clear sex-specific endocrine disturbance.
In first-episode, non- to minimally treated patients, there was a clear sex-specific endocrine disturbance.
🧠 Brain–Body in Postoperative Cognitive Dysfunction (POCD)
POCD is a common issue in older adults after surgery, causing memory loss + slower thinking
But what if the gut has something to do with it? 🦠
IJNP paper highlights how the gut–brain axis shapes recovery after surgery.
#GutBrainAxis
POCD is a common issue in older adults after surgery, causing memory loss + slower thinking
But what if the gut has something to do with it? 🦠
IJNP paper highlights how the gut–brain axis shapes recovery after surgery.
#GutBrainAxis
October 24, 2025 at 1:58 PM
🧠 Brain–Body in Postoperative Cognitive Dysfunction (POCD)
POCD is a common issue in older adults after surgery, causing memory loss + slower thinking
But what if the gut has something to do with it? 🦠
IJNP paper highlights how the gut–brain axis shapes recovery after surgery.
#GutBrainAxis
POCD is a common issue in older adults after surgery, causing memory loss + slower thinking
But what if the gut has something to do with it? 🦠
IJNP paper highlights how the gut–brain axis shapes recovery after surgery.
#GutBrainAxis
Duloxetine for Depression, how it is effectively targeting NET?
This is the first study to use PET imaging to track long-term NET occupancy, providing evidence on the SNRI mechanism without the influence of other medications.
This is the first study to use PET imaging to track long-term NET occupancy, providing evidence on the SNRI mechanism without the influence of other medications.
October 17, 2025 at 12:02 PM
Duloxetine for Depression, how it is effectively targeting NET?
This is the first study to use PET imaging to track long-term NET occupancy, providing evidence on the SNRI mechanism without the influence of other medications.
This is the first study to use PET imaging to track long-term NET occupancy, providing evidence on the SNRI mechanism without the influence of other medications.
In this month’s Editor’s Pick, Hashimoto et al. deliver an insightful meta-analysis comparing personality profiles in schizophrenia & bipolar disorder.
October 10, 2025 at 11:40 AM
In this month’s Editor’s Pick, Hashimoto et al. deliver an insightful meta-analysis comparing personality profiles in schizophrenia & bipolar disorder.
💊Lithium vs. Other Mood Stabilizers: Distinct Metabolic Signatures in #Bipolar Disorder (BP)
BD is primarily treated with mood stabilizers (MS): lithium represents the gold standard.
Despite its high clinical efficacy, the molecular players in treatment response remain partly unclear👇
#MedEd
BD is primarily treated with mood stabilizers (MS): lithium represents the gold standard.
Despite its high clinical efficacy, the molecular players in treatment response remain partly unclear👇
#MedEd
October 3, 2025 at 11:31 AM
New Study Alert: Anhedonia in MDD - Clinical Correlates & Treatment Response🧠
🚨New research published in IJNP confirms anhedonia (MADRS item 8 – inability to feel) as a key marker for severe MDD course.
🚨New research published in IJNP confirms anhedonia (MADRS item 8 – inability to feel) as a key marker for severe MDD course.
September 26, 2025 at 1:50 PM
New Study Alert: Anhedonia in MDD - Clinical Correlates & Treatment Response🧠
🚨New research published in IJNP confirms anhedonia (MADRS item 8 – inability to feel) as a key marker for severe MDD course.
🚨New research published in IJNP confirms anhedonia (MADRS item 8 – inability to feel) as a key marker for severe MDD course.
🚨Call for Symposia – CINP 2026, Glasgow🚨
Be part of shaping the scientific programme at one of Europe’s most vibrant cities!🌍✨
📅Deadline: 7th October 2025
💡30 symposia slots available – don’t miss this chance!
cinp2026.org/submissions/...
#cinp #neuropsychopharmacology
Be part of shaping the scientific programme at one of Europe’s most vibrant cities!🌍✨
📅Deadline: 7th October 2025
💡30 symposia slots available – don’t miss this chance!
cinp2026.org/submissions/...
#cinp #neuropsychopharmacology
Symposium Submission - Glasgow CINP2026
Symposia shall be of 75 minutes duration, and shall include three speakers, one of whom can, if desired, be the chairperson of the session.
cinp2026.org
September 23, 2025 at 9:49 AM
🚨Call for Symposia – CINP 2026, Glasgow🚨
Be part of shaping the scientific programme at one of Europe’s most vibrant cities!🌍✨
📅Deadline: 7th October 2025
💡30 symposia slots available – don’t miss this chance!
cinp2026.org/submissions/...
#cinp #neuropsychopharmacology
Be part of shaping the scientific programme at one of Europe’s most vibrant cities!🌍✨
📅Deadline: 7th October 2025
💡30 symposia slots available – don’t miss this chance!
cinp2026.org/submissions/...
#cinp #neuropsychopharmacology
📣Join CINP + BJPsych joint journal club to discuss the future of academic psychiatry with Prof Allan Young and experts!
September 19, 2025 at 7:02 PM
📣Join CINP + BJPsych joint journal club to discuss the future of academic psychiatry with Prof Allan Young and experts!
🧠🤖Affective states as clinical signals: AI models for decision-making and symptoms
This month’s Editor’s Pick examines the role of affective states in computational psychiatry—a field that uses mathematical and AI-based models to link behavior, brain function, and mental health.
This month’s Editor’s Pick examines the role of affective states in computational psychiatry—a field that uses mathematical and AI-based models to link behavior, brain function, and mental health.
September 19, 2025 at 6:32 PM
🧠🤖Affective states as clinical signals: AI models for decision-making and symptoms
This month’s Editor’s Pick examines the role of affective states in computational psychiatry—a field that uses mathematical and AI-based models to link behavior, brain function, and mental health.
This month’s Editor’s Pick examines the role of affective states in computational psychiatry—a field that uses mathematical and AI-based models to link behavior, brain function, and mental health.
📢Exciting news #CINP2026 in Glasgow will be a Joint Meeting of the Scandinavian College of Neuropsychopharmacology +the International College of Neuropsychopharmacology!
Join us for this unique event which promises to be an outstanding meeting of science &collaboration
@actaneuropsych.bsky.social
Join us for this unique event which promises to be an outstanding meeting of science &collaboration
@actaneuropsych.bsky.social
September 10, 2025 at 4:40 PM
📢Exciting news #CINP2026 in Glasgow will be a Joint Meeting of the Scandinavian College of Neuropsychopharmacology +the International College of Neuropsychopharmacology!
Join us for this unique event which promises to be an outstanding meeting of science &collaboration
@actaneuropsych.bsky.social
Join us for this unique event which promises to be an outstanding meeting of science &collaboration
@actaneuropsych.bsky.social
🧠🍷Neurogenesis, Ethanol & biomarker
It is known that excessive ethanol disrupts hippocampal structure/function, especially with adolescent onset. But how does neurogenesis plays out in this context?
It is known that excessive ethanol disrupts hippocampal structure/function, especially with adolescent onset. But how does neurogenesis plays out in this context?
September 5, 2025 at 1:09 PM
🧠🍷Neurogenesis, Ethanol & biomarker
It is known that excessive ethanol disrupts hippocampal structure/function, especially with adolescent onset. But how does neurogenesis plays out in this context?
It is known that excessive ethanol disrupts hippocampal structure/function, especially with adolescent onset. But how does neurogenesis plays out in this context?
⚡Beyond the Powerhouse: Mitochondria, Genes, and Depression in a Cross-Species Study
🧠🔋When mitochondrial function falters, the brain struggles to meet energy demands, contributing to the impaired plasticity observed in MDD.
#Mitochondria #Depression
🧠🔋When mitochondrial function falters, the brain struggles to meet energy demands, contributing to the impaired plasticity observed in MDD.
#Mitochondria #Depression
August 29, 2025 at 10:53 AM
⚡Beyond the Powerhouse: Mitochondria, Genes, and Depression in a Cross-Species Study
🧠🔋When mitochondrial function falters, the brain struggles to meet energy demands, contributing to the impaired plasticity observed in MDD.
#Mitochondria #Depression
🧠🔋When mitochondrial function falters, the brain struggles to meet energy demands, contributing to the impaired plasticity observed in MDD.
#Mitochondria #Depression
We are delighted to announce that the abstracts from CINP-AsCNP 2025 Joint Congress in Melbourne have been published as a Supplement to the International Journal of Neuropsychopharmacology
Read the abstracts here:
academic.oup.com/ijnp/issue/2...
Read the abstracts here:
academic.oup.com/ijnp/issue/2...
Volume 28 Issue Supplement_2 | International Journal of Neuropsychopharmacology | Oxford Academic
The official journal of Collegium Internationale Neuro-Psychopharmacologicum. Publishes papers that advance understanding of existing and new neuropsychopharmacological agents or provide insights into...
academic.oup.com
August 29, 2025 at 10:06 AM
We are delighted to announce that the abstracts from CINP-AsCNP 2025 Joint Congress in Melbourne have been published as a Supplement to the International Journal of Neuropsychopharmacology
Read the abstracts here:
academic.oup.com/ijnp/issue/2...
Read the abstracts here:
academic.oup.com/ijnp/issue/2...
Is it possible to predict antidepressant response?
📌 Check the Editor’s July Pick in #IJNP
This recent study investigated whether brain activity patterns (EEG) could help predict which patients with depression may respond to antidepressants (#vortioxetine or #escitalopram).
📌 Check the Editor’s July Pick in #IJNP
This recent study investigated whether brain activity patterns (EEG) could help predict which patients with depression may respond to antidepressants (#vortioxetine or #escitalopram).
August 26, 2025 at 8:20 PM
Is it possible to predict antidepressant response?
📌 Check the Editor’s July Pick in #IJNP
This recent study investigated whether brain activity patterns (EEG) could help predict which patients with depression may respond to antidepressants (#vortioxetine or #escitalopram).
📌 Check the Editor’s July Pick in #IJNP
This recent study investigated whether brain activity patterns (EEG) could help predict which patients with depression may respond to antidepressants (#vortioxetine or #escitalopram).
🔬 Personality Traits in Schizophrenia vs. Bipolar Disorder
Personality traits play pivotal roles in the onset, manifestation, and progression of schizophrenia (SCZ) and bipolar disorder (BD).
Personality traits play pivotal roles in the onset, manifestation, and progression of schizophrenia (SCZ) and bipolar disorder (BD).
August 15, 2025 at 7:58 PM
🔬 Personality Traits in Schizophrenia vs. Bipolar Disorder
Personality traits play pivotal roles in the onset, manifestation, and progression of schizophrenia (SCZ) and bipolar disorder (BD).
Personality traits play pivotal roles in the onset, manifestation, and progression of schizophrenia (SCZ) and bipolar disorder (BD).
🧠 More Than Mood: Anhedonia as a Public Health & Economic Issue
How one symptom can ripple through mental health, productivity, and the healthcare system.
In a large US study of ~75,000 adults (≥18 years) with depression, higher anhedonia was tied to:
How one symptom can ripple through mental health, productivity, and the healthcare system.
In a large US study of ~75,000 adults (≥18 years) with depression, higher anhedonia was tied to:
August 8, 2025 at 7:19 PM
🧠 More Than Mood: Anhedonia as a Public Health & Economic Issue
How one symptom can ripple through mental health, productivity, and the healthcare system.
In a large US study of ~75,000 adults (≥18 years) with depression, higher anhedonia was tied to:
How one symptom can ripple through mental health, productivity, and the healthcare system.
In a large US study of ~75,000 adults (≥18 years) with depression, higher anhedonia was tied to:
🧠 Over 100 types of RNA modifications exist, but N6-methyladenosine (m6A) is the most prevalent.
How are the modifications on neurotransmitters, plasticity and other mechanisms related to #Depression #Autism #Schizophrenia?
How are the modifications on neurotransmitters, plasticity and other mechanisms related to #Depression #Autism #Schizophrenia?
August 1, 2025 at 4:56 PM
🧠 Over 100 types of RNA modifications exist, but N6-methyladenosine (m6A) is the most prevalent.
How are the modifications on neurotransmitters, plasticity and other mechanisms related to #Depression #Autism #Schizophrenia?
How are the modifications on neurotransmitters, plasticity and other mechanisms related to #Depression #Autism #Schizophrenia?
🌍World Brain Day | 22 July - Brain Health for All Ages 🧠
As a journal dedicated to advancing neuropsychopharmacology, we join the global neuroscience community in recognizing World Brain Day
Understanding brain function in both health and disease is central to improving lives
As a journal dedicated to advancing neuropsychopharmacology, we join the global neuroscience community in recognizing World Brain Day
Understanding brain function in both health and disease is central to improving lives
July 22, 2025 at 10:00 PM
🌍World Brain Day | 22 July - Brain Health for All Ages 🧠
As a journal dedicated to advancing neuropsychopharmacology, we join the global neuroscience community in recognizing World Brain Day
Understanding brain function in both health and disease is central to improving lives
As a journal dedicated to advancing neuropsychopharmacology, we join the global neuroscience community in recognizing World Brain Day
Understanding brain function in both health and disease is central to improving lives