#Leucovorin
leucovorin even though it gained approval to treat #autism it is a medicine i won't take. I looked into it, its original purpose it was developed is related to folate deficiency and conditions associated with it. Autism was brute force in by our current administration. I don't trust that. 👎
February 18, 2026 at 10:35 PM
"A clinical trial that supported the use of leucovorin (Wellcovorin) for the treatment of autism spectrum disorder was retracted by the publisher. The US FDA touted leucovorin to treat autism, despite the lack of strong clinical evidence that it was safe and effective for this use."
Clinical trial supporting leucovorin for treating autism is retracted
A clinical trial supporting leucovorin for autism treatment was retracted due to data errors and statistical concerns.
www.skepticalraptor.com
February 18, 2026 at 6:38 PM
Of course they did this. He also stacked the IACC with leucovorin peddlers and “hyperbaric oxygen therapy” truthers. Not only is this about ableism against autistic people, it’s also about allowing a certain crowd of people to make thousands off of unevidenced “treatments” that insurance won’t cover
February 18, 2026 at 6:00 PM
A clinical trial supporting #leucovorin for #autism treatment was retracted due to data errors and statistical concerns, raising doubts about its efficacy. Evidence for leucovorin's effectiveness in autism is limited.
Clinical trial supporting leucovorin for treating autism is retracted
A clinical trial supporting leucovorin for autism treatment was retracted due to data errors and statistical concerns.
buff.ly
February 17, 2026 at 8:01 PM
Clinical trial supporting leucovorin for treating autism is retracted
Clinical trial supporting leucovorin for treating autism is retracted
A clinical trial supporting leucovorin for autism treatment was retracted due to data errors and statistical concerns.
buff.ly
February 17, 2026 at 1:54 AM
A clinical trial supporting #leucovorin for #autism treatment was retracted due to data errors and statistical concerns, raising doubts about its efficacy. Evidence for leucovorin's effectiveness in autism is limited. www.skepticalraptor.com/skepticalrap...
Clinical trial supporting leucovorin for treating autism is retracted
A clinical trial supporting leucovorin for autism treatment was retracted due to data errors and statistical concerns.
www.skepticalraptor.com
February 16, 2026 at 9:04 PM
Clinical trial supporting leucovorin for treating autism is retracted

A clinical trial supporting leucovorin for autism treatment was retracted due to data errors and statistical concerns, raising doubts about its efficacy. Despite FDA approval for a rare condition, evidence for leucovorin's…
Clinical trial supporting leucovorin for treating autism is retracted
A clinical trial supporting leucovorin for autism treatment was retracted due to data errors and statistical concerns, raising doubts about its efficacy. Despite FDA approval for a rare condition, evidence for leucovorin's effectiveness in autism is limited. Expert voices recommend against its use, emphasizing the absence of a simple autism cure.
www.skepticalraptor.com
February 16, 2026 at 9:02 PM
Trump-RFK Jr.’s FDA in science freefall: The leucovorin autism “cure” fiasco is one of many geneticliteracyproject.org/2026/02/16/t...
Trump-RFK Jr.’s FDA in science freefall: The leucovorin autism “cure” fiasco is one of many
he Food and Drug Administration is looking less and less like a regulator than a circus, with fresh, disconcerting episodes erupting week after week. Last
geneticliteracyproject.org
February 16, 2026 at 3:40 PM
Forbes gets the picture…we are casting suspicion on proven medicines, adjuvants, and a Nobel winning technology so we can study horse dewormer for cancer. And the big leucovorin paper was just retracted, that gets 0 mentions.

www.forbes.com/sites/joshua...
HHS Casts Doubts On mRNA Products, But Funds Studies On Debunked Ideas
It's conspicuous that HHS refuses to review Moderna's application for regulatory approval of an mRNA-based flu vaccine while it prioritizes research on debunked theories.
www.forbes.com
February 13, 2026 at 3:35 PM
Attendee at private investor meeting with FDA: Why did the FDA approve leucovorin calcium to treat a condition associated with autism? The largest study to date has been retracted by the journal after several of the authors admitted errors. Makary: The Dow is over $50,000!!! #medsky
February 12, 2026 at 1:38 AM
Remember back in the fall when RFKjr was looking for an autism cause and he came up with folate deficiency based on one study, and THEN the FDA then reissued a drug approval for leucovorin despite the fact there was no market for it?

About that Indian study...

link.springer.com/article/10.1...
February 11, 2026 at 8:57 PM
The FDA, Autism, Leucovorin and Cerebral Folate Deficiency: www.worstpills.org/newsletters/... (subscription required)
The FDA, Autism, Leucovorin and Cerebral Folate Deficiency
The “From the Editor” column discusses the FDA’s highly unusual action in September 2025 to initiate the approval of leucovorin calcium tablets (previously marketed as WELLCOVORIN and generics) for pa...
www.worstpills.org
February 11, 2026 at 5:59 PM
Leucovorin??? Leucovorin?
February 11, 2026 at 3:45 PM
Marty Makary: A 40,700-person study of mRNA vaccine isn't good enough!

Also Marty Makary: We're approving leucovorin for cerebral folate deficiency/autism based on the flimsiest of evidence! "gold standard science and common sense"! www.fda.gov/news-events/...
February 11, 2026 at 3:12 PM
Last Sept, RFK Jr. announced the govt had linked autism to taking Tylenol during pregnancy, to much derision. But he also stated the govt would approve an old drug, leucovorin, for autism.

For my latest feature, I took a deep dive into why leucovorin's probably a dud.

gizmodo.com/what-rfk-jr-...
What RFK Jr.’s Unproven Autism Treatment Could Mean for Autistic Patients and Their Families
RFK Jr. has stated leucovorin will help
gizmodo.com
February 11, 2026 at 2:57 PM
Well, well, well. This study finding at leucovorin (folinic acid) works as a treatment for autism was recently retracted for statistical errors and concerns over methods.

We are shocked❗️that yet another of RFKJ’s snake oil cures doesn’t stand up to scrutiny.

www.medpagetoday.com/neurology/au...
February 11, 2026 at 2:30 PM
By now, the decisions made by the FDA have nothing to do with science. The same goes for the decision on the use of Leucovorin for children with autism.
February 11, 2026 at 12:49 PM
Mentre dopo aver approvato il Leucovorin con grandi annunci della FDA per dei benefici sui bambini autistici (per aumentare la disponibilità di folati), il più grande studio clinico sul Leucovorin è stato ritirato. Ora in letteratura non c'è niente che indichi che il Leucovorin sia efficace. 2/2
February 11, 2026 at 8:10 AM
They didn't have the same juice for leucovorin when they were touting it as a cure for autism.
February 11, 2026 at 4:51 AM
The same problem for schizophrenia or bipolar disorder or any disease that HHS Secretary Kennedy believes can be treated or cured by a keto diet or "Real Food" or whatever he says. What was FDA's basis for approving leucovorin for autism? #medsky ⬇️
This is troubling for multiple reasons, but one big one is companies won’t want to invest in R&D and clinical trials if they don’t think they can get a fair regulatory review—which is at the end of a long and extremely expensive process.

www.nytimes.com/2026/02/10/h...
F.D.A. Refuses to Review Moderna Flu Vaccine
www.nytimes.com
February 11, 2026 at 1:06 AM
#PedSky #MedSky #EpiSky #policysky #polisky #neuroskyence #neurosci 🧪🛟 💊

In September 25 FDA approved leucovorin suggesting it can treat autism. Now, the biggest clinical trial cited in that decision was retracted.
Retraction Note: Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial - European Journal of Pediatrics
European Journal of Pediatrics -
link.springer.com
February 11, 2026 at 12:51 AM
I suspect that the same Marty Makary who insisted we need to "restore trust in public health" by demonizing doctors and scientists won't be sharing this news that leucovorin doesn't actually treat autism. Whoops. www.thetransmitter.org/spectrum/lar...
Largest leucovorin-autism trial retracted
A reanalysis of the data revealed errors and failed to replicate the results.
www.thetransmitter.org
February 10, 2026 at 10:08 PM
One of the largest autism trials of leucovorin (Wellcovorin), a drug used to treat cerebral folate deficiency, was retracted on Jan. 29 by the European Journal of Pediatrics, a Springer Nature journal.
https://www.medpagetoday.com/neurology/autism/119787
February 10, 2026 at 1:00 AM
Leucovorin, the methotrexate “antidote?” ⚠️
February 9, 2026 at 7:38 AM
"While leucovorin is generally well-tolerated when used for chemotherapy, it isn’t risk-free either. […] it can cause vomiting, diarrhea, and alopecia. And there’s at least the possibility that it could have more serious complications when used long-term for autism."

gizmodo.com/what-rfk-jr-...
What RFK Jr.’s Unproven Autism Treatment Could Mean for Autistic Patients and Their Families
RFK Jr. has stated leucovorin will help
gizmodo.com
February 8, 2026 at 8:56 PM