Glucocorticoid injections for knee osteoarthritis:
Intra-articular glucocorticoid injections can be considered for short-term (2- to 6-week) management of pain in patients with knee osteoarthritis.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250719
Intra-articular glucocorticoid injections can be considered for short-term (2- to 6-week) management of pain in patients with knee osteoarthritis.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250719
Intra-articular glucocorticoid injections for knee osteoarthritis
These injections provide modest relief (on average, an absolute reduction in pain of 3 points on a 0 to 10 scale[3][1]), with a peak response at 1 to 2 weeks[2][2] and an expected response in 44% of p...
www.cmaj.ca
January 26, 2026 at 9:13 PM
Glucocorticoid injections for knee osteoarthritis:
Intra-articular glucocorticoid injections can be considered for short-term (2- to 6-week) management of pain in patients with knee osteoarthritis.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250719
Intra-articular glucocorticoid injections can be considered for short-term (2- to 6-week) management of pain in patients with knee osteoarthritis.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250719
Glucocorticoid injections for knee osteoarthritis: what are the indications and risks?
CMAJ Volume 198, Issue 3, features new articles on glucocorticoid injections for knee osteoarthritis; stillbirth definition; planetary heath diet and chronic kidney disease, and more.
➡️ www.cmaj.ca/content/198/3
CMAJ Volume 198, Issue 3, features new articles on glucocorticoid injections for knee osteoarthritis; stillbirth definition; planetary heath diet and chronic kidney disease, and more.
➡️ www.cmaj.ca/content/198/3
January 26, 2026 at 9:10 PM
Glucocorticoid injections for knee osteoarthritis: what are the indications and risks?
CMAJ Volume 198, Issue 3, features new articles on glucocorticoid injections for knee osteoarthritis; stillbirth definition; planetary heath diet and chronic kidney disease, and more.
➡️ www.cmaj.ca/content/198/3
CMAJ Volume 198, Issue 3, features new articles on glucocorticoid injections for knee osteoarthritis; stillbirth definition; planetary heath diet and chronic kidney disease, and more.
➡️ www.cmaj.ca/content/198/3
Impacts of reproductive state and social environment on glucocorticoid concentrations in female Rwenzori Angolan colobus monkeys (Colobus angolensis ruwenzorii) Phys&Beh
Impacts of reproductive state and social environment on glucocorticoid concentrations in female Rwenzori Angolan colobus monkeys (Colobus angolensis ruwenzorii)
Publication date: Available online 23 January 2026
Source: Physiology & Behavior
Author(s): Samantha M. Stead, Phoebe Edwards, Rudy Boonstra, Rupert Palme, Edward Mujjuzi, Julie A. Teichroeb
dlvr.it
January 25, 2026 at 1:35 AM
Impacts of reproductive state and social environment on glucocorticoid concentrations in female Rwenzori Angolan colobus monkeys (Colobus angolensis ruwenzorii) Phys&Beh
Fragility #fractures remain a common & serious
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#osteoporosis
#EndoSky
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#osteoporosis
#EndoSky
January 24, 2026 at 3:30 PM
Fragility #fractures remain a common & serious
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#osteoporosis
#EndoSky
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#osteoporosis
#EndoSky
All patients with #Addison’s disease should be given a steroid emergency card and provided with and trained to use a glucocorticoid injection kit www.thelancet.com/journals/lan...
#adrenal insufficiency
#adrenal crisis
#adrenal insufficiency
#adrenal crisis
January 24, 2026 at 9:19 AM
All patients with #Addison’s disease should be given a steroid emergency card and provided with and trained to use a glucocorticoid injection kit www.thelancet.com/journals/lan...
#adrenal insufficiency
#adrenal crisis
#adrenal insufficiency
#adrenal crisis
Addison's disease is the manifestation of adrenal glucocorticoid and mineralocorticoid deficiency from T-cell mediated destruction of the adrenal cortex, and is the commonest cause of primary adrenal insufficiency in adults www.thelancet.com/journals/lan...
#adrenal insufficiency
#MedSky #EndoSky
#adrenal insufficiency
#MedSky #EndoSky
January 23, 2026 at 11:35 PM
Addison's disease is the manifestation of adrenal glucocorticoid and mineralocorticoid deficiency from T-cell mediated destruction of the adrenal cortex, and is the commonest cause of primary adrenal insufficiency in adults www.thelancet.com/journals/lan...
#adrenal insufficiency
#MedSky #EndoSky
#adrenal insufficiency
#MedSky #EndoSky
Obvious to my mind is the immune system and inflammation, including mast cell activation and (iirc) prostaglandin inhibition (which all links to glucocorticoid action)
January 23, 2026 at 8:27 PM
Obvious to my mind is the immune system and inflammation, including mast cell activation and (iirc) prostaglandin inhibition (which all links to glucocorticoid action)
What I was less pleased to see is the lack of discussion of *other* possible mechanisms, with the only mention I could find being this:
"but it is possible dexamethasone may be having a pharmacological effect independent of endogenous glucocorticoid action"
"but it is possible dexamethasone may be having a pharmacological effect independent of endogenous glucocorticoid action"
January 23, 2026 at 8:27 PM
What I was less pleased to see is the lack of discussion of *other* possible mechanisms, with the only mention I could find being this:
"but it is possible dexamethasone may be having a pharmacological effect independent of endogenous glucocorticoid action"
"but it is possible dexamethasone may be having a pharmacological effect independent of endogenous glucocorticoid action"
The mechanism proposed is one I'd never heard of: Local endometrial glucocorticoid deficiency
As such, the study aimed to replace that deficiency with dexamethasone. I was pleased to see in the discussion consideration for local (rather than oral/systemic) administration
As such, the study aimed to replace that deficiency with dexamethasone. I was pleased to see in the discussion consideration for local (rather than oral/systemic) administration
January 23, 2026 at 8:27 PM
The mechanism proposed is one I'd never heard of: Local endometrial glucocorticoid deficiency
As such, the study aimed to replace that deficiency with dexamethasone. I was pleased to see in the discussion consideration for local (rather than oral/systemic) administration
As such, the study aimed to replace that deficiency with dexamethasone. I was pleased to see in the discussion consideration for local (rather than oral/systemic) administration
Anti-inflammatory therapies keep the Glucocorticoid Agonist Market essential. www.marketresearchfuture.com/reports/gluc... #Pharma
Glucocorticoid Agonist Market Size, Share, Trends, 2035
Glucocorticoid Agonist Market share is projected to reach USD 29.93 Billion By 2035, at a 4.48 % CAGR by driving industry size, top company analysis, segments research, trends and forecast report 2025...
www.marketresearchfuture.com
January 23, 2026 at 1:01 PM
Anti-inflammatory therapies keep the Glucocorticoid Agonist Market essential. www.marketresearchfuture.com/reports/gluc... #Pharma
JMIR Res Protocols: Correction: #Smartphone #mHealth #App–Based Eating Behavior Monitoring and Feedback Intervention for Glucocorticoid-Induced Appetite Increase in Patients With Systemic Lupus Erythematosus: #Protocol for a Pilot #RCT #ClinicalTrial
Correction: Smartphone App–Based Eating Behavior Monitoring and Feedback Intervention for Glucocorticoid-Induced Appetite Increase in Patients With Systemic Lupus Erythematosus: Protocol for a Pilot Randomized Controlled Trial
dlvr.it
January 21, 2026 at 8:46 PM
JMIR Res Protocols: Correction: #Smartphone #mHealth #App–Based Eating Behavior Monitoring and Feedback Intervention for Glucocorticoid-Induced Appetite Increase in Patients With Systemic Lupus Erythematosus: #Protocol for a Pilot #RCT #ClinicalTrial
Glucocorticoids activate glucocorticoid receptors but also mineralcorticoid receptors. Recently vamorolone was approved as an alternative steroid for Duchenne. Vamorolone binds less to the glucocorticoid receptor and thus does not translocate to the cell nucleus.
January 20, 2026 at 8:11 AM
Glucocorticoids activate glucocorticoid receptors but also mineralcorticoid receptors. Recently vamorolone was approved as an alternative steroid for Duchenne. Vamorolone binds less to the glucocorticoid receptor and thus does not translocate to the cell nucleus.
"A significant risk associated with long-term [ #Glucocorticoid ] therapy is suppression of the #HPAaxis, which wld cause life-threatening #AdrenalInsufficiency on #withdrawal .. #ClinicalTrials [reveal] a significant unreported prevalence of [that].": buff.ly/StB5JAI
via @cureusmedical.bsky.social
via @cureusmedical.bsky.social
Adverse Effects and Withdrawal Symptoms of Prolonged Glucocorticoid Therapy in Chronic Rheumatoid Arthritis and Systemic Lupus Erythematosus: A Systematic Review
The objective of this systematic review was to assess adverse effects and long-term withdrawal symptoms of prolonged glucocorticoid (GC) therapy in patients with rheumatic diseases, e.g., rheumatoid…
buff.ly
January 19, 2026 at 6:30 PM
"A significant risk associated with long-term [ #Glucocorticoid ] therapy is suppression of the #HPAaxis, which wld cause life-threatening #AdrenalInsufficiency on #withdrawal .. #ClinicalTrials [reveal] a significant unreported prevalence of [that].": buff.ly/StB5JAI
via @cureusmedical.bsky.social
via @cureusmedical.bsky.social
Tourism impacts on fecal glucocorticoid metabolites of free-ranging mountain gorillas in Bwindi Impenetrable National Park, Uganda https://www.biorxiv.org/content/10.64898/2026.01.15.699166v1
January 16, 2026 at 11:31 PM
Tourism impacts on fecal glucocorticoid metabolites of free-ranging mountain gorillas in Bwindi Impenetrable National Park, Uganda https://www.biorxiv.org/content/10.64898/2026.01.15.699166v1
Tourism impacts on fecal glucocorticoid metabolites of free-ranging mountain gorillas in Bwindi Impenetrable National Park, Uganda https://www.biorxiv.org/content/10.64898/2026.01.15.699166v1
January 16, 2026 at 11:31 PM
Tourism impacts on fecal glucocorticoid metabolites of free-ranging mountain gorillas in Bwindi Impenetrable National Park, Uganda https://www.biorxiv.org/content/10.64898/2026.01.15.699166v1
Glucocorticoid injection shows little benefit for knee osteoarthritis, clinical trial finds medicalxpress.com/news/2026-01...
So much of what is done for knees totally useless (and exploitive).
So much of what is done for knees totally useless (and exploitive).
Glucocorticoid injection shows little benefit for knee osteoarthritis, clinical trial finds
Researchers in China have found no statistically significant advantage for infrapatellar fat pad glucocorticoid injection over saline for 12-week knee pain change or effusion synovitis volume change i...
medicalxpress.com
January 16, 2026 at 9:34 PM
Glucocorticoid injection shows little benefit for knee osteoarthritis, clinical trial finds medicalxpress.com/news/2026-01...
So much of what is done for knees totally useless (and exploitive).
So much of what is done for knees totally useless (and exploitive).
A rare case study published in #JCEMCR details the first known instance of a decades-dormant hormonal disorder, Cyclic #Cushing Syndrome, relapsing after a patient contracted #COVID19 and received standard glucocorticoid treatment. #EndoSky
endocrinenews.endocrine.org/covid-19-inf...
endocrinenews.endocrine.org/covid-19-inf...
COVID-19 Infection Linked to Relapse of Rare Endocrine Disorder After 19 Years - Endocrine News
A rare case study published in JCEM Case Reports details the first known instance of a decades-dormant hormonal disorder, Cyclic Cushing Syndrome (CS), relapsing after a patient contracted COVID-19 an...
endocrinenews.endocrine.org
January 15, 2026 at 11:01 PM
A rare case study published in #JCEMCR details the first known instance of a decades-dormant hormonal disorder, Cyclic #Cushing Syndrome, relapsing after a patient contracted #COVID19 and received standard glucocorticoid treatment. #EndoSky
endocrinenews.endocrine.org/covid-19-inf...
endocrinenews.endocrine.org/covid-19-inf...
New research from Society for Endocrinology member, Rajeev Mehta et al. shows that symptom-led tapering of physiological glucocorticoid doses promotes safe adrenal recovery, challenging current guidelines.
Read the full article here: doi.org/10.1530/EC-2...
Read the full article here: doi.org/10.1530/EC-2...
January 15, 2026 at 4:01 PM
New research from Society for Endocrinology member, Rajeev Mehta et al. shows that symptom-led tapering of physiological glucocorticoid doses promotes safe adrenal recovery, challenging current guidelines.
Read the full article here: doi.org/10.1530/EC-2...
Read the full article here: doi.org/10.1530/EC-2...
I contracted COVID-19 in 2021. In 2022, I was diagnosed with APS and lupus, in addition to pre-existing VWF type 2 and type 5 abnormalities and a 40-year history of adrenal insufficiency.
I suspect chronic inflammation related to glucocorticoid dysfunction contributes to vascular damage.
I suspect chronic inflammation related to glucocorticoid dysfunction contributes to vascular damage.
January 15, 2026 at 1:36 PM
I contracted COVID-19 in 2021. In 2022, I was diagnosed with APS and lupus, in addition to pre-existing VWF type 2 and type 5 abnormalities and a 40-year history of adrenal insufficiency.
I suspect chronic inflammation related to glucocorticoid dysfunction contributes to vascular damage.
I suspect chronic inflammation related to glucocorticoid dysfunction contributes to vascular damage.
A glucocorticoid-responsive polygenic signature in the anterior cingulate cortex moderates the association of early-life adversity and vulnerability for depression https://www.biorxiv.org/content/10.64898/2026.01.14.699350v1
January 15, 2026 at 6:15 AM
A glucocorticoid-responsive polygenic signature in the anterior cingulate cortex moderates the association of early-life adversity and vulnerability for depression https://www.biorxiv.org/content/10.64898/2026.01.14.699350v1
A glucocorticoid-responsive polygenic signature in the anterior cingulate cortex moderates the association of early-life adversity and vulnerability for depression https://www.biorxiv.org/content/10.64898/2026.01.14.699350v1
January 15, 2026 at 6:15 AM
A glucocorticoid-responsive polygenic signature in the anterior cingulate cortex moderates the association of early-life adversity and vulnerability for depression https://www.biorxiv.org/content/10.64898/2026.01.14.699350v1
As a patient with APS/lupus, VWF2 and 5 abnormalities, and 40 years of confirmed adrenal insufficiency, I suspect that not only viral but also bacterial inflammation, along with glucocorticoid dysfunction, contribute to blood vessel damage.
January 15, 2026 at 5:41 AM
As a patient with APS/lupus, VWF2 and 5 abnormalities, and 40 years of confirmed adrenal insufficiency, I suspect that not only viral but also bacterial inflammation, along with glucocorticoid dysfunction, contribute to blood vessel damage.
@biorxivpreprint.bsky.social Reducing Glucocorticoid Burden in Lupus with Omega-3 Fatty Acids: Docosahexaenoic Acid Augments Prednisone Efficacy in Maintaining Cyclophosphamide-Induced Remission of Preclinical Lupus Nephritis @michiganstateu.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 15, 2026 at 3:20 AM
@biorxivpreprint.bsky.social Reducing Glucocorticoid Burden in Lupus with Omega-3 Fatty Acids: Docosahexaenoic Acid Augments Prednisone Efficacy in Maintaining Cyclophosphamide-Induced Remission of Preclinical Lupus Nephritis @michiganstateu.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Glucocorticoid injection into the infrapatellar fat pad did not significantly reduce knee pain or effusion synovitis volume over 12 weeks in individuals with inflammatory knee osteoarthritis. doi.org/hbj2b7
Glucocorticoid injection shows little benefit for knee osteoarthritis, clinical trial finds
Researchers in China have found no statistically significant advantage for infrapatellar fat pad glucocorticoid injection over saline for 12-week knee pain change or effusion synovitis volume change in inflammatory knee osteoarthritis.
medicalxpress.com
January 14, 2026 at 5:50 PM
Glucocorticoid injection into the infrapatellar fat pad did not significantly reduce knee pain or effusion synovitis volume over 12 weeks in individuals with inflammatory knee osteoarthritis. doi.org/hbj2b7
Romosozumab Enhances Implant Stability in Glucocorticoid-Induced Osteoporotic Bone: A Rabbit Model Study. Ji-Won Kwon et al. Neurospine 2025 Dec 31 shorturl.at/LL9Zy
January 14, 2026 at 9:07 AM
Romosozumab Enhances Implant Stability in Glucocorticoid-Induced Osteoporotic Bone: A Rabbit Model Study. Ji-Won Kwon et al. Neurospine 2025 Dec 31 shorturl.at/LL9Zy