This Friday (14 Nov), join us for our next Research Seminar & Journal Club!
🎙️ Chao Su — microRNAs in cancer cachexia
📘 Apurva Jagateri — exosomal miR-210-3p in triple-negative breast cancer
Coffee, pastries & great science await! 🧬
#GalwayRNAResearchCluster
@uniofgalway.bsky.social
🎙️ Chao Su — microRNAs in cancer cachexia
📘 Apurva Jagateri — exosomal miR-210-3p in triple-negative breast cancer
Coffee, pastries & great science await! 🧬
#GalwayRNAResearchCluster
@uniofgalway.bsky.social
November 11, 2025 at 10:00 AM
This Friday (14 Nov), join us for our next Research Seminar & Journal Club!
🎙️ Chao Su — microRNAs in cancer cachexia
📘 Apurva Jagateri — exosomal miR-210-3p in triple-negative breast cancer
Coffee, pastries & great science await! 🧬
#GalwayRNAResearchCluster
@uniofgalway.bsky.social
🎙️ Chao Su — microRNAs in cancer cachexia
📘 Apurva Jagateri — exosomal miR-210-3p in triple-negative breast cancer
Coffee, pastries & great science await! 🧬
#GalwayRNAResearchCluster
@uniofgalway.bsky.social
Graz Researchers Identify IL-6 as Key Driver of Fatal Weight Loss in Cancer – New Therapy Hope Emerges
A research team from the University of Graz has pinpointed interleukin-6 (IL-6) as the central trigger for cancer cachexia, the severe, life-threatening weight loss that claims the lives of about…
A research team from the University of Graz has pinpointed interleukin-6 (IL-6) as the central trigger for cancer cachexia, the severe, life-threatening weight loss that claims the lives of about…
Graz Researchers Identify IL-6 as Key Driver of Fatal Weight Loss in Cancer – New Therapy Hope Emerges
A research team from the University of Graz has pinpointed interleukin-6 (IL-6) as the central trigger for cancer cachexia, the severe, life-threatening weight loss that claims the lives of about one in five cancer patients. The breakthrough, stemming from an unexpected observation in cell cultures, has paved the way for a compound that halted tissue breakdown in animal models. A clinical trial is now underway in the United States.
labnews.io
November 10, 2025 at 12:56 PM
Graz Researchers Identify IL-6 as Key Driver of Fatal Weight Loss in Cancer – New Therapy Hope Emerges
A research team from the University of Graz has pinpointed interleukin-6 (IL-6) as the central trigger for cancer cachexia, the severe, life-threatening weight loss that claims the lives of about…
A research team from the University of Graz has pinpointed interleukin-6 (IL-6) as the central trigger for cancer cachexia, the severe, life-threatening weight loss that claims the lives of about…
Belt-type electrical muscle stimulation preserves muscle fiber size but does not improve muscle function in a rat model of cancer cachexia
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Belt-type electrical muscle stimulation preserves muscle fiber size but does not improve muscle function in a rat model of cancer cachexia
Cancer cachexia causes severe muscle wasting, and current treatments remain limited. Belt-type electrical muscle stimulation (bEMS) has emerged as a passive rehabilitation tool capable of activating m...
journals.plos.org
November 7, 2025 at 6:48 PM
Belt-type electrical muscle stimulation preserves muscle fiber size but does not improve muscle function in a rat model of cancer cachexia
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Telerehabilitation improves cardiorespiratory and muscular fitness and body composition in older people with post-COVID-19 syndrome.
J Cachexia Sarcopenia Muscle 2024
2/5
J Cachexia Sarcopenia Muscle 2024
2/5
November 6, 2025 at 3:07 AM
Telerehabilitation improves cardiorespiratory and muscular fitness and body composition in older people with post-COVID-19 syndrome.
J Cachexia Sarcopenia Muscle 2024
2/5
J Cachexia Sarcopenia Muscle 2024
2/5
Whole life pinned down by being unable to drive
Double jeopardy to require medical system access to stay alive
Even if I could drive, I couldn’t keep it before of the former
And then we have the struggle of just, keeping a roof over head w/ a weak immune system & staying nourished bc cachexia
Double jeopardy to require medical system access to stay alive
Even if I could drive, I couldn’t keep it before of the former
And then we have the struggle of just, keeping a roof over head w/ a weak immune system & staying nourished bc cachexia
November 4, 2025 at 12:03 AM
Whole life pinned down by being unable to drive
Double jeopardy to require medical system access to stay alive
Even if I could drive, I couldn’t keep it before of the former
And then we have the struggle of just, keeping a roof over head w/ a weak immune system & staying nourished bc cachexia
Double jeopardy to require medical system access to stay alive
Even if I could drive, I couldn’t keep it before of the former
And then we have the struggle of just, keeping a roof over head w/ a weak immune system & staying nourished bc cachexia
COVID is the new cancer with multiple subtypes. The parallels are astounding.
For example, cancer with cachexia is a lot like Long Covid due to the systemic inflammation issues causing all sorts of problems.
For example, cancer with cachexia is a lot like Long Covid due to the systemic inflammation issues causing all sorts of problems.
November 3, 2025 at 5:20 PM
COVID is the new cancer with multiple subtypes. The parallels are astounding.
For example, cancer with cachexia is a lot like Long Covid due to the systemic inflammation issues causing all sorts of problems.
For example, cancer with cachexia is a lot like Long Covid due to the systemic inflammation issues causing all sorts of problems.
This is one of the reasons why #LongCOVID and cancer with cachexia are a serious impediment to maintaining heart health: long walks are impossible on the average day.
November 3, 2025 at 4:17 PM
This is one of the reasons why #LongCOVID and cancer with cachexia are a serious impediment to maintaining heart health: long walks are impossible on the average day.
ICYMI: Ponalrestat, an aldose reductase inhibitor, inhibits cachexia syndrome induced by colon26 adenocarcinoma in mice
Ponalrestat, an aldose reductase inhibitor, inhibits cachexia syndrome induced by colon26 adenocarcinoma in mice
Our recent study has demonstrated that ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase activity and alleviates B16 melanoma-induced cachexia in mice. In this study, the effect of ponalrestat on murine adenocarcinoma...
eurekamag.com
November 2, 2025 at 8:17 AM
ICYMI: Ponalrestat, an aldose reductase inhibitor, inhibits cachexia syndrome induced by colon26 adenocarcinoma in mice
Ponalrestat, an aldose reductase inhibitor, inhibits cachexia syndrome induced by colon26 adenocarcinoma in mice
Ponalrestat, an aldose reductase inhibitor, inhibits cachexia syndrome induced by colon26 adenocarcinoma in mice
Our recent study has demonstrated that ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase activity and alleviates B16 melanoma-induced cachexia in mice. In this study, the effect of ponalrestat on murine adenocarcinoma...
eurekamag.com
November 1, 2025 at 8:16 AM
Ponalrestat, an aldose reductase inhibitor, inhibits cachexia syndrome induced by colon26 adenocarcinoma in mice
Sex Differences in Cachexia Outcomes and Branched-Chain Amino Acid Metabolism Following Chemotherapy in Aged Mice https://www.biorxiv.org/content/10.1101/2025.10.30.685610v1
November 1, 2025 at 7:01 AM
Sex Differences in Cachexia Outcomes and Branched-Chain Amino Acid Metabolism Following Chemotherapy in Aged Mice https://www.biorxiv.org/content/10.1101/2025.10.30.685610v1
Sex Differences in Cachexia Outcomes and Branched-Chain Amino Acid Metabolism Following Chemotherapy in Aged Mice https://www.biorxiv.org/content/10.1101/2025.10.30.685610v1
November 1, 2025 at 7:01 AM
Sex Differences in Cachexia Outcomes and Branched-Chain Amino Acid Metabolism Following Chemotherapy in Aged Mice https://www.biorxiv.org/content/10.1101/2025.10.30.685610v1
The cancer itself creates a local state of inflammation known as the Tumor Microenvironment (TME). This is considered the root cause of the systemic inflammation that leads to symptoms like cachexia and chemo brain.
It's systemic because it spreads through the vascular system.
It's systemic because it spreads through the vascular system.
October 31, 2025 at 9:27 PM
The cancer itself creates a local state of inflammation known as the Tumor Microenvironment (TME). This is considered the root cause of the systemic inflammation that leads to symptoms like cachexia and chemo brain.
It's systemic because it spreads through the vascular system.
It's systemic because it spreads through the vascular system.
OPPORTUNITIES
⏰Nov 13➡️Project “REBALANCE - taRgEting a circulating metaBolic signAture associated with tumour aberrant gLycosylation for gAstric cancer patieNts’ Cachexia” at i3S.
Profile: MSc in Biochem., Biol., Biomed., Biotech. or related with a final ...👇
👉https://tinyurl.com/5dr84wzk
#i3Sjobs
⏰Nov 13➡️Project “REBALANCE - taRgEting a circulating metaBolic signAture associated with tumour aberrant gLycosylation for gAstric cancer patieNts’ Cachexia” at i3S.
Profile: MSc in Biochem., Biol., Biomed., Biotech. or related with a final ...👇
👉https://tinyurl.com/5dr84wzk
#i3Sjobs
tinyurl.com
October 30, 2025 at 2:45 PM
OPPORTUNITIES
⏰Nov 13➡️Project “REBALANCE - taRgEting a circulating metaBolic signAture associated with tumour aberrant gLycosylation for gAstric cancer patieNts’ Cachexia” at i3S.
Profile: MSc in Biochem., Biol., Biomed., Biotech. or related with a final ...👇
👉https://tinyurl.com/5dr84wzk
#i3Sjobs
⏰Nov 13➡️Project “REBALANCE - taRgEting a circulating metaBolic signAture associated with tumour aberrant gLycosylation for gAstric cancer patieNts’ Cachexia” at i3S.
Profile: MSc in Biochem., Biol., Biomed., Biotech. or related with a final ...👇
👉https://tinyurl.com/5dr84wzk
#i3Sjobs
Our November issue is live! Read more about drugs for cancer cachexia, RNA chemistry and therapeutics, targeting the Hippo pathway in cancer, the changing landscape of medicinal chemistry optimization and more here www.nature.com/nrd/volumes/...
October 30, 2025 at 2:42 PM
Our November issue is live! Read more about drugs for cancer cachexia, RNA chemistry and therapeutics, targeting the Hippo pathway in cancer, the changing landscape of medicinal chemistry optimization and more here www.nature.com/nrd/volumes/...
Congrats to the CMR's Alastair Saunders, Paul Gregorevic and Team for their new AJPCellPhys paper "Cachexia progression differs among mouse models of metastatic triple-negative breast cancer"
#Cancer #cachexia
journals.physiology.org/doi/full/10....
#Cancer #cachexia
journals.physiology.org/doi/full/10....
Cachexia progression differs among mouse models of metastatic triple-negative breast cancer | American Journal of Physiology-Cell Physiology | American Physiological Society
Cancer-associated cachexia decreases the quality of life, reduces therapy response, and diminishes survival prospects. Effective cachexia countermeasures remain a significant unmet need. Research into...
journals.physiology.org
October 25, 2025 at 6:04 PM
Congrats to the CMR's Alastair Saunders, Paul Gregorevic and Team for their new AJPCellPhys paper "Cachexia progression differs among mouse models of metastatic triple-negative breast cancer"
#Cancer #cachexia
journals.physiology.org/doi/full/10....
#Cancer #cachexia
journals.physiology.org/doi/full/10....
Cachexia progression differs among mouse models of metastatic triple-negative breast cancer
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
Cachexia progression differs among mouse models of metastatic triple-negative breast cancer | American Journal of Physiology-Cell Physiology | American Physiological Society
Cancer-associated cachexia decreases the quality of life, reduces therapy response, and diminishes survival prospects. Effective cachexia countermeasures remain a significant unmet need. Research into...
journals.physiology.org
October 25, 2025 at 5:56 PM
Cachexia progression differs among mouse models of metastatic triple-negative breast cancer
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
Journal of Cachexia, Sarcopenia and Muscle (oct 2025).
Antonio García-Hermoso y su equipo midieron la fuerza de agarre
en 1124 escolares españoles de 8-11 años.
Y lo que hallaron es brutal:
👉 Los niños con menos fuerza relativa al peso
tenían más grasa abdominal, peor colesterol y más insulina.
Antonio García-Hermoso y su equipo midieron la fuerza de agarre
en 1124 escolares españoles de 8-11 años.
Y lo que hallaron es brutal:
👉 Los niños con menos fuerza relativa al peso
tenían más grasa abdominal, peor colesterol y más insulina.
October 25, 2025 at 10:39 AM
Journal of Cachexia, Sarcopenia and Muscle (oct 2025).
Antonio García-Hermoso y su equipo midieron la fuerza de agarre
en 1124 escolares españoles de 8-11 años.
Y lo que hallaron es brutal:
👉 Los niños con menos fuerza relativa al peso
tenían más grasa abdominal, peor colesterol y más insulina.
Antonio García-Hermoso y su equipo midieron la fuerza de agarre
en 1124 escolares españoles de 8-11 años.
Y lo que hallaron es brutal:
👉 Los niños con menos fuerza relativa al peso
tenían más grasa abdominal, peor colesterol y más insulina.
Discovery of a Selective Inhibitor of ZIP14 with Therapeutic Potential for Cancer-associated Cachexia [new]
PPTD: selective ZIP14 inhibitor. Dimer binding, metal uptake blocker, reduces cytotoxicity, ameliorates cachexia (mice).
PPTD: selective ZIP14 inhibitor. Dimer binding, metal uptake blocker, reduces cytotoxicity, ameliorates cachexia (mice).
October 24, 2025 at 3:01 AM
Discovery of a Selective Inhibitor of ZIP14 with Therapeutic Potential for Cancer-associated Cachexia [new]
PPTD: selective ZIP14 inhibitor. Dimer binding, metal uptake blocker, reduces cytotoxicity, ameliorates cachexia (mice).
PPTD: selective ZIP14 inhibitor. Dimer binding, metal uptake blocker, reduces cytotoxicity, ameliorates cachexia (mice).
Discovery of a Selective Inhibitor of ZIP14 with Therapeutic Potential for Cancer-associated Cachexia https://www.biorxiv.org/content/10.1101/2025.10.23.682519v1
October 24, 2025 at 2:46 AM
Discovery of a Selective Inhibitor of ZIP14 with Therapeutic Potential for Cancer-associated Cachexia https://www.biorxiv.org/content/10.1101/2025.10.23.682519v1
Discovery of a Selective Inhibitor of ZIP14 with Therapeutic Potential for Cancer-associated Cachexia https://www.biorxiv.org/content/10.1101/2025.10.23.682519v1
October 24, 2025 at 2:46 AM
Discovery of a Selective Inhibitor of ZIP14 with Therapeutic Potential for Cancer-associated Cachexia https://www.biorxiv.org/content/10.1101/2025.10.23.682519v1
Excited to see @stephenorahilly.bsky.social discuss the current understanding of GDF15/GFAL signaling.
Implications for feeding, cancer cachexia, pregnancy, lean/fat ratio.
Bonus: adipose imperfecta discussion!
Implications for feeding, cancer cachexia, pregnancy, lean/fat ratio.
Bonus: adipose imperfecta discussion!
October 23, 2025 at 9:40 PM
Excited to see @stephenorahilly.bsky.social discuss the current understanding of GDF15/GFAL signaling.
Implications for feeding, cancer cachexia, pregnancy, lean/fat ratio.
Bonus: adipose imperfecta discussion!
Implications for feeding, cancer cachexia, pregnancy, lean/fat ratio.
Bonus: adipose imperfecta discussion!
Breakthrough genetic research holds keys to fighting devastating muscle wasting in cancer.
Genome mapping reveals hidden architecture of muscle in patients with cancer cachexia and offers new direction in the search for treatments. www.ualberta.ca/en/folio/202... #CdnPSE
Genome mapping reveals hidden architecture of muscle in patients with cancer cachexia and offers new direction in the search for treatments. www.ualberta.ca/en/folio/202... #CdnPSE
Breakthrough genetic research holds keys to fighting devastating muscle wasting in cancer
In a new Nature paper, a U of A team has for the first time mapped the genome of muscles from cancer patients and identified molecular subtypes associated with cancer cachexia, a severe…
www.ualberta.ca
October 23, 2025 at 3:03 PM
Breakthrough genetic research holds keys to fighting devastating muscle wasting in cancer.
Genome mapping reveals hidden architecture of muscle in patients with cancer cachexia and offers new direction in the search for treatments. www.ualberta.ca/en/folio/202... #CdnPSE
Genome mapping reveals hidden architecture of muscle in patients with cancer cachexia and offers new direction in the search for treatments. www.ualberta.ca/en/folio/202... #CdnPSE
Researchers found that the FLIS derived from gadoxetic acid-enhanced #MRI
helps detect #Cachexia and predict prognosis in #HCC, advancing noninvasive imaging biomarkers
for early intervention. #medsky
Read more: link.springer.com/article/10.1...
helps detect #Cachexia and predict prognosis in #HCC, advancing noninvasive imaging biomarkers
for early intervention. #medsky
Read more: link.springer.com/article/10.1...
October 23, 2025 at 6:30 AM
Researchers found that the FLIS derived from gadoxetic acid-enhanced #MRI
helps detect #Cachexia and predict prognosis in #HCC, advancing noninvasive imaging biomarkers
for early intervention. #medsky
Read more: link.springer.com/article/10.1...
helps detect #Cachexia and predict prognosis in #HCC, advancing noninvasive imaging biomarkers
for early intervention. #medsky
Read more: link.springer.com/article/10.1...
JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food Intake https://www.biorxiv.org/content/10.1101/2025.10.21.683287v1
October 22, 2025 at 9:48 PM
JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food Intake https://www.biorxiv.org/content/10.1101/2025.10.21.683287v1