These molecular changes matched symptom severity.
Patients with higher GDF15 had worse fatigue scores.
Those with lower 12,13-diHOME had more physical fatigue and reduced activity.
Inflammation markers like S100A8 also tracked with fatigue and motivation loss.
Patients with higher GDF15 had worse fatigue scores.
Those with lower 12,13-diHOME had more physical fatigue and reduced activity.
Inflammation markers like S100A8 also tracked with fatigue and motivation loss.
September 4, 2025 at 3:55 PM
These molecular changes matched symptom severity.
Patients with higher GDF15 had worse fatigue scores.
Those with lower 12,13-diHOME had more physical fatigue and reduced activity.
Inflammation markers like S100A8 also tracked with fatigue and motivation loss.
Patients with higher GDF15 had worse fatigue scores.
Those with lower 12,13-diHOME had more physical fatigue and reduced activity.
Inflammation markers like S100A8 also tracked with fatigue and motivation loss.
The fat-burning problem was worse after exercise.
In ME/CFS, carnitine dropped even more, and fatty acids built up. One compound called 12,13-diHOME, which helps cells take up fat, was low before exercise and abnormally high after.
This pattern was not seen in controls.
In ME/CFS, carnitine dropped even more, and fatty acids built up. One compound called 12,13-diHOME, which helps cells take up fat, was low before exercise and abnormally high after.
This pattern was not seen in controls.
September 4, 2025 at 3:55 PM
The fat-burning problem was worse after exercise.
In ME/CFS, carnitine dropped even more, and fatty acids built up. One compound called 12,13-diHOME, which helps cells take up fat, was low before exercise and abnormally high after.
This pattern was not seen in controls.
In ME/CFS, carnitine dropped even more, and fatty acids built up. One compound called 12,13-diHOME, which helps cells take up fat, was low before exercise and abnormally high after.
This pattern was not seen in controls.
A non-viral gene therapy that used a lipid-controlling hormone, 12,13-diHOME, successfully improved cardiovascular health and function in aged mice.
www.lifespan.io/news/a-non-v...
By: Anna Drangowska-Way
www.lifespan.io/news/a-non-v...
By: Anna Drangowska-Way
A Non-Viral Gene Therapy Restores Mouse Hearts
A recent study investigated the roles of brown adipose tissue and a lipid-controlling hormone, 12,13-diHOME, in cardiac health. The researchers examined the molecular […]
www.lifespan.io
September 3, 2025 at 6:32 PM
A non-viral gene therapy that used a lipid-controlling hormone, 12,13-diHOME, successfully improved cardiovascular health and function in aged mice.
www.lifespan.io/news/a-non-v...
By: Anna Drangowska-Way
www.lifespan.io/news/a-non-v...
By: Anna Drangowska-Way
Nonviral gene therapy that increases levels of the brown fat-derived molecule 12,13-diHOME may help preserve heart function in age-related cardiovascular disease. doi.org/g9xjw4
Nonviral gene therapy shows potential for age-related heart diseases
Researchers at The Ohio State University Wexner Medical Center are using novel nonviral gene therapy technology to gain insight into how to treat age-related heart disease.
medicalxpress.com
August 19, 2025 at 5:28 PM
Nonviral gene therapy that increases levels of the brown fat-derived molecule 12,13-diHOME may help preserve heart function in age-related cardiovascular disease. doi.org/g9xjw4
Sharing the result of a collaboration with Kristin Stanford and team @OhioStateDHLRI: The brown fat–derived lipokine 12,13-diHOME combats age-related heart decline by inhibiting CaMKII and reducing ER stress.
doi.org/10.1038/s414...
@AdventHealthMD
doi.org/10.1038/s414...
@AdventHealthMD
12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII - Nature Communications
Cardiovascular function declines with age. In this study, the authors show that the BAT-derived lipokine 12,13-diHOME preserves cardiac function in aged mice by attenuating pathological CaMKII activit...
doi.org
August 2, 2025 at 11:01 PM
Sharing the result of a collaboration with Kristin Stanford and team @OhioStateDHLRI: The brown fat–derived lipokine 12,13-diHOME combats age-related heart decline by inhibiting CaMKII and reducing ER stress.
doi.org/10.1038/s414...
@AdventHealthMD
doi.org/10.1038/s414...
@AdventHealthMD
The BATokine 12,13-diHOME revealed as a promising candidate for combating age-related cardiovascular dysfunction www.nature.com/articles/s41...
12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII - Nature Communications
Cardiovascular function declines with age. In this study, the authors show that the BAT-derived lipokine 12,13-diHOME preserves cardiac function in aged mice by attenuating pathological CaMKII activit...
www.nature.com
August 2, 2025 at 10:50 AM
The BATokine 12,13-diHOME revealed as a promising candidate for combating age-related cardiovascular dysfunction www.nature.com/articles/s41...
Do baby poop #microbiomes correlate with higher risk for allergies & #asthma in early childhood? #SusanLynch #ucsfmicrobiome has evidence that microbiota products can promote #allergic #inflammation in mouse model! #intergenerational #12,13-diHOME #epigenetics #siolta @sfstatebio.bsky.social seminar
April 17, 2025 at 9:50 PM
Do baby poop #microbiomes correlate with higher risk for allergies & #asthma in early childhood? #SusanLynch #ucsfmicrobiome has evidence that microbiota products can promote #allergic #inflammation in mouse model! #intergenerational #12,13-diHOME #epigenetics #siolta @sfstatebio.bsky.social seminar