Znger4
@znger4.bsky.social
Alumnus WIS-Technion-IIT Madras. Dream works believer. mAbs,NIK in NFkB pathway-G-proteins-,Chl Binding Proteins, DmNucleobindin-Microb Diversity-Reduviids
Reposted by Znger4
New EMBO J
𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 uses “on-off switch” to pause or restart its growth
DarT tags DNA to halt replication, DarG removes the tag to resume activity
Stop-start mechanism helps TB evade antibiotics and immune clearance, establish chronic infection
www.embopress.org/doi/full/10....
𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 uses “on-off switch” to pause or restart its growth
DarT tags DNA to halt replication, DarG removes the tag to resume activity
Stop-start mechanism helps TB evade antibiotics and immune clearance, establish chronic infection
www.embopress.org/doi/full/10....
May 25, 2025 at 12:05 PM
New EMBO J
𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 uses “on-off switch” to pause or restart its growth
DarT tags DNA to halt replication, DarG removes the tag to resume activity
Stop-start mechanism helps TB evade antibiotics and immune clearance, establish chronic infection
www.embopress.org/doi/full/10....
𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 uses “on-off switch” to pause or restart its growth
DarT tags DNA to halt replication, DarG removes the tag to resume activity
Stop-start mechanism helps TB evade antibiotics and immune clearance, establish chronic infection
www.embopress.org/doi/full/10....
Reposted by Znger4
Excited to introduce evoCAST: a platform for efficient, programmable gene integration in human cells. This work, a close collab between my PhD lab (Liu group) and @sternberglab.bsky.social, has been such a fun journey to help lead. Huge thanks to all contributors!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase
Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life sciences. CRISP...
www.science.org
May 15, 2025 at 7:06 PM
Excited to introduce evoCAST: a platform for efficient, programmable gene integration in human cells. This work, a close collab between my PhD lab (Liu group) and @sternberglab.bsky.social, has been such a fun journey to help lead. Huge thanks to all contributors!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Znger4
www.nature.com/articles/d41...
Coverage of our collaboration with the Liu group..
' “This is crazy directed evolution!” - Makoto Saito'
Coverage of our collaboration with the Liu group..
' “This is crazy directed evolution!” - Makoto Saito'
Powerful CRISPR system inserts whole gene into human DNA
‘Directed’ evolution in the laboratory creates an editing tool that outperforms classic CRISPR systems.
www.nature.com
May 16, 2025 at 5:54 PM
www.nature.com/articles/d41...
Coverage of our collaboration with the Liu group..
' “This is crazy directed evolution!” - Makoto Saito'
Coverage of our collaboration with the Liu group..
' “This is crazy directed evolution!” - Makoto Saito'
Reposted by Znger4
Reposted by Znger4
Tomorrow, Tuesday March 25th at 11am ET, @jpassmore.bsky.social from Utrecht University, The Netherlands, will present "Outcome-driven microscopy: integrating smart microscopy and optogenetics for precise biological control"!
Join us on Zoom, more information on biocontrolseminars.org
Join us on Zoom, more information on biocontrolseminars.org
March 24, 2025 at 10:35 AM
Tomorrow, Tuesday March 25th at 11am ET, @jpassmore.bsky.social from Utrecht University, The Netherlands, will present "Outcome-driven microscopy: integrating smart microscopy and optogenetics for precise biological control"!
Join us on Zoom, more information on biocontrolseminars.org
Join us on Zoom, more information on biocontrolseminars.org
Reposted by Znger4
How amino acids taste 🧪
September 25, 2024 at 5:33 AM
How amino acids taste 🧪
Reposted by Znger4
A number of people who run those resources were contractors. In December, some of them were transitioned into Federal employee status to protect them.
Unfortunately, this means they were probably on the list of employees with probationary status.
I am trying to find out what actually happened.
Unfortunately, this means they were probably on the list of employees with probationary status.
I am trying to find out what actually happened.
People around the world are using NIH resources like NCBI, GEO, Pubmed everyday… what will happen to them…
February 15, 2025 at 3:00 PM
A number of people who run those resources were contractors. In December, some of them were transitioned into Federal employee status to protect them.
Unfortunately, this means they were probably on the list of employees with probationary status.
I am trying to find out what actually happened.
Unfortunately, this means they were probably on the list of employees with probationary status.
I am trying to find out what actually happened.
Reposted by Znger4
Birth defects are the #1 cause of death in the first year of life (🧵). Birth defects kill more than twice as many children as cancer. Birth defects are diseases of developmental biology. Here are CDC statistics for 2021. 1/5
wisqars.cdc.gov/pdfs/leading...
wisqars.cdc.gov/pdfs/leading...
February 4, 2025 at 3:07 PM
Birth defects are the #1 cause of death in the first year of life (🧵). Birth defects kill more than twice as many children as cancer. Birth defects are diseases of developmental biology. Here are CDC statistics for 2021. 1/5
wisqars.cdc.gov/pdfs/leading...
wisqars.cdc.gov/pdfs/leading...
Reposted by Znger4
Really interesting paper 🧪 🤩
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Cancer cells ‘poison’ the immune system with tainted mitochondria
Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.
www.nature.com
January 23, 2025 at 6:41 PM
Really interesting paper 🧪 🤩
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Reposted by Znger4
Here's a link to the pdf: rdcu.be/d6aZw
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells
Nature Metabolism - Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase...
rdcu.be
January 14, 2025 at 8:23 PM
Here's a link to the pdf: rdcu.be/d6aZw
Reposted by Znger4
A seminar on the history of protein structure prediction and protein design. By Mohammed AlQuraishi
youtu.be/Ahwn-KS8fd0?...
youtu.be/Ahwn-KS8fd0?...
A brief history of protein structure prediction and design
YouTube video by RosettaCommons
youtu.be
January 22, 2025 at 3:35 AM
A seminar on the history of protein structure prediction and protein design. By Mohammed AlQuraishi
youtu.be/Ahwn-KS8fd0?...
youtu.be/Ahwn-KS8fd0?...
Reposted by Znger4
1/2: MSK is the first hospital in New York City to offer gene therapy for sickle cell disease and beta thalassemia through its pediatric program, MSK Kids. Learn more: bit.ly/4gUKC3a
MSK Kids: First in New York City Offering Gene Therapy for Sickle Cell Disease and Beta Thalassemia
A Q&A with Jaap-Jan Boelens, MD, PhD, Chief of the Pediatric Transplant and Cellular Therapy Service at MSK.
bit.ly
January 17, 2025 at 3:06 PM
1/2: MSK is the first hospital in New York City to offer gene therapy for sickle cell disease and beta thalassemia through its pediatric program, MSK Kids. Learn more: bit.ly/4gUKC3a
Reposted by Znger4
191 children with diverse solid tumors, immune variation with age and tumor type provide a reference for future precision immunotherapies tailored for the evolving immune systems of children
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @petterbrodin.bsky.social
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @petterbrodin.bsky.social
Systems-level immunomonitoring in children with solid tumors to enable precision medicine
In a population-based cohort of 191 children with diverse solid tumors, systems-level
analyses unravel immune variation with age and tumor type and provide a reference
for future precision immunothera...
www.cell.com
January 21, 2025 at 8:53 PM
191 children with diverse solid tumors, immune variation with age and tumor type provide a reference for future precision immunotherapies tailored for the evolving immune systems of children
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @petterbrodin.bsky.social
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @petterbrodin.bsky.social
Reposted by Znger4
