Zoltán Kutalik
@zkutalik.bsky.social
Statistical Geneticist, Group leader at University of Lausanne/Unisante, father, climber, runner
Reposted by Zoltán Kutalik
Interested in whole genomes, AI and functional validation? Sign up to hear more about our summer school in the sunny southwest U.K. @exeter.ac.uk in Sept 2026, in partnership with the U.K. Functional Genomics Initiative @uk-fgx.bsky.social and Google Deepmind @nihrexeterbrc.bsky.social
November 17, 2025 at 1:45 PM
Interested in whole genomes, AI and functional validation? Sign up to hear more about our summer school in the sunny southwest U.K. @exeter.ac.uk in Sept 2026, in partnership with the U.K. Functional Genomics Initiative @uk-fgx.bsky.social and Google Deepmind @nihrexeterbrc.bsky.social
Reposted by Zoltán Kutalik
It has been disappointing to see the general lack of interest and investment into population genetics and genomic medicine in Switzerland. While we can resort to other national cohorts for research the country can only benefit if the know-how can be applied locally
www.sfa-phrt.ch/success-stor...
www.sfa-phrt.ch/success-stor...
Didier Trono Interview “Switzerlands Genetic Diversity is Unique” - PHRT – Personalized Health & Related Technologies
Success Story Didier Trono While other countries are pressing ahead with the Genome of Europe, Switzerland is still hesitating. A huge mistake, says Didier Trono from the Genome Center in Geneva “I do...
www.sfa-phrt.ch
November 11, 2025 at 8:42 AM
It has been disappointing to see the general lack of interest and investment into population genetics and genomic medicine in Switzerland. While we can resort to other national cohorts for research the country can only benefit if the know-how can be applied locally
www.sfa-phrt.ch/success-stor...
www.sfa-phrt.ch/success-stor...
Reposted by Zoltán Kutalik
The 2025 state of the climate report: a planet on the brink
doi.org/10.1093/bios...
doi.org/10.1093/bios...
November 6, 2025 at 3:26 PM
The 2025 state of the climate report: a planet on the brink
doi.org/10.1093/bios...
doi.org/10.1093/bios...
Reposted by Zoltán Kutalik
SIB is organizing the next edition of #eccb2026 (Geneva, 31.08.2026 - 04.09.2026), and we are now inviting the community to submit their tutorial and workshop proposals.
👉 A great opportunity to share tools, methods and expertise with 1,000+ international participants. Deadline: 5 January 2026.
👉 A great opportunity to share tools, methods and expertise with 1,000+ international participants. Deadline: 5 January 2026.
📣 The call for tutorials & workshops at #ECCB2026 is now open! Share your tools, methods or expertise with the community.
🗓️ Deadline: 5 January 2026
👉 Submit: tinyurl.com/tw-eccb26
💡 ECCB will take place on 31 Aug–4 Sept in Geneva, gathering 1,000+ scientists from academia, industry, & healthcare.
🗓️ Deadline: 5 January 2026
👉 Submit: tinyurl.com/tw-eccb26
💡 ECCB will take place on 31 Aug–4 Sept in Geneva, gathering 1,000+ scientists from academia, industry, & healthcare.
November 3, 2025 at 8:10 AM
SIB is organizing the next edition of #eccb2026 (Geneva, 31.08.2026 - 04.09.2026), and we are now inviting the community to submit their tutorial and workshop proposals.
👉 A great opportunity to share tools, methods and expertise with 1,000+ international participants. Deadline: 5 January 2026.
👉 A great opportunity to share tools, methods and expertise with 1,000+ international participants. Deadline: 5 January 2026.
Reposted by Zoltán Kutalik
🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics
This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.
www.nature.com
October 6, 2025 at 6:57 AM
🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China
Reposted by Zoltán Kutalik
🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
September 26, 2025 at 5:10 PM
🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
Reposted by Zoltán Kutalik
Wow! If this holds up, it will be a triumph of science (i.e., of many hundreds of dedicated scientists over decades) over a devastating disease.
September 24, 2025 at 1:12 PM
Wow! If this holds up, it will be a triumph of science (i.e., of many hundreds of dedicated scientists over decades) over a devastating disease.
Reposted by Zoltán Kutalik
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
www.medrxiv.org
September 2, 2025 at 11:08 PM
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Reposted by Zoltán Kutalik
I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:
Beneath the surface of the sum
When genetic interactions matter and when they don't
open.substack.com
August 27, 2025 at 8:41 PM
I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:
Reposted by Zoltán Kutalik
Study of 230,000 people finds many examples where the effect of a genetic variant differs depending on the parent of origin, especially for growth and metabolism - fascinating!
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 22, 2025 at 11:01 AM
Study of 230,000 people finds many examples where the effect of a genetic variant differs depending on the parent of origin, especially for growth and metabolism - fascinating!
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
Reposted by Zoltán Kutalik
Extremely cool paper from @rjhfmstr.bsky.social @zkutalik.bsky.social and team. I still need to get my head around how the same genetic variant has opposite effects depending if it’s maternally or paternally inherited and why.
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 22, 2025 at 5:26 PM
Extremely cool paper from @rjhfmstr.bsky.social @zkutalik.bsky.social and team. I still need to get my head around how the same genetic variant has opposite effects depending if it’s maternally or paternally inherited and why.
Reposted by Zoltán Kutalik
🚨 News recherche
Des caractéristiques telles que la taille, le métabolisme ou encore le risque de développer certaines #maladies peuvent être influencées de manière différente selon que le variant #génétique en cause provient de la mère ou du père.
➡ www.unil.ch/news/1754464...
Des caractéristiques telles que la taille, le métabolisme ou encore le risque de développer certaines #maladies peuvent être influencées de manière différente selon que le variant #génétique en cause provient de la mère ou du père.
➡ www.unil.ch/news/1754464...
August 7, 2025 at 9:42 AM
🚨 News recherche
Des caractéristiques telles que la taille, le métabolisme ou encore le risque de développer certaines #maladies peuvent être influencées de manière différente selon que le variant #génétique en cause provient de la mère ou du père.
➡ www.unil.ch/news/1754464...
Des caractéristiques telles que la taille, le métabolisme ou encore le risque de développer certaines #maladies peuvent être influencées de manière différente selon que le variant #génétique en cause provient de la mère ou du père.
➡ www.unil.ch/news/1754464...
Reposted by Zoltán Kutalik
Congratulations to Zoltan @zkutalik.bsky.social , Robin @rjhfmstr.bsky.social and the whole team for this fantastic work out today in @nature.com 👍 www.nature.com/articles/s41... Your parents' genome matters more than you think 😉https://www.unil.ch/dbc/en/home.html @fbm-unil.bsky.social
Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature
A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.
www.nature.com
August 7, 2025 at 10:23 AM
Congratulations to Zoltan @zkutalik.bsky.social , Robin @rjhfmstr.bsky.social and the whole team for this fantastic work out today in @nature.com 👍 www.nature.com/articles/s41... Your parents' genome matters more than you think 😉https://www.unil.ch/dbc/en/home.html @fbm-unil.bsky.social
Reposted by Zoltán Kutalik
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 6, 2025 at 6:27 PM
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Reposted by Zoltán Kutalik
Thrilled to see this project come to life — a huge team effort with collaborators in 🇨🇭 🇪🇪 🇳🇴! Huge thanks to all co-authors and funders!
@zkutalik.bsky.social @lilimilani.bsky.social @srubinacci.bsky.social @adriaan-vd-graaf.bsky.social @unil.bsky.social @estbiobank.bsky.social and many more !
@zkutalik.bsky.social @lilimilani.bsky.social @srubinacci.bsky.social @adriaan-vd-graaf.bsky.social @unil.bsky.social @estbiobank.bsky.social and many more !
August 6, 2025 at 6:27 PM
Thrilled to see this project come to life — a huge team effort with collaborators in 🇨🇭 🇪🇪 🇳🇴! Huge thanks to all co-authors and funders!
@zkutalik.bsky.social @lilimilani.bsky.social @srubinacci.bsky.social @adriaan-vd-graaf.bsky.social @unil.bsky.social @estbiobank.bsky.social and many more !
@zkutalik.bsky.social @lilimilani.bsky.social @srubinacci.bsky.social @adriaan-vd-graaf.bsky.social @unil.bsky.social @estbiobank.bsky.social and many more !
Reposted by Zoltán Kutalik
Traits like disease risk can be affected differently, and in opposite ways, depending on which parent the genetic variant responsible comes from. Work led by SIB scientists @zkutalik.bsky.social & Robin Hofmeister at @unil.bsky.social/UniSanté & published in Nature👇
www.sib.swiss/news/the-imp...
www.sib.swiss/news/the-imp...
The impact of genetic variants can depend on the parent they come from
Traits such as height, metabolism, and disease risk can be affected differently – and even in opposite directions – depending on whether the genetic variant responsible is inherited from the mothe...
www.sib.swiss
August 6, 2025 at 3:10 PM
Traits like disease risk can be affected differently, and in opposite ways, depending on which parent the genetic variant responsible comes from. Work led by SIB scientists @zkutalik.bsky.social & Robin Hofmeister at @unil.bsky.social/UniSanté & published in Nature👇
www.sib.swiss/news/the-imp...
www.sib.swiss/news/the-imp...
Reposted by Zoltán Kutalik
🚨New preprint is out!
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
Design and model choices shape inference of age-varying genetic effects on complex traits
Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...
shorturl.at
July 8, 2025 at 12:47 PM
🚨New preprint is out!
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
This represents a real tour-de-force by @adriaan-vd-graaf.bsky.social. It has so many strong aspects: (i) establishment of large scale ground truth data for causal inference [metabolomics/transcriptomics]; (ii) sophisticated method and (iii) biological insights through real data application.
Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...
July 4, 2025 at 11:54 AM
This represents a real tour-de-force by @adriaan-vd-graaf.bsky.social. It has so many strong aspects: (i) establishment of large scale ground truth data for causal inference [metabolomics/transcriptomics]; (ii) sophisticated method and (iii) biological insights through real data application.
Reposted by Zoltán Kutalik
Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...
July 4, 2025 at 8:52 AM
Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...
Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch)
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
June 27, 2025 at 10:00 AM
Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch)
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
Reposted by Zoltán Kutalik
🔥 18-19/9/25 🔥 Computational Biology Symposium in Lausanne! Meet the speakers: Mo Lotfollahi @sangerinstitute.bsky.social is expert of cutting-edge #AI approaches to study #singlecell biology , #generativeAI, and #spatialbiology lotfollahi.com
June 3, 2025 at 2:10 PM
🔥 18-19/9/25 🔥 Computational Biology Symposium in Lausanne! Meet the speakers: Mo Lotfollahi @sangerinstitute.bsky.social is expert of cutting-edge #AI approaches to study #singlecell biology , #generativeAI, and #spatialbiology lotfollahi.com
Reposted by Zoltán Kutalik
You can still apply to this postdoc job opportunity!
Postdoc job opportunity! We're looking for ECR in evolutionary genomics to study the relation between intra-specific gene expression variability, polymorphism, and macro-evolutionary rates. We have the data in 3 fishes & amphioxus, just waiting for your expertise and enthusiasm!
tinyurl.com/3aewk286
tinyurl.com/3aewk286
Opportunités de carrière : Postdoctoral position in evolutionary genomics (22280)
Saisissez une liste de termes, que nous allons rechercher dans le titre du poste et sa description. \nAstuces\xa0:\n\nNous rechercherons tous les mots figurant dans la recherche.\nLes r\xe9sultats…
tinyurl.com
June 4, 2025 at 3:12 PM
You can still apply to this postdoc job opportunity!
Reposted by Zoltán Kutalik
Come join 5Prime as we grow our team to use human genetics and other —omics to accelerate drug development.
New post for a Software Engineer:
5primesciences.com/careers/
New post for a Software Engineer:
5primesciences.com/careers/
Careers - 5PrimeSciences
Careers 5 Prime Sciences uses insights from human genetics to accelerate drug development and increase return on investment in the life sciences. Using unique datasets and advanced human genetics anal...
5primesciences.com
June 3, 2025 at 4:55 PM
Come join 5Prime as we grow our team to use human genetics and other —omics to accelerate drug development.
New post for a Software Engineer:
5primesciences.com/careers/
New post for a Software Engineer:
5primesciences.com/careers/
Reposted by Zoltán Kutalik
We have 2-3 group leader positions opening @fimm-uh.bsky.social !!
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
FIMM-EMBL Group Leaders in Molecular Medicine
FIMM-EMBL Group Leaders in Molecular Medicine
jobs.helsinki.fi
June 1, 2025 at 3:38 PM
We have 2-3 group leader positions opening @fimm-uh.bsky.social !!
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
Meet another speaker of the Computational Biology Symposium [https://cbiosymposium.unil.ch/]: Blagoje Soskic [https://tinyurl.com/ybs82xuu]! He studies the genetic control of T – B cell interaction and antibody production with innovative combinations of experimental and computational approaches.
May 28, 2025 at 12:23 PM
Meet another speaker of the Computational Biology Symposium [https://cbiosymposium.unil.ch/]: Blagoje Soskic [https://tinyurl.com/ybs82xuu]! He studies the genetic control of T – B cell interaction and antibody production with innovative combinations of experimental and computational approaches.