York Biomedical Research Institute
@ybri-uoy.bsky.social
Our mission at the York Biomedical Research Institute (YBRI) is to advance discoveries in biomedical science, to inspire, train, and mentor the next generation of biomedical researchers.
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Exciting news! 🎉 We'd like to welcome Professor Ian Hitchcock as our new Director. With a passion for innovation and collaboration, @ian-hitchcock.bsky.social will lead us into an inspiring new chapter of research excellence
Delighted to have Prof Jenna Gregory as today's Biomedical Science seminar speaker from @uniofaberdeen.bsky.social
Jenna presented her work on improving translation in neurodegenerative diseases
Hosted by Prof Stephen Smith
Jenna presented her work on improving translation in neurodegenerative diseases
Hosted by Prof Stephen Smith
November 14, 2025 at 1:51 PM
Delighted to have Prof Jenna Gregory as today's Biomedical Science seminar speaker from @uniofaberdeen.bsky.social
Jenna presented her work on improving translation in neurodegenerative diseases
Hosted by Prof Stephen Smith
Jenna presented her work on improving translation in neurodegenerative diseases
Hosted by Prof Stephen Smith
Excited to have Dr Adrian Najer as today's Biomedical Science seminar speaker from @imperialcollegeldn.bsky.social
Adrian presented his work on nanomedicines and nanodiagnostics for parasites, viruses, and bacteria
Hosted by Dr Stuart Higgins
Adrian presented his work on nanomedicines and nanodiagnostics for parasites, viruses, and bacteria
Hosted by Dr Stuart Higgins
November 7, 2025 at 1:12 PM
Excited to have Dr Adrian Najer as today's Biomedical Science seminar speaker from @imperialcollegeldn.bsky.social
Adrian presented his work on nanomedicines and nanodiagnostics for parasites, viruses, and bacteria
Hosted by Dr Stuart Higgins
Adrian presented his work on nanomedicines and nanodiagnostics for parasites, viruses, and bacteria
Hosted by Dr Stuart Higgins
Exciting news! 🎉 We'd like to welcome Professor Ian Hitchcock as our new Director. With a passion for innovation and collaboration, @ian-hitchcock.bsky.social will lead us into an inspiring new chapter of research excellence
November 3, 2025 at 11:00 AM
Exciting news! 🎉 We'd like to welcome Professor Ian Hitchcock as our new Director. With a passion for innovation and collaboration, @ian-hitchcock.bsky.social will lead us into an inspiring new chapter of research excellence
Congrats to @joanarcf.bsky.social @biologyatyork.bsky.social who has been awarded a BBSRC responsive mode grant, with
@mottramlab.bsky.social as a co-I & collaborators @ipmontevideo.bsky.social @warwickuni.bsky.social
@mottramlab.bsky.social as a co-I & collaborators @ipmontevideo.bsky.social @warwickuni.bsky.social
October 31, 2025 at 1:28 PM
Congrats to @joanarcf.bsky.social @biologyatyork.bsky.social who has been awarded a BBSRC responsive mode grant, with
@mottramlab.bsky.social as a co-I & collaborators @ipmontevideo.bsky.social @warwickuni.bsky.social
@mottramlab.bsky.social as a co-I & collaborators @ipmontevideo.bsky.social @warwickuni.bsky.social
Reposted by York Biomedical Research Institute
🚨 We have 3 fully funded PhD studentships open!
Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology
📍Start Oct 2026 | 💡Apply via MRC & BBSRC
👇Details in thread 👇
Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology
📍Start Oct 2026 | 💡Apply via MRC & BBSRC
👇Details in thread 👇
October 31, 2025 at 1:20 PM
🚨 We have 3 fully funded PhD studentships open!
Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology
📍Start Oct 2026 | 💡Apply via MRC & BBSRC
👇Details in thread 👇
Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology
📍Start Oct 2026 | 💡Apply via MRC & BBSRC
👇Details in thread 👇
Thrilled to have @ewanbirney.bsky.social as today's BMS seminar speaker & as a keynote in the @biologyatyork.bsky.social Postdoc Symposium
Ewan presented his work on "Genomics, Imaging and AI: three technologies changing research and healthcare"
Hosted by Prof Gavin Wright
Ewan presented his work on "Genomics, Imaging and AI: three technologies changing research and healthcare"
Hosted by Prof Gavin Wright
October 31, 2025 at 1:21 PM
Thrilled to have @ewanbirney.bsky.social as today's BMS seminar speaker & as a keynote in the @biologyatyork.bsky.social Postdoc Symposium
Ewan presented his work on "Genomics, Imaging and AI: three technologies changing research and healthcare"
Hosted by Prof Gavin Wright
Ewan presented his work on "Genomics, Imaging and AI: three technologies changing research and healthcare"
Hosted by Prof Gavin Wright
Discovery Medicine North (DiMeN) PhD projects are now open for applications!
Are you looking for exceptional research training and support, access to outstanding facilities and expertise, and enhanced funding and training to support career development and research excellence?
Are you looking for exceptional research training and support, access to outstanding facilities and expertise, and enhanced funding and training to support career development and research excellence?
October 31, 2025 at 11:39 AM
Discovery Medicine North (DiMeN) PhD projects are now open for applications!
Are you looking for exceptional research training and support, access to outstanding facilities and expertise, and enhanced funding and training to support career development and research excellence?
Are you looking for exceptional research training and support, access to outstanding facilities and expertise, and enhanced funding and training to support career development and research excellence?
Excited to have @sankarinagarajan.bsky.social @mcf-uom.bsky.social as our Biomedical Science seminar speaker today, hosted by @andrewholding.bsky.social
Sankari presented her work on the role of transcription factors in mediating the progression to drug resistance and metastasis in breast cancer
Sankari presented her work on the role of transcription factors in mediating the progression to drug resistance and metastasis in breast cancer
October 10, 2025 at 12:16 PM
Excited to have @sankarinagarajan.bsky.social @mcf-uom.bsky.social as our Biomedical Science seminar speaker today, hosted by @andrewholding.bsky.social
Sankari presented her work on the role of transcription factors in mediating the progression to drug resistance and metastasis in breast cancer
Sankari presented her work on the role of transcription factors in mediating the progression to drug resistance and metastasis in breast cancer
Excited to have @alainkohlvirology.bsky.social as this weeks Biomedical Science seminar speaker, talking about his work on antiviral RNAi in mosquitoes. Hosted by Dr Natalie Prow.
October 3, 2025 at 12:13 PM
Excited to have @alainkohlvirology.bsky.social as this weeks Biomedical Science seminar speaker, talking about his work on antiviral RNAi in mosquitoes. Hosted by Dr Natalie Prow.
Reposted by York Biomedical Research Institute
We are delighted that our latest @york.ac.uk & @ybri-uoy.bsky.social work showcasing our photonic biosensor for Alzheimer's disease blood biomarkers has been published in @optica.org!
👇
opg.optica.org/optica/fullt...
Thanks to @alzheimerssoc.bsky.social & @alzheimersresearchuk.org for support!
👇
opg.optica.org/optica/fullt...
Thanks to @alzheimerssoc.bsky.social & @alzheimersresearchuk.org for support!
Optica Publishing Group
opg.optica.org
October 2, 2025 at 7:04 PM
We are delighted that our latest @york.ac.uk & @ybri-uoy.bsky.social work showcasing our photonic biosensor for Alzheimer's disease blood biomarkers has been published in @optica.org!
👇
opg.optica.org/optica/fullt...
Thanks to @alzheimerssoc.bsky.social & @alzheimersresearchuk.org for support!
👇
opg.optica.org/optica/fullt...
Thanks to @alzheimerssoc.bsky.social & @alzheimersresearchuk.org for support!
Reposted by York Biomedical Research Institute
New preprint! 🚨 I'm delighted to share our latest @york.ac.uk & @ybri-uoy.bsky.social pre-print: "Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching." Congratulations to Claudia from the team on her first manuscript!
👇👇
www.biorxiv.org/content/10.1...
👇👇
www.biorxiv.org/content/10.1...
Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching
Detergent-induced membrane solubilization is important for several biotechnological applications including membrane protein isolation, cell lysis and virus inactivation. The thermodynamic details of t...
www.biorxiv.org
September 29, 2025 at 9:38 AM
New preprint! 🚨 I'm delighted to share our latest @york.ac.uk & @ybri-uoy.bsky.social pre-print: "Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching." Congratulations to Claudia from the team on her first manuscript!
👇👇
www.biorxiv.org/content/10.1...
👇👇
www.biorxiv.org/content/10.1...
Pleased to have @elkslab.bsky.social kicking off the 2025-26 series of our Biomedical Seminars, hosted by @noemiehamilton.bsky.social
Phil presented his work on using zebrafish models to study the roles of HIF in host response to infection
Phil presented his work on using zebrafish models to study the roles of HIF in host response to infection
September 26, 2025 at 12:09 PM
Pleased to have @elkslab.bsky.social kicking off the 2025-26 series of our Biomedical Seminars, hosted by @noemiehamilton.bsky.social
Phil presented his work on using zebrafish models to study the roles of HIF in host response to infection
Phil presented his work on using zebrafish models to study the roles of HIF in host response to infection
Reposted by York Biomedical Research Institute
Research conducted by our Director @ian-hitchcock.bsky.social's collaborators in Oxford has found that platelets could help make cancer-detecting blood tests much more effective
Read more about the study on @cancerresearchuk.org website
news.cancerresearchuk.org/2025/08/14/p...
Read more about the study on @cancerresearchuk.org website
news.cancerresearchuk.org/2025/08/14/p...
The "humble" blood cells that could expose cancer's secrets - Cancer Research UK - Cancer News
Our scientists have discovered that platelets are swelling with information which could help us detect cancers earlier.
news.cancerresearchuk.org
September 17, 2025 at 9:46 AM
Research conducted by our Director @ian-hitchcock.bsky.social's collaborators in Oxford has found that platelets could help make cancer-detecting blood tests much more effective
Read more about the study on @cancerresearchuk.org website
news.cancerresearchuk.org/2025/08/14/p...
Read more about the study on @cancerresearchuk.org website
news.cancerresearchuk.org/2025/08/14/p...
Reposted by York Biomedical Research Institute
We're kicking off the third #NeuroBioUK - an exciting day full of neuronal cell biology ahead!
Massive thank for @bscb-official.bsky.social support and a shout out to our industry sponsors!
Massive thank for @bscb-official.bsky.social support and a shout out to our industry sponsors!
September 12, 2025 at 10:13 AM
We're kicking off the third #NeuroBioUK - an exciting day full of neuronal cell biology ahead!
Massive thank for @bscb-official.bsky.social support and a shout out to our industry sponsors!
Massive thank for @bscb-official.bsky.social support and a shout out to our industry sponsors!
Reposted by York Biomedical Research Institute
What’s the difference between female and male Th cells? We have a new paper on this! The mighty Malat1 controls Th2 differentiation in female but not male cells.
Work by Mags Gwynne and Katie West
@jimmunol.bsky.social
doi.org/10.1093/jimm...
@york.ac.uk, @ybri-uoy.bsky.social, @hyms.ac.uk
Work by Mags Gwynne and Katie West
@jimmunol.bsky.social
doi.org/10.1093/jimm...
@york.ac.uk, @ybri-uoy.bsky.social, @hyms.ac.uk
Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2
Abstract. Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is
doi.org
August 28, 2025 at 10:41 AM
What’s the difference between female and male Th cells? We have a new paper on this! The mighty Malat1 controls Th2 differentiation in female but not male cells.
Work by Mags Gwynne and Katie West
@jimmunol.bsky.social
doi.org/10.1093/jimm...
@york.ac.uk, @ybri-uoy.bsky.social, @hyms.ac.uk
Work by Mags Gwynne and Katie West
@jimmunol.bsky.social
doi.org/10.1093/jimm...
@york.ac.uk, @ybri-uoy.bsky.social, @hyms.ac.uk
Reposted by York Biomedical Research Institute
Delighted with our new paper on a novel itaconate transporter in the human pathogen Pseudomonas aeruginosa, led by Javeria and Reyme. @ybri-uoy.bsky.social @javeriamehboob.bsky.social @bethkw.bsky.social A duplicated transporter on its way to itaconate selectivity
portlandpress.com/biochemj/art...
portlandpress.com/biochemj/art...
Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter
Pseudomonas aeruginosa PA01 is one of the major causes of disease persistence and mortality in patients with lung pathologies, relying on various host metabolites as carbon and energy sources for grow...
portlandpress.com
September 2, 2025 at 7:57 AM
Delighted with our new paper on a novel itaconate transporter in the human pathogen Pseudomonas aeruginosa, led by Javeria and Reyme. @ybri-uoy.bsky.social @javeriamehboob.bsky.social @bethkw.bsky.social A duplicated transporter on its way to itaconate selectivity
portlandpress.com/biochemj/art...
portlandpress.com/biochemj/art...
Reposted by York Biomedical Research Institute
First paper from Orlagh Anderson PhD project is out. She found a chromid is a distinct & unique feature of Clostridium butyricum. More to come on the virulence related genes.. @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
Comparative genomics of Clostridium butyricum reveals a conserved genome architecture and novel virulence-related gene clusters
Bacteria from the species Clostridium butyricum encompass a diverse range of phenotypes. While some strains are used as probiotics, others have been isolated from cases of botulism and necrotizing ent...
www.microbiologyresearch.org
August 12, 2025 at 8:11 PM
First paper from Orlagh Anderson PhD project is out. She found a chromid is a distinct & unique feature of Clostridium butyricum. More to come on the virulence related genes.. @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
Reposted by York Biomedical Research Institute
How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social !
@biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr
www.sciencedirect.com/science/arti...
@biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr
www.sciencedirect.com/science/arti...
August 11, 2025 at 6:40 AM
How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social !
@biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr
www.sciencedirect.com/science/arti...
@biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr
www.sciencedirect.com/science/arti...
Reposted by York Biomedical Research Institute
🚨 New preprint!🚨We introduce a DNA-scaffold strategy for efficient dye labelling of structured RNAs, enabling #smFRET studies of freely-diffusing SARS-CoV-2 pseudoknots🧬
👉 biorxiv.org/content/10.1...
#smFRET #RNA #biophysics #SARSCoV2 #singlemolecule #Covid
👉 biorxiv.org/content/10.1...
#smFRET #RNA #biophysics #SARSCoV2 #singlemolecule #Covid
A DNA scaffold approach facilitates 5′ labelling of the SARS-CoV-2 RNA pseudoknot for smFRET investigation
Single-molecule Förster resonance energy transfer (smFRET) studies of highly structured RNA molecules are often frustrated by issues with efficient dye conjugation. Here, we develop a DNA scaffold-bas...
biorxiv.org
July 30, 2025 at 9:16 AM
🚨 New preprint!🚨We introduce a DNA-scaffold strategy for efficient dye labelling of structured RNAs, enabling #smFRET studies of freely-diffusing SARS-CoV-2 pseudoknots🧬
👉 biorxiv.org/content/10.1...
#smFRET #RNA #biophysics #SARSCoV2 #singlemolecule #Covid
👉 biorxiv.org/content/10.1...
#smFRET #RNA #biophysics #SARSCoV2 #singlemolecule #Covid
Reposted by York Biomedical Research Institute
🚨New Preprint! Latest research led by
@jemmabetts.bsky.social & @chillzaa.bsky.social
reveals the structure of a protein-dependent riboswitch, revealing new mechanistic principles that could inspire novel antivirals! Thanks @ukri.org, @ei-science.bsky.social, @ybri-uoy.bsky.social for support! 🔬
@jemmabetts.bsky.social & @chillzaa.bsky.social
reveals the structure of a protein-dependent riboswitch, revealing new mechanistic principles that could inspire novel antivirals! Thanks @ukri.org, @ei-science.bsky.social, @ybri-uoy.bsky.social for support! 🔬
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
A new protein-dependent riboswitch activates ribosomal frameshifting
Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...
www.biorxiv.org
July 21, 2025 at 9:45 AM
🚨New Preprint! Latest research led by
@jemmabetts.bsky.social & @chillzaa.bsky.social
reveals the structure of a protein-dependent riboswitch, revealing new mechanistic principles that could inspire novel antivirals! Thanks @ukri.org, @ei-science.bsky.social, @ybri-uoy.bsky.social for support! 🔬
@jemmabetts.bsky.social & @chillzaa.bsky.social
reveals the structure of a protein-dependent riboswitch, revealing new mechanistic principles that could inspire novel antivirals! Thanks @ukri.org, @ei-science.bsky.social, @ybri-uoy.bsky.social for support! 🔬
Reposted by York Biomedical Research Institute
Yorkshire Cancer Research hosted the White Rose Cancer Report launch event in Sheffield on 3rd July
Yorkshire is one of the regions hardest hit by cancer
Karen, David and Geoff shared their positive experiences, and how patient-centric care has literally saved their lives
Yorkshire is one of the regions hardest hit by cancer
Karen, David and Geoff shared their positive experiences, and how patient-centric care has literally saved their lives
July 18, 2025 at 1:04 PM
Yorkshire Cancer Research hosted the White Rose Cancer Report launch event in Sheffield on 3rd July
Yorkshire is one of the regions hardest hit by cancer
Karen, David and Geoff shared their positive experiences, and how patient-centric care has literally saved their lives
Yorkshire is one of the regions hardest hit by cancer
Karen, David and Geoff shared their positive experiences, and how patient-centric care has literally saved their lives
Reposted by York Biomedical Research Institute
We have a new 3-year PDRA post in Cancer Immunology. Ideal if you have a background in T cells, ideally human, and are interested in cancer immunology and RNA medicine. It’ll be fun!
www.jobs.ac.uk/job/DNV085/r...
Funded by @yorkagainstcancer.bsky.social
@hyms.ac.uk
@ybri-uoy.bsky.social
www.jobs.ac.uk/job/DNV085/r...
Funded by @yorkagainstcancer.bsky.social
@hyms.ac.uk
@ybri-uoy.bsky.social
jobs.york.ac.uk
July 15, 2025 at 11:36 AM
We have a new 3-year PDRA post in Cancer Immunology. Ideal if you have a background in T cells, ideally human, and are interested in cancer immunology and RNA medicine. It’ll be fun!
www.jobs.ac.uk/job/DNV085/r...
Funded by @yorkagainstcancer.bsky.social
@hyms.ac.uk
@ybri-uoy.bsky.social
www.jobs.ac.uk/job/DNV085/r...
Funded by @yorkagainstcancer.bsky.social
@hyms.ac.uk
@ybri-uoy.bsky.social
Reposted by York Biomedical Research Institute
(1/4) Three new pieces of research have been published from the ProteoStem ( www.proteostem.co.uk ) research group @billgrey.bsky.social working in @biologyatyork.bsky.social @ybri-uoy.bsky.social @cbr-uoy.bsky.social
Homepage - Proteo Stem
www.proteostem.co.uk
July 10, 2025 at 2:04 PM
(1/4) Three new pieces of research have been published from the ProteoStem ( www.proteostem.co.uk ) research group @billgrey.bsky.social working in @biologyatyork.bsky.social @ybri-uoy.bsky.social @cbr-uoy.bsky.social
Reposted by York Biomedical Research Institute
www.nature.com/articles/s41...
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications
Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...
www.nature.com
July 5, 2025 at 9:08 AM
www.nature.com/articles/s41...
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
Reposted by York Biomedical Research Institute
New review on synthetic HEG drives in Ae. aegypti from Joshua Ang and Luke Alphey (@ybri-uoy.bsky.social) They examine challenges, propose the CHIROS framework to guide future development, and discuss paths forward for this vector control strategy. pmc.ncbi.nlm.nih.gov/articles/PMC...
Synthetic Homing Endonuclease Gene Drives to Revolutionise Aedes aegypti Biocontrol - Game Changer or Pipe Dream?
The increasing burden of Aedes aegypti-borne diseases, particularly dengue, is a growing global concern, further exacerbated by climate change. Current control strategies have proven insufficient, nec...
pmc.ncbi.nlm.nih.gov
July 1, 2025 at 8:27 AM
New review on synthetic HEG drives in Ae. aegypti from Joshua Ang and Luke Alphey (@ybri-uoy.bsky.social) They examine challenges, propose the CHIROS framework to guide future development, and discuss paths forward for this vector control strategy. pmc.ncbi.nlm.nih.gov/articles/PMC...