Yap Research group
@yap-lab.bsky.social
We explore how cells stick together and fall apart..focussing on how cell-cell adhesion, apoptotic extrusion and tissue mechanics regulate epithelial homeostasis 🧫🔬
@AlphaYap’s lab at IMB, Brisbane
@AlphaYap’s lab at IMB, Brisbane
Reposted by Yap Research group
A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding
Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.
tinyurl.com
September 13, 2025 at 6:05 PM
A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2
Excellent work by @juliaeckert.bsky.social- now online!
Now published in @natcomms.nature.com! 🥳
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
August 22, 2025 at 6:02 AM
Excellent work by @juliaeckert.bsky.social- now online!
Reposted by Yap Research group
What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations?
I'm @juliaeckert.bsky.social. Let's explore some analysis software!
I'm @juliaeckert.bsky.social. Let's explore some analysis software!
June 8, 2025 at 7:01 AM
What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations?
I'm @juliaeckert.bsky.social. Let's explore some analysis software!
I'm @juliaeckert.bsky.social. Let's explore some analysis software!
Reposted by Yap Research group
Got this fantastic opportunity to attend a special interest symposium at MIMS2025, and present a poster about my ongoing scRNAseq work. Brilliant talks and engaging discussions- thank you Australian and New Zealand Society for Immunology for hosting such an insightful event! #scrnaseq #immunology
May 24, 2025 at 8:43 AM
Got this fantastic opportunity to attend a special interest symposium at MIMS2025, and present a poster about my ongoing scRNAseq work. Brilliant talks and engaging discussions- thank you Australian and New Zealand Society for Immunology for hosting such an insightful event! #scrnaseq #immunology
How do epithelia adapt to mechanical stresses? What roles do junctional complexes AJs & desmosomes play in this mechanotransduction?
Check out our new review article by @juliaeckert.bsky.social & Virgile Viasnoff, discussing these ideas! 👇
Check out our new review article by @juliaeckert.bsky.social & Virgile Viasnoff, discussing these ideas! 👇
Our new review paper from @yap-lab.bsky.social is online - together with Virgile Viasnoff!
👉 'New directions in epithelial mechanoadaptation'
www.sciencedirect.com/science/arti...
👉 'New directions in epithelial mechanoadaptation'
www.sciencedirect.com/science/arti...
May 25, 2025 at 6:50 AM
How do epithelia adapt to mechanical stresses? What roles do junctional complexes AJs & desmosomes play in this mechanotransduction?
Check out our new review article by @juliaeckert.bsky.social & Virgile Viasnoff, discussing these ideas! 👇
Check out our new review article by @juliaeckert.bsky.social & Virgile Viasnoff, discussing these ideas! 👇
Congratulations @juliaeckert.bsky.social for this feat!
Started my first day as a Walter Benjamin Fellow! 🥳
Looking forward to study symmetry-breaking in morphogenesis using and connecting concepts from soft matter physics & cell/molecular biology @yap-lab.bsky.social. 👉 physics meets biology!
Big thanks to the @dfg.de for funding my research.
Looking forward to study symmetry-breaking in morphogenesis using and connecting concepts from soft matter physics & cell/molecular biology @yap-lab.bsky.social. 👉 physics meets biology!
Big thanks to the @dfg.de for funding my research.
May 1, 2025 at 4:30 AM
Congratulations @juliaeckert.bsky.social for this feat!
Reposted by Yap Research group
Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A TRPV4–dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin–based lamellipodia protrusions...
www.biorxiv.org
March 30, 2025 at 11:41 AM
Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Yap Research group
How is extrusion of infected host cells related to ERK (extracellular signal-regulated kinase) activity?
Hi, I’m @hundsdorfer.bsky.social from the @effiebastounis.bsky.social lab. Let’s follow the recent development of bacterially-infected cell extrusion & mechanochemical ERK activity waves.
Hi, I’m @hundsdorfer.bsky.social from the @effiebastounis.bsky.social lab. Let’s follow the recent development of bacterially-infected cell extrusion & mechanochemical ERK activity waves.
March 30, 2025 at 7:57 AM
How is extrusion of infected host cells related to ERK (extracellular signal-regulated kinase) activity?
Hi, I’m @hundsdorfer.bsky.social from the @effiebastounis.bsky.social lab. Let’s follow the recent development of bacterially-infected cell extrusion & mechanochemical ERK activity waves.
Hi, I’m @hundsdorfer.bsky.social from the @effiebastounis.bsky.social lab. Let’s follow the recent development of bacterially-infected cell extrusion & mechanochemical ERK activity waves.
Reposted by Yap Research group
Happy to share our new publication in
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...
March 14, 2025 at 12:10 PM
Happy to share our new publication in
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...
Reposted by Yap Research group
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
March 10, 2025 at 2:43 AM
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
Reposted by Yap Research group
This dot is a region that intersect multiple cell junctions in an epithelia. These dots act as tiny anchors of cell contacts and they’re critical for epithelial coherence during homeostasis AND development.
I’m @katecavanaugh.bsky.social and I’ll be your guide on this 🧵 about tricellular vertices.
I’m @katecavanaugh.bsky.social and I’ll be your guide on this 🧵 about tricellular vertices.
March 9, 2025 at 6:45 AM
This dot is a region that intersect multiple cell junctions in an epithelia. These dots act as tiny anchors of cell contacts and they’re critical for epithelial coherence during homeostasis AND development.
I’m @katecavanaugh.bsky.social and I’ll be your guide on this 🧵 about tricellular vertices.
I’m @katecavanaugh.bsky.social and I’ll be your guide on this 🧵 about tricellular vertices.
Reposted by Yap Research group
ICYMI: Discover new insights on chromosome size sensing by kinetochores, mechanical resistance at tight junctions, force-exerting focal adhesions formed by T cells, and how nuclei serve as mechanical bumpers, in our new #Mechanobiology collection 👉 https://buff.ly/3EK0uaq
February 26, 2025 at 8:12 PM
ICYMI: Discover new insights on chromosome size sensing by kinetochores, mechanical resistance at tight junctions, force-exerting focal adhesions formed by T cells, and how nuclei serve as mechanical bumpers, in our new #Mechanobiology collection 👉 https://buff.ly/3EK0uaq
Reposted by Yap Research group
🚨 We are thrilled to announce our amazing list of keynote speakers!!
@PCusachs
@GeorgHalder
@hirashima0203.bsky.social
@iberd.bsky.social
@johannaivaska.bsky.social
@gijsjekoenderink.bsky.social
@laurentnguyen.com
@renkawitzteam.bsky.social
@Sixt_Lab
...
@PCusachs
@GeorgHalder
@hirashima0203.bsky.social
@iberd.bsky.social
@johannaivaska.bsky.social
@gijsjekoenderink.bsky.social
@laurentnguyen.com
@renkawitzteam.bsky.social
@Sixt_Lab
...
February 4, 2025 at 7:30 AM
🚨 We are thrilled to announce our amazing list of keynote speakers!!
@PCusachs
@GeorgHalder
@hirashima0203.bsky.social
@iberd.bsky.social
@johannaivaska.bsky.social
@gijsjekoenderink.bsky.social
@laurentnguyen.com
@renkawitzteam.bsky.social
@Sixt_Lab
...
@PCusachs
@GeorgHalder
@hirashima0203.bsky.social
@iberd.bsky.social
@johannaivaska.bsky.social
@gijsjekoenderink.bsky.social
@laurentnguyen.com
@renkawitzteam.bsky.social
@Sixt_Lab
...
Reposted by Yap Research group
Epigenetics Gordon Research Conference. Consider joining us for what will be an excellent, exciting meeting and will be held in Europe for the first time: 10-15 Aug25 Barcelona, Spain. Please repost and apply early - this meeting is popular! www.grc.org/epigenetics-...
2025 Epigenetics Conference GRC
The 2025 Gordon Research Conference on Epigenetics will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
www.grc.org
February 25, 2025 at 4:54 PM
Epigenetics Gordon Research Conference. Consider joining us for what will be an excellent, exciting meeting and will be held in Europe for the first time: 10-15 Aug25 Barcelona, Spain. Please repost and apply early - this meeting is popular! www.grc.org/epigenetics-...
Want to learn more about cell extrusion? What causes it and why is it essential? Check out this fantastic thread by our student @zoya-mann.bsky.social elaborating on the epithelial mechanics of cell extrusion!👇
Follow @epimechfc.bsky.social for more such cool threads..
Follow @epimechfc.bsky.social for more such cool threads..
How do epithelial monolayers respond to apoptotic cells? What happens to these cells within hypertensile epithelia?More importantly, what is hypertensile epithelia and what leads to it?
I am @zoya-mann.bsky.social and I will talk about epithelial mechanics of apoptotic cell extrusion.
I am @zoya-mann.bsky.social and I will talk about epithelial mechanics of apoptotic cell extrusion.
February 22, 2025 at 8:55 PM
Want to learn more about cell extrusion? What causes it and why is it essential? Check out this fantastic thread by our student @zoya-mann.bsky.social elaborating on the epithelial mechanics of cell extrusion!👇
Follow @epimechfc.bsky.social for more such cool threads..
Follow @epimechfc.bsky.social for more such cool threads..
Reposted by Yap Research group
My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email
Cell and Tissue Dynamics (Wickström)
www.mpi-muenster.mpg.de
February 15, 2025 at 8:42 PM
My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email
Reposted by Yap Research group
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
January 3, 2025 at 3:33 PM
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Reposted by Yap Research group
Roffay, C., Chan, C. J., Guirao, B., Hiiragi, T., & Graner, F. (2021). Inferring cell junction tension and pressure from cell geometry. Development (Cambridge, England), 148(18), dev192773. #EpithelialMechanicsReview
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
February 13, 2025 at 7:30 AM
Roffay, C., Chan, C. J., Guirao, B., Hiiragi, T., & Graner, F. (2021). Inferring cell junction tension and pressure from cell geometry. Development (Cambridge, England), 148(18), dev192773. #EpithelialMechanicsReview
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Check this out!👇
Our new work reveals anilin’s putative role in mediating actomyosin remodeling and membrane composition
Our new work reveals anilin’s putative role in mediating actomyosin remodeling and membrane composition
Congratulations to Denni from our @yap-lab.bsky.social team and all authors on the new paper! 🥳
'Advecting scaffolds: Controlling the remodeling of actomyosin with anillin' 👇
journals.aps.org/pre/abstract...
'Advecting scaffolds: Controlling the remodeling of actomyosin with anillin' 👇
journals.aps.org/pre/abstract...
February 10, 2025 at 9:33 AM
Check this out!👇
Our new work reveals anilin’s putative role in mediating actomyosin remodeling and membrane composition
Our new work reveals anilin’s putative role in mediating actomyosin remodeling and membrane composition
Reposted by Yap Research group
Two post-doctoral positions to study the mechanisms of epithelial homeostasis are available in the laboratory of Professor Alpha Yap @yap-lab.bsky.social (Institute for Molecular Bioscience, IMB, University of Queensland).
focalplane.biologists.com/cell-biology...
focalplane.biologists.com/cell-biology...
Two post-doctoral positions to study the mechanisms of epithelial homeostasis - FocalPlane
Two post-doctoral positions to study the mechanisms of epithelial homeostasis are available in the laboratory of Professor Alpha Yap (Institute for Molecular Bioscience, IMB, University of Queensland)...
focalplane.biologists.com
February 7, 2025 at 1:21 PM
Two post-doctoral positions to study the mechanisms of epithelial homeostasis are available in the laboratory of Professor Alpha Yap @yap-lab.bsky.social (Institute for Molecular Bioscience, IMB, University of Queensland).
focalplane.biologists.com/cell-biology...
focalplane.biologists.com/cell-biology...
Reposted by Yap Research group
🚨Postdoc vacancy alert!
Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?
2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...
Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?
2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...
February 3, 2025 at 1:06 AM
🚨Postdoc vacancy alert!
Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?
2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...
Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?
2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...
Looking for a tool to analyse cell / tissue orientation on surfaces of 3D systems?
Check out this extremely user friendly tool generated by @juliaeckert.bsky.social in her new preprint👇
Check out this extremely user friendly tool generated by @juliaeckert.bsky.social in her new preprint👇
Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems!
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇
February 3, 2025 at 11:17 PM
Looking for a tool to analyse cell / tissue orientation on surfaces of 3D systems?
Check out this extremely user friendly tool generated by @juliaeckert.bsky.social in her new preprint👇
Check out this extremely user friendly tool generated by @juliaeckert.bsky.social in her new preprint👇
🚨Postdoc vacancy alert!
Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?
2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...
Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?
2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...
February 3, 2025 at 1:06 AM
🚨Postdoc vacancy alert!
Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?
2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...
Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?
2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...
Reposted by Yap Research group
Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems!
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇
January 29, 2025 at 11:01 PM
Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems!
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇