The West Lab @ The Crick
@westlabcrick.bsky.social
The West Lab @TheCrick studies mechanisms of DNA Recombination and Repair. Tweets by lab members, unless signed SCW. Views are own.
https://www.crick.ac.uk/research/labs/stephen-west
https://www.crick.ac.uk/research/labs/stephen-west
Pinned
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
Reposted by The West Lab @ The Crick
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 4, 2025 at 8:18 PM
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Reposted by The West Lab @ The Crick
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cohesin drives chromatin scanning during the RAD51-mediated homology search
Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...
www.science.org
December 4, 2025 at 9:50 PM
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by The West Lab @ The Crick
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
A role for human senataxin in contending with pausing and backtracking during transcript elongation
Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. Howev…
www.sciencedirect.com
November 12, 2025 at 5:36 PM
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
November 7, 2025 at 10:15 AM
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
New review out on molecular glues: turning serendipitous hits into smartly designed drugs that tag cancer-linked proteins for destruction 🧬💥💊
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
From serendipity to strategy: molecular glue degraders in cancer therapeutics
Targeted protein degradation is an elegant therapeutic strategy that harnesses the cell’s own degradation machinery to selectively eliminate target proteins. This approach marks a paradigm shift in...
www.tandfonline.com
November 4, 2025 at 9:53 PM
New review out on molecular glues: turning serendipitous hits into smartly designed drugs that tag cancer-linked proteins for destruction 🧬💥💊
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Reposted by The West Lab @ The Crick
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
June 20, 2025 at 9:38 AM
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
A photo from the recombination mechanisms conference in Crete last week. Thanks to the @fusionconf.bsky.social team, speakers, poster presenters and attendees for a great meeting!
May 20, 2025 at 6:51 PM
A photo from the recombination mechanisms conference in Crete last week. Thanks to the @fusionconf.bsky.social team, speakers, poster presenters and attendees for a great meeting!
Reposted by The West Lab @ The Crick
Update on #Recombination25 Conference! 🚨
📅RD & PS Deadline: 13th March 2025. DON'T MISS OUT!
🌟Grants are available for students, postdocs & junior investigators!🌟
For more details, visit bit.ly/41v8IuK or email Felicity at 📧felicity@fusion-conferences.com
@westlabcrick.bsky.social
📅RD & PS Deadline: 13th March 2025. DON'T MISS OUT!
🌟Grants are available for students, postdocs & junior investigators!🌟
For more details, visit bit.ly/41v8IuK or email Felicity at 📧felicity@fusion-conferences.com
@westlabcrick.bsky.social
March 6, 2025 at 9:01 AM
Update on #Recombination25 Conference! 🚨
📅RD & PS Deadline: 13th March 2025. DON'T MISS OUT!
🌟Grants are available for students, postdocs & junior investigators!🌟
For more details, visit bit.ly/41v8IuK or email Felicity at 📧felicity@fusion-conferences.com
@westlabcrick.bsky.social
📅RD & PS Deadline: 13th March 2025. DON'T MISS OUT!
🌟Grants are available for students, postdocs & junior investigators!🌟
For more details, visit bit.ly/41v8IuK or email Felicity at 📧felicity@fusion-conferences.com
@westlabcrick.bsky.social
Talk submission deadline coming up on 10th February 2025!
🚨 DEADLINE UPDATE 🚨
The #Recombination25 talk submission deadline has been EXTENDED! 📅
🔔 NEW DEADLINE: 10th February 2025.
This is the FINAL extension, so don’t miss out on the chance to share your research!
Submit your abstract today! 🌟 bit.ly/3VunqAk
The #Recombination25 talk submission deadline has been EXTENDED! 📅
🔔 NEW DEADLINE: 10th February 2025.
This is the FINAL extension, so don’t miss out on the chance to share your research!
Submit your abstract today! 🌟 bit.ly/3VunqAk
February 3, 2025 at 12:33 AM
Talk submission deadline coming up on 10th February 2025!
The West lab @crick.ac.uk has finally joined bluesky! Looking forward to sharing (and discovering!) new work 🧬 #recombination #dnarepair #BRCA #cryoEM #cellbiology
January 31, 2025 at 7:19 PM
The West lab @crick.ac.uk has finally joined bluesky! Looking forward to sharing (and discovering!) new work 🧬 #recombination #dnarepair #BRCA #cryoEM #cellbiology