William Amoyal
wamoyal.bsky.social
William Amoyal
@wamoyal.bsky.social
Regional Account Manager at Vizgen. Passionate about omics sciences, entrepreneurship, classical music, opera, history.
Reposted by William Amoyal
🔦 #MERFISH 2.0 enables high-resolution spatial transcriptomics, even in challenging fixed frozen PDAC tissue.

🔬 Through Vizgen Lab Services, Marco Genua (Fondazione Telethon) mapped the tumor microenvironment, overcoming RNA quality challenges.

🔗 hubs.ly/Q038VZgB0
March 4, 2025 at 9:50 PM
Reposted by William Amoyal
A new pre-print study from researchers at Stanford utilized the MERSCOPE® Platform to reveal how aging alters the function, morphology, and mRNA distribution of microglia.

Read the full pre-print: t.co/RmW36N6zni
#SpatialBiology #MERSCOPE #MERFISH
April 2, 2025 at 10:48 PM
Reposted by William Amoyal
A new @cp-cellreports.bsky.social study leveraging MERFISH tech links RNA localization to cell migration, deepening our understanding of gene regulation. This research could help inform future studies in wound healing, cancer metastasis, and mechanobiology.

Read here: www.cell.com/cell-reports...
April 15, 2025 at 9:46 PM
Reposted by William Amoyal
Today, Vizgen takes a major step forward in our mission to unlock deeper biological insights from foundational discovery to translational research with the global launch of MERFISH 2.0 and ADC OmniVUE™ panels.

Learn more in today’s announcement: vizgen.com/vizgen-expan...
April 22, 2025 at 7:15 PM
🧠 𝗧𝗵𝗿𝗶𝗹𝗹𝗲𝗱 𝘁𝗼 𝘀𝗵𝗮𝗿𝗲 𝘁𝗵𝗲 𝗹𝗮𝘁𝗲𝘀𝘁 𝗴𝗿𝗼𝘂𝗻𝗱𝗯𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗼𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿'𝘀 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 🚀

www.biorxiv.org/content/10.1...
A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature
Human microglial heterogeneity is only beginning to be appreciated at the molecular level. Here, we present a large, single-cell atlas of expression signatures from 441,088 live microglia broadly samp...
www.biorxiv.org
March 30, 2025 at 12:11 PM
Reposted by William Amoyal
📣 Registration and abstract submission is now open for the 2025 Norwich #SingleCell and #Spatial Symposium!

We're excited to share our four Keynote Speakers discussing the latest research, technologies, and applications across the field.

Register ➡️ https://buff.ly/4ifjTib
February 27, 2025 at 10:07 AM
Reposted by William Amoyal
🧬 Chromosome Folding Insights! 🧬

Research using #MERFISH reveals stable, long-range chromosome loops over 100 Mb, driven by nucleation centers. This offers new understanding of chromatin organization and cellular function.

#Genomics #ChromosomeFolding #MERFISH

www.biorxiv.org/content/10.1...
Long-range genomic loci stochastically assemble into combinatorial forms of chromosome skeleton
One fundamental yet open question is how eukaryotic chromosomes fold into segregated territories, a process essential for gene transcription and cell fate. Through analyzing Hi-C and chromatin-tracing...
www.biorxiv.org
February 11, 2025 at 12:54 PM
Reposted by William Amoyal
🌟 Bacterial-MERFISH revolutionizes microbiology! Profiles thousands of genes in single cells, revealing spatial gene expression. Unlocks insights into antibiotic resistance and gut health. 🧬✨

#MERFISH #BacterialTranscriptomics #Microbiology

www.science.org/doi/10.1126/...
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
February 12, 2025 at 12:22 PM
🌟 Groundbreaking research maps unique gene expression in human liver using #MERSCOPE and #MERFISH, unveiling key insights into liver function and early steatosis. This spatial atlas sets a new standard for understanding liver health and disease

#MERFISH #MERSCOPE

www.biorxiv.org/content/10.1...
A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liver
Reconstructing gene expression atlases for human tissues is challenging due to limited access to healthy samples from live donors. Neurologically deceased donors often show ischemic changes, while tis...
www.biorxiv.org
February 24, 2025 at 4:25 PM
🌟 Bacterial-MERFISH revolutionizes microbiology! Profiles thousands of genes in single cells, revealing spatial gene expression. Unlocks insights into antibiotic resistance and gut health. 🧬✨

#MERFISH #BacterialTranscriptomics #Microbiology

www.science.org/doi/10.1126/...
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
February 12, 2025 at 12:22 PM
🧬 Chromosome Folding Insights! 🧬

Research using #MERFISH reveals stable, long-range chromosome loops over 100 Mb, driven by nucleation centers. This offers new understanding of chromatin organization and cellular function.

#Genomics #ChromosomeFolding #MERFISH

www.biorxiv.org/content/10.1...
Long-range genomic loci stochastically assemble into combinatorial forms of chromosome skeleton
One fundamental yet open question is how eukaryotic chromosomes fold into segregated territories, a process essential for gene transcription and cell fate. Through analyzing Hi-C and chromatin-tracing...
www.biorxiv.org
February 11, 2025 at 12:54 PM
Reposted by William Amoyal
Bacterial-MERFISH combines 1000-fold volumetric expansion with multiplexed fluorescence in situ hybridization, enabling high-throughput, spatially resolved profiling of thousands of operons within individual bacteria. www.science.org/doi/10.1126/... #NBThighlight
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 24, 2025 at 4:55 PM
Reposted by William Amoyal
🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈

“Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 25, 2025 at 5:33 PM
Reposted by William Amoyal
📣 We're excited to share our invited speakers for the 2025 Norwich #SingleCell and #Spatial symposium!

Abstract submission is open for PhD and Early-Career researchers to present a short talk or poster during the symposium.
buff.ly/3WPzXyJ
February 5, 2025 at 4:04 PM
🚀 New Insights into Endothelial Cell Development! 🧬

Thanks to #MERFISH spatial transcriptomics a team uncovered how tissue origin and vascular positioning shape blood vessel formation.

#SpatialTranscriptomics #MERFISH #SingleCell #VascularDevelopment #CRISPR

www.ahajournals.org/doi/10.1161/...
Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution | Circulation Research
BACKGROUND: Mature endothelial cells (ECs) are heterogeneous, with subtypes defined by tissue origin and position within the vascular bed (ie, artery, capillary, vein, and lymphatic). How this heterog...
www.ahajournals.org
February 7, 2025 at 5:09 PM
Reposted by William Amoyal
Led by Ashleigh Lister at the Earlham Institute and Katie Long at JIC, the study uses EI's @vizgen.bsky.social MERSCOPE platform to profile 200 genes across four stages of #wheat inflorescence development to cellular resolution. 🖥️🧬

#SpatialTranscriptomics @whatchamacaulay.bsky.social
January 2, 2025 at 11:17 AM
Reposted by William Amoyal
ICYMI, our first preprint of 2025 is out, showcasing our first exploration of #SpatialTranscriptomics in plants using @vizgen.bsky.social #MERSCOPE.

A great collab with @katielong.bsky.social and @cristobaluauy.bsky.social at JIC, and Ashleigh Lister and the #SingleCell team at Earlham Institute.
1/10 We are thrilled to share our preprint on spatial transcriptomics in wheat spikes led by the amazing @katielong.bsky.social and Ashleigh Lister. We resolved expression of 200 genes to cellular resolution. Pre-print👉 tinyurl.com/c7t3kncf., @johninnescentre.bsky.social @earlhaminst.bsky.social
January 7, 2025 at 8:21 AM
Reposted by William Amoyal
9/10 Huge merit to @katielong.bsky.social who ensured all data and analysis for this project are publicly accessible. Code👉 tinyurl.com/mtenndje , raw data at 👉 tinyurl.com/2s9cn4s7 , in addition to files that can be explored with the @vizgen.bsky.social MERSCOPE Visualizer Tool.
GitHub - katielong3768/Wheat-Inflorescence-Spatial-Transcriptomics: MERFISH in Wheat Inflorescence Code
MERFISH in Wheat Inflorescence Code. Contribute to katielong3768/Wheat-Inflorescence-Spatial-Transcriptomics development by creating an account on GitHub.
tinyurl.com
January 7, 2025 at 7:32 AM
Reposted by William Amoyal
📣 Registration and abstract submission is now open for the 2025 Norwich #SingleCell and #Spatial Symposium!

We're excited to share our four Keynote Speakers discussing the latest research, technologies, and applications across the field.

Register ➡️ www.earlham.ac.uk/events/norwi...
January 8, 2025 at 8:17 AM
Reposted by William Amoyal
🌾Excited to share a new pre-print from researchers at the
@johninnescentre.bsky.social & @earlhaminst.bsky.social!

Using #MERFISH, the team resolved the expression of 200 genes to cellular resolution, uncovering remarkable insights into inflorescence development.

www.biorxiv.org/content/10.1...
January 8, 2025 at 3:42 PM
Reposted by William Amoyal
We're excited to start 2025 with this preprint from a great collaboration between the Earlham Institute's #singlecell team and the Uauy Group at the @johninnescentre.bsky.social. 👏

#Spatial #Genomics
Spatial Transcriptomics Reveals Expression Gradients in Developing Wheat Inflorescences at Cellular Resolution
The diversity of plant inflorescence architectures is specified by gene expression patterns. In wheat ( Triticum aestivum ), the lanceolate-shaped inflorescence (spike) is defined by rudimentary spike...
www.biorxiv.org
January 2, 2025 at 11:17 AM