Sarah Walmsley Lab
@walmsley-lab.bsky.social
Lab updates from the Walmsley Lab EdinUni_CIR & @edinuni-irr.bsky.social
Studying how oxygen and nutrient availability reprogram #neutrophils posts by @ajbrenes.com
Studying how oxygen and nutrient availability reprogram #neutrophils posts by @ajbrenes.com
Pinned
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...
www.biorxiv.org
A nice thread explaining our recent work using mass spectrometry-based single cell proteomics to study tumour associated neutrophils in human glioblastoma.
Exciting populations with clear functional states that correlate well with neutrophil effector functions. Go take a look
Exciting populations with clear functional states that correlate well with neutrophil effector functions. Go take a look
Reposted by Sarah Walmsley Lab
We (@walmsley-lab.bsky.social) are thrilled to have our pre-print highlighted by the Journal Club from @natrevimmunol.nature.com
We think single cell proteomics has the capacity to revolutionise our understanding of neutrophil functional heterogeneity, shown here in glioblastoma.
We think single cell proteomics has the capacity to revolutionise our understanding of neutrophil functional heterogeneity, shown here in glioblastoma.
Single-cell proteomics sheds light on neutrophil diversity in glioblastoma - Nature Reviews Immunology
A preprint by Sadiku et al. characterizes neutrophil diversity in glioblastoma using a new workflow for single-cell proteomic profiling.
www.nature.com
November 11, 2025 at 2:25 PM
We (@walmsley-lab.bsky.social) are thrilled to have our pre-print highlighted by the Journal Club from @natrevimmunol.nature.com
We think single cell proteomics has the capacity to revolutionise our understanding of neutrophil functional heterogeneity, shown here in glioblastoma.
We think single cell proteomics has the capacity to revolutionise our understanding of neutrophil functional heterogeneity, shown here in glioblastoma.
Reposted by Sarah Walmsley Lab
🎉Thrilled to share that my Wellcome ECA has been funded.🎉 I'll be using ultra-sensitive proteomics—mini-bulk and single-cell—to map neutrophil functional states in COPD.
Hugely grateful to @wellcometrust.bsky.social, my host @walmsley-lab.bsky.social and @edinuni-irr.bsky.social colleagues 🙏.
Hugely grateful to @wellcometrust.bsky.social, my host @walmsley-lab.bsky.social and @edinuni-irr.bsky.social colleagues 🙏.
November 6, 2025 at 7:05 PM
🎉Thrilled to share that my Wellcome ECA has been funded.🎉 I'll be using ultra-sensitive proteomics—mini-bulk and single-cell—to map neutrophil functional states in COPD.
Hugely grateful to @wellcometrust.bsky.social, my host @walmsley-lab.bsky.social and @edinuni-irr.bsky.social colleagues 🙏.
Hugely grateful to @wellcometrust.bsky.social, my host @walmsley-lab.bsky.social and @edinuni-irr.bsky.social colleagues 🙏.
Reposted by Sarah Walmsley Lab
Highlight of @natimmunol.nature.com paper by @mas-g.bsky.social @walmsley-lab.bsky.social showing epigenetic reprogramming of neutrophils in response to hypoxia to reduce lung tissue damage
#immunosky
#immunosky
Hypoxia-induced epigenetic reprogramming of neutrophil progenitors - Nature Reviews Immunology
Sanchez-Garcia et al. report that systemic hypoxia-induced epigenetic reprogramming of neutrophil progenitors in the bone marrow reduces their effector function to limit lung tissue damage.
www.nature.com
November 5, 2025 at 11:43 AM
Highlight of @natimmunol.nature.com paper by @mas-g.bsky.social @walmsley-lab.bsky.social showing epigenetic reprogramming of neutrophils in response to hypoxia to reduce lung tissue damage
#immunosky
#immunosky
Reposted by Sarah Walmsley Lab
Thrilled to see online our latest paper on hypoxia and neutrophil memory #Huge_team_effort @walmsley-lab.bsky.social in @edinuni-irr.bsky.social. Huge thanks to all our collaborators and blood donors.
rdcu.be/eM5MT
rdcu.be/eM5MT
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
rdcu.be
October 28, 2025 at 6:38 PM
Thrilled to see online our latest paper on hypoxia and neutrophil memory #Huge_team_effort @walmsley-lab.bsky.social in @edinuni-irr.bsky.social. Huge thanks to all our collaborators and blood donors.
rdcu.be/eM5MT
rdcu.be/eM5MT
Reposted by Sarah Walmsley Lab
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
rdcu.be
October 28, 2025 at 11:24 AM
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Reposted by Sarah Walmsley Lab
Students celebrate their IRR internship 🧑🔬
For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes.
Read about the experience on IRR stories: edin.ac/4oPP33G
For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes.
Read about the experience on IRR stories: edin.ac/4oPP33G
Students celebrate their IRR internship | Institute for Regeneration and Repair | Institute for Regeneration and Repair
For four weeks this summer, IRR hosted local high school students as part of both the BioQuarter’s Summer Interns and University’s Career Ready programmes.
edin.ac
August 25, 2025 at 2:05 PM
Students celebrate their IRR internship 🧑🔬
For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes.
Read about the experience on IRR stories: edin.ac/4oPP33G
For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes.
Read about the experience on IRR stories: edin.ac/4oPP33G
Reposted by Sarah Walmsley Lab
🚨 New preprint alert!
@pranvera.bsky.social uses single-cell proteomics + #Spectronaut® to decode neutrophil roles in glioblastoma.
1,100 proteins from single cells—revealing dynamic states in brain cancer.
🔬 Read more: www.biorxiv.org/content/10.1...
@pranvera.bsky.social uses single-cell proteomics + #Spectronaut® to decode neutrophil roles in glioblastoma.
1,100 proteins from single cells—revealing dynamic states in brain cancer.
🔬 Read more: www.biorxiv.org/content/10.1...
August 15, 2025 at 11:34 AM
🚨 New preprint alert!
@pranvera.bsky.social uses single-cell proteomics + #Spectronaut® to decode neutrophil roles in glioblastoma.
1,100 proteins from single cells—revealing dynamic states in brain cancer.
🔬 Read more: www.biorxiv.org/content/10.1...
@pranvera.bsky.social uses single-cell proteomics + #Spectronaut® to decode neutrophil roles in glioblastoma.
1,100 proteins from single cells—revealing dynamic states in brain cancer.
🔬 Read more: www.biorxiv.org/content/10.1...
Reposted by Sarah Walmsley Lab
Excellent work!! I just love the term Mini-Bulk so I had chatGPT help me whip something up
July 28, 2025 at 11:19 PM
Excellent work!! I just love the term Mini-Bulk so I had chatGPT help me whip something up
Reposted by Sarah Walmsley Lab
In summary, we do single cell proteomics of glioblastoma neutrophils and find exciting functional states invisible to scRNAseq which further define the roles that neutrophils play within glioblastomas, showing some pro-tumorigenic and anti-tumorigenic populations and properties
July 27, 2025 at 12:41 PM
In summary, we do single cell proteomics of glioblastoma neutrophils and find exciting functional states invisible to scRNAseq which further define the roles that neutrophils play within glioblastomas, showing some pro-tumorigenic and anti-tumorigenic populations and properties
Reposted by Sarah Walmsley Lab
So excited to see this powerful work out from @ajbrenes.com and team. Neutrophils never cease to amaze. Read on for an awesome science thread. Pushing the limits of single cell proteomics at ~30 picograms per cell 🤯
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...
www.biorxiv.org
July 27, 2025 at 2:30 PM
So excited to see this powerful work out from @ajbrenes.com and team. Neutrophils never cease to amaze. Read on for an awesome science thread. Pushing the limits of single cell proteomics at ~30 picograms per cell 🤯
Reposted by Sarah Walmsley Lab
I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!
July 26, 2025 at 12:17 PM
I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!
A nice thread explaining our recent work using mass spectrometry-based single cell proteomics to study tumour associated neutrophils in human glioblastoma.
Exciting populations with clear functional states that correlate well with neutrophil effector functions. Go take a look
Exciting populations with clear functional states that correlate well with neutrophil effector functions. Go take a look
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...
www.biorxiv.org
July 27, 2025 at 1:53 PM
A nice thread explaining our recent work using mass spectrometry-based single cell proteomics to study tumour associated neutrophils in human glioblastoma.
Exciting populations with clear functional states that correlate well with neutrophil effector functions. Go take a look
Exciting populations with clear functional states that correlate well with neutrophil effector functions. Go take a look
Reposted by Sarah Walmsley Lab
New work from @soehnleinlab.bsky.social
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus
@natimmunol.bsky.social
www.nature.com/articles/s41...
@natimmunol.bsky.social
www.nature.com/articles/s41...
January 9, 2025 at 9:00 PM
New work from @soehnleinlab.bsky.social
Reposted by Sarah Walmsley Lab
12th Day of Research: IRR in the community🔎
Last but not least in our #12DaysOfResearch we’re spotlighting our partnership with the local community. This year we have been thrilled with the vibrant activity from researchers, local schools and members of the public. #Community
Last but not least in our #12DaysOfResearch we’re spotlighting our partnership with the local community. This year we have been thrilled with the vibrant activity from researchers, local schools and members of the public. #Community
December 24, 2024 at 8:48 PM
12th Day of Research: IRR in the community🔎
Last but not least in our #12DaysOfResearch we’re spotlighting our partnership with the local community. This year we have been thrilled with the vibrant activity from researchers, local schools and members of the public. #Community
Last but not least in our #12DaysOfResearch we’re spotlighting our partnership with the local community. This year we have been thrilled with the vibrant activity from researchers, local schools and members of the public. #Community
Reposted by Sarah Walmsley Lab
Just less than a month to apply for this exciting PhD project working toward #salivarygland #regeneration after #cancer treatment.
If you're interested in joining us as a #PhD student at @edinuni-irr.bsky.social we are advertising a project to develop a localised #drug delivery system for #salivarygland #regeneration after #cancer #radiotherapy usher.ed.ac.uk/node/158254 Q&A session on 5/12/24, application deadline 13/01/25.
Developing a novel catalytic uncaging drug delivery system to deliver a focal therapy for post-radiotherapy tissue regeneration
Precision Medicine Project - Developing a novel catalytic uncaging drug delivery system to deliver a focal therapy for post-radiotherapy tissue regeneration
usher.ed.ac.uk
December 17, 2024 at 8:25 AM
Just less than a month to apply for this exciting PhD project working toward #salivarygland #regeneration after #cancer treatment.
Reposted by Sarah Walmsley Lab
Thinking of starting your own research group? Why not choose the IRR?
We spoke to 2019 UKRI Future Leaders Fellow Rod Mitchell about the fellowship and the opportunities it can bring.
🎞️Watch the video and find out more on our website: regeneration-repair.ed.ac.uk/work-with-us...
We spoke to 2019 UKRI Future Leaders Fellow Rod Mitchell about the fellowship and the opportunities it can bring.
🎞️Watch the video and find out more on our website: regeneration-repair.ed.ac.uk/work-with-us...
December 17, 2024 at 5:22 PM
Thinking of starting your own research group? Why not choose the IRR?
We spoke to 2019 UKRI Future Leaders Fellow Rod Mitchell about the fellowship and the opportunities it can bring.
🎞️Watch the video and find out more on our website: regeneration-repair.ed.ac.uk/work-with-us...
We spoke to 2019 UKRI Future Leaders Fellow Rod Mitchell about the fellowship and the opportunities it can bring.
🎞️Watch the video and find out more on our website: regeneration-repair.ed.ac.uk/work-with-us...
Reposted by Sarah Walmsley Lab
What a treat to have @ajmhowden.bsky.social visiting @edinuni-irr.bsky.social to talk to us about studying B cell metabolism and protein synthesis capacity using proteomics.
December 3, 2024 at 11:14 AM
What a treat to have @ajmhowden.bsky.social visiting @edinuni-irr.bsky.social to talk to us about studying B cell metabolism and protein synthesis capacity using proteomics.
Reposted by Sarah Walmsley Lab
🥳As we approach the end of 2024, we’re celebrating our year of fantastic community and scientific achievement with our #12DaysOfResearch series.
Stay tuned for our posts throughout December, reminiscing on the incredible work achieved by our IRR colleagues.
Stay tuned for our posts throughout December, reminiscing on the incredible work achieved by our IRR colleagues.
December 2, 2024 at 12:21 PM
🥳As we approach the end of 2024, we’re celebrating our year of fantastic community and scientific achievement with our #12DaysOfResearch series.
Stay tuned for our posts throughout December, reminiscing on the incredible work achieved by our IRR colleagues.
Stay tuned for our posts throughout December, reminiscing on the incredible work achieved by our IRR colleagues.
Reposted by Sarah Walmsley Lab
1st Day of Research: Grand Opening of IRR South 🍾
In January we were joined by Chancellor of the University of Edinburgh, Her Royal Highness The Princess Royal, to officially open the state-of-the-art IRR South building.
📰 Read more here: edin.ac/4eoFtym
#12DaysOfResearch
In January we were joined by Chancellor of the University of Edinburgh, Her Royal Highness The Princess Royal, to officially open the state-of-the-art IRR South building.
📰 Read more here: edin.ac/4eoFtym
#12DaysOfResearch
December 2, 2024 at 12:24 PM
1st Day of Research: Grand Opening of IRR South 🍾
In January we were joined by Chancellor of the University of Edinburgh, Her Royal Highness The Princess Royal, to officially open the state-of-the-art IRR South building.
📰 Read more here: edin.ac/4eoFtym
#12DaysOfResearch
In January we were joined by Chancellor of the University of Edinburgh, Her Royal Highness The Princess Royal, to officially open the state-of-the-art IRR South building.
📰 Read more here: edin.ac/4eoFtym
#12DaysOfResearch
Reposted by Sarah Walmsley Lab
Join us!! On here where the sky is blue, & in the Society. A fantastic place to talk #cytokines, #interferons, the coolest #immunology, and a very nice place to meet new people, make new friends, & start new collaborations!
Please help us add voices to our Starter Pack go.bsky.app/J3zbtA2 (I think this is how this works....)
November 25, 2024 at 2:21 PM
Join us!! On here where the sky is blue, & in the Society. A fantastic place to talk #cytokines, #interferons, the coolest #immunology, and a very nice place to meet new people, make new friends, & start new collaborations!
Reposted by Sarah Walmsley Lab
As World AMR Awareness Week comes to a close, we have written a quick digest of some of the activites and events happening in Edinburgh.
It is imperative that the work continues all year round if we are ever to beat this crisis.
#WAAW24
edinburgh-infectious-diseases.ed.ac.uk/news-and-eve...
It is imperative that the work continues all year round if we are ever to beat this crisis.
#WAAW24
edinburgh-infectious-diseases.ed.ac.uk/news-and-eve...
World Antimicrobial Resistance Awareness Week at the University of Edinburgh
November 2024: A digest of events, research papers and activities happening in and around the University of Edinburgh to mark World AMR Awareness Week 24 (#WAAW24).
edinburgh-infectious-diseases.ed.ac.uk
November 25, 2024 at 11:08 AM
As World AMR Awareness Week comes to a close, we have written a quick digest of some of the activites and events happening in Edinburgh.
It is imperative that the work continues all year round if we are ever to beat this crisis.
#WAAW24
edinburgh-infectious-diseases.ed.ac.uk/news-and-eve...
It is imperative that the work continues all year round if we are ever to beat this crisis.
#WAAW24
edinburgh-infectious-diseases.ed.ac.uk/news-and-eve...
Reposted by Sarah Walmsley Lab
📣 Announcing our latest BSI Career Enhancing Grant winners!
Congratulations to our 12 members who have been awarded #funding to advance their #CareerDevelopment 🚀
Discover the projects we're supporting to boost #CareersInImmunology here 👉 bit.ly/4fXdtD1
1/2
Congratulations to our 12 members who have been awarded #funding to advance their #CareerDevelopment 🚀
Discover the projects we're supporting to boost #CareersInImmunology here 👉 bit.ly/4fXdtD1
1/2
November 21, 2024 at 4:06 PM
📣 Announcing our latest BSI Career Enhancing Grant winners!
Congratulations to our 12 members who have been awarded #funding to advance their #CareerDevelopment 🚀
Discover the projects we're supporting to boost #CareersInImmunology here 👉 bit.ly/4fXdtD1
1/2
Congratulations to our 12 members who have been awarded #funding to advance their #CareerDevelopment 🚀
Discover the projects we're supporting to boost #CareersInImmunology here 👉 bit.ly/4fXdtD1
1/2
Reposted by Sarah Walmsley Lab
Dr Neil Ryan, Clinical Lecturer at our Centre for Reproductive Health and the Institute for Genetics and Cancer at UoE, has been awarded an Eve scholarship from The Eve Appeal
and North West Cancer Research
regeneration-repair.ed.ac.uk/crh-research... Congratulations Neil!
and North West Cancer Research
regeneration-repair.ed.ac.uk/crh-research... Congratulations Neil!
November 22, 2024 at 4:07 PM
Dr Neil Ryan, Clinical Lecturer at our Centre for Reproductive Health and the Institute for Genetics and Cancer at UoE, has been awarded an Eve scholarship from The Eve Appeal
and North West Cancer Research
regeneration-repair.ed.ac.uk/crh-research... Congratulations Neil!
and North West Cancer Research
regeneration-repair.ed.ac.uk/crh-research... Congratulations Neil!
Several Walmsley lab members are already on Bluesky. Please give them a follow if you haven't already:
@patriciacoelho.bsky.social
@pranvera.bsky.social
@mas-g.bsky.social
@alejandrobrenes.bsky.social
#neutrophil #teamNeutrophil
@patriciacoelho.bsky.social
@pranvera.bsky.social
@mas-g.bsky.social
@alejandrobrenes.bsky.social
#neutrophil #teamNeutrophil
November 21, 2024 at 9:02 PM
Several Walmsley lab members are already on Bluesky. Please give them a follow if you haven't already:
@patriciacoelho.bsky.social
@pranvera.bsky.social
@mas-g.bsky.social
@alejandrobrenes.bsky.social
#neutrophil #teamNeutrophil
@patriciacoelho.bsky.social
@pranvera.bsky.social
@mas-g.bsky.social
@alejandrobrenes.bsky.social
#neutrophil #teamNeutrophil
Hello Bluesky & #immunosky we are a lab researching how oxygen and nutrient availability reprogram #neutrophils
We are based in the Centre for Inflammation Research at @edinuni-irr.bsky.social
Link up if you're a fan of the most interesting immune cell #teamNeutrophil
We are based in the Centre for Inflammation Research at @edinuni-irr.bsky.social
Link up if you're a fan of the most interesting immune cell #teamNeutrophil
November 21, 2024 at 7:34 PM
Hello Bluesky & #immunosky we are a lab researching how oxygen and nutrient availability reprogram #neutrophils
We are based in the Centre for Inflammation Research at @edinuni-irr.bsky.social
Link up if you're a fan of the most interesting immune cell #teamNeutrophil
We are based in the Centre for Inflammation Research at @edinuni-irr.bsky.social
Link up if you're a fan of the most interesting immune cell #teamNeutrophil