Will Aisenberg
@waisenberg.bsky.social
Neuroscientist using microglia replacement to understand the influence of brain macrophages on neurodegenerative disease | postdoc FC Bennett lab @ UPenn | Hopkins Sumner lab and CMM alum
Macrophages mediate mesoscale brain mechanical homeostasis
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Macrophages Mediate Mesoscale Brain Mechanical Homeostasis
We investigated the role of infiltrating immune cells in sculpting the developing brain. Using Brillouin microscopy and active microrheology, we found microglia actively maintain tissue viscoelastici...
advanced.onlinelibrary.wiley.com
November 25, 2025 at 1:04 AM
Macrophages mediate mesoscale brain mechanical homeostasis
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis - Nature Communications
Human cortical development involves dynamic changes in matrisome gene expression across cell types and developmental stages. Here, authors show that these changes reveal links to neurodevelopmental di...
www.nature.com
November 22, 2025 at 6:22 PM
Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Will Aisenberg
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
November 20, 2025 at 1:23 PM
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Reposted by Will Aisenberg
Thrilled to share this last little bit of my thesis work w/ @siegenthalerlab.bsky.social! 🐭🧠 Generating the PDGFRa cKO line we use in this paper was no trivial task, spanning multiple years (& a pandemic!) We were extremely excited to see this phenotype & even more excited to share it with everyone!
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
November 20, 2025 at 8:01 PM
Thrilled to share this last little bit of my thesis work w/ @siegenthalerlab.bsky.social! 🐭🧠 Generating the PDGFRa cKO line we use in this paper was no trivial task, spanning multiple years (& a pandemic!) We were extremely excited to see this phenotype & even more excited to share it with everyone!
I learned so much at the @amsocmatbio.bsky.social meeting! I’m really grateful for the welcoming community, enthusiastic to offer advice and share protocols. They’re also actively building incredible public resources which lower the barrier to studying the matrix in your preexisting omics datasets.
November 20, 2025 at 4:58 PM
I learned so much at the @amsocmatbio.bsky.social meeting! I’m really grateful for the welcoming community, enthusiastic to offer advice and share protocols. They’re also actively building incredible public resources which lower the barrier to studying the matrix in your preexisting omics datasets.
Reposted by Will Aisenberg
"Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates"
http://dlvr.it/TPKJSH
@liddelowsa.bsky.social @philiphasel.bsky.social & colleagues
@cp-cellreports.bsky.social
#SfN2025
http://dlvr.it/TPKJSH
@liddelowsa.bsky.social @philiphasel.bsky.social & colleagues
@cp-cellreports.bsky.social
#SfN2025
November 18, 2025 at 1:01 AM
"Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates"
http://dlvr.it/TPKJSH
@liddelowsa.bsky.social @philiphasel.bsky.social & colleagues
@cp-cellreports.bsky.social
#SfN2025
http://dlvr.it/TPKJSH
@liddelowsa.bsky.social @philiphasel.bsky.social & colleagues
@cp-cellreports.bsky.social
#SfN2025
Reposted by Will Aisenberg
New feature article from TNJ (nation's best student magazine): Inside Yale’s Quiet Reckoning with AI thenewjournalatyale.com/2025/10/insi...
November 16, 2025 at 4:43 PM
New feature article from TNJ (nation's best student magazine): Inside Yale’s Quiet Reckoning with AI thenewjournalatyale.com/2025/10/insi...
Reposted by Will Aisenberg
Stoked to be repping the @korblab.bsky.social at #sfn25 this week! Come learn histone variant H2BE and its relevance to neurodevelopmental disorders on:
1. Saturday at the Early Career Session (#B1)
2. Monday at the Molecular Mechanisms Underlying Developmental Disorders II session (#A59)
🧠🧬🧪
1. Saturday at the Early Career Session (#B1)
2. Monday at the Molecular Mechanisms Underlying Developmental Disorders II session (#A59)
🧠🧬🧪
November 14, 2025 at 11:29 PM
Stoked to be repping the @korblab.bsky.social at #sfn25 this week! Come learn histone variant H2BE and its relevance to neurodevelopmental disorders on:
1. Saturday at the Early Career Session (#B1)
2. Monday at the Molecular Mechanisms Underlying Developmental Disorders II session (#A59)
🧠🧬🧪
1. Saturday at the Early Career Session (#B1)
2. Monday at the Molecular Mechanisms Underlying Developmental Disorders II session (#A59)
🧠🧬🧪
Reposted by Will Aisenberg
Come say hi tomorrow! LBP 167 1:00-5:00PM
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 14, 2025 at 1:50 PM
Come say hi tomorrow! LBP 167 1:00-5:00PM
Reposted by Will Aisenberg
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
November 14, 2025 at 3:06 AM
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
Big advance from Lombroso et al. — microglia replacement without chemo, irradiation, or direct CNS delivery!
CSF1R inhibition + vascular delivery of Csf1r-G793A donor cells → specific brain engraftment. This study opens the door to microglia replacement across models & diseases.
CSF1R inhibition + vascular delivery of Csf1r-G793A donor cells → specific brain engraftment. This study opens the door to microglia replacement across models & diseases.
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
tinyurl.com/3wvmm8v3
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …
tinyurl.com
November 12, 2025 at 11:11 PM
Big advance from Lombroso et al. — microglia replacement without chemo, irradiation, or direct CNS delivery!
CSF1R inhibition + vascular delivery of Csf1r-G793A donor cells → specific brain engraftment. This study opens the door to microglia replacement across models & diseases.
CSF1R inhibition + vascular delivery of Csf1r-G793A donor cells → specific brain engraftment. This study opens the door to microglia replacement across models & diseases.
Reposted by Will Aisenberg
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
tinyurl.com/3wvmm8v3
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …
tinyurl.com
November 12, 2025 at 10:41 PM
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
tinyurl.com/3wvmm8v3
Reposted by Will Aisenberg
#ASMB2025 is using #WhovaApp for the meeting! Download the App & start customize your Schedule TODAY.
No printed program will be provided. #PRINT the program if you need one! See you in Baltimore!
Whova link and program PDF can be found 👇 asmb.memberclicks.net/biennial-mee...
No printed program will be provided. #PRINT the program if you need one! See you in Baltimore!
Whova link and program PDF can be found 👇 asmb.memberclicks.net/biennial-mee...
November 12, 2025 at 9:34 PM
#ASMB2025 is using #WhovaApp for the meeting! Download the App & start customize your Schedule TODAY.
No printed program will be provided. #PRINT the program if you need one! See you in Baltimore!
Whova link and program PDF can be found 👇 asmb.memberclicks.net/biennial-mee...
No printed program will be provided. #PRINT the program if you need one! See you in Baltimore!
Whova link and program PDF can be found 👇 asmb.memberclicks.net/biennial-mee...
Reposted by Will Aisenberg
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 4:43 PM
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Reposted by Will Aisenberg
I wrote some reflections this afternoon about how the discovery of the double helix changed the course of science. Gift link: nyti.ms/4qPS3y6
November 8, 2025 at 3:43 AM
I wrote some reflections this afternoon about how the discovery of the double helix changed the course of science. Gift link: nyti.ms/4qPS3y6
Reposted by Will Aisenberg
MindCORE Summer Fellowship Program
May 31-Aug 7, 2026
This is a paid 10-wk research experience for undergrad students matched with select Penn faculty in mind sciences.
Open to both Penn students & non-Penn US students through our REU.
Apply by Jan 11: mindcore.sas.upenn.edu/research/sum...
May 31-Aug 7, 2026
This is a paid 10-wk research experience for undergrad students matched with select Penn faculty in mind sciences.
Open to both Penn students & non-Penn US students through our REU.
Apply by Jan 11: mindcore.sas.upenn.edu/research/sum...
October 30, 2025 at 7:36 PM
MindCORE Summer Fellowship Program
May 31-Aug 7, 2026
This is a paid 10-wk research experience for undergrad students matched with select Penn faculty in mind sciences.
Open to both Penn students & non-Penn US students through our REU.
Apply by Jan 11: mindcore.sas.upenn.edu/research/sum...
May 31-Aug 7, 2026
This is a paid 10-wk research experience for undergrad students matched with select Penn faculty in mind sciences.
Open to both Penn students & non-Penn US students through our REU.
Apply by Jan 11: mindcore.sas.upenn.edu/research/sum...
Reposted by Will Aisenberg
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
October 28, 2025 at 9:31 PM
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
Reposted by Will Aisenberg
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
October 24, 2025 at 4:32 PM
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Reposted by Will Aisenberg
Last night I could not put this book down. The opening chapter is 🤯 and the final chapters full of great ideas about what we can collectively do to ensure women & underrepresented groups stay in science. We need diversity in science as diversity breeds discovery
October 9, 2025 at 2:17 AM
Last night I could not put this book down. The opening chapter is 🤯 and the final chapters full of great ideas about what we can collectively do to ensure women & underrepresented groups stay in science. We need diversity in science as diversity breeds discovery
Reposted by Will Aisenberg
October 2, 2025 at 5:25 PM
Reposted by Will Aisenberg
Reposted by Will Aisenberg
A fresh supply of the immune cells that keep the brain tidy might one day help to treat a host of conditions, from ultra-rare genetic disorders to more familiar scourges, such as Alzheimer’s disease.
go.nature.com/46mGgPA
go.nature.com/46mGgPA
Swapping old immune cells in the brain with fresh ones could treat disease
Nature - Replacing immune cells called microglia holds promise for addressing brain conditions such as Alzheimer’s disease.
go.nature.com
September 28, 2025 at 1:15 PM
A fresh supply of the immune cells that keep the brain tidy might one day help to treat a host of conditions, from ultra-rare genetic disorders to more familiar scourges, such as Alzheimer’s disease.
go.nature.com/46mGgPA
go.nature.com/46mGgPA
Reposted by Will Aisenberg
Replacing old immune cells called microglia with fresh ones holds promise for addressing brain conditions such as Alzheimer’s disease @nature.com @heidiledford.bsky.social
nature.com/articles/d41...
nature.com/articles/d41...
Swapping old immune cells in the brain with fresh ones could treat disease
Replacing immune cells called microglia holds promise for addressing brain conditions such as Alzheimer’s disease.
nature.com
September 26, 2025 at 4:39 PM
Replacing old immune cells called microglia with fresh ones holds promise for addressing brain conditions such as Alzheimer’s disease @nature.com @heidiledford.bsky.social
nature.com/articles/d41...
nature.com/articles/d41...
Reposted by Will Aisenberg
SPP1 = osteopontin
CD61 = integrin β3
CD61 = integrin β3
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature
Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.
www.nature.com
September 25, 2025 at 1:47 PM
SPP1 = osteopontin
CD61 = integrin β3
CD61 = integrin β3
Reposted by Will Aisenberg
Commentary @cp-cancercell.bsky.social @maxkrummel.bsky.social
The coming era of nudge drugs for cancer
www.cell.com/cancer-cell/...
The coming era of nudge drugs for cancer
www.cell.com/cancer-cell/...
September 11, 2025 at 2:55 PM
Commentary @cp-cancercell.bsky.social @maxkrummel.bsky.social
The coming era of nudge drugs for cancer
www.cell.com/cancer-cell/...
The coming era of nudge drugs for cancer
www.cell.com/cancer-cell/...