Vindigni Lab
@vindignilab.bsky.social
Washington University in St. Louis
https://vindignilab.wustl.edu/
https://vindignilab.wustl.edu/
Congratulations @seppai99.bsky.social for defending her thesis last week!!! Such an honor having her in the lab and excited about the next steps in her career!!!
August 19, 2025 at 9:03 PM
Congratulations @seppai99.bsky.social for defending her thesis last week!!! Such an honor having her in the lab and excited about the next steps in her career!!!
Reposted by Vindigni Lab
The proposed budget slashes NIH by ~40%, devastating medical research, clinical trials, treatment breakthroughs—life-saving work.
Thousands of lives at risk for tax cuts for the rich? NO THANKS.
Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX
zurl.co/RCR0y
#CutsCostLives
Thousands of lives at risk for tax cuts for the rich? NO THANKS.
Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX
zurl.co/RCR0y
#CutsCostLives
Will the Senate Save NIH?
Rescuing biomedical research is every bit as important as saving Medicaid.
zurl.co
June 29, 2025 at 1:57 PM
The proposed budget slashes NIH by ~40%, devastating medical research, clinical trials, treatment breakthroughs—life-saving work.
Thousands of lives at risk for tax cuts for the rich? NO THANKS.
Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX
zurl.co/RCR0y
#CutsCostLives
Thousands of lives at risk for tax cuts for the rich? NO THANKS.
Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX
zurl.co/RCR0y
#CutsCostLives
Reposted by Vindigni Lab
Call your legislators to stop slashing the budget of federal funded research in the “Big Beautiful Bill”. Find numbers @5calls.org
June 29, 2025 at 2:55 PM
Call your legislators to stop slashing the budget of federal funded research in the “Big Beautiful Bill”. Find numbers @5calls.org
Reposted by Vindigni Lab
Congratulations Isabelle for winning the Future of Science Fund at the Keystone!! We are very honored to have such a fantastic student in the lab!!!
May 8, 2025 at 2:05 AM
Congratulations Isabelle for winning the Future of Science Fund at the Keystone!! We are very honored to have such a fantastic student in the lab!!!
Reposted by Vindigni Lab
Wrapping up an insightful conference on DNA Replication Gaps, Cancer, and Disease! 🎉 Congrats to our Future of Science Fund winners, Larissa Milano and @seppai99.bsky.social! Your achievements inspire us. 🌟 #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
April 30, 2025 at 5:08 PM
Wrapping up an insightful conference on DNA Replication Gaps, Cancer, and Disease! 🎉 Congrats to our Future of Science Fund winners, Larissa Milano and @seppai99.bsky.social! Your achievements inspire us. 🌟 #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
Reposted by Vindigni Lab
Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
DNA Repair | The replication stress response: mechanisms and functions | ScienceDirect.com by ElsevierScienceDirect
High-fidelity DNA replication is constantly challenged by a diverse range of obstacles, including endogenous lesions and secondary structures in the DNA template, tightly bound protein-DNA complexes, ...
www.sciencedirect.com
April 17, 2025 at 4:01 AM
Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
Reposted by Vindigni Lab
An interesting collaboration with the @vindignilab.bsky.social on the mechanism of resection at gaps. Spoiler alert: the MRE11 complex acts very differently at gaps vs. at DNA breaks genesdev.cshlp.org/content/earl...
March 26, 2025 at 9:45 AM
An interesting collaboration with the @vindignilab.bsky.social on the mechanism of resection at gaps. Spoiler alert: the MRE11 complex acts very differently at gaps vs. at DNA breaks genesdev.cshlp.org/content/earl...
Check out our new paper led by @seppai99.bsky.social from the Vindigni Lab in collaboration with @cejkalab.bsky.social delving into the role of nucleases resecting ssDNA gaps generated by PARPi. You can read more here: genesdev.cshlp.org/content/earl...
March 26, 2025 at 5:20 PM
Check out our new paper led by @seppai99.bsky.social from the Vindigni Lab in collaboration with @cejkalab.bsky.social delving into the role of nucleases resecting ssDNA gaps generated by PARPi. You can read more here: genesdev.cshlp.org/content/earl...
Reposted by Vindigni Lab
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
March 17, 2025 at 9:58 PM
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
Reposted by Vindigni Lab
this is breaking through
keep up the full court press
* patients harmed right now
* hurts our economy right now
* destroys our STEM infrastructure
* gift to global competitors and adversaries
* dirty tricks by bureaucrats who failed HS chemistry twice
keep up the full court press
* patients harmed right now
* hurts our economy right now
* destroys our STEM infrastructure
* gift to global competitors and adversaries
* dirty tricks by bureaucrats who failed HS chemistry twice
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
NIH funding freeze stalls applications on $1.5 billion in medical research funds
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
www.npr.org
February 22, 2025 at 8:29 PM
this is breaking through
keep up the full court press
* patients harmed right now
* hurts our economy right now
* destroys our STEM infrastructure
* gift to global competitors and adversaries
* dirty tricks by bureaucrats who failed HS chemistry twice
keep up the full court press
* patients harmed right now
* hurts our economy right now
* destroys our STEM infrastructure
* gift to global competitors and adversaries
* dirty tricks by bureaucrats who failed HS chemistry twice
Reposted by Vindigni Lab
a great way of framing the issue — the bureaucrats are scheming to wreck science they can’t criticize or understand👇🏽
“This really feels like an evil way of using bureaucracy against the process of science, to the contrary of what they say they are doing — streamlining bureaucracy,” Cooper said.
“This really feels like an evil way of using bureaucracy against the process of science, to the contrary of what they say they are doing — streamlining bureaucracy,” Cooper said.
Deep and thoughtful reporting on the crises of the NIH funding and review blocks. Share locally, share widely. And make sure your reps know!
www.washingtonpost.com/science/2025...
www.washingtonpost.com/science/2025...
Scientists warn of long-term damage as Trump’s orders slow research
By blocking announcements in the Federal Register, the administration is keeping experts from meeting to evaluate funding proposals.
www.washingtonpost.com
February 22, 2025 at 5:35 PM
a great way of framing the issue — the bureaucrats are scheming to wreck science they can’t criticize or understand👇🏽
“This really feels like an evil way of using bureaucracy against the process of science, to the contrary of what they say they are doing — streamlining bureaucracy,” Cooper said.
“This really feels like an evil way of using bureaucracy against the process of science, to the contrary of what they say they are doing — streamlining bureaucracy,” Cooper said.
Reposted by Vindigni Lab
Federal Register Blackout Blocks NIH Funding www.medpagetoday.com/special-repo...
The White House found a loophole around the judge’s orders to lift the freeze that will cripple research and scientific discovery for years.
The White House found a loophole around the judge’s orders to lift the freeze that will cripple research and scientific discovery for years.
Federal Register Blackout Blocks NIH Funding
New strategy is like pouring 'cement in the pipes of the federal funding infrastructure'
www.medpagetoday.com
February 20, 2025 at 9:49 PM
Federal Register Blackout Blocks NIH Funding www.medpagetoday.com/special-repo...
The White House found a loophole around the judge’s orders to lift the freeze that will cripple research and scientific discovery for years.
The White House found a loophole around the judge’s orders to lift the freeze that will cripple research and scientific discovery for years.
Reposted by Vindigni Lab
Very important to get this word out!
I just covered this for @thetransmitter.bsky.social — will keep following! www.thetransmitter.org/funding/fede...
Federal Register hold makes ‘end run’ around court pause on NIH funding freeze
NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...
www.thetransmitter.org
February 19, 2025 at 12:26 PM
Very important to get this word out!
Reposted by Vindigni Lab
Trump Cuts Target Next Generation of Scientists and Public Health Leaders www.nytimes.com/2025/02/18/u...
Trump Cuts Target Next Generation of Scientists and Public Health Leaders
A core group of so-called disease detectives, who track outbreaks, was apparently spared. But other young researchers are out of jobs.
www.nytimes.com
February 18, 2025 at 12:38 PM
Trump Cuts Target Next Generation of Scientists and Public Health Leaders www.nytimes.com/2025/02/18/u...
Reposted by Vindigni Lab
Reposted by Vindigni Lab
Petition to Reverse the NIH Indirect Cost Cap.
Sign and Circulate.
Mobilize. Organize.
chng.it/LS57Nk7r6k
Sign and Circulate.
Mobilize. Organize.
chng.it/LS57Nk7r6k
This campaign needs you now
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
chng.it
February 10, 2025 at 3:38 PM
Petition to Reverse the NIH Indirect Cost Cap.
Sign and Circulate.
Mobilize. Organize.
chng.it/LS57Nk7r6k
Sign and Circulate.
Mobilize. Organize.
chng.it/LS57Nk7r6k
Reposted by Vindigni Lab
Check out our (@vindignilab.bsky.social) Spotlight article highlighting @durocher1.bsky.social group's discovery of synthetic lethal SMARCAL1-FANCM interaction, revealing a novel genetic buffering mechanism for genome stability at simple repeat regions during replication
www.cell.com/trends/genet...
www.cell.com/trends/genet...
Genetic buffering mechanisms in SNF2-family translocases
SNF2-family DNA translocases, a large family of ATPases, have poorly defined roles
in genomic stability. In a recent study, Feng et al. identified a synthetic lethal
interaction between the SNF2 trans...
www.cell.com
January 31, 2025 at 10:12 PM
Check out our (@vindignilab.bsky.social) Spotlight article highlighting @durocher1.bsky.social group's discovery of synthetic lethal SMARCAL1-FANCM interaction, revealing a novel genetic buffering mechanism for genome stability at simple repeat regions during replication
www.cell.com/trends/genet...
www.cell.com/trends/genet...
The Vindigni, Krais and @vermalab-washu.bsky.social Labsgiving 2024 featured a full turkey, many laughs and lots of multi-cultural food! 🦃
November 26, 2024 at 9:26 PM
The Vindigni, Krais and @vermalab-washu.bsky.social Labsgiving 2024 featured a full turkey, many laughs and lots of multi-cultural food! 🦃
Finally got on the trend and moved to bluer skies! Though our lab photo got the memo long ago 🧬
November 22, 2024 at 8:06 PM
Finally got on the trend and moved to bluer skies! Though our lab photo got the memo long ago 🧬