Ville Kujala
@villekujala.bsky.social
I bring you…STAN
Science, Technology, Art, and Nature
Science, Technology, Art, and Nature
Reposted by Ville Kujala
A protein that cuts double-stranded DNA contributes to chromosome scrambling in human cancer cells.
Learn more in a new #SciencePerspective: https://scim.ag/4aKry7p
Learn more in a new #SciencePerspective: https://scim.ag/4aKry7p
Chromosome shattering in cancer
A protein that cuts double-stranded DNA contributes to chromosome scrambling in human cancer cells
scim.ag
December 25, 2025 at 7:07 PM
A protein that cuts double-stranded DNA contributes to chromosome scrambling in human cancer cells.
Learn more in a new #SciencePerspective: https://scim.ag/4aKry7p
Learn more in a new #SciencePerspective: https://scim.ag/4aKry7p
Reposted by Ville Kujala
An in vivo imaging technique can track the way molecules move through the nuclear pore complex
go.nature.com/3KODM4A
go.nature.com/3KODM4A
Live-cell super-resolution microscopy reveals how molecules enter and exit the nucleus
The nuclear pore complex is the gateway to the nucleus of cells. Now an in vivo imaging technique can track the way in which molecules move through this complex.
go.nature.com
December 22, 2025 at 4:38 PM
An in vivo imaging technique can track the way molecules move through the nuclear pore complex
go.nature.com/3KODM4A
go.nature.com/3KODM4A
Reposted by Ville Kujala
Now online! A 3D in vitro model for studying human implantation and implantation failure
A 3D in vitro model for studying human implantation and implantation failure
A 3D in-chip implantation model is developed using a bioengineered human endometrioid and human blastoids or blastocysts and used to identify candidate compounds that can enhance implantation rates in endometrioids derived from patients experiencing recurrent implantation failure.
dlvr.it
December 23, 2025 at 4:00 PM
Now online! A 3D in vitro model for studying human implantation and implantation failure
Kidney progenitor assembloids demonstrated filtration, hormone secretion, and urine production at levels comparable to newborn kidneys. Human assembloids successfully modeled polycystic kidney disease pathology including cyst formation, inflammation, and fibrosis.
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling
Recapitulating the self-assembly of kidney progenitors, Huang, Medina, He, Zeng, and
colleagues have developed mouse and human kidney progenitor assembloids, exhibiting
enhanced cellular complexity, s...
www.cell.com
December 15, 2025 at 11:48 PM
Kidney progenitor assembloids demonstrated filtration, hormone secretion, and urine production at levels comparable to newborn kidneys. Human assembloids successfully modeled polycystic kidney disease pathology including cyst formation, inflammation, and fibrosis.
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Reposted by Ville Kujala
A scaffold-free bioprinting approach achieves physiological cell densities, and is used to print in vitro models of heart and liver structures, and neural circuits #NBThighlight www.cell.com/cell/fulltex...
Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues
We developed a bioprinting strategy that turns living cells into cell-only bioinks,
enabling light-based 3D bioprinting of tissues at native, ultrahigh cell densities
(up to ∼109 cells mL−1) to rapidl...
www.cell.com
December 9, 2025 at 2:46 PM
A scaffold-free bioprinting approach achieves physiological cell densities, and is used to print in vitro models of heart and liver structures, and neural circuits #NBThighlight www.cell.com/cell/fulltex...
Reposted by Ville Kujala
Now online! Membrane potential mediates the cellular response to mechanical pressure
Membrane potential mediates the cellular response to mechanical pressure
Cells in tissues need to know when to start growing and when to stop growing to quickly heal wounds but prevent tumorous overgrowth. Membrane potential allows cells to sense physical forces, including those from neighboring cells, and thereby regulates growth.
dlvr.it
December 2, 2025 at 11:39 PM
Now online! Membrane potential mediates the cellular response to mechanical pressure
Reposted by Ville Kujala
Kathrin Marchenko is a textile artist recognized for her expressive embroidery on delicate tulle fabric.
Working in a “painting with thread” style, she crafts portraits, anatomical forms & airy figures that appear to float inside wooden hoops, merging traditional craft with fine art elegance.
Working in a “painting with thread” style, she crafts portraits, anatomical forms & airy figures that appear to float inside wooden hoops, merging traditional craft with fine art elegance.
November 29, 2025 at 2:39 PM
Kathrin Marchenko is a textile artist recognized for her expressive embroidery on delicate tulle fabric.
Working in a “painting with thread” style, she crafts portraits, anatomical forms & airy figures that appear to float inside wooden hoops, merging traditional craft with fine art elegance.
Working in a “painting with thread” style, she crafts portraits, anatomical forms & airy figures that appear to float inside wooden hoops, merging traditional craft with fine art elegance.
Reposted by Ville Kujala
Ischaemic stroke remains a leading cause of disability. This article discusses the design of biomaterials that can engage and modulate pro-repair mechanisms in the brain to improve repair after ischaemic stroke:
Biology-driven material design for ischaemic stroke repair - Nature Reviews Bioengineering
Rehabilitation after ischaemic stroke can promote only limited recovery for many patients with stroke. This Review discusses how the distinctly reparative environment of the subacute time window after stroke can inform the design of biology-driven biomaterial-based stroke therapies.
go.nature.com
November 25, 2025 at 3:06 PM
Ischaemic stroke remains a leading cause of disability. This article discusses the design of biomaterials that can engage and modulate pro-repair mechanisms in the brain to improve repair after ischaemic stroke:
Reposted by Ville Kujala
Nature interviewed six AI leaders on where the technology is heading. Perspectives from Microsoft, Google DeepMind, Anthropic, and UN representatives on both development ambitions and societal adaptation.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
The future of AI
Artificial intelligence is flying high. Nature asked leading innovators what they think will happen next.
www.nature.com
November 22, 2025 at 12:38 AM
Nature interviewed six AI leaders on where the technology is heading. Perspectives from Microsoft, Google DeepMind, Anthropic, and UN representatives on both development ambitions and societal adaptation.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
Reposted by Ville Kujala
Biopharma’s reawakened interest in cardiovascular diseases spans new targets and modalities, with more convenient formulations to boost access and adherence go.nature.com/4r9HhTw
Heart matters: new treatments, tools and access channels - Nature Biotechnology
Biopharma’s reawakened interest in cardiovascular diseases spans new targets and modalities, with more convenient formulations to boost access and adherence.
go.nature.com
November 21, 2025 at 6:55 PM
Biopharma’s reawakened interest in cardiovascular diseases spans new targets and modalities, with more convenient formulations to boost access and adherence go.nature.com/4r9HhTw
“With this new approach, the agency is essentially shifting the regulatory focus from approving each individual drug to clearing the therapeutic platform for some individualized treatments based on the same technology.”
www.fiercebiotech.com/biotech/fdas...
www.fiercebiotech.com/biotech/fdas...
Prasad, Makary unveil new FDA path for accelerating custom gene editing therapies
In a highly anticipated article, FDA officials Vinay Prasad, M.D., and Martin Makary, M.D., outlined a novel regulatory pathway that could trigger a seismic shift in how bespoke gene editing therap | ...
www.fiercebiotech.com
November 12, 2025 at 10:57 PM
“With this new approach, the agency is essentially shifting the regulatory focus from approving each individual drug to clearing the therapeutic platform for some individualized treatments based on the same technology.”
www.fiercebiotech.com/biotech/fdas...
www.fiercebiotech.com/biotech/fdas...
In this HBR article Sir Andrew Likierman identifies six elements of good judgment: active listening, seeking challenging advisers, broad experience, countering biases, expanding options, and execution feasibility. These skills separate sound decisions from luck.
hbr.org/2020/01/the-...
hbr.org/2020/01/the-...
The Elements of Good Judgment
Judgment—the ability to combine personal qualities with relevant knowledge and experience to form opinions and make decisions—is “the core of exemplary leadership,” according to Noel Tichy and Warren ...
hbr.org
November 12, 2025 at 4:38 PM
In this HBR article Sir Andrew Likierman identifies six elements of good judgment: active listening, seeking challenging advisers, broad experience, countering biases, expanding options, and execution feasibility. These skills separate sound decisions from luck.
hbr.org/2020/01/the-...
hbr.org/2020/01/the-...
Reposted by Ville Kujala
Big pharma shares its machine learning models with biotechs, but awaits definitive data on success of artificial intelligence-generated drugs www.nature.com/articles/s41...
Drugmakers share data to feed voracious foundation models - Nature Biotechnology
Big pharma shares its machine learning models with biotechs, but awaits definitive data on success of artificial intelligence-generated drugs.
www.nature.com
November 10, 2025 at 9:09 PM
Big pharma shares its machine learning models with biotechs, but awaits definitive data on success of artificial intelligence-generated drugs www.nature.com/articles/s41...
AHA 2025: Amgen’s Repatha cut first heart attacks by 36%, Merck’s oral PCSK9 pill matched injectables, and gene therapies from Intellia and CRISPR showed durable cholesterol and triglyceride reductions alongside Ionis’ 72% triglyceride drop.
www.biospace.com/drug-develop...
www.biospace.com/drug-develop...
Amgen, Merck, Novo, More Take Cardiovascular Benefits to New Heights at AHA 2025
Data presented at this year’s American Heart Association Scientific Sessions in New Orleans underline rapid advancements in the cardiovascular field.
www.biospace.com
November 11, 2025 at 4:35 PM
AHA 2025: Amgen’s Repatha cut first heart attacks by 36%, Merck’s oral PCSK9 pill matched injectables, and gene therapies from Intellia and CRISPR showed durable cholesterol and triglyceride reductions alongside Ionis’ 72% triglyceride drop.
www.biospace.com/drug-develop...
www.biospace.com/drug-develop...
“The user receives an instruction to copy a string of text, open a terminal window, paste it in, and press Enter.”
Never do this. Real CAPTCHA doesn’t require command line operations. If you get a sketchy email from a hotel, call them.
arstechnica.com/security/202...
Never do this. Real CAPTCHA doesn’t require command line operations. If you get a sketchy email from a hotel, call them.
arstechnica.com/security/202...
ClickFix may be the biggest security threat your family has never heard of
Relatively new technique can bypass many endpoint protections.
arstechnica.com
November 11, 2025 at 3:31 PM
“The user receives an instruction to copy a string of text, open a terminal window, paste it in, and press Enter.”
Never do this. Real CAPTCHA doesn’t require command line operations. If you get a sketchy email from a hotel, call them.
arstechnica.com/security/202...
Never do this. Real CAPTCHA doesn’t require command line operations. If you get a sketchy email from a hotel, call them.
arstechnica.com/security/202...
Reposted by Ville Kujala
Nature research paper: Spatial dynamics of brain development and neuroinflammation
go.nature.com/4hO36DQ
go.nature.com/4hO36DQ
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
go.nature.com
November 10, 2025 at 6:27 PM
Nature research paper: Spatial dynamics of brain development and neuroinflammation
go.nature.com/4hO36DQ
go.nature.com/4hO36DQ
Ranked “top genes” can look important partly because of gene length and statistical structure, so high rank doesn’t always mean central to the biology
Nature research paper: Specificity, length and luck drive gene rankings in association studies
go.nature.com/47Fsqax
go.nature.com/47Fsqax
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
go.nature.com
November 10, 2025 at 7:36 PM
Ranked “top genes” can look important partly because of gene length and statistical structure, so high rank doesn’t always mean central to the biology
Wireless artificial muscles activated by sound waves can grip delicate zebrafish, crawl through intestines, and attach to beating hearts
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ultrasound-driven programmable artificial muscles - Nature
A soft artificial muscle with programmable actuation is achieved using microbubble arrays and targeted ultrasound activation, with potential applications in soft robotics, wearable technologies, hapti...
www.nature.com
November 10, 2025 at 2:33 AM
Wireless artificial muscles activated by sound waves can grip delicate zebrafish, crawl through intestines, and attach to beating hearts
www.nature.com/articles/s41...
www.nature.com/articles/s41...
It’s not new, but Thinking, Fast and Slow still feels essential. Kahneman unpacks how our quick, instinctive thinking quietly shapes and often distorts our judgments, reminding us that clear thought begins with recognizing how easily we fool ourselves.
us.macmillan.com/books/978037...
us.macmillan.com/books/978037...
Thinking, Fast and Slow
*Major New York Times Bestseller*More than 2.6 million copies sold*One of The New York Times Book Review's ten best books of the year*Selected by The Wall St...
us.macmillan.com
November 9, 2025 at 2:49 AM
It’s not new, but Thinking, Fast and Slow still feels essential. Kahneman unpacks how our quick, instinctive thinking quietly shapes and often distorts our judgments, reminding us that clear thought begins with recognizing how easily we fool ourselves.
us.macmillan.com/books/978037...
us.macmillan.com/books/978037...
Large language models are being trained to read DNA, decode proteins, and design drugs. The code of life meets the code that learns.
www.cell.com/patterns/ful...
www.cell.com/patterns/ful...
November 9, 2025 at 1:15 AM
Large language models are being trained to read DNA, decode proteins, and design drugs. The code of life meets the code that learns.
www.cell.com/patterns/ful...
www.cell.com/patterns/ful...
BioContext.ai lets AI assistants query real biomedical databases directly, replacing hallucinations with actual scientific data
BioContextAI - Biomedical Model Context Protocol for Agentic AI
Connect agentic AI with biomedical resources using the Model Context Protocol. Discover and contribute FAIR biomedical MCP servers.
BioContext.ai
November 9, 2025 at 12:40 AM
BioContext.ai lets AI assistants query real biomedical databases directly, replacing hallucinations with actual scientific data
Reposted by Ville Kujala
Scientists have created the most detailed maps yet of how our brains differentiate from stem cells during embryonic development and early life
go.nature.com/4qIpjr3
go.nature.com/4qIpjr3
First ever atlas of brain development shows how stem cells turn into neurons
A collection of studies that chart how mammalian brain cells grow and differentiate is a ‘very valuable’ tool for neuroscientists.
go.nature.com
November 7, 2025 at 11:17 AM
Scientists have created the most detailed maps yet of how our brains differentiate from stem cells during embryonic development and early life
go.nature.com/4qIpjr3
go.nature.com/4qIpjr3