Vincent
@vdion.bsky.social
Prof of DNA repair and neurodegeneration at the UK DRI at Cardiff university.
Huntington’s disease
Myotonic dystrophy and others
Huntington’s disease
Myotonic dystrophy and others
Pinned
Vincent
@vdion.bsky.social
· Jan 23
Centre Director, MRC UK Dementia Research Institut - Cardiff University - Job Details
Job Details: Centre Director, MRC UK Dementia Research Institute at CardiffChair in Neuroscience, Clinical or Non-ClinicalS
krb-sjobs.brassring.com
We are looking for a new director of the UK Dementia Research Institute at Cardiff University! We are doing work on #Huntingtons #Alzheimers #PD.
This is a unique opportunity to be my boss!
To apply:
krb-sjobs.brassring.com/TGnewUI/Sear...
This is a unique opportunity to be my boss!
To apply:
krb-sjobs.brassring.com/TGnewUI/Sear...
Ever wondered why there are interruptions in expanded repeats?
Here are our thoughts:
www.sciencedirect.com/science/arti...
(We think the answer is double-strand break repair)
PS: I’ve not been on here for a bit, but I needed to do some self promotion.
Here are our thoughts:
www.sciencedirect.com/science/arti...
(We think the answer is double-strand break repair)
PS: I’ve not been on here for a bit, but I needed to do some self promotion.
Interruptions impact clinical features of repeat expansion diseases, but how are they gained and lost?
Interruptions within expanded tandem repeats reduce somatic expansion and alter the severity of the resulting diseases. Consequently, much has been do…
www.sciencedirect.com
August 30, 2025 at 8:49 AM
Ever wondered why there are interruptions in expanded repeats?
Here are our thoughts:
www.sciencedirect.com/science/arti...
(We think the answer is double-strand break repair)
PS: I’ve not been on here for a bit, but I needed to do some self promotion.
Here are our thoughts:
www.sciencedirect.com/science/arti...
(We think the answer is double-strand break repair)
PS: I’ve not been on here for a bit, but I needed to do some self promotion.
Reposted by Vincent
Next up prof. Vincent Dion from the @ukdri.ac.uk is talking science fact, not science fiction, and telling us about his groups approach to finding a treatment for Huntingtons. @alzheimersresearchuk.org
May 15, 2025 at 12:47 PM
Next up prof. Vincent Dion from the @ukdri.ac.uk is talking science fact, not science fiction, and telling us about his groups approach to finding a treatment for Huntingtons. @alzheimersresearchuk.org
Reposted by Vincent
Our second speaker of the day, Dr Lelos talking to us about cell therapy and how this might be used to treat Huntingtons. @alzheimersresearchuk.org
May 15, 2025 at 11:10 AM
Our second speaker of the day, Dr Lelos talking to us about cell therapy and how this might be used to treat Huntingtons. @alzheimersresearchuk.org
Reposted by Vincent
ARUK public engagement at the @cardiffcity.bsky.social stadium. Dr Massey kicking it off by talking to us about Huntington’s Disease, what it is and how we might be cure it. @alzheimersresearchuk.org
May 15, 2025 at 10:36 AM
ARUK public engagement at the @cardiffcity.bsky.social stadium. Dr Massey kicking it off by talking to us about Huntington’s Disease, what it is and how we might be cure it. @alzheimersresearchuk.org
We are lucky to be among the funded projects (We’re in good company!)
We’re de-risking our gene editing approach for expanded repeat disorders (e.g. Huntington’s disease, myotonic dystrophy…).
One step closer to the clinic!
www.ukdri.ac.uk/news-and-eve...
We’re de-risking our gene editing approach for expanded repeat disorders (e.g. Huntington’s disease, myotonic dystrophy…).
One step closer to the clinic!
www.ukdri.ac.uk/news-and-eve...
Gene therapy, brain stimulation and drug targets: latest round of Translation Awards announced
We are pleased to announce the eight awardees in the fifth round of the UK DRI Translation Award programme – designed to unlock impact and drive translation within the Institute, kick starting the ear...
www.ukdri.ac.uk
April 3, 2025 at 7:31 AM
We are lucky to be among the funded projects (We’re in good company!)
We’re de-risking our gene editing approach for expanded repeat disorders (e.g. Huntington’s disease, myotonic dystrophy…).
One step closer to the clinic!
www.ukdri.ac.uk/news-and-eve...
We’re de-risking our gene editing approach for expanded repeat disorders (e.g. Huntington’s disease, myotonic dystrophy…).
One step closer to the clinic!
www.ukdri.ac.uk/news-and-eve...
Reposted by Vincent
Postdoc position still available in my group at Imperial. We are looking for talented and enthusiastic candidates with significant experience with live imaging/ electrophysiology. Deadline 3/4/25 www.imperial.ac.uk/jobs/search-...
@bioclocksuk.bsky.social @imperialbrains.bsky.social @ukdri.ac.uk
@bioclocksuk.bsky.social @imperialbrains.bsky.social @ukdri.ac.uk
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
March 10, 2025 at 10:30 AM
Postdoc position still available in my group at Imperial. We are looking for talented and enthusiastic candidates with significant experience with live imaging/ electrophysiology. Deadline 3/4/25 www.imperial.ac.uk/jobs/search-...
@bioclocksuk.bsky.social @imperialbrains.bsky.social @ukdri.ac.uk
@bioclocksuk.bsky.social @imperialbrains.bsky.social @ukdri.ac.uk
I’ll say it again because it is important. American scientists will not en masse leave the US.
This is for several reasons. Here are a few.
For those already on the fence, we are recruiting a new centre director.
www.ukdri.ac.uk/vacancies/ce...
This is for several reasons. Here are a few.
For those already on the fence, we are recruiting a new centre director.
www.ukdri.ac.uk/vacancies/ce...
Centre Director, UK DRI at Cardiff
The UK Dementia Research Institute (UK DRI), principally funded by the Medical Research Council (MRC), and Cardiff University are seeking to appoint an outstanding established academic to a new Chair ...
www.ukdri.ac.uk
February 26, 2025 at 5:55 AM
I’ll say it again because it is important. American scientists will not en masse leave the US.
This is for several reasons. Here are a few.
For those already on the fence, we are recruiting a new centre director.
www.ukdri.ac.uk/vacancies/ce...
This is for several reasons. Here are a few.
For those already on the fence, we are recruiting a new centre director.
www.ukdri.ac.uk/vacancies/ce...
I did this podcast about where we are with our gene editing approach for expanded repeat disorders. I think you’ll enjoy it. I did anyway!
open.spotify.com/episode/5aPX...
open.spotify.com/episode/5aPX...
Huntington's Disease: Professor Vincent Dion on The Promise of a Cure
In Two Minds · Episode
open.spotify.com
February 18, 2025 at 8:19 PM
I did this podcast about where we are with our gene editing approach for expanded repeat disorders. I think you’ll enjoy it. I did anyway!
open.spotify.com/episode/5aPX...
open.spotify.com/episode/5aPX...
I need your help in spreading the word. We need a new director. The link is here:
www.ukdri.ac.uk/vacancies/ce...
www.ukdri.ac.uk/vacancies/ce...
Centre Director, UK DRI at Cardiff
The UK Dementia Research Institute (UK DRI), principally funded by the Medical Research Council (MRC), and Cardiff University are seeking to appoint an outstanding established academic to a new Chair ...
www.ukdri.ac.uk
February 11, 2025 at 7:56 PM
I need your help in spreading the word. We need a new director. The link is here:
www.ukdri.ac.uk/vacancies/ce...
www.ukdri.ac.uk/vacancies/ce...
Reposted by Vincent
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
January 28, 2025 at 9:45 PM
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
I don’t think many of my American scientist friends will leave the US despite the recent political changes affecting the NIH.
But if they were interested, they should apply to become centre director here in Cardiff!
www.ukdri.ac.uk/vacancies/ce...
But if they were interested, they should apply to become centre director here in Cardiff!
www.ukdri.ac.uk/vacancies/ce...
Centre Director, UK DRI at Cardiff
The UK Dementia Research Institute (UK DRI), principally funded by the Medical Research Council (MRC), and Cardiff University are seeking to appoint an outstanding established academic to a new Chair ...
www.ukdri.ac.uk
January 29, 2025 at 6:20 AM
I don’t think many of my American scientist friends will leave the US despite the recent political changes affecting the NIH.
But if they were interested, they should apply to become centre director here in Cardiff!
www.ukdri.ac.uk/vacancies/ce...
But if they were interested, they should apply to become centre director here in Cardiff!
www.ukdri.ac.uk/vacancies/ce...
We are looking for a new director of the UK Dementia Research Institute at Cardiff University! We are doing work on #Huntingtons #Alzheimers #PD.
This is a unique opportunity to be my boss!
To apply:
krb-sjobs.brassring.com/TGnewUI/Sear...
This is a unique opportunity to be my boss!
To apply:
krb-sjobs.brassring.com/TGnewUI/Sear...
Centre Director, MRC UK Dementia Research Institut - Cardiff University - Job Details
Job Details: Centre Director, MRC UK Dementia Research Institute at CardiffChair in Neuroscience, Clinical or Non-ClinicalS
krb-sjobs.brassring.com
January 23, 2025 at 7:06 PM
We are looking for a new director of the UK Dementia Research Institute at Cardiff University! We are doing work on #Huntingtons #Alzheimers #PD.
This is a unique opportunity to be my boss!
To apply:
krb-sjobs.brassring.com/TGnewUI/Sear...
This is a unique opportunity to be my boss!
To apply:
krb-sjobs.brassring.com/TGnewUI/Sear...
Reposted by Vincent
Dr Gabriel Balmus at the UK Dementia Research Institute @ukdri.bsky.social, University of Cambridge is seekign a Research Assistant to work on DNA Damage and Huntington's Disease. Closing date: 19th January
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Assistant: DNA Damage and Huntington’s Disease
Dr Gabriel Balmus at the UK Dementia Research Institute, University of Cambridge is seekign a Research Assistant to work on DNA Damage and Huntington's Disease
www.dementiaresearcher.nihr.ac.uk
January 6, 2025 at 12:55 PM
Dr Gabriel Balmus at the UK Dementia Research Institute @ukdri.bsky.social, University of Cambridge is seekign a Research Assistant to work on DNA Damage and Huntington's Disease. Closing date: 19th January
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Reposted by Vincent
Another week, another great paper! Kudos to the amazing grad student, Chiara Masnovo who single-handedly initiated and led the project, and arranged a terrific collaboration with the Aharoni lab from Ben-Gurion University, and to the great members of the two labs.
www.nature.com/articles/s41...?
Stabilization of expandable DNA repeats by the replication factor Mcm10 promotes cell viability - Nature Communications
DNA repeats can lengthen or shorten during their replication, which may lead to a human disease. Here, the authors discovered that an essential replication protein, Mcm10, counteracts instability of G...
www.nature.com
December 4, 2024 at 12:34 AM
Another week, another great paper! Kudos to the amazing grad student, Chiara Masnovo who single-handedly initiated and led the project, and arranged a terrific collaboration with the Aharoni lab from Ben-Gurion University, and to the great members of the two labs.
www.nature.com/articles/s41...?
Reposted by Vincent
Mcm10 — an important replication and elongation factor, counteracts repeat instability and ensures survival of yeast cells containing large homopurine homopyrimidine repeats, such as GAA associated with Friedreich’s Ataxia and AAGGG associated with CANVAS. 🧬 @natureportfolio.bsky.social
Stabilization of expandable DNA repeats by the replication factor Mcm10 promotes cell viability
Nature Communications - DNA repeats can lengthen or shorten during their replication, which may lead to a human disease. Here, the authors discovered that an essential replication protein, Mcm10,...
rdcu.be
December 4, 2024 at 12:30 PM
Mcm10 — an important replication and elongation factor, counteracts repeat instability and ensures survival of yeast cells containing large homopurine homopyrimidine repeats, such as GAA associated with Friedreich’s Ataxia and AAGGG associated with CANVAS. 🧬 @natureportfolio.bsky.social
Reposted by Vincent
In a study of brain cells from mice and humans, researchers have uncovered a 'chemical metronome' which tells us when its time to sleep.😴
The scientists say this could have implications for treating jetlag and sleep disorders.👇
www.imperial.ac.uk/news/258953/...
The scientists say this could have implications for treating jetlag and sleep disorders.👇
www.imperial.ac.uk/news/258953/...
‘Chemical metronome’ helps the brain to keep time | Imperial News | Imperial College London
Imperial researchers uncover a ‘chemical metronome’ in the brain, which helps to synchronise the master clock telling us when it’s time to sleep.
www.imperial.ac.uk
December 4, 2024 at 3:04 PM
In a study of brain cells from mice and humans, researchers have uncovered a 'chemical metronome' which tells us when its time to sleep.😴
The scientists say this could have implications for treating jetlag and sleep disorders.👇
www.imperial.ac.uk/news/258953/...
The scientists say this could have implications for treating jetlag and sleep disorders.👇
www.imperial.ac.uk/news/258953/...
I’m a fan! 😍
Well done @semirkin.bsky.social and team!
Looks like where you nick DNA matters a lot!
www.pnas.org/doi/abs/10.1...
Well done @semirkin.bsky.social and team!
Looks like where you nick DNA matters a lot!
www.pnas.org/doi/abs/10.1...
Recurrent DNA nicks drive massive expansions of (GAA)n repeats | PNAS
Over 50 hereditary degenerative disorders are caused by expansions of short tandem
DNA repeats (STRs). (GAA)n repeat expansions are responsible for...
www.pnas.org
November 26, 2024 at 11:21 AM
I’m a fan! 😍
Well done @semirkin.bsky.social and team!
Looks like where you nick DNA matters a lot!
www.pnas.org/doi/abs/10.1...
Well done @semirkin.bsky.social and team!
Looks like where you nick DNA matters a lot!
www.pnas.org/doi/abs/10.1...
Reposted by Vincent
Major announcement on support for a new social media source December 3rd
a cartoon character with the words the truth will be revealed on the bottom
Alt: a cartoon character with the words the truth will be revealed on the bottom
media.tenor.com
November 18, 2024 at 4:25 PM
Major announcement on support for a new social media source December 3rd