Umut Kilik
@umut-kilik.bsky.social
Postdoc @ FMI Basel (Turco Lab) | Exploring endometrium regeneration & niche 🌱🩸 | Human model systems + single-cell genomics + evo-devo | Former PhD @ IHB (Camp Lab)
Pinned
Umut Kilik
@umut-kilik.bsky.social
· Jul 24
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11
🚨 After 7 years in the making, my PhD thesis work is finally published in @science.org 🧬✨
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves
Reposted by Umut Kilik
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 1:26 PM
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Reposted by Umut Kilik
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 12:50 PM
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Reposted by Umut Kilik
Join us on November 4th!
The winners of our best short talk awards will be telling their research on the @isscr.org stage!
Thank you @stemcellreports.bsky.social for co-organizing this webinar!
The winners of our best short talk awards will be telling their research on the @isscr.org stage!
Thank you @stemcellreports.bsky.social for co-organizing this webinar!
September 8, 2025 at 11:09 AM
Join us on November 4th!
The winners of our best short talk awards will be telling their research on the @isscr.org stage!
Thank you @stemcellreports.bsky.social for co-organizing this webinar!
The winners of our best short talk awards will be telling their research on the @isscr.org stage!
Thank you @stemcellreports.bsky.social for co-organizing this webinar!
Reposted by Umut Kilik
This is it. The act of science -like art- is not the output, it is the interaction and the process. What makes us the kind of scientists we are is how we approach the problem 🧪
It’s a common complaint to spend an afternoon reading papers in search of something that turns into half a sentence (that you delete next week) – I’d argue that the “foraging” benefits are real, only pay off if you’re engaging with the actual material, & worth the “inefficiency” to learn more.
August 24, 2025 at 7:04 PM
This is it. The act of science -like art- is not the output, it is the interaction and the process. What makes us the kind of scientists we are is how we approach the problem 🧪
Reposted by Umut Kilik
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 22, 2025 at 9:04 PM
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Umut Kilik
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
August 10, 2025 at 1:19 PM
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
Reposted by Umut Kilik
Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11
July 24, 2025 at 12:36 PM
Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11
Reposted by Umut Kilik
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11
July 24, 2025 at 12:32 PM
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11
🚨 After 7 years in the making, my PhD thesis work is finally published in @science.org 🧬✨
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11
July 24, 2025 at 12:49 PM
🚨 After 7 years in the making, my PhD thesis work is finally published in @science.org 🧬✨
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves
Reposted by Umut Kilik
My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...
July 12, 2025 at 10:11 PM
My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...
Reposted by Umut Kilik
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature
Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...
www.nature.com
July 16, 2025 at 3:23 PM
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
Reposted by Umut Kilik
Elegant and insightful study on gut evolution and development - congratulations 🎊@graycamplab.bsky.social @umut-kilik.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Recent evolution of the developing human intestine affects metabolic and barrier functions
Diet, microbiota, and other exposures place the intestinal epithelium as a nexus for evolutionary change; however, little is known about genomic changes associated with adaptation to a uniquely human ...
www.science.org
July 19, 2025 at 8:41 PM
Elegant and insightful study on gut evolution and development - congratulations 🎊@graycamplab.bsky.social @umut-kilik.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Umut Kilik
Recent evolution of the developing human intestine affects metabolic and barrier functions @science.org @graycamplab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
July 17, 2025 at 7:23 PM
Recent evolution of the developing human intestine affects metabolic and barrier functions @science.org @graycamplab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Umut Kilik
An organoid model of the menstrual cycle reveals the role of the luminal epithelium in regeneration of the human endometrium https://www.biorxiv.org/content/10.1101/2025.07.03.663000v1
July 7, 2025 at 10:30 AM
An organoid model of the menstrual cycle reveals the role of the luminal epithelium in regeneration of the human endometrium https://www.biorxiv.org/content/10.1101/2025.07.03.663000v1
Reposted by Umut Kilik
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social @jasperjanssens.bsky.social and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
July 11, 2025 at 8:59 PM
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social @jasperjanssens.bsky.social and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
Reposted by Umut Kilik
✨Exciting news!✨
The World Endometriosis Research Foundation (#WERF) – Endometriosis Phenome and Biobanking Harmonisation Project (#EPHect) today publishes #SOPs to optimize the use of experimental in vivo and in vitro models in #endometriosis research.
The World Endometriosis Research Foundation (#WERF) – Endometriosis Phenome and Biobanking Harmonisation Project (#EPHect) today publishes #SOPs to optimize the use of experimental in vivo and in vitro models in #endometriosis research.
July 9, 2025 at 10:29 PM
✨Exciting news!✨
The World Endometriosis Research Foundation (#WERF) – Endometriosis Phenome and Biobanking Harmonisation Project (#EPHect) today publishes #SOPs to optimize the use of experimental in vivo and in vitro models in #endometriosis research.
The World Endometriosis Research Foundation (#WERF) – Endometriosis Phenome and Biobanking Harmonisation Project (#EPHect) today publishes #SOPs to optimize the use of experimental in vivo and in vitro models in #endometriosis research.
Reposted by Umut Kilik
Katie Kubek from @novartis.bsky.social showed the work they have been doing with dog intestinal organoids 🐶 Exciting insights into serotonin signalling in mammals!
July 1, 2025 at 7:37 AM
Katie Kubek from @novartis.bsky.social showed the work they have been doing with dog intestinal organoids 🐶 Exciting insights into serotonin signalling in mammals!
Reposted by Umut Kilik
🤩We had a fantastic time at #BaCell3D in Basel (June 23–25)! 🧬It was great to #exchange ideas on 3D cell culture, #organoids & in-vitro systems.
🤝Thanks to our Swiss #partner Vitaris AG – for joining us!🇨🇭
👋See you at the next #BaCell3D!
#organoids #BaCell3D #networking
🤝Thanks to our Swiss #partner Vitaris AG – for joining us!🇨🇭
👋See you at the next #BaCell3D!
#organoids #BaCell3D #networking
July 2, 2025 at 7:02 AM
🤩We had a fantastic time at #BaCell3D in Basel (June 23–25)! 🧬It was great to #exchange ideas on 3D cell culture, #organoids & in-vitro systems.
🤝Thanks to our Swiss #partner Vitaris AG – for joining us!🇨🇭
👋See you at the next #BaCell3D!
#organoids #BaCell3D #networking
🤝Thanks to our Swiss #partner Vitaris AG – for joining us!🇨🇭
👋See you at the next #BaCell3D!
#organoids #BaCell3D #networking
Reposted by Umut Kilik
Highlights from our day1 conference dinner and networking event at the local favorite multi-cuisine bar and restaurant-Klara. Nerdy N2 B27 shots to welcome everyone , table soccer tournament, music and lots of discussions !
June 25, 2025 at 2:42 PM
Highlights from our day1 conference dinner and networking event at the local favorite multi-cuisine bar and restaurant-Klara. Nerdy N2 B27 shots to welcome everyone , table soccer tournament, music and lots of discussions !
Reposted by Umut Kilik
Incredibly impressed by the student/postdoc run @bacell3d.bsky.social conference. Great talks, a vibrant community, and so well organised 👏
June 26, 2025 at 3:47 AM
Incredibly impressed by the student/postdoc run @bacell3d.bsky.social conference. Great talks, a vibrant community, and so well organised 👏
Reposted by Umut Kilik
@sbwil91.bsky.social is our next speaker from Melissa Little’s group at the reNEW @novonordisk.bsky.social telling us about his work on multi lineage kidney assembloids
June 23, 2025 at 11:59 AM
@sbwil91.bsky.social is our next speaker from Melissa Little’s group at the reNEW @novonordisk.bsky.social telling us about his work on multi lineage kidney assembloids
Reposted by Umut Kilik
Beautiful selected talk by Hao-An Hsiung from EPFL showing us human trunk assembloids with remarkable cell diversity, notochord and the gut tube!
June 25, 2025 at 9:39 AM
Beautiful selected talk by Hao-An Hsiung from EPFL showing us human trunk assembloids with remarkable cell diversity, notochord and the gut tube!
Reposted by Umut Kilik
@maxmmahe.bsky.social Human intestinal organoids mature much faster when transplanted in vivo. Surprising discoveries on tubular organoids demonstrating higher cellular complexity!
June 25, 2025 at 11:51 AM
@maxmmahe.bsky.social Human intestinal organoids mature much faster when transplanted in vivo. Surprising discoveries on tubular organoids demonstrating higher cellular complexity!
Reposted by Umut Kilik
Amazing presentation by @mendjanlab.bsky.social explaining the potential of human cardioids. Increasing complexity step by step to generate more in vivo-like organoids!
June 25, 2025 at 12:14 PM
Amazing presentation by @mendjanlab.bsky.social explaining the potential of human cardioids. Increasing complexity step by step to generate more in vivo-like organoids!
Reposted by Umut Kilik
A selected talk from @clarissebrunet.bsky.social investigating gliogenesis in brain organoids 🧠
June 25, 2025 at 12:17 PM
A selected talk from @clarissebrunet.bsky.social investigating gliogenesis in brain organoids 🧠