Theo Hirsch
@tz-hirsch.bsky.social
Cancer genomics researcher in Paris
Liver cancer evolution in children and adults
🖥️🧬 Bulk, single-cell, spatial | Mosaicism
http://zucmanlab.com Cordeliers Research Center
Liver cancer evolution in children and adults
🖥️🧬 Bulk, single-cell, spatial | Mosaicism
http://zucmanlab.com Cordeliers Research Center
Reposted by Theo Hirsch
![4-panel comic. (1) [Person 1 with ponytail flanked by person with short hair and another person speaking into microphone at podium] PERSON 1: In the early 2010s, researchers found that many major scientific results couldn’t be reproduced. (2) PERSON 1: Over a decade into the replication crisis, we wanted to see if today’s studies have become more robust. (3) PERSON 1: Unfortunately, our replication analysis has found exactly the same problems that those 2010s researchers did. (4) [newspaper with image of speakers from previous panels] Headline: Replication Crisis Solved](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreibwuu57ullc7vacjyno6c5z3gtyakkg2qub6cn3dbbjdpn2kaowmi@jpeg)
July 21, 2025 at 11:54 PM
Check out my editorial about immune exclusion in hepatoblastoma and a possible role of beta-catenin:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
June 15, 2025 at 7:29 PM
Check out my editorial about immune exclusion in hepatoblastoma and a possible role of beta-catenin:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Thank you @easlnews.bsky.social for giving me the opportunity to present our work on hepatoblastoma genomics and future therapeuties in Amsterdam, together with my mentor @zucmanrossi.bsky.social
@crcordeliers.bsky.social
@crcordeliers.bsky.social
May 7, 2025 at 7:53 PM
Thank you @easlnews.bsky.social for giving me the opportunity to present our work on hepatoblastoma genomics and future therapeuties in Amsterdam, together with my mentor @zucmanrossi.bsky.social
@crcordeliers.bsky.social
@crcordeliers.bsky.social
Reposted by Theo Hirsch
🔙 on our Hepatology and Liver Transplantation Days!
🤝 We had the pleasure of welcoming @tz-hirsch.bsky.social for a presentation titled: Evolution of Hepatoblastoma: From #Liver Development to Chemoresistance.
🧫 His talk sparked dynamic discussions during the session on #hepatic #pathogenesis.
🤝 We had the pleasure of welcoming @tz-hirsch.bsky.social for a presentation titled: Evolution of Hepatoblastoma: From #Liver Development to Chemoresistance.
🧫 His talk sparked dynamic discussions during the session on #hepatic #pathogenesis.
April 15, 2025 at 2:30 PM
🔙 on our Hepatology and Liver Transplantation Days!
🤝 We had the pleasure of welcoming @tz-hirsch.bsky.social for a presentation titled: Evolution of Hepatoblastoma: From #Liver Development to Chemoresistance.
🧫 His talk sparked dynamic discussions during the session on #hepatic #pathogenesis.
🤝 We had the pleasure of welcoming @tz-hirsch.bsky.social for a presentation titled: Evolution of Hepatoblastoma: From #Liver Development to Chemoresistance.
🧫 His talk sparked dynamic discussions during the session on #hepatic #pathogenesis.
Thank you @ihuhepatolyon.bsky.social for the invitation and the opportunity to present our team work on hepatoblastoma evolution, in a nice castle in Lyon! #FunGeST @crcordeliers.bsky.social
April 8, 2025 at 12:53 PM
Thank you @ihuhepatolyon.bsky.social for the invitation and the opportunity to present our team work on hepatoblastoma evolution, in a nice castle in Lyon! #FunGeST @crcordeliers.bsky.social
Reposted by Theo Hirsch
🚀 C'est parti pour le Young Investigators Mentoring Symposium au CRC, organisé par le consortium GENIAL en collaboration avec le laboratoire de @zucmanrossi.bsky.social.
Une occasion de favoriser l'échange, la collaboration et la visibilité des talents émergents dans le monde de la recherche!
Une occasion de favoriser l'échange, la collaboration et la visibilité des talents émergents dans le monde de la recherche!
April 3, 2025 at 4:45 PM
🚀 C'est parti pour le Young Investigators Mentoring Symposium au CRC, organisé par le consortium GENIAL en collaboration avec le laboratoire de @zucmanrossi.bsky.social.
Une occasion de favoriser l'échange, la collaboration et la visibilité des talents émergents dans le monde de la recherche!
Une occasion de favoriser l'échange, la collaboration et la visibilité des talents émergents dans le monde de la recherche!
Great scientific day about mosaicism 👾 at @institutimagine.bsky.social including inspiring talks from Serge Romana and Peter Campbell
March 20, 2025 at 2:41 PM
Great scientific day about mosaicism 👾 at @institutimagine.bsky.social including inspiring talks from Serge Romana and Peter Campbell
Thrilled to reconnect with colleagues from around the globe at the SIOPEL meeting in Cardiff! Working together to better understand and treat childhood liver cancer. 🌍 @crcordeliers.bsky.social
March 13, 2025 at 12:01 PM
Thrilled to reconnect with colleagues from around the globe at the SIOPEL meeting in Cardiff! Working together to better understand and treat childhood liver cancer. 🌍 @crcordeliers.bsky.social
Reposted by Theo Hirsch
Tools like our Single-cell #PediatricCancer Atlas (ScPCA) Portal make data widely available and easier for researchers to use for their own experiments. Currently, you can explore and download data from 700 samples across 55 cancer types at scpca.alexslemonade.org!
January 21, 2025 at 5:06 PM
Tools like our Single-cell #PediatricCancer Atlas (ScPCA) Portal make data widely available and easier for researchers to use for their own experiments. Currently, you can explore and download data from 700 samples across 55 cancer types at scpca.alexslemonade.org!
Reposted by Theo Hirsch
Re-upping these two #CancerResearch 🧪 starter packs for any new arrivals
go.bsky.app/FEoaJMc
go.bsky.app/6EcjWNA
Together they include PIs, oncologists, students, postdocs, journals, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
Both are full - sorry I can't add any more 😅
go.bsky.app/FEoaJMc
go.bsky.app/6EcjWNA
Together they include PIs, oncologists, students, postdocs, journals, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
Both are full - sorry I can't add any more 😅
Both #Cancer #Research starter packs are now completely full!
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
January 20, 2025 at 12:44 PM
Re-upping these two #CancerResearch 🧪 starter packs for any new arrivals
go.bsky.app/FEoaJMc
go.bsky.app/6EcjWNA
Together they include PIs, oncologists, students, postdocs, journals, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
Both are full - sorry I can't add any more 😅
go.bsky.app/FEoaJMc
go.bsky.app/6EcjWNA
Together they include PIs, oncologists, students, postdocs, journals, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
Both are full - sorry I can't add any more 😅
Reposted by Theo Hirsch
Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵
This was an incredible team effort w/ @jennifergarrison.bsky.social #TammyLan @davidsebfischer.bsky.social #AlisonKochersberger #RuthRaichur #SophiaSzady
This was an incredible team effort w/ @jennifergarrison.bsky.social #TammyLan @davidsebfischer.bsky.social #AlisonKochersberger #RuthRaichur #SophiaSzady
December 18, 2024 at 2:32 PM
Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵
This was an incredible team effort w/ @jennifergarrison.bsky.social #TammyLan @davidsebfischer.bsky.social #AlisonKochersberger #RuthRaichur #SophiaSzady
This was an incredible team effort w/ @jennifergarrison.bsky.social #TammyLan @davidsebfischer.bsky.social #AlisonKochersberger #RuthRaichur #SophiaSzady
Reposted by Theo Hirsch
Try out SpatialLeiden for identifying spatial domains/clusters in your #SpatialTranscriptomics data: www.biorxiv.org/content/10.1...
github.com/HiDiHlabs/sp...
It's as easy as Leiden, but as performant as the best in class. Give it a try and let us know if it works for you!
github.com/HiDiHlabs/sp...
It's as easy as Leiden, but as performant as the best in class. Give it a try and let us know if it works for you!
SpatialLeiden - Spatially-aware Leiden clustering
Clustering can identify the natural structure that is inherent to measured data. For single-cell omics, clustering finds cells with similar molecular phenotype after which cell types are annotated. Le...
www.biorxiv.org
December 3, 2024 at 7:55 PM
Try out SpatialLeiden for identifying spatial domains/clusters in your #SpatialTranscriptomics data: www.biorxiv.org/content/10.1...
github.com/HiDiHlabs/sp...
It's as easy as Leiden, but as performant as the best in class. Give it a try and let us know if it works for you!
github.com/HiDiHlabs/sp...
It's as easy as Leiden, but as performant as the best in class. Give it a try and let us know if it works for you!
Reposted by Theo Hirsch
My first post on Bluesky ! I officially announce that after 15 years at the PARCC HEGP, the Favier Lab has moved today to the Centre de Recherche des Cordeliers. We are very exited to be part of such a prestigious institute ! A new era begins!🤩
November 28, 2024 at 9:49 PM
My first post on Bluesky ! I officially announce that after 15 years at the PARCC HEGP, the Favier Lab has moved today to the Centre de Recherche des Cordeliers. We are very exited to be part of such a prestigious institute ! A new era begins!🤩
Reposted by Theo Hirsch
Only a subset of patients respond to immunotherapy
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
November 27, 2024 at 2:13 PM
Only a subset of patients respond to immunotherapy
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Reposted by Theo Hirsch
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
November 25, 2024 at 12:38 PM
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
Reposted by Theo Hirsch
Children who develop two independent tumors during childhood are extremely rare
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
November 25, 2024 at 3:07 PM
Children who develop two independent tumors during childhood are extremely rare
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
A paradigm-shifting concept 😮 When there’s no mutated target for your CAR-T cells, why not target the wild-type and mutate all non-cancer cells to protect them?
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
To target, to escape, perchance to cure: Borrowing a page from cancer’s playbook, scientists learn to evade their own therapies
Borrowing a page from cancer’s playbook, scientists learn to evade their own therapies
www.science.org
November 25, 2024 at 9:28 AM
A paradigm-shifting concept 😮 When there’s no mutated target for your CAR-T cells, why not target the wild-type and mutate all non-cancer cells to protect them?
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Theo Hirsch
We recently announced a dual new release of intOGen and boostDM
Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations
➡️ Compendium of Cancer Driver Genes - www.intogen.org
➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm
Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations
➡️ Compendium of Cancer Driver Genes - www.intogen.org
➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm
November 25, 2024 at 3:37 AM
We recently announced a dual new release of intOGen and boostDM
Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations
➡️ Compendium of Cancer Driver Genes - www.intogen.org
➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm
Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations
➡️ Compendium of Cancer Driver Genes - www.intogen.org
➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm
Reposted by Theo Hirsch
Happy to be here & share our work on hepatoblastoma - using transcriptomics and patient-derived tumoroids to identify embryonic biliary transcription factor SOX4 as a modifier of Wnt activation & proliferation - published today in #NatComms @natureportfolio.bsky.social www.nature.com/articles/s41...
A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma - Nature Communications
Epigenetic causes of intra-tumoural heterogeneity are crucial in paediatric cancers with low mutation rates, such as hepatoblastoma. Here, the authors characterise transcriptional heterogeneity in hep...
www.nature.com
November 20, 2024 at 2:29 PM
Happy to be here & share our work on hepatoblastoma - using transcriptomics and patient-derived tumoroids to identify embryonic biliary transcription factor SOX4 as a modifier of Wnt activation & proliferation - published today in #NatComms @natureportfolio.bsky.social www.nature.com/articles/s41...
Reposted by Theo Hirsch
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas - Nature Cancer 🧪
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas - Nature Cancer
Wu et al. perform single-cell analyses to explore the switch from low-grade to high-grade isocitrate-dehydrogenase-mutant glioma and show that it is characterized by oligodendrocyte progenitor cell-li...
www.nature.com
November 24, 2024 at 6:57 AM
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas - Nature Cancer 🧪
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Theo Hirsch
Let's build a starter pack for childhood cancer research.
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
November 24, 2024 at 3:27 PM
Let's build a starter pack for childhood cancer research.
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
Reposted by Theo Hirsch
NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma - by Katherine Lindblad1, @amaialujambio.bsky.social and colleagues doi.org/10.1158/2159...
November 20, 2024 at 6:38 PM
NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma - by Katherine Lindblad1, @amaialujambio.bsky.social and colleagues doi.org/10.1158/2159...
Reposted by Theo Hirsch
Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...
Somatic mutation and selection at epidemiological scale
As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...
www.medrxiv.org
November 20, 2024 at 2:28 PM
Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...
Reposted by Theo Hirsch
1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces.
biorxiv.org/content/10.1101/2024.11.06.622266v1
biorxiv.org/content/10.1101/2024.11.06.622266v1
November 20, 2024 at 2:29 PM
1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces.
biorxiv.org/content/10.1101/2024.11.06.622266v1
biorxiv.org/content/10.1101/2024.11.06.622266v1