Tom Trainer
@tomtrainersci.bsky.social
Prion guy. PhD researcher, Cryo-ET in situ 🧠 as part of the Manka Lab at Imperial College London.
Reposted by Tom Trainer
"I'm kind of an AI skeptic, because I find that the machine learned something, but I didn't." - David DeRosier (paraphrase), at the "Cryo-EM: the next 50 years" symposium.
January 11, 2025 at 10:48 PM
"I'm kind of an AI skeptic, because I find that the machine learned something, but I didn't." - David DeRosier (paraphrase), at the "Cryo-EM: the next 50 years" symposium.
Reposted by Tom Trainer
Take a look at my personal perspective on the past, present, and future of in situ structural biology with cryo-ET+
While initially skeptical about the genre, I found it fun to write and hopefully, you can enjoy my experiences and some thoughts. Nice weekend y'all
www.cambridge.org/core/journal...
While initially skeptical about the genre, I found it fun to write and hopefully, you can enjoy my experiences and some thoughts. Nice weekend y'all
www.cambridge.org/core/journal...
The big chill: Growth of in situ structural biology with cryo-electron tomography | QRB Discovery | Cambridge Core
The big chill: Growth of in situ structural biology with cryo-electron tomography - Volume 5
www.cambridge.org
December 13, 2024 at 4:45 PM
Take a look at my personal perspective on the past, present, and future of in situ structural biology with cryo-ET+
While initially skeptical about the genre, I found it fun to write and hopefully, you can enjoy my experiences and some thoughts. Nice weekend y'all
www.cambridge.org/core/journal...
While initially skeptical about the genre, I found it fun to write and hopefully, you can enjoy my experiences and some thoughts. Nice weekend y'all
www.cambridge.org/core/journal...
Reposted by Tom Trainer
High-resolution template matching of the human ribosome in situ by Lippincott-Schwartz Lab @hhmijanelia.bsky.social @hhmi.bsky.social. >40 conformations within together reveal molecular dynamics of the elongation cycle with previously unknown bending and “spring-like” motion.
December 3, 2024 at 12:21 PM
High-resolution template matching of the human ribosome in situ by Lippincott-Schwartz Lab @hhmijanelia.bsky.social @hhmi.bsky.social. >40 conformations within together reveal molecular dynamics of the elongation cycle with previously unknown bending and “spring-like” motion.
Reposted by Tom Trainer
Our #CryoET paper on ciliary rootlet ultrastructure from mouse retina is now out in @elife.bsky.social! Have a peek with this video or dive deeper at bit.ly/3ZJzhgc. Big thanks to @carter-lab.bsky.social and #teamtomo.
#CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science
#CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science
December 8, 2024 at 2:38 PM
Our #CryoET paper on ciliary rootlet ultrastructure from mouse retina is now out in @elife.bsky.social! Have a peek with this video or dive deeper at bit.ly/3ZJzhgc. Big thanks to @carter-lab.bsky.social and #teamtomo.
#CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science
#CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science
Reposted by Tom Trainer
Absolutely thrilled to be awarded a BBSRC ALERT2024 grant to buy a cryoFIB-SEM for in situ #cryoEM! This was a brilliant team effort, with >35 researchers contributing projects/ideas. In situ structural biology has an exciting future here in #Bristol and the south-west UK! gw4.ac.uk/news/game-ch...
‘Game-changer' equipment will enable GW4 researchers to accelerate integrated understanding of health - GW4
£2.6million secured by GW4 Alliance researchers will open-up groundbreaking health research possibilities through new equipment.
gw4.ac.uk
November 13, 2024 at 6:42 PM
Absolutely thrilled to be awarded a BBSRC ALERT2024 grant to buy a cryoFIB-SEM for in situ #cryoEM! This was a brilliant team effort, with >35 researchers contributing projects/ideas. In situ structural biology has an exciting future here in #Bristol and the south-west UK! gw4.ac.uk/news/game-ch...
Reposted by Tom Trainer
Reposted by Tom Trainer
OK, here goes: if no better evidence gets presented, then the concept that non-fibrillar oligomers of the proteins that form filamentous aggregates are the toxic species in neurodegenerative disease should be abandoned, in favour of small filaments.
November 17, 2024 at 10:12 AM
OK, here goes: if no better evidence gets presented, then the concept that non-fibrillar oligomers of the proteins that form filamentous aggregates are the toxic species in neurodegenerative disease should be abandoned, in favour of small filaments.
Reposted by Tom Trainer
A cool surprise for me today -- So this is what happens when my first two labs (undergrad: Larabell / grad: Marshall) team up!?🤩
Automated segmentation of soft x-ray tomography data to quantify 3D organelle geometry and interactions. Lots of great morphometric analysis in here! #TeamTomo🧪🔬
Automated segmentation of soft x-ray tomography data to quantify 3D organelle geometry and interactions. Lots of great morphometric analysis in here! #TeamTomo🧪🔬
How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 22, 2024 at 11:20 AM
A cool surprise for me today -- So this is what happens when my first two labs (undergrad: Larabell / grad: Marshall) team up!?🤩
Automated segmentation of soft x-ray tomography data to quantify 3D organelle geometry and interactions. Lots of great morphometric analysis in here! #TeamTomo🧪🔬
Automated segmentation of soft x-ray tomography data to quantify 3D organelle geometry and interactions. Lots of great morphometric analysis in here! #TeamTomo🧪🔬