LightNews LightNews
chrisvanhoorn.bsky.social
@chrisvanhoorn.bsky.social
130 followers 130 following 2 posts
Former @MRC_LMB @Carter Lab & Gates Cambridge Scholar, occasional linocut print maker. #cryoEM #cryoET #cilia #centrioles #centrosome #Rootlet (he/him)
Posts Replies Media Videos
Reposted
abidalilab.bsky.social
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.
November 27, 2024 at 12:15 PM
chrisvanhoorn.bsky.social
Our #CryoET paper on ciliary rootlet ultrastructure from mouse retina is now out in @elife.bsky.social! Have a peek with this video or dive deeper at bit.ly/3ZJzhgc. Big thanks to @carter-lab.bsky.social and #teamtomo.

#CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science
December 8, 2024 at 2:38 PM