Tom Brett
@tombrettlab.bsky.social
PhD AAZF ATSF. Associate Prof of Medicine at WashU, Co-Director BBSB PhD Program, Structural Biology, Molecular Mechanisms of Inflammation, lung disease, Alzheimer's Disease. Girlsdad. Outdoor Enthusiast.
Reposted by Tom Brett
A little time off the grid….
March 22, 2025 at 5:08 PM
A little time off the grid….
Reposted by Tom Brett
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.
James Harrison, whose blood donations saved over 2 million babies, has died
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.
www.npr.org
March 4, 2025 at 2:06 AM
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.
George was a great guy. I vividly remember meeting him at a mixer at the IUCr meeting in Seattle in '97 when I was a grad student. We had an hour long conversation about SHELX and crystallography and other things over beers. Both a deep thinker and down to earth guy. He leaves a big impact.
The CCDC team are saddened to learn that George Sheldrick has passed away.
His impact in #Crystallography was immense; from the SHELX software used globally, to teaching, structures, journals, and more.
More by the ECA here: ccdc-info.com/41gvV3M
His impact in #Crystallography was immense; from the SHELX software used globally, to teaching, structures, journals, and more.
More by the ECA here: ccdc-info.com/41gvV3M
George M. Sheldrick (1942-2025) - European Crystallographic Association
It is with a heavy heart, that we must announce the passing of George Michael Sheldrick. Everyone in crystallography knows George as a giant in the development of computing methods […]
ccdc-info.com
February 25, 2025 at 4:10 PM
George was a great guy. I vividly remember meeting him at a mixer at the IUCr meeting in Seattle in '97 when I was a grad student. We had an hour long conversation about SHELX and crystallography and other things over beers. Both a deep thinker and down to earth guy. He leaves a big impact.
Fun fact about George Sheldrick: he wrote a paper on his SHELX software (that everyone uses for small molecule crystallography) in Acta Cryst A which caused the journal to go from Impact Factor 2 to an IF = 50. Spawned discussion on the relevance of IFs. Huge impact.
We are saddened to hear of the passing of George Sheldrick. A dedicated professional with a distinguished career, his work and leadership touched countless lives. Our hearts go out to his family during this difficult time. Remember George with us: bit.ly/3QtoTUy
February 25, 2025 at 4:09 PM
Fun fact about George Sheldrick: he wrote a paper on his SHELX software (that everyone uses for small molecule crystallography) in Acta Cryst A which caused the journal to go from Impact Factor 2 to an IF = 50. Spawned discussion on the relevance of IFs. Huge impact.
Reposted by Tom Brett
Mapping Trem2 ligand interactions by the group who brought us the first Trem2 crystal structure @tombrettlab.bsky.social
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...
molecularneurodegeneration.biomedcentral.com
February 11, 2025 at 3:10 AM
Mapping Trem2 ligand interactions by the group who brought us the first Trem2 crystal structure @tombrettlab.bsky.social
Reposted by Tom Brett
Right about now wondering how many Trump voters work at Universities in:
Facilities Management
Environmental Services
Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters)
Large equipment installation or repair
Security
IT
Need I go on…..
Facilities Management
Environmental Services
Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters)
Large equipment installation or repair
Security
IT
Need I go on…..
February 8, 2025 at 4:08 PM
Right about now wondering how many Trump voters work at Universities in:
Facilities Management
Environmental Services
Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters)
Large equipment installation or repair
Security
IT
Need I go on…..
Facilities Management
Environmental Services
Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters)
Large equipment installation or repair
Security
IT
Need I go on…..
One of the joys of mentoring is getting a glimpse into your students “outside the lab” life. Got to see the amazing #LNYF25 performance including our amazing undergrad researcher Cynthia Zhi!
February 2, 2025 at 1:21 PM
One of the joys of mentoring is getting a glimpse into your students “outside the lab” life. Got to see the amazing #LNYF25 performance including our amazing undergrad researcher Cynthia Zhi!
Beautiful day for a snow hike with @jablab3.bsky.social ! Really amazing out there today!
January 12, 2025 at 12:00 AM
Beautiful day for a snow hike with @jablab3.bsky.social ! Really amazing out there today!
I am so thrilled to share our latest collab with @jablab3.bsky.social ! Structural mapping of #TREM2 ligand interactions by #BLI. Led by Jessica Greven; thanks to big contributions by Josh Wydra, Cynthia Zhi,...
molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com/articles/10....
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...
molecularneurodegeneration.biomedcentral.com
January 10, 2025 at 1:39 PM
I am so thrilled to share our latest collab with @jablab3.bsky.social ! Structural mapping of #TREM2 ligand interactions by #BLI. Led by Jessica Greven; thanks to big contributions by Josh Wydra, Cynthia Zhi,...
molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com/articles/10....
Reposted by Tom Brett
Check out the latest from our groups on TREM2, driven by rockstar postbac Jess Greven and @tombrettlab.bsky.social!
@washumedicine.bsky.social
doi.org/10.1186/s130...
@washumedicine.bsky.social
doi.org/10.1186/s130...
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...
doi.org
January 9, 2025 at 6:18 PM
Check out the latest from our groups on TREM2, driven by rockstar postbac Jess Greven and @tombrettlab.bsky.social!
@washumedicine.bsky.social
doi.org/10.1186/s130...
@washumedicine.bsky.social
doi.org/10.1186/s130...
As a Minnesota native, I can’t pass up the opportunity for a snow run! Nice storm out there!
January 5, 2025 at 7:25 PM
As a Minnesota native, I can’t pass up the opportunity for a snow run! Nice storm out there!
Reposted by Tom Brett
Right, fun’s over, back to our regularly scheduled programming.
January 5, 2025 at 10:22 AM
Right, fun’s over, back to our regularly scheduled programming.
You know how the emails pile up over the holidays, and when you clean your inbox out by quick screen/delete, you hope you didn't get rid of something important? Just found out we @jablab3.bsky.social had a big paper accepted a week ago because the notice got deleted. Happy discoveries!
a person is typing on a keyboard with the words deleting delete intensifies
ALT: a person is typing on a keyboard with the words deleting delete intensifies
media.tenor.com
January 4, 2025 at 3:57 PM
You know how the emails pile up over the holidays, and when you clean your inbox out by quick screen/delete, you hope you didn't get rid of something important? Just found out we @jablab3.bsky.social had a big paper accepted a week ago because the notice got deleted. Happy discoveries!
Achievement unlocked! Chestnuts roasted on an open fire! Happy New Year to all!
January 2, 2025 at 1:42 AM
Achievement unlocked! Chestnuts roasted on an open fire! Happy New Year to all!
Reposted by Tom Brett
Had the opportunity tonight to say Hi to my ‘baby blue’
December 31, 2024 at 4:20 AM
Had the opportunity tonight to say Hi to my ‘baby blue’
Reposted by Tom Brett
Photo credit in image, I NEED to see this bird that is reportedly in the area.
December 30, 2024 at 11:51 PM
Photo credit in image, I NEED to see this bird that is reportedly in the area.
Reposted by Tom Brett
Reposted by Tom Brett
Ok, finally a science post for BlueSky: Check out our latest editorial in @TheJHLT, strong work as always from Ghandi (@Ghandi_Hassan_ on X)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Harnessing Mesenchymal Stem Cells for Improving Lung Transplant Outcomes
www.sciencedirect.com
December 26, 2024 at 4:53 PM
Ok, finally a science post for BlueSky: Check out our latest editorial in @TheJHLT, strong work as always from Ghandi (@Ghandi_Hassan_ on X)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Tom Brett
Jim Manley trumpet at Jazz STL
December 14, 2024 at 2:01 AM
Jim Manley trumpet at Jazz STL
Reposted by Tom Brett
December 16, 2024 at 2:26 AM
Reposted by Tom Brett
Reposted by Tom Brett
He doesn’t get it. That’s ok. Fellow karaoke enthusiasts IYKYK ❤️ 🎤
Bobby Gillespie in today’s Guardian, “I don’t think I’ve ever done karaoke. I hate hearing people murder songs.” 👀
December 7, 2024 at 2:54 PM
He doesn’t get it. That’s ok. Fellow karaoke enthusiasts IYKYK ❤️ 🎤
Reposted by Tom Brett
👀!!!
Nothing encapsulates Vinay Prasad better than seeing him defend an objectively evil corporation, UHC, and attack a truly wonderful human, @glaucomflecken.bsky.social, only to find out he is a paid consultant for UHC
December 6, 2024 at 2:09 AM
👀!!!
Reposted by Tom Brett
Interesting riff on science inspired by a story about Chappell Roan. I like it. Equally good food for those:
1) quietly struggling to find the motivation to keep going with their science
2) ignorantly raging about the process and taxpayer value of science
www.instagram.com/reel/DCjzrMJ...
1) quietly struggling to find the motivation to keep going with their science
2) ignorantly raging about the process and taxpayer value of science
www.instagram.com/reel/DCjzrMJ...
December 3, 2024 at 5:42 PM
Interesting riff on science inspired by a story about Chappell Roan. I like it. Equally good food for those:
1) quietly struggling to find the motivation to keep going with their science
2) ignorantly raging about the process and taxpayer value of science
www.instagram.com/reel/DCjzrMJ...
1) quietly struggling to find the motivation to keep going with their science
2) ignorantly raging about the process and taxpayer value of science
www.instagram.com/reel/DCjzrMJ...
Reposted by Tom Brett
Some know I have a thing for making playlists, but top 4% worldwide? Ok 🤣
If you wanna check them out
Jen AB on @Spotify
sites.wustl.edu/jablab
(we all know the winner is @Hozier)
If you wanna check them out
Jen AB on @Spotify
sites.wustl.edu/jablab
(we all know the winner is @Hozier)
December 10, 2024 at 8:37 PM
Some know I have a thing for making playlists, but top 4% worldwide? Ok 🤣
If you wanna check them out
Jen AB on @Spotify
sites.wustl.edu/jablab
(we all know the winner is @Hozier)
If you wanna check them out
Jen AB on @Spotify
sites.wustl.edu/jablab
(we all know the winner is @Hozier)