Jen A-Brett
@jablab3.bsky.social
Jen A-Brett MD PhD ATSF | 🫁 transplant & critical care | mechanisms of epithelial-immune crosstalk | cytokines & EVs in airway disease | #extracellularlife | Twitter @jablab3
So incredibly proud of the hard work from the JAB lab and especially for recent PhD graduate Omar Osorio leading the charge on this exciting work just published online in JCI Insight!
insight.jci.org/articles/view/…
insight.jci.org/articles/view/…
June 25, 2025 at 11:21 AM
So incredibly proud of the hard work from the JAB lab and especially for recent PhD graduate Omar Osorio leading the charge on this exciting work just published online in JCI Insight!
insight.jci.org/articles/view/…
insight.jci.org/articles/view/…
There are no words adequate to express the gratitude I feel for those who contributed to and supported me through this effort. It’s the product of their talent, fortitude, guidance and belief that made it possible. Especially @tombrettlab and countless others who will hear from me in due time ❤️🙏🥂
May 3, 2025 at 2:07 PM
There are no words adequate to express the gratitude I feel for those who contributed to and supported me through this effort. It’s the product of their talent, fortitude, guidance and belief that made it possible. Especially @tombrettlab and countless others who will hear from me in due time ❤️🙏🥂
A little time off the grid….
March 22, 2025 at 5:08 PM
A little time off the grid….
What can I say, I work with an amazing group of thoughtful, supportive and talented people, who also enjoy birthdays 🙏🙏🙏
March 22, 2025 at 5:06 PM
What can I say, I work with an amazing group of thoughtful, supportive and talented people, who also enjoy birthdays 🙏🙏🙏
Reposted by Jen A-Brett
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
March 22, 2025 at 10:44 AM
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
Reposted by Jen A-Brett
If you think DOGE has created massive inefficiencies and waste in their activities to date, and you live in the state of MO, you might want to flood their portal with your comments:
February 8, 2025 at 4:45 PM
If you think DOGE has created massive inefficiencies and waste in their activities to date, and you live in the state of MO, you might want to flood their portal with your comments:
Reposted by Jen A-Brett
Right about now wondering how many Trump voters work at Universities in:
Facilities Management
Environmental Services
Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters)
Large equipment installation or repair
Security
IT
Need I go on…..
Facilities Management
Environmental Services
Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters)
Large equipment installation or repair
Security
IT
Need I go on…..
February 8, 2025 at 4:08 PM
Right about now wondering how many Trump voters work at Universities in:
Facilities Management
Environmental Services
Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters)
Large equipment installation or repair
Security
IT
Need I go on…..
Facilities Management
Environmental Services
Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters)
Large equipment installation or repair
Security
IT
Need I go on…..
Pleased to share our latest work now posted on @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
HSP70 is a chaperone for IL-33 secretion and function in chronic airway disease
Rationale IL-33 is a key driver of type 2 inflammation relevant to airway epithelial biology. However, the mechanisms for IL-33 secretion and regulation in the context of chronic airway disease is poo...
www.biorxiv.org
February 6, 2025 at 11:48 PM
Pleased to share our latest work now posted on @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jen A-Brett
Beautiful day for a snow hike with @jablab3.bsky.social ! Really amazing out there today!
January 12, 2025 at 12:00 AM
Beautiful day for a snow hike with @jablab3.bsky.social ! Really amazing out there today!
Reposted by Jen A-Brett
I am so thrilled to share our latest collab with @jablab3.bsky.social ! Structural mapping of #TREM2 ligand interactions by #BLI. Led by Jessica Greven; thanks to big contributions by Josh Wydra, Cynthia Zhi,...
molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com/articles/10....
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...
molecularneurodegeneration.biomedcentral.com
January 10, 2025 at 1:39 PM
I am so thrilled to share our latest collab with @jablab3.bsky.social ! Structural mapping of #TREM2 ligand interactions by #BLI. Led by Jessica Greven; thanks to big contributions by Josh Wydra, Cynthia Zhi,...
molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com/articles/10....
Check out the latest from our groups on TREM2, driven by rockstar postbac Jess Greven and @tombrettlab.bsky.social!
@washumedicine.bsky.social
doi.org/10.1186/s130...
@washumedicine.bsky.social
doi.org/10.1186/s130...
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...
doi.org
January 9, 2025 at 6:18 PM
Check out the latest from our groups on TREM2, driven by rockstar postbac Jess Greven and @tombrettlab.bsky.social!
@washumedicine.bsky.social
doi.org/10.1186/s130...
@washumedicine.bsky.social
doi.org/10.1186/s130...
Reposted by Jen A-Brett
My bluebirds flocking to the feeders in the fresh snow, the BEST biscuits, and a new Spotify playlist (JAB Classical).
The unit tomorrow, but today is a good day 💙
The unit tomorrow, but today is a good day 💙
January 5, 2025 at 9:29 PM
My bluebirds flocking to the feeders in the fresh snow, the BEST biscuits, and a new Spotify playlist (JAB Classical).
The unit tomorrow, but today is a good day 💙
The unit tomorrow, but today is a good day 💙
Reposted by Jen A-Brett
You know how the emails pile up over the holidays, and when you clean your inbox out by quick screen/delete, you hope you didn't get rid of something important? Just found out we @jablab3.bsky.social had a big paper accepted a week ago because the notice got deleted. Happy discoveries!
a person is typing on a keyboard with the words deleting delete intensifies
ALT: a person is typing on a keyboard with the words deleting delete intensifies
media.tenor.com
January 4, 2025 at 3:57 PM
You know how the emails pile up over the holidays, and when you clean your inbox out by quick screen/delete, you hope you didn't get rid of something important? Just found out we @jablab3.bsky.social had a big paper accepted a week ago because the notice got deleted. Happy discoveries!
Reposted by Jen A-Brett
So excited to have our new paper out now!
Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3
#innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social
Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3
#innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social
December 31, 2024 at 4:39 PM
So excited to have our new paper out now!
Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3
#innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social
Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3
#innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social
Reposted by Jen A-Brett
Photo credit in image, I NEED to see this bird that is reportedly in the area.
December 30, 2024 at 11:51 PM
Photo credit in image, I NEED to see this bird that is reportedly in the area.
Ok, finally a science post for BlueSky: Check out our latest editorial in @TheJHLT, strong work as always from Ghandi (@Ghandi_Hassan_ on X)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Harnessing Mesenchymal Stem Cells for Improving Lung Transplant Outcomes
www.sciencedirect.com
December 26, 2024 at 4:53 PM
Ok, finally a science post for BlueSky: Check out our latest editorial in @TheJHLT, strong work as always from Ghandi (@Ghandi_Hassan_ on X)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Time to wait out the soufflé cheesecake, this spot will do 😊
December 16, 2024 at 3:11 AM
Time to wait out the soufflé cheesecake, this spot will do 😊
Jim Manley trumpet at Jazz STL
December 14, 2024 at 2:01 AM
Jim Manley trumpet at Jazz STL
Reposted by Jen A-Brett
Isn’t it amazing that when bullying behavior happens to others, it’s easy to give advice and guidance. But when it happens to you, it’s hard to figure out what to do in the moment.
December 11, 2024 at 8:42 PM
Isn’t it amazing that when bullying behavior happens to others, it’s easy to give advice and guidance. But when it happens to you, it’s hard to figure out what to do in the moment.
Some know I have a thing for making playlists, but top 4% worldwide? Ok 🤣
If you wanna check them out
Jen AB on @Spotify
sites.wustl.edu/jablab
(we all know the winner is @Hozier)
If you wanna check them out
Jen AB on @Spotify
sites.wustl.edu/jablab
(we all know the winner is @Hozier)
December 10, 2024 at 8:37 PM
Some know I have a thing for making playlists, but top 4% worldwide? Ok 🤣
If you wanna check them out
Jen AB on @Spotify
sites.wustl.edu/jablab
(we all know the winner is @Hozier)
If you wanna check them out
Jen AB on @Spotify
sites.wustl.edu/jablab
(we all know the winner is @Hozier)
Reposted by Jen A-Brett
#PCCMSky Update
146 members- only 4 more slots in this starter pack
Repost so the noobs know who the cool PCCM kids are
Reply if you are not included and should be (make sure your creds are in your bio I am not putting randos on here)
go.bsky.app/88wg6oG
146 members- only 4 more slots in this starter pack
Repost so the noobs know who the cool PCCM kids are
Reply if you are not included and should be (make sure your creds are in your bio I am not putting randos on here)
go.bsky.app/88wg6oG
December 10, 2024 at 12:51 PM
#PCCMSky Update
146 members- only 4 more slots in this starter pack
Repost so the noobs know who the cool PCCM kids are
Reply if you are not included and should be (make sure your creds are in your bio I am not putting randos on here)
go.bsky.app/88wg6oG
146 members- only 4 more slots in this starter pack
Repost so the noobs know who the cool PCCM kids are
Reply if you are not included and should be (make sure your creds are in your bio I am not putting randos on here)
go.bsky.app/88wg6oG
Reposted by Jen A-Brett
Reposted by Jen A-Brett
"If talent and opportunity were equally distributed, the average winner would come from a middle income background.
The reality?
The average laureate grew up in a household just below the top 10%. More than 50% come from the top 5%"
By Torsten Bell
www.theguardian.com/commentisfre...
The reality?
The average laureate grew up in a household just below the top 10%. More than 50% come from the top 5%"
By Torsten Bell
www.theguardian.com/commentisfre...
The science behind winning a Nobel Prize? Being a man from a wealthy family | Torsten Bell
A lot of talent is wasted in a world where more than half of laureates come from households in the richest 5%
www.theguardian.com
December 8, 2024 at 2:59 PM
"If talent and opportunity were equally distributed, the average winner would come from a middle income background.
The reality?
The average laureate grew up in a household just below the top 10%. More than 50% come from the top 5%"
By Torsten Bell
www.theguardian.com/commentisfre...
The reality?
The average laureate grew up in a household just below the top 10%. More than 50% come from the top 5%"
By Torsten Bell
www.theguardian.com/commentisfre...