Tonya Zeczycki
@tnzeczycki.bsky.social
Physical biochemist | Mass spectrometrist | Director, BSOM MS core facilities | Associate Professor studying IDPs, allostery, and neurodegenerative diseases | Opinions all my own
Reposted by Tonya Zeczycki
Kingfisher: An open‐sourced web‐based platform for the analysis of hydrogen exchange mass spectrometry data onlinelibrary.wiley....
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#proteomics #prot-paper
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#proteomics #prot-paper
March 19, 2025 at 10:00 AM
Kingfisher: An open‐sourced web‐based platform for the analysis of hydrogen exchange mass spectrometry data onlinelibrary.wiley....
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#proteomics #prot-paper
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#proteomics #prot-paper
Reposted by Tonya Zeczycki
“You don't start out writing good stuff. You start out writing crap and thinking it's good stuff, and then gradually you get better at it. That's why I say one of the most valuable traits is persistence.”
― Octavia E. Butler
#WritingSky #AcademicSky
― Octavia E. Butler
#WritingSky #AcademicSky
March 14, 2025 at 1:49 PM
“You don't start out writing good stuff. You start out writing crap and thinking it's good stuff, and then gradually you get better at it. That's why I say one of the most valuable traits is persistence.”
― Octavia E. Butler
#WritingSky #AcademicSky
― Octavia E. Butler
#WritingSky #AcademicSky
Reposted by Tonya Zeczycki
Celebrate International Women's Day by reading the Special Issue of the Journal of Proteome Research, highlighting the essential contributions women scientists have made—and continue to make—in the fields of Proteomics and Metabolomics. ow.ly/eBcV50TWOpV #InternationalWomensDay 🧪
March 8, 2025 at 9:00 PM
Celebrate International Women's Day by reading the Special Issue of the Journal of Proteome Research, highlighting the essential contributions women scientists have made—and continue to make—in the fields of Proteomics and Metabolomics. ow.ly/eBcV50TWOpV #InternationalWomensDay 🧪
Reposted by Tonya Zeczycki
Reposted by Tonya Zeczycki
Upon learning that yesterday would be my last day as a program officer at the National Science Foundation, I shared this parting message with my colleagues. The next few months will be frenetic and stressful for them. Here are some things that you can do to help them with the mission ahead. (1)
February 19, 2025 at 7:08 PM
Upon learning that yesterday would be my last day as a program officer at the National Science Foundation, I shared this parting message with my colleagues. The next few months will be frenetic and stressful for them. Here are some things that you can do to help them with the mission ahead. (1)
Reposted by Tonya Zeczycki
Absolutely captivating article from @fraserlab.bsky.social and Mark Murcko! Very down to earth discussion on what protein "structures" really are
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
February 1, 2024 at 4:52 PM
Absolutely captivating article from @fraserlab.bsky.social and Mark Murcko! Very down to earth discussion on what protein "structures" really are
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Tonya Zeczycki
Radha follows up her work with a publication in Langmuir. She used NMR hydrogen exchange and methylation mass spec to probe the structure of a small protein binding to a polystyrene nanoparticle. She finds evidence consistent with the adsorbotope model. doi.org/10.1021/acs....
January 22, 2024 at 4:32 PM
Radha follows up her work with a publication in Langmuir. She used NMR hydrogen exchange and methylation mass spec to probe the structure of a small protein binding to a polystyrene nanoparticle. She finds evidence consistent with the adsorbotope model. doi.org/10.1021/acs....
#MassspecSOS
Here’s a good one for TeamMassSpec (I hope!)- I’m working on a small project which involves enrichment and MRM of circulating neuropeptides (from blood plasma).
Most are hydrophilic peptides (< 3 kDa), 1 is amphipathic (~60 kDa).
Most are hydrophilic peptides (< 3 kDa), 1 is amphipathic (~60 kDa).
January 19, 2024 at 12:49 PM
#MassspecSOS
Reposted by Tonya Zeczycki
Here’s a good one for TeamMassSpec (I hope!)- I’m working on a small project which involves enrichment and MRM of circulating neuropeptides (from blood plasma).
Most are hydrophilic peptides (< 3 kDa), 1 is amphipathic (~60 kDa).
Most are hydrophilic peptides (< 3 kDa), 1 is amphipathic (~60 kDa).
January 18, 2024 at 8:20 PM
Here’s a good one for TeamMassSpec (I hope!)- I’m working on a small project which involves enrichment and MRM of circulating neuropeptides (from blood plasma).
Most are hydrophilic peptides (< 3 kDa), 1 is amphipathic (~60 kDa).
Most are hydrophilic peptides (< 3 kDa), 1 is amphipathic (~60 kDa).
Reposted by Tonya Zeczycki
Anyone with experience of converting Waters .raw files into mzML (or something) that can be searched with Fragpipe and other software? MS Convert settings that work would be very helpful. #MassSOS
January 8, 2024 at 4:21 AM
Anyone with experience of converting Waters .raw files into mzML (or something) that can be searched with Fragpipe and other software? MS Convert settings that work would be very helpful. #MassSOS
Reposted by Tonya Zeczycki
Pls reskeet: We're accepting PhD apps to Syracuse University Biology! (Priority deadline of 1/4/24) Join a vibrant department: we are also recruiting three new faculty in epigenetics and neuroscience! Labs actively recruiting grad students are here: artsandsciences.syracuse.edu/biology/grad...
December 28, 2023 at 9:58 PM
Pls reskeet: We're accepting PhD apps to Syracuse University Biology! (Priority deadline of 1/4/24) Join a vibrant department: we are also recruiting three new faculty in epigenetics and neuroscience! Labs actively recruiting grad students are here: artsandsciences.syracuse.edu/biology/grad...
#massspecsos Best way/software for peptide mapping from limited proteolysis or full proteolysis experiments for a single, purified recombinant protein? Something that I can use/search against the Fasta for so the search would be our protein and contaminants with Thermo data.
December 21, 2023 at 1:05 PM
#massspecsos Best way/software for peptide mapping from limited proteolysis or full proteolysis experiments for a single, purified recombinant protein? Something that I can use/search against the Fasta for so the search would be our protein and contaminants with Thermo data.
Reposted by Tonya Zeczycki
A new season of #TheProteomicsShow with me and @proteomicsnews.bsky.social?!!!
Find it wherever you podcast and expect a weekly-ish release schedule to bath your ears in proteomic goodness.
Find it wherever you podcast and expect a weekly-ish release schedule to bath your ears in proteomic goodness.
December 1, 2023 at 6:43 PM
A new season of #TheProteomicsShow with me and @proteomicsnews.bsky.social?!!!
Find it wherever you podcast and expect a weekly-ish release schedule to bath your ears in proteomic goodness.
Find it wherever you podcast and expect a weekly-ish release schedule to bath your ears in proteomic goodness.
Reposted by Tonya Zeczycki
Learning my way around Bluesky; hoping to re-establish the many awesome scientific connections from X!
We are a molecular biophysics lab also doing cell biology to better understand protein quality control mechanisms in ALS and other neurodegenerative disorders; keen on IDPs, condensates, and NMR!
We are a molecular biophysics lab also doing cell biology to better understand protein quality control mechanisms in ALS and other neurodegenerative disorders; keen on IDPs, condensates, and NMR!
November 22, 2023 at 1:01 AM
Learning my way around Bluesky; hoping to re-establish the many awesome scientific connections from X!
We are a molecular biophysics lab also doing cell biology to better understand protein quality control mechanisms in ALS and other neurodegenerative disorders; keen on IDPs, condensates, and NMR!
We are a molecular biophysics lab also doing cell biology to better understand protein quality control mechanisms in ALS and other neurodegenerative disorders; keen on IDPs, condensates, and NMR!
Reposted by Tonya Zeczycki
A novel clinical metaproteomics workflow enables bioinformatic analysis of host-microbe dynamics in disease https://www.biorxiv.org/content/10.1101/2023.11.21.568121v1
A novel clinical metaproteomics workflow enables bioinformatic analysis of host-microbe dynamics in disease https://www.biorxiv.org/content/10.1101/2023.11.21.568121v1
Clinical metaproteomics has the potential to offer insights into the host-microbiome interactions un
www.biorxiv.org
November 22, 2023 at 5:50 PM
A novel clinical metaproteomics workflow enables bioinformatic analysis of host-microbe dynamics in disease https://www.biorxiv.org/content/10.1101/2023.11.21.568121v1
Reposted by Tonya Zeczycki
A Review of Fifteen Years Developing Computational Tools to Study Protein Aggregation www.mdpi.com/2673-41...
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#proteomics #prot-paper
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#proteomics #prot-paper
November 23, 2023 at 9:40 AM
A Review of Fifteen Years Developing Computational Tools to Study Protein Aggregation www.mdpi.com/2673-41...
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#proteomics #prot-paper
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#proteomics #prot-paper
Reposted by Tonya Zeczycki
A true tour de force by Ben Orsburn ( @proteomicsnews.bsky.social) killing it with some metabolomic and proteomic badassery. Well done!
Metabolomic, Proteomic, and Single-Cell Proteomic Analysis of Cancer Cells Treated with the KRASG12D...
Mutations in KRAS are common drivers of human cancers and are often those with the poorest overall prognosis for patients. A recently developed compound, MRTX1133, has shown promise in inhibiting the ...
pubs.acs.org
November 20, 2023 at 7:55 PM
A true tour de force by Ben Orsburn ( @proteomicsnews.bsky.social) killing it with some metabolomic and proteomic badassery. Well done!
Reposted by Tonya Zeczycki
To all you #TeamMassSpec and proteomics tweeps who came over, or maybe came over and left, read this blog post: federation is real.
It's been exactly a year since the very first post on Bluesky was created!
We just published a new blog post with some updates:
We just published a new blog post with some updates:
Toward Federation and an Open Network
One year ago, the first post on Bluesky was created. Now, we're working toward federation and a truly open network.
blueskyweb.xyz
November 16, 2023 at 11:27 PM
To all you #TeamMassSpec and proteomics tweeps who came over, or maybe came over and left, read this blog post: federation is real.
Reposted by Tonya Zeczycki
Wait, The Proteomics Show is one years old today?!!! 7300 listens later and no one has told us to stop, but @proteomicsnews.bsky.social said that would accomplish the opposite anyways, so 🤷♂️.
Glad people are liking it, we definitely are enjoying doing it. So thanks!
Glad people are liking it, we definitely are enjoying doing it. So thanks!
The Proteomics Show • A podcast on Spotify for Podcasters
Ben Orsburn and Ben Neely co-host a podcast series in a “fireside chat” format with prestigious proteomics researchers. The guests are great, the hosts are questionable.
anchor.fm
November 15, 2023 at 8:58 PM
Wait, The Proteomics Show is one years old today?!!! 7300 listens later and no one has told us to stop, but @proteomicsnews.bsky.social said that would accomplish the opposite anyways, so 🤷♂️.
Glad people are liking it, we definitely are enjoying doing it. So thanks!
Glad people are liking it, we definitely are enjoying doing it. So thanks!
Okay my MS peeps- I feel like I am going crazy. I *thought* I read there is a way to calculate a "threshold"/limits for significant fold-changes in a data set based on CV/confidence intervals or something. Arbitrarily going with 2-fold change in abundances as sig always makes me uncomfortable.
November 15, 2023 at 2:29 AM
Okay my MS peeps- I feel like I am going crazy. I *thought* I read there is a way to calculate a "threshold"/limits for significant fold-changes in a data set based on CV/confidence intervals or something. Arbitrarily going with 2-fold change in abundances as sig always makes me uncomfortable.
Reposted by Tonya Zeczycki
Can you believe it’s time for the Proteomics Old-Time Radio Hour again?! This Wednesday at 10am Pacific/1pm eastern with me, @leannewg.bsky.social, @ucdproteomics.bsky.social and you! Join on clubhouse and bring your friends/questions/topics/secrets.
Proteomics Old-Time Radio Hour - Clubhouse
Huuuge group voice notes with all of your friends
www.clubhouse.com
November 6, 2023 at 8:58 PM
Can you believe it’s time for the Proteomics Old-Time Radio Hour again?! This Wednesday at 10am Pacific/1pm eastern with me, @leannewg.bsky.social, @ucdproteomics.bsky.social and you! Join on clubhouse and bring your friends/questions/topics/secrets.
Conversation in my house tonight:
Me: Really? You fell asleep at 2 am? When I came to bed at midnight you were snoring.
Him (slightly insulted): I don't snore. I "breathe agressively".
Me:🤨
Him:😁
Me: You snore.
Me: Really? You fell asleep at 2 am? When I came to bed at midnight you were snoring.
Him (slightly insulted): I don't snore. I "breathe agressively".
Me:🤨
Him:😁
Me: You snore.
November 5, 2023 at 10:10 PM
Conversation in my house tonight:
Me: Really? You fell asleep at 2 am? When I came to bed at midnight you were snoring.
Him (slightly insulted): I don't snore. I "breathe agressively".
Me:🤨
Him:😁
Me: You snore.
Me: Really? You fell asleep at 2 am? When I came to bed at midnight you were snoring.
Him (slightly insulted): I don't snore. I "breathe agressively".
Me:🤨
Him:😁
Me: You snore.
Reposted by Tonya Zeczycki
November 3, 2023 at 11:53 AM
Reposted by Tonya Zeczycki
@rcsbpdb.bsky.social has joined Bluesky! Please follow them and post to them. Let's form a strong structural biology community on this site as the bird site continues to descend into...
November 1, 2023 at 9:26 PM
@rcsbpdb.bsky.social has joined Bluesky! Please follow them and post to them. Let's form a strong structural biology community on this site as the bird site continues to descend into...
Reposted by Tonya Zeczycki
The final episode of #TheProteomicsShow Faces of US HUPO series (well, maybe a special is on deck 😉).
@proteomicsnews.bsky.social and I sat down with @garcialabms.bsky.social. Definitely deserves a listen. 🧪
Find it here or anywhere you find podcasts.
#proteomics
@proteomicsnews.bsky.social and I sat down with @garcialabms.bsky.social. Definitely deserves a listen. 🧪
Find it here or anywhere you find podcasts.
#proteomics
The Proteomics Show • A podcast on Spotify for Podcasters
Ben Orsburn and Ben Neely co-host a podcast series in a “fireside chat” format with prestigious proteomics researchers. The guests are great, the hosts are questionable.
anchor.fm
October 27, 2023 at 11:12 AM
The final episode of #TheProteomicsShow Faces of US HUPO series (well, maybe a special is on deck 😉).
@proteomicsnews.bsky.social and I sat down with @garcialabms.bsky.social. Definitely deserves a listen. 🧪
Find it here or anywhere you find podcasts.
#proteomics
@proteomicsnews.bsky.social and I sat down with @garcialabms.bsky.social. Definitely deserves a listen. 🧪
Find it here or anywhere you find podcasts.
#proteomics